4.1 Article Proceedings Paper

SYNTHESIS OF CONFORMATIONALLY CONSTRAINED ANALOGUES OF BIOACTIVE AMINO ACIDS BASED ON ASYMMETRIC CYCLOPROPANATION

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Publisher

TAYLOR & FRANCIS LTD
DOI: 10.1080/10426507.2010.527311

Keywords

Asymmetric synthesis; cyclopropanes; neurotransmitters; sulfonium ylides; sulfoxides

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Multistep syntheses of selected constrained amino acids were performed, where asymmetric cyclopropanation using sulfinyl auxiliary was the crucial step of the conversion. The influence of cyclopropane structure on regio- and stereoselectivity of sulfoxide removal is described.

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