Article
Oncology
Dong-bin Wang, Xuan Li, Xi-Ke Lu, Zhong-yi Sun, Xun Zhang, Xia Chen, Lan Ma, Hong-gang Xia
Summary: Lung malignancy is a major cause of disease mortality worldwide, with TTR serving as a specific biomarker for clinical diagnosis. Research on the impact of abnormal TTR expression on NSCLC showed that upregulation of TTR suppressed cell proliferation, migration, invasion, and increased apoptosis. In vivo experiments confirmed that overexpression of TTR promoted cell apoptosis and inhibited tumor growth, suggesting a potential antitumor effect of TTR in human NSCLC progression.
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
(2021)
Article
Environmental Sciences
Mingjun Sun, Jingwen Tan, Mengjie Wang, Weihua Wen, Yuefeng He
Summary: The study found that arsenic increased the expression of AS3MT in vivo and in vitro, directly acting on cells and affecting the progression of non-small cell lung cancer by regulating cell cycle genes.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Danylo Kravchuk, Ganna Sotkis, Mykola M. Shcherbatiuk, Ruslan M. Kravchuk, Vassili G. Nazarenko, Petro P. Gorbyk, Yaroslav M. Shuba
Summary: The study demonstrates that RuBi-caged nicotine can release free nicotine upon photolysis, leading to the proliferation of A549 nonsmall-cell lung cancer cells. The photolysis of RuBi-nicotine can effectively produce biologically relevant concentrations of nicotine using simple, inexpensive, and easily accessible light sources.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2023)
Article
Cell Biology
Changhui Li, Jiaqi Zhang, Xiaohua Yang, Cheng Hu, Tianqing Chu, Runbo Zhong, Yinchen Shen, Fang Hu, Feng Pan, Jianlin Xu, Jun Lu, Xiaoxuan Zheng, Hai Zhang, Wei Nie, Baohui Han, Xueyan Zhang
Summary: The study has demonstrated the significant role of hsa_circ_0003222 in NSCLC progression and resistance, with its high expression associated with disease stage, metastasis, and patient survival rate. Silencing hsa_circ_0003222 led to reduced stemness-like properties and chemoresistance in tumor cells.
CELL DEATH & DISEASE
(2021)
Article
Multidisciplinary Sciences
Yuki Onozato, Takahiro Nakajima, Hajime Yokota, Jyunichi Morimoto, Akira Nishiyama, Takahide Toyoda, Terunaga Inage, Kazuhisa Tanaka, Yuichi Sakairi, Hidemi Suzuki, Takashi Uno, Ichiro Yoshino
Summary: This study utilized radiomic features and machine learning to establish a predictive model for STAS, which might be helpful in selecting appropriate NSCLC patients for sublobar resection.
SCIENTIFIC REPORTS
(2021)
Review
Pharmacology & Pharmacy
Zi-Xian Liao, Ivan M. Kempson, Chia-Chen Hsieh, S-Ja Tseng, Pan-Chyr Yang
Summary: The presence of lactate and its relationship with drug resistance and genetic mutations in NSCLC highlights the potential for improving therapeutic outcomes by enzymatically lowering lactate levels. Targeting lactate may promote an oncolytic immune microenvironment within the tumor, offering a promising approach for enhancing NSCLC treatment efficacy.
DRUG DISCOVERY TODAY
(2021)
Article
Biochemistry & Molecular Biology
Bin Wang, Xiao-yong Shen, Lin-yue Pan, Zheng Li, Chun-ji Chen, Yuan-shan Yao, Dong-fang Tang, Wen Gao
Summary: Genome-wide association studies have found an association between HDAC2 rs13213007 and nonsmall cell lung cancer (NSCLC). HDAC2 is upregulated in both peripheral blood mononuclear cells (PBMCs) and NSCLC tissues with the rs13213007 A/A genotype. Clinical data showed a strong association between rs13213007 genotype and N classification. Higher expression of HDAC2 was confirmed to be associated with NSCLC progression. In cell experiments, HDAC2 was found to upregulate c-Myc and cyclin D1 expression, promoting NSCLC cell proliferation, migration, and invasion. MTA3 was also found to interact with HDAC2 and rescue the migration and invasion abilities of NSCLC cells.
