Article
Endocrinology & Metabolism
Mario Detomas, Barbara Altieri, Wiebke Schlotelburg, Silke Appenzeller, Sven Schlaffer, Roland Coras, Andreas Schirbel, Vanessa Wild, Matthias Kroiss, Silviu Sbiera, Martin Fassnacht, Timo Deutschbein
Summary: The case presented a rare occurrence where a patient first had ACTH-independent CS and then developed CD. The successful treatment of CD after surgery and pathological examination indicated that different subtypes of Cushing's syndrome can develop in a single individual.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Paramita Saha, Sudhir Kumar, Kasturi Datta, Rakesh K. Tyagi
Summary: Polycystic ovarian syndrome (PCOS) is a complex gynecological endocrine disorder affecting fertility and predisposing to insulin resistance and other related diseases. Studies have revealed a close connection between autophagy and PCOS, with anti-inflammatory phytochemical thymoquinone showing promising effects in alleviating PCO condition by modulating autophagy modules and related markers.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Valentina Vozella, Bryan Cruz, Luis A. Natividad, Federica Benvenuti, Nazzareno Cannella, Scott Edwards, Eric P. Zorrilla, Roberto Ciccocioppo, Marisa Roberto
Summary: Marchigian Sardinian alcohol-preferring (msP) rats are a unique model of heightened alcohol preference and anxiety disorders, displaying enhanced stress response and anxiety-like behaviors driven by genetic polymorphisms. The study found that despite treatment with a GR antagonist known to reduce alcohol consumption in dependent rats, the innate anxiety symptoms in msP rats were not alleviated.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Jan Kroon, Eva M. G. Viho, Max Gentenaar, Lisa L. Koorneef, Cees van Kooten, Patrick C. N. Rensen, Sander Kooijman, Hazel Hunt, Onno C. Meijer
Summary: The study identified a selective GR antagonist, CORT125329, with strong beneficial activities in metabolic disease models. By stimulating metabolic activity in brown adipose tissue, the compound improved metabolic parameters and showed activity in both male and female mice.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Endocrinology & Metabolism
Mitsuru Nishiyama, Yasumasa Iwasaki, Shinya Makino
Summary: This paper reviews recent studies on animal models of Cushing's syndrome, including features and complications induced by different glucocorticoid excess. Researchers found that administering exogenous corticosterone or implanting CORT pellets in mice successfully induced a Cushing's phenotype. They also developed other types of animal models to study the effects of corticotropin-releasing hormone overexpression and adrenal-specific Prkar1a deficiency on Cushing's syndrome, and designed transplantation methods for related medical treatments. In addition, this paper reviews the latest advances in using animal models to study glucocorticoid-induced complications.
Article
Oncology
Ya-Hui Huang, Kwang-Huei Lin, Ming-Wei Lai, Chau-Ting Yeh
Summary: This study found that Mifepristone inhibits the growth of hepatocellular carcinoma (HCC) by altering the subcellular distribution of HSP60 and enhancing the formation of cytosolic GR-HSP60-survivin complexes, leading to the degradation of survivin.
Article
Multidisciplinary Sciences
Ashley L. Severance, Jeremy M. Kinder, Lijun Xin, Ashley R. Burg, Tzu-Yu Shao, Giang Pham, Tamara Tilburgs, Wendy A. Goodman, Sam Mesiano, Sing Sing Way
Summary: During pregnancy, progesterone stimulates the expansion of regulatory T cells to promote immune tolerance, ensuring fetal growth and preventing rejection from the mother's immune system. This study reveals the role of progesterone in promoting fetal tolerance and establishes a molecular link between immune and other physiological adaptations during pregnancy.
