Article
Pediatrics
Tingyan He, Yu Xia, Ying Luo, Jun Yang
Summary: This study aimed to evaluate the efficacy and potential adverse effects of JAKi in patients with systemic juvenile idiopathic arthritis (SJIA). The results showed that JAKi may be an alternative or adjuvant agent for patients with persistently active disease, glucocorticoid-related adverse reactions, or SJIA-MAS.
FRONTIERS IN PEDIATRICS
(2023)
Article
Immunology
Shuya Kaneko, Masaki Shimizu, Futaba Miyaoka, Asami Shimbo, Hitoshi Irabu, Mao Mizuta, Yasuo Nakagishi, Naomi Iwata, Junya Fujimura, Masaaki Mori, Tomohiro Morio
Summary: This study validates the correlation between laboratory markers reflecting disease activity of macrophage activation syndrome (MAS) and serum cytokine levels, and identifies valuable laboratory markers that change over time for a prompt MAS diagnosis.
CLINICAL IMMUNOLOGY
(2023)
Review
Rheumatology
Claas H. Hinze, Dirk Foell, Christoph Kessel
Summary: Systemic juvenile idiopathic arthritis (sJIA) is a disease characterized by severe systemic inflammation and arthritis. It poses challenges to rheumatologists treating pediatric and adult patients worldwide. Although treatment plans exist for classic sJIA, there is still a lack of clear treatment approaches for early sJIA without arthritis and complicated sJIA.
NATURE REVIEWS RHEUMATOLOGY
(2023)
Article
Pediatrics
Ellen Go, Mira van Veenendaal, Cedric Manlhiot, Rayfel Schneider, Brian W. McCrindle, Rae S. M. Yeung
Summary: This study describes the disease course of a small proportion of patients with both Kawasaki disease and systemic juvenile idiopathic arthritis, characterized by refractory Kawasaki disease, high prevalence of coronary artery dilatation, and shared immunopathology potentially linking the two conditions.
FRONTIERS IN PEDIATRICS
(2021)
Article
Rheumatology
Rosemary G. Peterson, Rui Xiao, Karen E. James, Hannah Katcoff, Brian T. Fisher, Pamela F. Weiss
Summary: The study found significant variation in the use of biologics and glucocorticoids in children hospitalized with new-onset systemic JIA, with noticeable differences between hospitals. Despite increasing evidence supporting the use of biologics for improved outcomes, many children did not receive biologic treatment and a high rate of glucocorticoid exposure persisted.
ARTHRITIS CARE & RESEARCH
(2021)
Review
Rheumatology
Eduardo Liquidano-Perez, Gibert Maza-Ramos, Jose Luis Salazar-Bailon, Marco Antonio Yamazaki-Nakashimada, Francisco Rivas-Larrauri
Summary: This study presents a refractory case of soJIA complicated with MAS successfully treated with plasma exchange, resulting in significant improvement.
RHEUMATOLOGY INTERNATIONAL
(2022)
Article
Rheumatology
Masaki Shimizu, Kenichi Nishimura, Naomi Iwata, Takahiro Yasumi, Hiroaki Umebayashi, Yasuo Nakagishi, Yuka Okura, Nami Okamoto, Noriko Kinjo, Mao Mizuta, Masato Yashiro, Junko Yasumura, Hiroyuki Wakiguchi, Tomohiro Kubota, Mariko Mouri, Utako Kaneko, Masaaki Mori
Summary: A multicenter, retrospective study in Japan revealed that the first-line treatment for MAS in pediatric rheumatology institutes is methylprednisolone pulse therapy and/or cyclosporine A. Dexamethasone palmitate (DEX-P) can be considered as an effective and safe therapeutic option for patients with corticosteroid-resistant MAS.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Article
Pediatrics
Mikhail M. Kostik, Eugenia A. Isupova, Konstantin Belozerov, Tatyana S. Likhacheva, Evgeny N. Suspitsin, Rinat Raupov, Vera V. Masalova, Irina A. Chikova, Margarita F. Dubko, Olga V. Kalashnikova, Vyacheslav G. Chasnyk, Randy Q. Cron
Summary: This study provides evidence for the efficacy and safety of short-term increased doses (2-3 times normal) of canakinumab in treating MAS associated with sJIA. Further research on the efficacy and safety of increased doses of canakinumab for the treatment of MAS in children with sJIA is warranted.
