Review
Biochemistry & Molecular Biology
Nayra Felipez, Sheyla Montori, Naroa Mendizuri, Joan Llach, Pedro G. G. Delgado, Leticia Moreira, Enrique Santamaria, Joaquin Fernandez-Irigoyen, Eduardo Albeniz
Summary: Gastric cancer is a global public health problem with high mortality rates. Biomarker research is crucial for early detection of gastric cancer. Technological advances have identified several potential biomarkers, but their low specificity in biofluids limits their clinical use. Recent research focuses on exploring gastric juice as an alternative source for biomarker identification, as it contains disease-specific biomarkers generated at the site of damage. This narrative review describes potential biomarkers for gastric cancer screening in gastric juice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Xue Li, Nai-Ren Zheng, Lin-Heng Wang, Zhong-Wu Li, Zong-Chao Liu, Hua Fan, Yi Wang, Jin Dai, Xiao-Tian Ni, Xin Wei, Ming-Wei Liu, Kai Li, Zhe-Xuan Li, Tong Zhou, Yang Zhang, Jing-Ying Zhang, Gaohaer Kadeerhan, Sha Huang, Wen-Hui Wu, Wei-Dong Liu, Xiu-Zhen Wu, Lan-Fu Zhang, Jian-Ming Xu, Markus Gerhard, Wei-Cheng You, Kai-Feng Pan, Wen-Qing Li, Jun Qin
Summary: By analyzing the proteomic landscape, we identified protein signatures associated with the progression of gastric lesions and the risk of early gastric cancer. These findings have important implications for identifying high-risk populations and early detection of gastric cancer.
Review
Biochemistry & Molecular Biology
Cristina Herrera-Pariente, Sheyla Montori, Joan Llach, Alex Bofill, Eduardo Albeniz, Leticia Moreira
Summary: Gastric cancer is a common cancer worldwide, with early detection being crucial for improving clinical outcomes. Current screening programs are effective in high-incidence populations but not cost-effective in low-incidence populations, highlighting the need for new noninvasive biomarkers.
Review
Biochemistry & Molecular Biology
Yiwu Yan, Su Yeon Yeon, Chen Qian, Sungyong You, Wei Yang
Summary: Prostate cancer is a leading cause of morbidity and mortality among men worldwide, and advancements in multiple protein biomarkers offer hope for its diagnosis and prognosis. The identification of multi-protein biomarkers with high sensitivity and specificity, as well as their integration with clinicopathologic parameters, imaging, and other molecular biomarkers, can help achieve optimal personalized management for PC patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ana M. Moreira, Rui M. Ferreira, Patricia Carneiro, Joana Figueiredo, Hugo Osorio, Jose Barbosa, John Preto, Perpetua Pinto-do-O, Fatima Carneiro, Raquel Seruca
Summary: The extracellular matrix (ECM) plays a crucial role in the development and progression of gastric cancer. Through proteomic analysis, we identified a common ECM signature in gastric cancer and normal mucosa, and found that remodeling of gastric ECM promotes tumor progression. Additionally, we identified COL10A1 and other differentially expressed ECM proteins as important biomarkers in gastric cancer, with some ECM proteins correlating with patient prognosis.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Biochemical Research Methods
Chao-Jung Chen, Che-Yi Chou, Kuo-Hsiung Shu, Hung-Chun Chen, Ming-Cheng Wang, Chia-Chu Chang, Bang-Gee Hsu, Mai-Szu Wu, Yuan-Lung Yang, Wen-Ling Liao, Chieh Yang, Yu-Tien Hsiao, Chiu-Ching Huang
Summary: This study identified BRDT, CYBP, GARS, and HDGF as novel urinary UC biomarkers with high discrimination ability. These markers showed better diagnostic values compared to other reported UC markers, and a panel including BRDT, HDGF, GARS, and CYFR21.1 had high AUC values for discriminating between UC and normal or control groups.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Peng Zhang, Yao Tong, Xiaowen Huang, Yuqing Chen, Yanru Li, Dongrui Luan, Juan Li, Chuanxin Wang, Peilong Li, Lutao Du, Jiayi Wang
Summary: Gastric cancer (GC) is a common and deadly tumor, and better diagnostic markers and methods are needed. This study developed a fluorescent nanomachine that can detect GC biomarkers miR-5585-5p and PLS3mRNA with high sensitivity. It is a PCR-free biosensor that allows tumor cell imaging and serum diagnosis. The nanomachine achieved ultrasensitive detection and performed better than clinically used biomarkers in distinguishing GC patients.
