Journal
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
Volume 92, Issue 3, Pages 521-527Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pbb.2009.02.001
Keywords
Dopamine; Adenosine; Parkinson's disease; Rat; Caffeine; CPT; SCH23390; A1; A2A; Basal ganglia
Funding
- CSUF New Faculty Grant [03412]
Ask authors/readers for more resources
The effects of adenosine antagonists were compared in two rodent models of Parkinsonian symptoms. In the first experiment the dopamine D-2 antagonist, haloperidol, was used to induce catalepsy. It was found that treatment with the non-selective adenosine antagonist caffeine significantly reduced catalepsy at each dose. Treatment with the selective A(1) antagonist CPT also produced a significant reduction in catalepsy, as did treatment with the selective A(2A) antagonist SCH58261. In the second experiment haloperidol was used to Suppress locomotor activity in an open field test. Treatment with caffeine significantly increased locomotion reduced by haloperidol, but not at all doses tested. Treatment with CPT also increased haloperidol-Suppressed locomotor activity in dose-dependent manner. Surprisingly, treatment with SCH58261 did not significantly increase locomotor activity in animals treated with haloperidol at any dose tested. While some of these results were unexpected, the overall pattern suggests that adenosine antagonists would be useful as therapies for Parkinsonian patients as they appear to increase movement. The results also suggest that in acute timelines A(1) antagonists may be more beneficial than previously supposed. (c) 2009 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available