Article
Endocrinology & Metabolism
Paulina Kober, Natalia Rusetska, Beata J. Mossakowska, Maria Maksymowicz, Monika Pekul, Grzegorz Zielinski, Andrzej Styk, Jacek Kunicki, Lukasz Dzialach, Przemyslaw Witek, Mateusz Bujko
Summary: Pituitary neuroendocrine corticotroph tumors commonly cause Cushing's disease (CD) due to increased ACTH secretion. However, some corticotroph tumors remain clinically non-functioning. Cortisol secretion is regulated by the hypothalamic-pituitary-adrenal axis, and glucocorticoids act through GR and MR receptors to reduce ACTH levels. This study aimed to determine the role of GR and MR expression in functioning and silent corticotroph tumors.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Food Science & Technology
Haoyang Zou, Jia Yu, Zhuolin Li, Yao Liu, Tuoyi Wang, Tiezhu Li, Chengyu Lv, Jie Zhang
Summary: This study identified 3,6-dibromocarbazole as a glucocorticoid receptor antagonist and demonstrated its endocrine disrupting effects by interfering with the gluconeogenesis pathway.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Pediatrics
Xiu Zhao, Zhongwei Xu, Huiping Su, Rongfei Zheng, Min Zhan, Yuge Huang, Zhe Su
Summary: Primary generalized glucocorticoid hypersensitivity (PGGH) is a very rare disease with unknown etiology. This study describes the cases of two Chinese children with infantile-onset PGGH in one family, one of whom died and one who was treated with mifepristone. They are the two youngest children with PGGH reported in the literature. PGGH is a very rare disease that can lead to death if not diagnosed and treated in a timely manner.
Article
Cell Biology
Theodosia Kazazoglou, Christina Panagiotou, Chrysovalantou Mihailidou, Ioanna Kokkinopoulou, Anna Papadopoulou, Paraskevi Moutsatsou
Summary: The study reveals that glucocorticoids can regulate astrocytic GS activity through pathways mediated by GR alpha and GR beta, with important implications in neurologic pathological conditions.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Mengmeng Sun, Jingliang Wu, Bo Lian, Jingxiang Cui, Na Xu, Zihan Xu, Yuhui Nie, Guohua Yu, Shuzhen Liu
Summary: The tumor microenvironment plays a crucial role in breast cancer development. This study successfully encapsulated mifepristone and curcumin into hyaluronic acid-modified liposomes, which showed stronger anti-proliferation and anti-migration effects compared to other groups. The in vivo results demonstrated that mice treated with these liposomes had smaller tumor volume, less angiogenesis, lower extracellular matrix deposition, and weaker lung metastasis. These findings suggest that combination therapy using hyaluronic acid-modified liposomes may be an effective approach for treating breast cancer.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tilo Pfalzgraff, Peter Vilhelm Skov
Summary: The gastrointestinal system of fish responds rapidly to food deprivation, with reductions in the masses of digestive organs and activities of digestive enzymes. Cortisol, an energy mobilizing hormone, is elevated during fasting but can be reduced by blocking glucocorticoid and mineralocorticoid receptors. However, the elevation of cortisol levels during fasting does not seem to affect the relative weight loss of digestive tissues.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2022)
Article
Obstetrics & Gynecology
Jin Luo, Qianrong Qi, Yinmei Chen, Yaqin Wang, Qingzhen Xie
Summary: GnRH-ant, mifepristone, and letrozole are beneficial in preventing the progression of OHSS through different luteolytic mechanisms. Combination treatment shows enhanced synergistic effect in preventing the progression of OHSS.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Article
Cell Biology
Ruifang Nie, Jian Lu, Rui Xu, Juanzhen Yang, Xingyi Shen, Xingnan Ouyang, Danyang Zhu, Yujie Huang, Tong Zhao, Xuejian Zhao, Yin Lu, Minyi Qian, Jiaying Wang, Xu Shen
Summary: This study found that ipriflavone, a non-steroidal glucocorticoid receptor antagonist, effectively improved learning and memory dysfunction in diabetic mice. The underlying mechanism involves the suppression of tau hyperphosphorylation, alleviation of neuronal inflammation, and protection against synaptic impairment.