Journal
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
Volume 185, Issue 12, Pages 2543-2550Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10426501003752161
Keywords
Analgesic; anti-inflammatory; antimicrobial activities; pyrimidoselenolo quinolines; pyrimidoselenolo triazolo quinolines; quinolines
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A new series of selenolo[2,3-b]quinoline, pyrimido[4',5':4,5]selenolo[2,3-b]quinoline, pyrimido[4',5':4,5]selenolo[2,3-b]-[1,2,4'triazolo[1,5-c]quinoline, and pyrimido[4',5':4,5]selenolo[2,3-b][1,2,4]triazolo[4,3-c]quinoline derivatives were prepared starting from diquinolinyl diselenide or 3-cyano-4-methylquinoline-2(1H)selenone with chloro acetonitrile or chloro acetamide. Elemental analysis, IR, 1H NMR, 13C NMR, and mass spectral data confirmed the structure of the newly synthesized compounds. In addition, the most active compounds were tested for their acute toxicity. Moreover, some of the tested compounds were screened for their antibacterial and antifungal activities. The minimum inhibitory concentration (MIC) of the most active compounds was 100 mg mL-1. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file.
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