Article
Pharmacology & Pharmacy
Marcin Siwek, Aleksandra Gorostowicz, Magdalena Bosak, Dominika Dudek
Summary: Epilepsy and depression often coexist, and there is a bidirectional relationship between the two disorders. However, current evidence on the effectiveness of antidepressant therapy in patients with epilepsy and comorbid depression is limited. Vortioxetine, a multimodal antidepressant, shows promise as a treatment option for depressed patients with cognitive dysfunctions, anhedonia, and anxiety.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Psychiatry
Steven L. Dubovsky, Biswarup M. Ghosh, Jordan C. Serotte, Victoria Cranwell
Summary: Psychotic depression is considered an independent trait that may accompany mood disorders of varying severity, with acute treatment typically involving a combination of antidepressants, antipsychotic drugs, or electroconvulsive therapy. Limited information exists on maintenance treatment for unipolar psychotic depression and on acute and chronic treatment for psychotic bipolar disorder, leading to a reliance on clinical experience for treatment decision-making.
PSYCHOTHERAPY AND PSYCHOSOMATICS
(2021)
Article
Clinical Neurology
Gregory Jones, Carola Rong, Courtney M. Vecera, Christopher Gurguis, Roshan Chudal, Rushaniya Khairova, Edison Leung, Ana C. Ruiz, Lokesh Shahani, Marcus Zanetti, Rafael T. de Sousa, Geraldo Busatto, Jair Soares, Wagner F. Gattaz, Rodrigo Machado-Vieira
Summary: Lithium may play an important role in treating comorbid anxiety in bipolar disorder, both as adjunct and monotherapy. Lower doses of lithium may provide equivalent efficacy and enhance tolerability and compliance.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychology, Clinical
Ilona Merikanto, Timo Partonen
Summary: This study found that evening-types show more pronounced mental health symptoms, diagnoses, and hospital treatments, especially when assessed by circadian type. Insufficient sleep mediates most but not all of the associations between eveningness and mental health.
DEPRESSION AND ANXIETY
(2021)
Article
Genetics & Heredity
Gerard Anmella, Silvia Vilches, Jordi Espadaler-Mazo, Andrea Murru, Isabella Pacchiarotti, Miquel Tuson, Marina Garriga, Eva Sole, Merce Brat, Giovanna Fico, Eduard Vieta
Summary: This study evaluated the impact of individual genes in the response to treatment in bipolar depression, finding that pharmacogenetic variables can predict patient response to medication and tolerability. These predictors could be useful for guiding pharmacological treatment in bipolar disorder, but further clinical studies are needed to confirm these findings.
Review
Pharmacology & Pharmacy
Malgorzata Borczyk, Marcin Piechota, Jan Rodriguez Parkitna, Michal Korostynski
Summary: This article discusses the variability of antidepressant effectiveness in treating major depressive disorder among patients, with genetic factors playing a significant role in individual responses. The integration of genomics and pharmacology can provide guidance for personalized treatment of depression.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Review
Psychology, Clinical
Sukanta Saha, Carmen C. W. Lim, Danielle L. Cannon, Lucinda Burton, Monique Bremner, Peter Cosgrove, Yan Huo, John J. McGrath
Summary: This study conducted a meta-analysis to explore the comorbidity between mood and anxiety disorders, finding consistent evidence of a substantial association regardless of diagnostic criteria, study timeframe, or adjustments. Clinicians should be aware of the high prevalence of this common comorbidity and ensure prompt identification and treatment.
DEPRESSION AND ANXIETY
(2021)
Review
Psychiatry
Lauro Estivalete Marchionatti, Thyago Antonelli-Salgado, Isadora Nunes Erthal, Savio Luiz Santos Lopes, Luiza Silveira Lucas, Diego Barreto Reboucas, Ives Cavalcante Passos
Summary: This systematic review on the impact of disease progression in the treatment of bipolar disorder patients found that efficacy decreases with clinical progression, supporting early intervention. However, tailored recommendations cannot be made based on disease stages currently, highlighting the need for further research.