FRONTIERS IN PEDIATRICS
(2022)
Review
Rheumatology
Emely L. Verweyen, Grant S. Schulert
Summary: Systemic JIA (SJIA) is characterized by severe complications, including macrophage activation syndrome (SJIA-MAS) and lung disease (SJIA-LD), which are driven by interferons (IFNs) and involve the JAK-STAT signaling pathway. New therapeutic advances, such as JAK inhibitors and antibodies targeting IFNs, are urgently needed to address the divergent disease pathogenesis observed in SJIA.
Review
Medicine, General & Internal
Charlotte Girard-Guyonvarc'h, Mathilde Harel, Cem Gabay
Summary: This review summarizes the role and importance of IL-18 and IL-18BP in AOSD and sJIA. It is found that the imbalance of IL-18/IL-18BP is associated with the occurrence of these diseases, and treatment with recombinant IL-18BP shows potential therapeutic effects.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Rheumatology
R. Naveen, Avinash Jain, Hafis Muhammed, Latika Gupta, Durga P. Misra, Able Lawrence, Vikas Agarwal, Ramnath Misra, Amita Aggarwal
Summary: This study compared the clinical and laboratory parameters of MAS in SLE and sJIA, finding that the two diseases are more similar than dissimilar in clinical features and outcome. The criteria meant for MAS in sJIA or SLE-MAS performed equally well in diagnosing both diseases.
RHEUMATOLOGY INTERNATIONAL
(2021)
Article
Pediatrics
Christopher Towe, Alexei A. Grom, Grant S. Schulert
Summary: Chronic lung disease in children with systemic juvenile idiopathic arthritis (SJIA-LD) is a potentially life-threatening complication. The optimal approaches to diagnosis and management of SJIA-LD are still unclear. This review discusses the current clinical understanding of SJIA-LD, including its potential pathogenesis and treatment options, and highlights the urgent unmet needs in this area.
Article
Multidisciplinary Sciences
Chao-Yi Wu, Wen-Lang Fan, Ying-Ming Chiu, Huang-Yu Yang, Wen- Lee, Jing-Long Huang
Summary: The study found that inflammatory cytokines in plasma and PBMC response levels can help differentiate CAPS and persistent sJIA. In stimulation assays, CAPS PBMCs showed stronger responses to LPS inflammasome stimulation.
SCIENTIFIC REPORTS
(2021)
Article
Rheumatology
Jianqiang Wu, Li Sun, Xuemei Tang, Qi Zheng, Li Guo, Li Xu, Yandie Li, Meiping Lu
Summary: This study retrospectively analyzed clinical data of 14 patients with sJIA-rMAS who failed conventional therapies and were treated with TCZ. The results showed that TCZ could safely and effectively improve the clinical symptoms and laboratory indicators of sJIA-rMAS, with no disease relapse or fatality recorded.
MODERN RHEUMATOLOGY
(2022)
Article
Pediatrics
A. Felix, F. Delion, B. Suzon, S. Pallara-Sirven, N. Elenga, P. Quartier, F. Louis-Sidney, M. Drame, Y. Hatchuel
Summary: This study describes the epidemiology and clinical presentation of systemic juvenile idiopathic arthritis (sJIA) in the Afro-Caribbean population. The findings suggest some specificities, such as a higher rate of macrophage activation syndrome (MAS) and coronary involvement at onset. Overall outcomes during childhood were similar to western countries.
