Journal
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
Volume 12, Issue 9, Pages 1622-1627Publisher
SPRINGERNATURE
DOI: 10.1039/c3pp50039j
Keywords
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Funding
- Ministry of Science and Higher Education (MNiSW) [IP2010 010970]
- National Centre for Research and Development [LIDER/32/36/L-2/10/NCRiR/2011]
- European Social Fund
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Staphylococcus aureus is a common etiological factor in infections of burns and other chronic wounds. The development of an effective and fast-acting treatment would be enormously beneficial and is highly desired. We focused on testing the bactericidal efficacy of photoinactivation using a known photosensitizer (protoporphyrin IX, PPIX) in sequential combination with silver nanoparticles against S. aureus. Using PPIX-based photoinactivation followed by silver nanoparticles we obtained a high bactericidal effect (7 log(10) units reduction) with limited harmful effects on human epidermal keratinocytes. Moreover, we observed that the use of silver nanoparticles prevents bacterial re-growth 24 h post-PDI treatment. A sequential combination of photoinactivation and silver nanoparticles represents a potentially effective antibacterial approach.
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