Mortality in hypertensive patients with coronary heart disease depends on chronopharmacotherapy and dipping status

Background: The goal of our study was to assess the influence of hypertension chronopharmacotherapy on diurnal blood pressure (BP) profile and mortality. Methods: Subjects with established coronary heart disease (CHD) (n = 1345, mean age 63.2 +/- 9.2 years) were included. Results: Non-dipping status was related to a lack of nighttime hypertensive drug administration (OR 3.87, 95% CI 3.00-4.98). In a Cox proportional hazards regression model, non-dipping status (HR 1.17, 95% CI 1.02-1.47) and non-nighttime antihypertensive drug administration (HR 1.13,95% CI 1.01-1.45) were predictors of all-cause mortality. Conclusions: The non-dipping profile of CHD patients and increased mortality were related to a lack of antihypertensive drug administration at bedtime. (c) 2014 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved.