Review
Psychiatry
Maike Salazar Kaempf, Philipp Kanske
Summary: Mimicry is shown to foster relationships and increase closeness in everyday communication. This review explores the connection between affective disorders and mimicry behavior. Different theories regarding the mechanisms and functionality of mimicry are examined, and suggestions are derived on how mimicry might impact individuals with bipolar disorders, dysthymia, or depression. The review emphasizes the need for expanding mimicry evidence in interactional settings for people with affective disorders.
FRONTIERS IN PSYCHIATRY
(2023)
Review
Clinical Neurology
Daniela Colita, Daiana Burdusel, Daniela Glavan, Dirk M. Hermann, Cezar-Ivan Colita, Eugen Colita, Ion Udristoiu, Aurel Popa-Wagner
Summary: Major depressive disorder (MDD) and post-stroke depression (PSD) are two common and debilitating mental health disorders worldwide. They share common underlying biological mechanisms but differ in onset and prognosis.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Multidisciplinary Sciences
Gordana Stanic, Snezana Marinkovic, Jelena Milin Lazovic, Dragana Ignjatovic Ristic
Summary: This study found differences in affective temperament and levels of psychosomatic symptoms between patients with Hashimoto's thyroiditis (HT) and healthy individuals. Patients with HT had higher levels of psychosomatic symptoms compared to the control group, and their affective temperament was associated with these symptoms. Further research is needed to better understand the relationship between affective temperament and psychosomatic symptoms.
Article
Clinical Neurology
Yajun Shang, Xinjie Chen, Mingda Ai, Xiaoran Gao, Shujuan Dai, Mingjie Zhao, Cen Yang, Liangfeng Wang, Junyan Zhang, Lianmei Zhong, Tianhao Bao, Xiaolei Liu
Summary: This meta-analysis found that cognitive impairments and affective disorders are common in patients with essential tremor (ET). Patients with ET showed lower scores on Mini-Mental State Examination (MMSE) and higher scores on depressive and anxiety symptoms scale compared to non-ET group. The risk for dementia and affective disorders was significantly higher in individuals with ET. However, the causal relationship between ET and dementia, depression, and anxiety remains unclear.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
A. Maget, N. Dalkner, C. Hamm, S. A. Bengesser, F. T. Fellendorf, M. Platzer, R. Queissner, A. Birner, M. Lenger, S. Moerkl, A. Kohlhammer-Dohr, A. Rieger, M. Seidl, L. Mendel, T. Faerber, L. Wetzlmair, K. Schwalsberger, D. Amberger-Otti, H. Schoeggl, T. Lahousen, B. Leitner-Afschar, R. Unterweger, S. Zelzer, H. Mangge, E. Z. Reininghaus
Summary: This study investigated the differences in serum zonulin levels between currently depressed and currently euthymic individuals with an affective disorder. It found that females had significantly higher serum zonulin levels than men, regardless of affective status, and that euthymic females had higher zonulin levels than euthymic males.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychiatry
Alessandro Miola, Ross J. Baldessarini, Marco Pinna, Leonardo Tondo
Summary: Ratings of affective temperament types using the TEMPS-A questionnaire can help differentiate diagnostic groups and predict types and amounts of affective morbidity, while also detecting suicidal risks.
EUROPEAN PSYCHIATRY
(2021)
Article
Medicine, General & Internal
Ruimin Ma, Gayan Perera, Eugenia Romano, Davy Vancampfort, Ai Koyanagi, Robert Stewart, Christoph Mueller, Brendon Stubbs
Summary: This study found that older age, comorbid physical disorders, and analgesic use were significant risk factors for falls and fractures in patients with affective disorders. Routine bone mineral density screening and fall prevention programs should be considered for this clinical group.
Article
Clinical Neurology
Amber John, Josh Stott, Marcus Richards
Summary: The study found that childhood reading problems are significantly associated with affective symptoms in adolescence, but this association does not persist into adulthood. Additionally, reading problems do not lead to accumulation of affective symptoms across the life course.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychiatry
Lone D. Horlyck, Andreas E. Jespersen, John A. King, Henrik Ullum, Kamilla W. Miskowiak
Summary: The study findings suggest impaired hippocampal functioning in patients with remitted UD/BD, as they showed selective impairment in high-load allocentric spatial memory compared to egocentric memory.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Psychiatry
Tobias Rohrmann, Peter Praus, Tanja Proctor, Anastasia Benedyk, Heike Tost, Oliver Hennig, Andreas Meyer-Lindenberg, Anna-Sophia Wahl
Summary: This study aimed to assess the feasibility of telemedicine treatment in psychiatric outpatient care and found that it is an effective treatment option for patients with depression. Particularly, female patients were more likely to find telepsychiatry equivalent to conventional treatment. However, further improvements are needed for chronic non-episodic psychiatric disorders.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Medicine, General & Internal
Nicole R. Nugent, Michael Armey, Steven Boker, Leslie Brick, Valerie Knopik, John E. McGeary, Anthony Spirito, Matthias R. Mehl
Summary: This research examines the genomics and in vivo dynamics of family context and experienced affect following discharge from psychiatric hospitalization for suicidal thoughts and behaviors. The study involves a longitudinal, multimethod observational investigation and participants are recruited from an inpatient child and adolescent psychiatric hospital. The research protocol aims to characterize the in vivo, real-world experienced affect and observed family context associated with STB in adolescents during the high-risk weeks post discharge, merging multiple fields of study.
Article
Psychology, Clinical
Maria Granros, Annmarie MacNamara, Heide Klumpp, K. Luan Phan, Katie L. Burkhouse
Summary: The current study examined how transdiagnostic internalizing psychopathology symptom dimensions relate to neural affective reactivity in a highly comorbid patient sample. Results revealed that fear-based anxiety was associated with enhanced LPP reactivity to unpleasant images, while distress/misery symptoms were related to attenuated overall LPP reactivity.
DEPRESSION AND ANXIETY
(2022)
Article
Medicine, General & Internal
Rasmus Schwarz, Lone Decker, Ida Seeberg, Kamilla Woznica Miskowiak, Lars Vedel Kessing, Maj Vinberg
Summary: This study aims to improve functioning and quality of life in patients with affective disorders using a comprehensive 360 degrees intervention. Participants will be randomly assigned to the intervention or treatment as usual group, with the primary outcome being the improvement of activities of daily living ability. The study results will contribute to optimizing the treatment for patients with affective disorders.
Review
Clinical Neurology
Giulia Lombardo, Valeria Mondelli, Paola Dazzan, Carmine Maria Pariante
Summary: Sex hormones and the immune system may be involved in the sex differences in affective disorders, suggesting potential for sex-specific tailored therapeutic approaches. Studies on the interplay between sex hormones and immune system in affective disorders are needed to improve the evidence base.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Raphael O. Cerqueira, Carolina Ziebold, Daniel Cavalcante, Giovany Oliveira, Javiera Vasquez, Juan Undurraga, Alfonso Gonzalez-Valderrama, Ruben Nachar, Carlos Lopez-Jaramillo, Cristiano Noto, Nicolas Crossley, Ary Gadelha
Summary: This study compares patients with affective and non-affective psychosis (A-FEP and NA-FEP) in a Latin American sample. The findings suggest that characteristics of FEP patients could be utilized to enhance diagnosis and inform treatment decisions.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Chemistry, Medicinal
Monika Marcinkowska, Barbara Mordyl, Nikola Fajkis-Zajaczkowska, Agata Siwek, Tadeusz Karcz, Alicja Gawalska, Adam Bucki, Pawel Zmudzki, Anna Partyka, Magdalena Jastrzebska-Wiesek, Bartosz Pomierny, Maria Walczak, Magdalena Smolik, Karolina Pytka, Kamil Mika, Magdalena Kotanskad, Marcin Kolaczkowski
Summary: There is evidence showing that the combination of GABA molecule and chemical fragments interacting with the serotonin 5-HT6 receptor can curb neuroinflammation and provide antidepressant-like activity. The hybrid molecule 3B has shown promising affinity for 5-HT6 receptors and agonistic properties on GABA-A receptors. In vivo studies have demonstrated its robust antidepressant-like activity and effectiveness in reducing oxidative stress markers and the pro-inflammatory cytokine IL-6.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Cell Biology
Ewelina Honkisz-Orzechowska, Katarzyna Popiolek-Barczyk, Zuzanna Linart, Jadwiga Filipek-Gorzala, Anna Rudnicka, Agata Siwek, Tobias Werner, Holger Stark, Jakub Chwastek, Katarzyna Starowicz, Katarzyna Kiec-Kononowicz, Dorota Lazewska
Summary: This study demonstrates the strong anti-inflammatory effect of new human H3R ligands with flavonoid structure in murine microglial cells. Further research is needed to understand the mechanism of action of flavonoids in reducing inflammation.
