Article
Medicine, Research & Experimental
Yoshihiko Chiba, Yukika Adachi, Yusuke Ando, Shigeki Fujii, Wataru Suto, Hiroyasu Sakai
Summary: This study aims to investigate the functional role of a long non-coding RNA MALAT1 in the expression and development of bronchial smooth muscle (BSM) hyper-contractility. The findings suggest that MALAT1 positively regulates RhoA protein expression by inhibiting miR-133a-3p in BSM cells, leading to augmented BSM contractility. These findings are of great significance for understanding the pathological mechanisms of airway hyper-responsiveness.
Review
Physiology
Dora (Jun Ping) Xiong, James G. Martin, Anne-Marie Lauzon
Summary: Asthma is a common chronic inflammatory disease of the airways that varies in its presentation and severity. Airway smooth muscle is the major contributor to airway narrowing and asthma symptoms. Various factors can contribute to the dysfunction of airway smooth muscle. Methodological limitations in studying the airways have hindered our understanding of asthma mechanisms.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Luigino Calzetta, Marina Aiello, Annalisa Frizzelli, Giuseppina Bertorelli, Beatrice Ludovica Ritondo, Paola Rogliani, Alfredo Chetta
Summary: AHR is a central pathophysiological feature of asthma, involving ASM with pro-inflammatory and immunomodulatory actions. mAbs target various inflammatory mediators to modulate ASM contractility, showing potential in treating severe asthma by preventing AHR.
Article
Cell Biology
Ruth M. Matthews, Eamonn Bradley, Caoimhin S. Griffin, Xin Rui Lim, Nicolas D. Mullins, Mark A. Hollywood, Fionnuala T. Lundy, Lorcan P. McGarvey, Gerard P. Sergeant, Keith D. Thornbury
Summary: Mouse bronchial smooth muscle cells express functional NaV1.7 channels that can modulate contractile activity under experimental conditions.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Environmental Sciences
Min Wang, Shujie Hou, Xi Lu, Jingwen Li, Rongqin Li, Xixin Yan
Summary: IL-37 has been found to inhibit airway hyperresponsiveness induced by PM2.5, reducing inflammation and disease severity. It decreases the expression of proliferation and migration-related proteins in lung tissues and protects human airway smooth muscle cells from the effects of PM2.5 exposure.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Medicine, General & Internal
Xuan Li, Shuan-Shuan Xie, Guo-Shu Li, Jie Zeng, Hong-Xia Duan, Chang-Hui Wang
Summary: This study compared the effects of bronchial thermoplasty (BT) and cryoballoon ablation (CBA) therapy on airway smooth muscle (ASM) and found that CBA therapy can effectively ablate ASM with a similar effect to BT but a shorter onset time. Additionally, both BT and CBA therapies involve neural mechanisms.
CHINESE MEDICAL JOURNAL
(2021)
Article
Critical Care Medicine
Annika W. M. Goorsenberg, Julia N. S. D'Hooghe, Karthikan Srikanthan, Nick H. T. Ten Hacken, Els J. M. Weersink, Joris J. T. H. Roelofs, Samuel Kemp, Elisabeth H. Bel, Pallav L. Shah, Jouke T. Annema, Peter Bonta
Summary: The study shows that bronchial thermoplasty can significantly reduce airway smooth muscle mass and treatment response is associated with serum IgE and eosinophil levels, rather than baseline ASM mass.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Cell Biology
Zijian Zeng, Mengxin Cheng, Meng Li, Tao Wang, Fuqiang Wen, Michael J. Sanderson, James Sneyd, Yongchun Shen, Jun Chen
Summary: BALB/c and C57BL/6 mouse strains are commonly used as animal models for respiratory diseases. This study found that BALB/c mice have a stronger extent of small airway narrowing and faster Ca2+ oscillations in airway smooth muscle (ASM) cells in response to agonists. These differences are associated with an increased store-operated Ca2+ entry (SOCE) current, resulting in higher airway responsiveness in BALB/c mice compared to C57BL/6 mice.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Allergy