Article
Biochemistry & Molecular Biology
Shahid Aziz, Faisal Rasheed, Rabaab Zahra, Simone Koenig
Summary: This study compared serum and tissue samples from patients with different gastroduodenal diseases to identify potential serum biomarkers for early gastric cancer diagnosis. It also identified specific serum markers for advanced gastric cancer independent of Helicobacter pylori infection. These findings have the potential to improve gastric cancer diagnostics.
Article
Medicine, General & Internal
Ju Yup Lee, Mae-Ja Park
Summary: In this study, the value of serum CD26 in gastric cancer and its relationship with serum HER2 levels were investigated. The results showed that serum CD26 levels were significantly lower in gastric cancer patients compared to healthy controls, and they tended to decrease with gastric cancer progression. Serum CD26 was found to be useful for diagnosing gastric cancer, but its levels did not correlate with HER2 status.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Yitian Xu, Pengshan Zhang, Kundong Zhang, Chen Huang
Summary: CA72-4, as a tumor marker, plays an important role in the diagnosis, prognosis, and treatment of GC, especially in the Chinese population. By combining with other biomarkers and improving detection techniques, the sensitivity and specificity of CA72-4 can be enhanced. Furthermore, CA72-4 can evaluate therapeutic effectiveness and enhance drug efficacy.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Article
Oncology
Weiwei Zhang, Ming Zheng, Shan Kong, Xian Li, Shuting Meng, Xudong Wang, Feng Wang, Chenxue Tang, Shaoqing Ju
Summary: The study identified Hsa_circ_0007507 as a potential biomarker for GC diagnosis and prognosis, showing higher expression levels in GC patients. It also demonstrated that serum Hsa_circ_0007507 lacked specificity for colorectal, thyroid, and breast cancer patients. Diagnostic efficacy analysis indicated that Hsa_circ_0007507 performed better in distinguishing GC patients from normal individuals compared to CEA and CA199.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medical Laboratory Technology
Ximeng Chen, Jianan Wang, Jinyang Wang, Jingyun Ye, Ping Di, Chang Dong, Hong Lei, Chengbin Wang
Summary: This study utilized proteomics to analyze serum proteins and identify potential biomarkers for the diagnosis of osteoarticular tuberculosis. ITIH2, CFHR2, CFHR3, and CFHR5 were found to be potential biomarkers, with CFHR2 and CFHR3 showing good diagnostic efficacy when combined in a diagnostic model.
CLINICA CHIMICA ACTA
(2023)
Review
Genetics & Heredity
Guiping Zhao, Anni Zhou, Xiao Li, Shengtao Zhu, Yongjun Wang, Shutian Zhang, Peng Li
Summary: Exosomal RNAs play a crucial role in the pathogenesis, development, diagnosis, and treatment of gastric cancer, potentially serving as diagnostic and therapeutic targets for the disease.
Article
Medical Laboratory Technology
Haiyan Zhang, Zhe Li, Yao Ruan, Weiliang Sun, Rui Yu
Summary: The study found that circular RNA (circRNA) hsa_circ_0001811 may become a new diagnostic biomarker for gastric cancer, with low expression in gastric cancer tissues and plasma from patients. Combining both tissues and plasma can improve diagnostic value, and it is associated with clinicopathological factors of gastric cancer.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Oncology
Lei Gu, Jin Chen, Yueying Yang, Yunpeng Zhang, Yuying Tian, Jinhua Jiang, Donglei Zhou, Lujian Liao
Summary: This study extracted extracellular vesicles from serum samples and identified a series of protein biomarkers for gastric cancer diagnosis. A panel of proteins was selected and logistic regression was used for classification. A classification panel with high performance and a protein panel for advanced stage gastric cancer diagnosis were identified.
FRONTIERS IN ONCOLOGY
(2022)