Journal
PHARMACOGENOMICS
Volume 14, Issue 14, Pages 1691-1700Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/pgs.13.146
Keywords
inflammatory bowel disease; meta-analysis; prediction; spondyloarthritis; TNF blocker; TNF--308 polymorphism; TNF--857 polymorphism
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Funding
- Shanghai Scientific Committee Basic Research Fund [08JC1406300, 08JC1406200]
- National Natural Science Foundation of China (NSFC) [H1008, 81302580]
- National Key Basic Research Program of China (973) Program [2014CB541804]
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Aim: To explore whether TNF- promoter -308 A/G and -857 C/T polymorphisms have an association with responsiveness to TNF blockers in spondyloarthritis and inflammatory bowel disease. Methods: A meta-analysis was performed. Pooled odds ratios (ORs) and 95% CIs were calculated. Results: Six relevant studies with a total of 211 spondyloarthritis patients and 392 inflammatory bowel disease patients were included. The results showed that the common allele (G and C, respectively) showed a better responsiveness than the minor allele (A and T, respectively). The -308 G/G genotype (OR: 2.31; 95% CI: 1.36-3.91; p = 0.002) and -857 C/C genotype (OR: 3.66; 95% CI: 1.35-9.92; p = 0.01) responded better to therapy, which was different from the results of some studies included. Conclusion: Individuals with the TNF--308 G allele and -857 C allele showed better anti-TNF- treatment responses than those with the TNF--308 A allele and -857 T allele. The -308 G/G genotype and -857 C/C genotype are predictors of good response. Original submitted 30 May 2013; Revised submitted 25 July 2013
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