Early Experience with Tedizolid: Clinical Efficacy, Pharmacodynamics, and Resistance

Rapid Emergence of Resistance to Linezolid and Mutator Phenotypes in Staphylococcus aureus Isolates from an Adult Cystic Fibrosis Patient

(2013) Asmaa Tazi et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In Vitro,In Vivo, and Clinical Studies of Tedizolid To Assess the Potential for Peripheral or Central Monoamine Oxidase Interactions

(2013) S. Flanagan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Characterization and monitoring of linezolid-resistant clinical isolates of Staphylococcus epidermidis in an intensive care unit 4 years after an outbreak of infection by cfr-mediated linezolid-resistant Staphylococcus aureus

(2013) Elvira Baos et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

Presence and dissemination of the multiresistance gene cfr in Gram-positive and Gram-negative bacteria

(2013) J. Shen et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Emergence of cfr-harbouring coagulase-negative staphylococci among patients receiving linezolid therapy in two hospitals in China

(2013) X.-J. Yang et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Pharmacokinetics of Tedizolid Following Oral Administration: Single and Multiple Dose, Effect of Food, and Comparison of Two Solid Forms of the Prodrug

(2013) Shawn D. Flanagan et al.   PHARMACOTHERAPY

Pulmonary Disposition of Tedizolid following Administration of Once-Daily Oral 200-Milligram Tedizolid Phosphate in Healthy Adult Volunteers

(2012) Seth T. Housman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Comparative Pharmacodynamics of the New Oxazolidinone Tedizolid Phosphate and Linezolid in a Neutropenic Murine Staphylococcus aureus Pneumonia Model

(2012) Alexander J. Lepak et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Comparative Efficacies of Human Simulated Exposures of Tedizolid and Linezolid against Staphylococcus aureus in the Murine Thigh Infection Model

(2012) R. A. Keel et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Pharmacokinetics and Pulmonary Disposition of Tedizolid and Linezolid in a Murine Pneumonia Model under Variable Conditions

(2012) Rebecca A. Keel et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

ComparativeIn VivoEfficacies of Epithelial Lining Fluid Exposures of Tedizolid, Linezolid, and Vancomycin for Methicillin-Resistant Staphylococcus aureus in a Mouse Pneumonia Model

(2012) Pamela R. Tessier et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Novel and uncommon antimicrobial resistance genes in livestock-associated methicillin-resistant Staphylococcus aureus

(2012) K. Kadlec et al.   CLINICAL MICROBIOLOGY AND INFECTION

Skin and soft tissue concentrations of tedizolid (formerly torezolid), a novel oxazolidinone, following a single oral dose in healthy volunteers

(2012) Martina Sahre et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Resistance to linezolid in a methicillin-susceptible Staphylococcus aureus clinical isolate without previous exposure to oxazolidinones

(2012) Immaculada Quiles-Melero et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Intensive care unit dissemination of multiple clones of linezolid-resistant Enterococcus faecalis and Enterococcus faecium

(2012) E. Ntokou et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

In VivoPharmacodynamics of Torezolid Phosphate (TR-701), a New Oxazolidinone Antibiotic, against Methicillin-Susceptible and Methicillin-Resistant Staphylococcus aureus Strains in a Mouse Thigh Infection Model

(2011) Arnold Louie et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Impact of Granulocytes on the Antimicrobial Effect of Tedizolid in a Mouse Thigh Infection Model

(2011) G. L. Drusano et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Structure-Activity Relationships of Diverse Oxazolidinones for Linezolid-Resistant Staphylococcus aureus Strains Possessing the cfr Methyltransferase Gene or Ribosomal Mutations

(2010) J. B. Locke et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Phase 2, Randomized, Double-Blind, Dose-Ranging Study Evaluating the Safety, Tolerability, Population Pharmacokinetics, and Efficacy of Oral Torezolid Phosphate in Patients with Complicated Skin and Skin Structure Infections

(2010) P. Prokocimer et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Elevated Linezolid Resistance in Clinical cfr-Positive Staphylococcus aureus Isolates Is Associated with Co-Occurring Mutations in Ribosomal Protein L3

(2010) J. B. Locke et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Comparative In Vitro Antimicrobial Activities of Torezolid (TR-700), the Active Moiety of a New Oxazolidinone, Torezolid Phosphate (TR-701), Determination of Tentative Disk Diffusion Interpretive Criteria, and Quality Control Ranges

(2010) S. D. Brown et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Resistance to Linezolid Is Mediated by thecfrGene in the First Report of an Outbreak of Linezolid‐ResistantStaphylococcus aureus

(2010) Gracia Morales et al.   CLINICAL INFECTIOUS DISEASES

Daptomycin Nonsusceptible Enterococci: An Emerging Challenge for Clinicians

(2010) T. Kelesidis et al.   CLINICAL INFECTIOUS DISEASES

Clinical Outbreak of Linezolid-Resistant Staphylococcus aureus in an Intensive Care Unit

(2010) Miguel Sánchez García   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Risk factors associated with the development of thrombocytopenia in patients who received linezolid therapy

(2010) Yoshiko Takahashi et al.   JOURNAL OF INFECTION AND CHEMOTHERAPY

Activity of oxazolidinone TR-700 against linezolid-susceptible and -resistant staphylococci and enterococci

(2009) D. M. Livermore et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Cellular pharmacokinetics and intracellular activity of torezolid (TR-700): studies with human macrophage (THP-1) and endothelial (HUVEC) cell lines

(2009) S. Lemaire et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Linezolid-resistant methicillin-resistant Staphylococcus aureus isolated after long-term, repeated use of linezolid

(2009) Koichiro Yoshida et al.   JOURNAL OF INFECTION AND CHEMOTHERAPY

Clinical and Microbiological Aspects of Linezolid Resistance Mediated by the cfr Gene Encoding a 23S rRNA Methyltransferase

(2008) C. A. Arias et al.   JOURNAL OF CLINICAL MICROBIOLOGY