Journal
PHARMACOLOGICAL REPORTS
Volume 62, Issue 5, Pages 938-941Publisher
POLISH ACAD SCIENCES INST PHARMACOLOGY
DOI: 10.1016/S1734-1140(10)70354-6
Keywords
BDNF; gene; alcohol dependence; TDT (transmission disequilibrium test); trios; family
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Funding
- Polish Ministry of Health and Higher Education [NN 402189335]
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Brain-derived neurotrophic factor (BDNF) belongs to a family of proteins related to the nerve growth factor family, which are responsible for the proliferation, survival and differentiation of neurons. BDNF is thought to be involved in the pathogenesis of bipolar disorder, schizophrenia, eating disorders and addiction. We hypothesize that a functionally relevant polymorphism of the BDNF gene promoter may be associated with the pathogenesis of alcohol dependence. We performed an association study of 141 families with alcohol dependence. One hundred and thirty-eight healthy control subjects were matched based on ethnicity and gender. An association between the BDNF Va166Met gene polymorphism and alcoholism was not found.
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