PSYCHIATRY RESEARCH
(2022)
Article
Psychiatry
Sarah Tebeka, Pierre A. Geoffroy, Caroline Dubertret, Yann Le Strat
Summary: This study confirmed the presence of a depressive continuum with sadness being a common symptom in the general population and sharing correlations with Major Depressive Disorder (MDD). They have shown a continuum where sadness serves as an intermediate state between well-being and psychiatric disorders. With high sensitivity and specificity, sadness appears to be a clear MDD prodrome and an at-risk state, potentially indicating a symptom of a transdiagnostic distress process.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Health Care Sciences & Services
Taichi Ochi, Natalya M. Vyalova, Innokentiy S. Losenkov, Diana Z. Paderina, Ivan Pozhidaev, Anton J. M. Loonen, German G. Simutkin, Nikolay A. Bokhan, Bob Wilffert, Svetlana A. Ivanova
Summary: This study found a possible association between genotype related to dopamine neurotransmission and antidepressant treatment response. DRD4 and MAOB genotypes were linked to improved HAMD 17 scores, but the preliminary nature of the results is noted due to the limited sample size. Further research into the role of habenular dopamine D4 receptors in antidepressant response is recommended.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Lorenza Lucidi, Mauro Pettorruso, Federica Vellante, Francesco Di Carlo, Franca Ceci, Maria Chiara Santovito, Ilenia Di Muzio, Michele Fornaro, Antonio Ventriglio, Carmine Tomasetti, Alessandro Valchera, Alessandro Gentile, Yong-Ku Kim, Giovanni Martinotti, Silvia Fraticelli, Massimo Di Giannantonio, Domenico De Berardis
Summary: The gut microbiota plays a crucial role in maintaining homeostasis, growth, and digestive processes. It also influences the intercommunication system between the gut and the brain, potentially impacting the pathogenesis and clinical management of Bipolar Disorder. Current literature suggests a relationship between compositional alterations in the gut microbiota and BD, with potential benefits in treating BD symptoms through modifications in the microbiota composition. Further research is needed to explore the potential of correcting gut microbiota alterations as a novel strategy in BD management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Clinical Neurology
Julia J. Meerman, Sophie E. ter Hark, Joost G. E. Janzing, Marieke J. H. Coenen
Summary: This review examines the genetic overlap between various traits and antidepressant treatment response in patients with unipolar MDD using polygenic risk scores (PRS). The results suggest that PRSs for several traits, including attention-deficit hyperactivity disorder and coronary artery disease, may be associated with antidepressant treatment response. However, the studies varied in sample size and outcome measures, highlighting the need for larger cohorts and standardized assessment methods.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
Roger S. McIntyre, Joshua D. Rosenblat, Nelson B. Rodrigues, Orly Lipsitz, David Chen-Li, Jung Goo Lee, Flora Nasri, Mehala Subramaniapillai, Kevin Kratiuk, Andrew Wang, Hartej Gill, Rodrigo B. Mansur, Roger Ho, Kangguang Lin, Yena Lee
Summary: The study found that intravenous ketamine can significantly improve cognitive function in TRD patients, especially in tests like DSST and PDQ-5-D. This improvement is mainly mediated by reduced depressive symptoms, indicating that ketamine has independent and rapid effects in promoting cognition.
PSYCHIATRY RESEARCH
(2021)
Review
Clinical Neurology
Claudia Pisanu, Giovanni Severino, Ilario De Toma, Mara Dierssen, Paolo Fusar-Poli, Massimo Gennarelli, Pietro Lio, Elisabetta Maffioletti, Eduard Maron, Divya Mehta, Alessandra Minelli, Marie-Claude Potier, Alessandro Serretti, David Stacey, Roos van Westrhenen, Laura Xicota, Bernhard T. Baune, Alessio Squassina
Summary: The study focused on investigating the expression levels of genes involved in drug disposition and action in tissues of pharmacological importance in patients treated with psychotropic drugs. Promising findings include the role of genes in inflammation, neurotransmission, and mitochondrial function. However, studies on antipsychotics or mood stabilizers often had smaller sample sizes and lacked replication compared to studies on antidepressants.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hui Hua Chang, Yuan-Shuo Hsueh, Yung Wen Cheng, Huai-Hsuan Tseng
Summary: This study investigated the associations between LEPR gene polymorphisms and treatment response to valproate (VPA) in patients with bipolar disorder (BD). The results showed that LEPR gene polymorphisms significantly affected changes in disease severity after VPA treatment in BD patients, and the LEPR CAGG haplotype was associated with a better treatment response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Kathleen E. Morrison, Sneha Narasimhan, Ethan Fein, Tracy L. Bale
Article
Gastroenterology & Hepatology
Diana M. Lim, Sneha Narasimhan, Carmen Z. Michaylira, Mei-Lun Wang
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2009)
Article
Clinical Neurology
Wint Thu Saung, Sneha Narasimhan, Falk W. Lohoff
HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
(2014)
Article
Biochemistry & Molecular Biology
F. W. Lohoff, R. Hodge, S. Narasimhan, A. Nall, T. N. Ferraro, B. J. Mickey, M. M. Heitzeg, S. A. Langenecker, J-K Zubieta, R. Bogdan, Y. S. Nikolova, E. Drabant, A. R. Hariri, L. Bevilacqua, D. Goldman, G. A. Doyle
MOLECULAR PSYCHIATRY
(2014)
Article
Neurosciences
Sneha Narasimhan, Tiffany D. Aquino, Rachel Hodge, Karl Rickels, Falk W. Lohoff
NEUROSCIENCE LETTERS
(2011)
Article
Neurosciences
Pushpinder K. Multani, Toni-Kim Clarke, Sneha Narasimhan, Lisa Ambrose-Lanci, Kyle M. Kampman, Helen M. Pettinati, David W. Oslin, Charles P. O'Brien, Wade H. Berrettini, Falk W. Lohoff
NEUROSCIENCE LETTERS
(2012)
Article
Genetics & Heredity
F. W. Lohoff, T. D. Aquino, S. Narasimhan, P. K. Multani, B. Etemad, K. Rickels
PHARMACOGENOMICS JOURNAL
(2013)
Article
Genetics & Heredity
F. W. Lohoff, S. Narasimhan, K. Rickels
PHARMACOGENOMICS JOURNAL
(2013)
Editorial Material
Genetics & Heredity
Sneha Narasimhan, Rachel Hodge, Glenn A. Doyle, David J. M. Kraemer, Ranjani Prabhakaran, Karl Rickels, Tiffany Richardson, Paul J. Bloch, Falk W. Lohoff
PSYCHIATRIC GENETICS
(2011)
Article
Psychiatry
Sneha Narasimhan, Tiffany D. Aquino, Pushpinder K. Multani, Karl Rickels, Falk W. Lohoff
PSYCHIATRY RESEARCH
(2012)
Article
Psychiatry
Alissa J. Cooper, Sneha Narasimhan, Karl Rickels, Falk W. Lohoff
PSYCHIATRY RESEARCH
(2013)
