RRAD inhibits aerobic glycolysis, invasion, and migration and is associated with poor prognosis in hepatocellular carcinoma

Tumor suppressor p53 negatively regulates glycolysis stimulated by hypoxia through its target RRAD

(2015) Cen Zhang et al.   Oncotarget

Ras-induced Epigenetic Inactivation of theRRAD(Ras-related Associated with Diabetes) Gene Promotes Glucose Uptake in a Human Ovarian Cancer Model

(2014) Yan Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RRAD Promotes EGFR-Mediated STAT3 Activation and Induces Temozolomide Resistance of Malignant Glioblastoma

(2014) S.-Y. Yeom et al.   MOLECULAR CANCER THERAPEUTICS

How do glycolytic enzymes favour cancer cell proliferation by nonmetabolic functions?

(2014) H Lincet et al.   ONCOGENE

How does cancer cell metabolism affect tumor migration and invasion?

(2013) Tianyu Han et al.   Cell Adhesion & Migration

Promoter hypermethylation of Ras-related GTPase gene RRAD inactivates a tumor suppressor function in nasopharyngeal carcinoma

(2012) Yingxi Mo et al.   CANCER LETTERS

The TNF-α/ROS/HIF-1-induced Upregulation of FoxMI Expression Promotes HCC Proliferation and Resistance to Apoptosis

(2012) Limin Xia et al.   CARCINOGENESIS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Rad is a p53 direct transcriptional target that inhibits cell migration and is frequently silenced in lung carcinoma cells

(2011) Bo-Yuan Hsiao et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Anticancer Targets in the Glycolytic Metabolism of Tumors: A Comprehensive Review

(2011) Paolo E. Porporato et al.   Frontiers in Pharmacology

A Novel Senescence-Evasion Mechanism Involving Grap2 and Cyclin D Interacting Protein Inactivation by Ras Associated with Diabetes in Cancer Cells under Doxorubicin Treatment

(2010) Inkyoung Lee et al.   CANCER RESEARCH

GLUT1 Expression Is Increased in Hepatocellular Carcinoma and Promotes Tumorigenesis

(2009) Thomas Amann et al.   AMERICAN JOURNAL OF PATHOLOGY

GLUT1 as a therapeutic target in hepatocellular carcinoma

(2009) Thomas Amann et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Tumor Cell Metabolism: Cancer's Achilles' Heel

(2008) Guido Kroemer et al.   CANCER CELL