MOLECULAR CARCINOGENESIS
(2023)
Article
Chemistry, Medicinal
Kaizhen Wang, Ke Ye, Xiangyu Zhang, Tianyu Wang, Zhihao Qi, Youjun Wang, Sheng Jiang, Kuojun Zhang
Summary: Depleting NAD+ by blocking its biosynthesis has become an attractive anticancer strategy. Simultaneous blockade of NAD+ production from salvage and de novo synthesis pathways by targeting NAMPT and IDO1 could achieve more effective NAD+ reduction and, subsequently, more robust antitumor efficacy.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Medical Laboratory Technology
Lea Sinoquet, William Jacot, Xavier Quantin, Catherine Alix-Panabieres
Summary: This study discusses the application of immune checkpoint inhibitors in the treatment of metastatic nonsmall cell lung cancer and focuses on the evaluation of blood biomarkers such as circulating cell-free DNA, circulating tumor DNA, blood tumor mutational burden, and circulating tumor cells. Monitoring these biomarkers during immunotherapy may assist clinicians in making therapeutic decisions.
CLINICAL CHEMISTRY
(2023)
Article
Oncology
Zhe Zhang, Li Nong, Meng-Lei Chen, Xiao-Li Gu, Wei-Wei Zhao, Ming-Hui Liu, Wen-Wu Cheng
Summary: This study found that ELF3-AS1 is upregulated in non-small cell lung cancer (NSCLC) and promotes cancer cell invasion and migration by downregulating miR-212 through methylation.
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
(2022)
Article
Oncology
Brittney Chau, Philip H. G. Ituarte, Ashwin Shinde, Richard Li, Jessica Vazquez, Scott Glaser, Erminia Massarelli, Ravi Salgia, Loretta Erhunmwunsee, Kimlin Ashing, Arya Amini
Summary: The study found that foreign-born NSCLC patients in California have a lower risk of mortality compared to native-born patients after adjusting for treatments received and socioeconomic factors.
Article
Multidisciplinary Sciences
Agata Dutkowska, Bartosz Szmyd, Marcin Kaszkowiak, Daria Domanska-Senderowska, Dorota Pastuszak-Lewandoska, Ewa Brzezianska-Lasota, Jacek Kordiak, Adam Antczak
Summary: Tumours have the ability to avoid immune destruction and exhibit cancer-associated inflammation. The upregulation of interleukins IL-1 beta and IL-6 in non-small cell lung cancer (NSCLC) tissues suggests that inflammatory processes play a role in NSCLC, with a strong influence of smoking history on inflammation in tumourigenesis.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Yingjie Lu, Xuelin Zhang, Huibiao Zhang, Zhenghong Zhu
Summary: This study found that miR-3195 is downregulated in non-small cell lung cancer (NSCLC), and its low expression is associated with lymph node metastasis and high TNM stage. Low expression of miR-3195 is associated with worse overall survival in NSCLC patients. Enhanced expression of miR-3195 can inhibit the growth, migration, and invasion of NSCLC cells.
CANCER MANAGEMENT AND RESEARCH
(2022)
Review
Oncology
Kit Yee Wong, Alvin Ho-Kwan Cheung, Bonan Chen, Wai Nok Chan, Jun Yu, Kwok Wai Lo, Wei Kang, Ka Fai To
Summary: Lung cancer is a common and deadly disease, with the tumor microenvironment playing a crucial role. Cancer-associated fibroblasts (CAFs) have gained attention in the study of nonsmall cell lung carcinoma (NSCLC), as their heterogeneity and functions are closely associated with tumor development.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Medicine, General & Internal
Jiang Du, Haifeng Liu, Xiaoyun Mao, Yanan Qin, Chuifeng Fan
Summary: The study found that ATF4 expression in non-small cell lung cancer is associated with cancer cell growth and invasion, and it participates in cancer progression by promoting the activity of the Wnt signaling pathway. ICG001 can inhibit the function of ATF4, but when ATF4 and ICG001 are combined, the invasion ability of cancer cells significantly increases, indicating that ATF4's function is not solely dependent on the Wnt/beta-catenin signaling pathway.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)