Journal
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
Volume 363, Issue 1503, Pages 2519-2527Publisher
ROYAL SOC
DOI: 10.1098/rstb.2008.0037
Keywords
antisocial behaviour; genetic; environmental risk; callous-unemotional
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Funding
- Medical Research Council [G0401170] Funding Source: Medline
- Department of Health [MRD 12-37] Funding Source: Medline
- MRC [G0401170] Funding Source: UKRI
- Medical Research Council [G0401170] Funding Source: researchfish
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This paper will broadly review the currently available twin and adoption data on antisocial behaviour ( AB). It is argued that quantitative genetic research can make a significant contribution to further the understanding of how AB develops. Genetically informative study designs are particularly useful for investigating several important questions such as whether: the heritability estimates vary as a function of assessment method or gender; the relative importance of genetic and environmental influences varies for different types of AB; the environmental risk factors are truly environmental; and genetic vulnerability influences susceptibility to environmental risk. While the current data are not yet directly translatable for prevention and treatment programmes, quantitative genetic research has concrete translational potential. Quantitative genetic research can supplement neuroscience research in informing about different subtypes of AB, such as AB coupled with callous - unemotional traits. Quantitative genetic research is also important in advancing the understanding of the mechanisms by which environmental risk operates.
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