Article
Chemistry, Analytical
Xin Zhang, Xianghui Shi, Yong Pan, Juncheng Jiang
Summary: This study investigates the pyrolysis behavior of tert-butyl hydroperoxide (TBHP) through molecular dynamics simulations. The main pyrolysis products and reaction pathways are identified, and a detailed reaction mechanism is proposed. The calculated apparent activation energy agrees reasonably with experimental results. This research provides scientific guidance for the process safety of organic peroxides and the development of suppression technologies.
JOURNAL OF ANALYTICAL AND APPLIED PYROLYSIS
(2022)
Article
Chemistry, Organic
Zhang Yunqian, Zhou Chenfan, Liu Gongqing
Summary: Phosphoroselenoates are widely used in organic synthesis and drug discovery. This study developed a new method for the synthesis of phosphoroselenoates through the oxidative coupling reaction of diselenides with phosphites using t-butyl hydroperoxide (TBHP) as an oxidant. The advantages of this method include mild reaction conditions, broad substrate scope, excellent yields, and the absence of transition metals and bases.
CHINESE JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Thermodynamics
Wenlin Huang, Congjie Hong, Wuchuan Sun, Honghuan Wu, Zuohua Huang, Yingjia Zhang
Summary: In this study, tert-butyl hydroperoxide (TBHP) was investigated as an additive reactively enhancer to improve the auto-ignition of n-heptane. The results showed a nonlinear promotion effect of TBHP on the auto-ignition of n-heptane, with detonation caused by TBHP impacting the reflected shock temperature and pressure at high beginning temperatures. Addition of TBHP suppressed the negative temperature coefficient (NTC) behavior of first-stage ignition and strengthened the NTC behavior of ignition delay time (IDT). Analysis indicated that TBHP facilitated the quick production of OH and CH3 radicals, enhancing the reactivity of n-heptane and affecting the main exothermic reaction in the early period. This study highlights the potential of TBHP in regulating the combustion of hydrocarbon fuels and provides insights for efficient utilization in scramjet engines and micro internal combustion engines.
COMBUSTION AND FLAME
(2023)
Article
Microbiology
Shih-Jie Chen, Hung-Yu Shu, Guang-Huey Lin
Summary: This study showed that Acinetobacter baumannii ATCC 19606 harbors two sets of ohrR-ohr genes in chromosomal DNA and a pMAC plasmid. While the chromosomal ohrR-C-ohr-C genes act as the major system in protecting the bacteria from organic hydroperoxide stresses, the pMAC ohrR-p-ohr-p genes can provide a supplementary protective effect and their interaction may influence bacterial growth and virulence.
Article
Chemistry, Physical
Julia Bueker, Martin Muhler, Baoxiang Peng
Summary: This concept article provides a comprehensive overview of recent advances in selective oxidation of cyclohexene using heterogeneous transition metal-based catalysts and environmentally benign oxidants.
Article
Biochemistry & Molecular Biology
Woo Kwon Jung, Su-Bin Park, Hwa Young Yu, Yong Hwan Kim, Junghyun Kim
Summary: Esculetin, derived from coumarin, has been found to have antioxidant and anti-apoptotic effects. It improves cell viability and reduces apoptosis in HEK293 cells under t-BHP-induced oxidative stress. At the molecular level, esculetin regulates the expression of pro-apoptotic and anti-apoptotic factors.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Qifeng Ren, Wenfei Zhang, Ping Li, Jianli Zhou, Zhonghao Li, Yang Zhou, Ming Li
Summary: Necrosis of the femoral head (NFH) is an orthopedic disease associated with inadequate blood supply and increased intraosseous pressure. The present study revealed that the expression of osteoprotegerin (OPG) was significantly decreased in the femoral head of NFH patients, and overexpression of OPG reversed chondrocyte apoptosis induced by oxidative stress.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Engineering, Environmental
Ning Li, Mengzhen Yuan, Guoju Cui, Jiale Xu, Xiuyi Li, Guowei Wang, Xiaolin Zhu, Chunyi Li
Summary: This study proposes a novel route using molecular oxygen for the green synthesis of di-tert-butyl peroxide (DTBP) from isobutane. MoO3 was demonstrated as the selective catalyst for this reaction, and the selectivity to DTBP was determined by the amount of surface Mo = O sites. Under optimized conditions, high oxygen conversion (>95%) and stable product selectivities (DTBP -20 wt%, TBHP -13 wt%) were achieved. This work provides an environmentally friendly method for utilizing C4 hydrocarbon resources and producing DTBP.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Zhiqiang Wei, Lixian Wen, Tixian Wen, Kaidi Zhu, Qian Wang, Yanchuan Zhao, Jinbo Hu
Summary: We report a new synthetic protocol for the selective perfluoro-tert-butylation of arenes. By using PFtB phenyl sulfone as a source of PFtB anion, highly regioselective reactions with arynes can yield perfluoro-tert-butylated arenes with high yields. The method is demonstrated by the preparation of sensitive 19F-labeled NMR probes with exceptional resolving ability.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Engineering, Chemical
Jordi H. Badia, Carles Fite, Roger Bringue, Fidel Cunill, Javier Tejero
Summary: The kinetics of the simultaneous synthesis of ETBE and BTBE over A35 catalyst in the liquid phase was investigated. Various kinetic modeling approaches were compared, and it was found that empirical power-law modeling provided the best fit, while mechanistic modeling explained the reaction mechanisms.
CHEMICAL ENGINEERING SCIENCE
(2022)
Article
Chemistry, Applied
Hongwei Zhu, Junjie Yan, Zhichen Zhang, Junpeng Ren, Yunfeng Zhu, Hui Zhao, Wei Xu, Bing Sun, Chaohe Yang
Summary: This study optimized the synthesis conditions of tert-butyl hydroperoxide using sulfuric acid as a catalyst in a microchannel reactor. The kinetic model of the synthesis was established, and it was found that byproducts were also produced during the reaction.
ORGANIC PROCESS RESEARCH & DEVELOPMENT
(2023)
Article
Biochemistry & Molecular Biology
Jia Liang, Fei Yao, Dong Fang, Lu Chen, Zhenhua Zou, Lujia Feng, Yijing Zhuang, Ting Xie, Pengxue Wei, Pengfeng Li, Shaochong Zhang
Summary: Vision loss and blindness caused by photoreceptor degeneration can be protected using anti-aging treatment such as Hyperoside. Hyperoside can alleviate photoreceptor cell senescence and ameliorate the functional and morphological degeneration of the retina. It prevents MNU-induced photoreceptor degeneration by inhibiting cell senescence via the AMPK-ULK1 pathway.
Article
Chemistry, Multidisciplinary
Yaqiqi Jiang, Bao Li, Nana Ma, Sai Shu, Yujie Chen, Shan Yang, Zhibin Huang, Daqing Shi, Yingsheng Zhao
Summary: This study reported a light-promoted C-H trifluoromethylation of arylcarbamates using Langlois reagent under para-selective conditions. Preliminary mechanistic study indicated that the activated organic photocatalyst played a crucial role in achieving para-selective C-H trifluoromethylation. The successful performance of the reaction on a ten-gram scale highlights the synthetic importance of this new protocol.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Biochemistry & Molecular Biology
Mikhail G. Akimov, Elena V. Fomina-Ageeva, Polina V. Dudina, Ludmila A. Andreeva, Nikolay F. Myasoyedov, Vladimir V. Bezuglov
Summary: This study found that the peptide exhibited dose-dependent cytoprotective effects against oxidative stress induced by H2O2, tert-butyl hydroperoxide, and KCN, as well as proproliferative activity. Its mechanism of action involved modulation of proliferation-related NF-kappa B genes, stimulation of prosurvival NRF2-gene-related pathway, and reduction of apoptosis.
Article
Food Science & Technology
Selvakumari Ulagesan, Sathish Krishnan, Taek-Jeong Nam, Youn-Hee Choi
Summary: Exposure to t-BHP leads to cytotoxicity and oxidative stress. The Crassostrea gigas peptide, PEP-1, has protective and antioxidant effects on t-BHP-induced oxidative stress in HepG2 cells.
FOOD SCIENCE AND BIOTECHNOLOGY
(2023)