PEDIATRIC RHEUMATOLOGY
(2022)
Article
Rheumatology
Damla Kaynak, Mehmet Yildiz, Sezgin Sahin, Fatih Haslak, Aybuke Gunalp, Amra Adrovic, Kenan Barut, Mehmet Guven Gunver, Ozgur Kasapcopur, Selcuk Dasdemir
Summary: Although most autoinflammatory disorders have a known genetic cause, the genetic background of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome remains unclear. Variants in infammasome-associated genes such as CARD8, NLRP3, and MEFV have been found to contribute to the development of PFAPA syndrome. However, no statistically significant differences were observed in the frequencies of NLRP3 polymorphisms or NLRP3 serum levels between PFAPA patients and healthy controls. Mutations in the MEFV gene were detected in a subset of PFAPA patients.
CLINICAL RHEUMATOLOGY
(2023)
Article
Rheumatology
Pamela F. Weiss, Timothy G. Brandon, Robert G. Lambert, David M. Biko, Nancy A. Chauvin, Michael L. Francavilla, Jacob L. Jaremko, Nele Herregods, Ozgur Kasapcopur, Mehmet Yildiz, Alison M. Hendry, Walter P. Maksymowych
Summary: This study aims to determine quantitative cutoffs for active and structural lesions in sacroiliac joint MRI that will be included in the classification criteria of axial disease in juvenile spondyloarthritis. MRI scans from juvenile SpA patients were reviewed by experts and optimal cutoffs for defining lesions typical of axial disease were determined. The cutoffs were validated in an independent cohort.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Pediatrics
Chiara De Mutiis, Scott E. Wenderfer, Biswanath Basu, Arvind Bagga, Alvaro Orjuela, Tanmoy Sar, Amita Aggarwal, Avinash Jain, Hui-Kim Yap, Sharon Teo, Shuichi Ito, Ai Ohnishi, Naomi Iwata, Ozgur Kasapcopur, Mehmet Yildiz, Audrey Laurent, Antonio Mastrangelo, Masao Ogura, Yuko Shima, Pornpimol Rianthavorn, Clovis A. Silva, Vitor Trindade, Alessandra Gianviti, Miyazono Akinori, Riku Hamada, Junya Fujimura, Shogo Minamikawa, Naohiro Kamiyoshi, Hiroshi Kaito, Shingo Ishimori, Francesco Iannuzzella, Kjell Tullus
Summary: In this study, the clinical presentation, treatment, and 24-month kidney outcome of 382 children with lupus nephritis were retrospectively analyzed. The rate of complete remission was found to be low, and severe kidney involvement at diagnosis was identified as the most important risk factor for not achieving stable remission.
PEDIATRIC NEPHROLOGY
(2023)
Article
Rheumatology
Ezgi Deniz Batu, Seher Sener, Elif Arslanoglu Aydin, Emil Aliyev, Ilknur Bagrul, Seyma Turkmen, Ozlem Akgun, Zeynep Balik, Ayse Tanatar, Yagmur Bayindir, Zehra Kizildag, Ruya Torun, Aybuke Gunalp, Taner Coskuner, Rana Isguder, Tuncay Aydin, Fatih Haslak, Muserref Kasap Cuceoglu, Esra Esen, Ulas Akcay, Oezge Basaran, Aysenur Pac Kisaarslan, Fuat Akal, Deniz Yuce, Semanur Ozdel, Mehmet Bulbul, Yelda Bilginer, Nuray Aktay Ayaz, Betul Sozeri, Ozgur Kasapcopur, Erbil Unsal, Seza Ozen
Summary: The study aimed to compare the characteristics of colchicine-resistant and colchicine-responsive patients with familial Mediterranean fever (FMF) and develop a score for predicting colchicine resistance at the time of FMF diagnosis. The researchers found that colchicine-resistant patients had longer, more frequent attacks and were younger at symptom onset. By developing a score that includes age at symptom onset, attack frequency, arthritis, chest pain, and two exon 10 gene mutations, colchicine resistance can be predicted more accurately.