INFLAMMATION RESEARCH
(2023)
Article
Engineering, Electrical & Electronic
Grzegorz Taton, Artur Kacprzyk, Tomasz Rok, Anna Wasik, Marcin Siwek
Summary: In recent years, studies have been conducted on the impact of electromagnetic field (EMF) on humans, particularly focusing on electromagnetic hypersensitivity (EHS) in Poland and the characterization of individuals affected by this syndrome. Some researchers argue that EHS is not caused by the actual physical effects of EMF, but rather by psychological mechanisms. This paper provides an overview of three research projects that support this claim.
PRZEGLAD ELEKTROTECHNICZNY
(2023)
Article
Oncology
Adrian Andrzej Chrobak, Mikolaj Przydacz, Marcin Chlosta, Karolina Machalska, Aleksander Turek, Maja Popiol, Michal Skalski, Aleksandra Arciszewska-Leszczuk, Piotr Chlosta, Marcin Siwek, Dominika Dudek
Summary: This study aimed to evaluate bipolar spectrum symptoms in prostate cancer patients and establish their possible associations with stress related symptoms during diagnosis and treatment. Results showed that prostate cancer patients had higher HCL-32 scores compared to healthy individuals, and the symptoms were associated with more severe stress related to prostate cancer reflected by higher scores on IES-R and its subscales (Avoidance, Intrusions, and Hyperarousal).
Article
Cell Biology
Urszula Doboszewska, Katarzyna Socala, Mateusz Pierog, Dorota Nieoczym, Jan Sawicki, Adam Sajnog, Bernadeta Szewczyk, Katarzyna Mlyniec, Ireneusz Sowa, Danuta Baralkiewicz, Piotr Wlaz
Summary: The G-protein coupled receptor 39 (GPR39) is a potential target for future drugs, and its pharmacology is not fully understood. Zinc acts as an endogenous agonist or an allosteric modulator for GPR39, while TC-G 1008 is a synthetic agonist. Zinc also enhances the activity of TC-G 1008 at GPR39. Activation of GPR39 by TC-G 1008 promotes epileptogenesis in an epilepsy model and decreases seizure threshold in a seizure test. The amount of zinc in the diet contributes to the effects of TC-G 1008 in vivo.
Article
Neurosciences
Marcin Siwek, Aleksandra Gorostowicz, Adrian Andrzej Chrobak, Adrian Gerlich, Anna Julia Krupa, Andrzej Juryk, Dominika Dudek
Summary: These preliminary results report the findings of a 12-week study that compared the effectiveness of trazodone XR and SSRIs in treating MDD. The study showed that trazodone XR was more effective than SSRIs in reducing the severity of insomnia and depression.
Article
Biochemistry & Molecular Biology
Monika Marcinkowska, Barbara Mordyl, Agata Siwek, Monika Gluch-Lutwin, Tadeusz Karcz, Alicja Gawalska, Michal Sapa, Adam Bucki, Katarzyna Szafranska, Bartosz Pomierny, Karolina Pytka, Magdalena Kotanska, Kamil Mika, Marcin Kolaczkowski
Summary: In this study, a set of dually acting molecules were designed to modulate GABA-A and 5-HT6 receptor activity simultaneously, aiming to improve therapeutic outcomes in treatment-resistant depression. Lead molecule 16 showed desirable receptor profile and physicochemical properties, reducing proinflammatory cytokine secretion and oxidative stress markers. Animal studies demonstrated antidepressant-like activity of 16 through synergic interplay between 5-HT6 and GABA-A receptors. These findings suggest that hybrid molecule 16 is an interesting tool that interacts with pharmacologically relevant targets, matching the pathological dysfunction of depression associated with neuroinflammation.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Monika Marcinkowska, Nikola Fajkis-Zajaczkowska, Katarzyna Szafranska, Jakub Jonczyk, Agata Siwek, Barbara Mordyl, Tadeusz Karcz, Gniewomir Latacz, Marcin Kolaczkowski
Summary: Modulating the alpha 1 beta 2 gamma 2 GABA-A receptor subpopulation in the basal ganglia region is a promising pharmacological strategy for neurological dysfunction. However, the current chemical space of molecules targeting the alpha 1/gamma 2 interface of GABA-A receptors is limited. In this study, we identified a series of 2-(4-fluorophenyl)-1H-benzo-[d]imidazoles as positive allosteric modulators (PAMs) with improved stability and reduced hepatotoxicity. These PAMs showed preference for interaction with the alpha 1/gamma 2 interface of the GABA-A receptor, providing useful chemical templates for further exploration of therapeutic potential.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Pharmacology & Pharmacy
Gabriela Starowicz, Dominika Siodlak, Gabriel Nowak, Katarzyna Mlyniec
Summary: This study aimed to investigate the role of glutamatergic and GABAergic system activation in TC-G 1008 antidepressant-like effects and the disruptions caused by a low-zinc diet. The results showed that the antidepressant-like effect of TC-G 1008 was blocked by NMDA and picrotoxin, and joint administration with muscimol or SCH50911 showed a trend towards decreased immobility time. A zinc-deficient diet resulted in dysregulation of GluN1, PSD95, and KCC2 protein expression. These findings suggest the important role of glutamate/GABA signaling in the antidepressant-like effect of TC-G 1008 and imply that GPR39 may be a novel target for the development of antidepressants.