Alexis Celle, Pauline Esteves, Guillaume Cardouat, Fabien Beaufils, Edmee Eyraud, Isabelle Dupin, Elise Maurat, Sabrina Lacomme, Olga Ousova, Hugues Begueret, Matthieu Thumerel, Roger Marthan, Pierre-Olivier Girodet, Patrick Berger, Thomas Trian
Summary: This study demonstrates a novel mechanism of bronchial smooth muscle (BSM) remodeling in patients with severe asthma following rhinovirus (RV) exacerbation. The specific migration of BSM cells towards RV-infected bronchial epithelium (BE) is driven by the chemokine ligand C-X-C motif chemokine ligand 10. Decreased expression and activation of the CXCR3-B-specific isoform in BSM cells from patients with severe asthma contribute to this mechanism. These findings highlight the potential therapeutic target of the C-X-C motif chemokine ligand 10/CXCR3-A axis in severe asthma.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Respiratory System
Yoshihiko Chiba, Yamato Yamane, Tsubasa Sato, Wataru Suto, Motohiko Hanazaki, Hiroyasu Sakai
Summary: This study reveals the significant role of extracellular acidification in bronchial smooth muscle contraction. In an animal model of asthma, activation of G protein-coupled receptors by acidic pH leads to hypercontraction of bronchial smooth muscles.
Article
Respiratory System
Mariska P. M. van den Berg, Susan Nijboer-Brinksma, I. Sophie T. Bos, Maarten van den Berge, David Lamb, Martijn van Faassen, Ido P. Kema, Reinoud Gosens, Loes E. M. Kistemaker
Summary: The study evaluated the efficacy of the TRPA1 antagonist BI01305834 in guinea-pig models of asthma, showing that 1mg/kg BI01305834 effectively inhibited asthma characteristics without affecting inflammation.
RESPIRATORY RESEARCH
(2021)
Article
Physiology
G. M. Donovan, P. B. Noble, D. Langton
Summary: This study demonstrates the feasibility and constraints of predicting patient-specific response to bronchial thermoplasty using a computational model informed by pretreatment CT scans. The predictions were compared with functional outcomes and posttreatment CT scans. This has the potential to form the basis for improved clinical practice.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Medicine, Research & Experimental
Mi Cheng, Yang-lin Shi, Pan-pan Shang, Yan-jiao Chen, Yu-dong Xu
Summary: This study shows that S100A11 protein can alleviate airway hyperresponsiveness by relaxing airway smooth muscle independently of extracellular calcium. These results support the idea that S100A11 is a potential therapeutic target for reducing airway resistance in asthma patients.
CURRENT MEDICAL SCIENCE
(2022)
Article
Allergy
Lei Fang, Junling Li, Eleni Papakonstantinou, Meropi Karakioulaki, Qingzhu Sun, Desiree Schumann, Michael Tamm, Daiana Stolz, Michael Roth
Summary: The study found that bronchial thermoplasty significantly increased the expression of HSP70 and HSP90, playing a role in controlling airway remodeling. For epithelial cells, HSP70 and HSP90 improved their function, while inhibiting ASMC remodeling.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Review
Respiratory System
Cassandra Spector, Camden M. De Sanctis, Reynold A. Panettieri Jr, Cynthia J. Koziol-White
Summary: Rhinovirus infections can lead to airway remodeling, which is characterized by irreversible airway obstruction and diminished responsiveness to bronchodilators. Structural cells of the airways, including epithelial cells, smooth muscles, fibroblasts, myofibroblasts, and lung vascular endothelial cells, play a role in this process by producing various mediators and components that contribute to airway remodeling. Rhinovirus exposure can induce airway hyperresponsiveness and remodeling phenotypes such as mucus hypersecretion, epithelial-mesenchymal transition, and fibroblast-myofibroblast transdifferentiation. Different cellular responses to rhinovirus infection can lead to persistent airway remodeling in asthmatic individuals, including exaggerated type 2 inflammation, increased extracellular matrix deposition, and enhanced production of pro-angiogenic mediators.
RESPIRATORY RESEARCH
(2023)