Article
Rheumatology
A. Adrovic, G. Karatemiz, S. N. Esatoglu, M. Yildiz, S. Sahin, K. Barut, S. Ugurlu, G. Hatemi, O. Kasapcopur, E. Seyahi
Summary: This study compared the clinical features, treatment modalities, and survival rates between juvenile-onset and adult-onset systemic sclerosis. The results showed that adult-onset patients had a higher frequency of interstitial lung disease and systemic hypertension, while juvenile-onset patients had a higher frequency of diffuse cutaneous subset. The mortality rate was higher among adults. Age, interstitial lung disease, and cardiac insufficiency were independent risk factors for mortality. Therefore, pediatric and adult-onset systemic sclerosis have different clinical phenotypes, and pediatric patients have better survival rates.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Article
Rheumatology
Aysenur Pac Kisaarslan, Sumeyra Ozdemir Cicek, Ezgi D. Batu, Sezgin Sahin, Metin K. Gurgoze, Sibel Balci Cetinkaya, Miray Kisla Ekinci, Bahriye Atmis, Kenan Barut, Amra Adrovic, Buket Esen Agar, Nihal Sahin, Ferhat Demir, Esra Baglan, Mehtap Akbalik Kara, Senay Zirhli Selcuk, Semanur Ozdel, Elif Comak, Betuel Akkoyunlu, Guelcin Otar Yener, Deniz Gezgin Yildirim, Kubra Ozturk, Mehmet Yildiz, Fatih Haslak, Seher Sener, Hakan Kisaoglu, Oezge Baba, Zehra Kizildag, Rana Isguder, Senguel Caglayan, Raziye B. Gueven Bilgin, Guelcin Aytac, Burcu Bozkaya Yucel, Ayse Tanatar, Hafize E. Sonmez, Mustafa Cakan, Aslihan Kara, Ahmet T. Elmas, Beltinge Demircioglu Kilic, Nuray Aktay Ayaz, Belde Kasap, Banu Celikel Acar, Ozan Ozkaya, Selcuk Yueksel, Sevcan Bakkaloglu, Ozlem Aydog, Guzide Aksu, Sema Akman, Osman Donmez, Mehmet Bulbul, Mithat Buyukcelik, Yilmaz Tabel, Betuel Sozeri, Mukaddes Kalyoncu, Yelda Bilginer, Muammer H. Poyrazoglu, Erbil Unsal, Ozgur Kasapcopur, Seza Ozen, Ruhan Dusunsel
Summary: This study investigated the prevalence, demographic and clinical features, and outcomes of neurological involvement in Turkish juvenile-onset systemic lupus erythematosus (jSLE) patients. The results showed that neuropsychiatric involvement is common in jSLE, with headache, seizure, and acute confusional state being the most common symptoms.
Article
Rheumatology
Ezgi Deniz Batu, Aybuke Gunalp, Sezgin Sahin, Semanur Ozdel, Zehra Kizildag, Aysenur Pac Kisaarslan, Ilknur Bagrul, Muserref Kasap Cuceoglu, Ayse Tanatar, Hafize Emine Sonmez, Erdal Sag, Selcan Demir, Elif Celikel, Sengul Caglayan, Banu Celikel Acar, Betul Sozeri, Nuray Aktay Ayaz, Yelda Bilginer, M. Hakan Poyrazoglu, Erbil Unsal, Oezgur Kasapcopur, Seza Ozen
Summary: This study compared the characteristics and outcomes of pediatric MCTD and other overlap syndromes, finding differences in disease phenotype and prognosis. MCTD may be considered a more severe disease. Analyzing these patients could pave the way for early and effective treatment.
RHEUMATOLOGY INTERNATIONAL
(2023)
Article
Rheumatology
Sinem Oral Cebeci, Mehmet Yildiz, Aybuke Gunalp, Memnune Nur Cebi, Berivan Kilinc, Eymen Pinar, Elif Kilic Konte, Esma Aslan, Fatih Haslak, Amra Adrovic, Sezgin Sahin, Kenan Barut, Ozgur Kasapcopur
Summary: The aim of this retrospective study was to evaluate the efficacy of a single-dose anakinra during familial Mediterranean fever (FMF) attacks and its effect on the duration, severity, and frequency of attacks. The study found that a single dose of anakinra was effective in reducing the severity and duration of FMF attacks. Although prospective studies are needed to confirm these findings, the results suggest that the use of a single-dose anakinra during FMF attacks is promising.