PHARMACOLOGICAL REPORTS
(2023)
Review
Neurosciences
Marcin Siwek, Krzysztof Wojtasik-Bakalarz, Anna Julia Krupa, Adrian Andrzej Chrobak
Summary: The first III generation antipsychotic drug, aripiprazole, was registered in 2002. It has a unique mechanism of action and potentially beneficial influence on symptoms of schizophrenia. However, it can cause agitation, anxiety, or akathisia. Brexpiprazole, registered in 2015, was developed to retain the positive actions of aripiprazole while presenting a better clinical profile. It shows promise in treating symptoms that previous antipsychotics were not sufficiently effective in, including negative, depressive, or cognitive symptoms.
Editorial Material
Neurosciences
Marcin Siwek, Bernadeta Szewczyk, Adrian Andrzej Chrobak
Article
Pharmacology & Pharmacy
Dominika Dudek, Adrian Andrzej Chrobak, Anna Julia Krupa, Aleksandra Gorostowicz, Adrian Gerlich, Andrzej Juryk, Marcin Siwek
Summary: This study aimed to compare the effectiveness and tolerability of SSRIs and trazodone XR in treating MDD. The results showed that trazodone XR was more effective than SSRIs in reducing the severity of depression, anxiety, and insomnia. It also showed potential superiority in reducing anhedonia.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Psychiatry
Ewa Drozdowicz-Jastrzebska, Anna Mach, Michal Skalski, Piotr Januszko, Zoulikha Jabiry-Zieniewicz, Marcin Siwek, Zbigniew Maciej Wawrzyniak, Maria Radziwon-Zaleska
Summary: This study found a relationship between anxiety, insomnia, and postpartum depression. Assessing anxiety symptoms and sleep quality is important in screening women at risk of postpartum depression. Additionally, divorced and single women were shown to be at higher risk of postpartum depression.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychiatry
Adrian Andrzej Chrobak, Katarzyna Siuda-Krzywicka, Zbigniew Soltys, Sylwia Bielak, Dominik Nowaczek, Aleksandra Zyrkowska, Magdalena Fafrowicz, Tadeusz Marek, Ewa Pecherzewska, Jan Kuzdzal, Anna Starowicz-Filip, Aleksandra Gorostowicz, Dominika Dudek, Marcin Siwek
Summary: This study aimed to verify previously observed deficits in implicit motor learning in schizophrenia and bipolar disorder patients. Results showed that both clinical groups presented decreased indices of implicit motor learning compared to healthy controls, with a paradoxical learning pattern. The new limited response time SRTT variant replicated the findings of disrupted implicit motor learning in SZ and BD.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychiatry
Aleksandra Gorostowicz, Sakina J. Rizvi, Sidney H. Kennedy, Adrian Andrzej Chrobak, Dominika Dudek, Katarzyna Cyranka, Joanna Piekarska, Eve Krawczyk, Marcin Siwek
Summary: The aim of this study was to validate the Polish adaptation of the Dimensional Anhedonia Rating Scale (DARS) in patients with mood disorders and healthy controls. The results showed that the Polish DARS had excellent internal consistency and very good validity, making it a valuable tool for measuring anhedonia in patients with mood disorders.
FRONTIERS IN PSYCHIATRY
(2023)