RHEUMATOLOGY INTERNATIONAL
(2023)
Article
Pediatrics
Fatih Haslak, Vafa Guliyeva, Busra Hotaman, Cisem Duman, Mehmet Yildiz, Aybuke Gunalp, Esma Aslan, Elif Kilic Konte, Ayten Aliyeva, Amra Adrovic, Sezgin Sahin, Kenan Barut, Ozgur Kasapcopur
Summary: This study aimed to identify the non-rheumatic comorbidities in juvenile idiopathic arthritis (JIA) patients. The study included 459 patients with female dominance (62.1%, n = 285). The most common non-rheumatic accompanying medical conditions in the patients were allergic rhinitis (n = 37, 8.1%), attention-deficit hyperactivity disorder (n = 35, 7.6%), and atopic dermatitis (n = 28, 6.1%).
TURKISH ARCHIVES OF PEDIATRICS
(2023)
Article
Pediatrics
Serkan Turkucar, Ummusen Akca Kaya, Figen Cakmak, Fatih Haslak, Ferhat Demir, Erdem Karabulut, Balahan Makay, Yelda Bilginer, Nuray Aktay Ayaz, Betul Sozeri, Ozgur Kasapcopur, Tevfik Karagoz, Nurettin Unal, Seza Ozen, Erbil Unsal
Summary: This study aimed to identify the risk factors for coronary arterial lesions (CALs) in Turkish children with Kawasaki disease (KD). The results showed that age <= 12 months, male gender, and duration of fever before IVIG >= 9.5 days were identified as independent risk factors for predicting CALs in Turkish children with KD. These findings provide useful insights for choosing appropriate treatment and follow-up for KD to prevent coronary artery involvement.
TURKISH JOURNAL OF PEDIATRICS
(2023)
Article
Rheumatology
Huseyin Kilic, Sezgin Sahin, Mekiya Filiz Toprak, Gokce Hale Hatay, Kubra Yilmaz, Amra Adrovic, Kenan Barut, Esin Ozturk Isik, Erdem Tuzun, Osman Kizilkilic, Sema Saltik, Ozgur Kasapcopur
Summary: The study found no association between MOG-Ab and cSLE, regardless of the presence of neuropsychiatric symptoms. Since no patients had positive MOG-Ab and there was no difference in choline, choline/creatine between groups, a causal relationship between immune-mediated myelinopathy and cognitive impairment could not be suggested.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
Article
Pediatrics
Elif Kilic Konte, Fatih Haslak, Mehmet Yildiz, Neslihan Gucuyener, Ipek Ulkersoy, Aybuke Gunalp, Esma Aslan, Amra Adrovic, Sezgin Sahin, Kenan Barut, Ozgur Kasapcopur
Summary: This study aimed to investigate the demographic and clinical characteristics of children with both FMF and PFAPA syndromes and their response to colchicine and tonsillectomy. The results showed that patients with tonsillopharyngitis, aphthous stomatitis, and PFAPA family history were more likely to be colchicine-resistant and tonsillectomy responsive, while those with exon 10 MEFV gene mutations were more prone to have a favorable response to colchicine.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Rheumatology
Yavuz Ozer, Mehmet Yildiz, Hande Turan, Gurkan Tarcin, Dilek Bingol Aydin, Aybuke Gunalp, Fatih Haslak, Elif Kilic Konte, Esma Aslan, Oya Koker, Elvan Bayramoglu, Sezgin Sahin, Amra Adrovic, Kenan Barut, Ozgur Kasapcopur, Olcay Evliyaoglu
Summary: This study aims to evaluate the effect of juvenile idiopathic arthritis (JIA) and biologic disease-modifying anti-rheumatic drugs (bDMARDs) on ovarian reserve in children. The results show that bDMARDs are reassuring in terms of ovarian reserve in girls with JIA, as they have little impact on anti-Mullerian hormone (AMH).
CLINICAL RHEUMATOLOGY
(2023)