Article
Gastroenterology & Hepatology
Sun-Ho Lee, Margaret Walshe, Eun Hye Oh, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Tomer Greener, Adam Weizman, Mark S. Silverberg, Byong Duk Ye
Summary: The study suggests that changes in serum albumin levels within the first 2 weeks of anti-TNF treatment can predict primary nonresponse, endoscopic outcomes, time to colectomy, and anti-TNF failure in patients with UC. Early access to this biomarker may help identify patients at risk of treatment failure and guide early optimization of anti-TNF therapy.
INFLAMMATORY BOWEL DISEASES
(2021)
Article
Chemistry, Analytical
Zhiwei Miao, Kang Ding, Shuyin Jin, Lin Dai, Chen Dai, Xiang Li
Summary: The study utilized peptidomics to identify serum diagnostic markers for different stages of ulcerative colitis (UC), involving the identification of 40 peptides and the screening of six biomarker peptides derived from proteins associated with coagulation and complement activation. The perturbation of these peptides was found to effectively distinguish patients with active UC, patients with remitting UC, and healthy individuals, demonstrating the potential of serum peptidomics in diagnosing various stages of UC.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Article
Gastroenterology & Hepatology
Kengo Kanayama, Jun Kato, Wataru Shiratori, Ariki Nagashima, Yuki Ohta, Takashi Taida, Keiko Saito, Chihiro Goto, Satsuki Takahashi, Ryosuke Horio, Akane Kurosugi, Tsubasa Ishikawa, Tatsuya Kaneko, Naoki Akizue, Kenichiro Okimoto, Tomoaki Matsumura, Naoya Kato
Summary: This study found that selecting subsequent treatment based on the response to initial anti-tumor necrosis factor (TNF)alpha antibody (ATA) is feasible in refractory ulcerative colitis (UC) patients. Non-ATA may be suitable as subsequent biologics for UC patients regardless of the efficacy of the first ATA.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Biology
Kacper Nijakowski, Piotr Eder, Marek Simon, Katarzyna Korybalska, Janusz Witowski, Anna Surdacka
Summary: The study found that the levels of S100A8/calprotectin, myeloperoxidase, and IgA in the saliva of patients with inflammatory bowel disease were significantly decreased. Myeloperoxidase and TNF-R1 concentrations showed high differentiation potential for distinguishing between Crohn's disease and ulcerative colitis.
Article
Immunology
Samantha Rodriguez-Muguruza, Antonio Altuna-Coy, Veronica Arreaza-Gil, Marina Mendieta-Homs, Sonia Castro-Oreiro, Maria Jose Poveda-Elices, Nuria del Castillo-Pinol, Ramon Fontova-Garrofe, Matilde R. Chacon
Summary: This study identified new serum biomarkers for ERA using metabolomics and constructed a biomarker panel composed of glyceric acid, lactic acid, and 3-hydroxisovaleric acid, which shows potential for improving the early clinical diagnosis of RA.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tomasz Wysocki, Agnieszka Paradowska-Gorycka
Summary: Rheumatoid arthritis is a common inflammatory arthritis in which tumor necrosis factor plays a key role. However, there is variation in response to TNF-targeting drugs, which may be influenced by genetic factors. The field of pharmacogenomics offers potential for developing novel prognostic tools.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Amin Ravaei, Lia Pulsatelli, Elisa Assirelli, Jacopo Ciaffi, Riccardo Meliconi, Carlo Salvarani, Marcello Govoni, Michele Rubini
Summary: This study investigated the association of two RA-related genetic polymorphisms in the MTHFR gene as response markers to an anti-TNF-alpha therapy. The results showed that both polymorphisms were associated with a response to therapy in an allele dose-dependent manner. This suggests a potential significance of one-carbon metabolism in anti-TNF-alpha drug efficacy for personalized RA interventions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Borja Hernandez-Breijo, Ioannis Parodis, Marta Novella-Navarro, Ana Martinez-Feito, Victoria Navarro-Compan, Mariana Diaz-Almiron, Dora Pascual-Salcedo, Alejandro Balsa, Chamaida Plasencia-Rodriguez
Summary: This study found that serum BAFF concentrations are associated with response to TNF inhibitors in rheumatoid arthritis patients, highlighting the importance of B-cells in RA.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Marina Liso, Giulio Verna, Elisabetta Cavalcanti, Stefania De Santis, Raffaele Armentano, Angela Tafaro, Antonio Lippolis, Pietro Campiglia, Antonio Gasbarrini, Mauro Mastronardi, Theresa Torres Pizarro, Fabio Cominelli, Loris Riccardo Lopetuso, Marcello Chieppa
Summary: This study provides new insights and alternative approaches to treat ulcerative colitis (UC) patients. It suggests that anti-interleukin (IL)1 strategies, such as anakinra, may be a more effective therapeutic option for primary nonresponders to anti-tumor necrosis factor (TNF) therapy.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Immunology
Peng Han, Chao Hou, Xi Zheng, Lulu Cao, Xiaomeng Shi, Xiaohui Zhang, Hua Ye, Hudan Pan, Liang Liu, Tingting Li, Fanlei Hu, Zhanguo Li
Summary: This study investigated the serum antigenomic profiling in rheumatoid arthritis (RA) using label-free proteomic technology and machine-learning algorithm. The results identified potential diagnostic biomarkers and developed a model to classify different types of RA patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Jeffrey R. Curtis, Xiaofeng Zhou, David T. Rubin, Walter Reinisch, Jinoos Yazdany, Philip C. Robinson, Yan Chen, Birgitta Benda, Ann Madsen, Jamie Geier
Summary: Compared with the general population, patients with rheumatoid arthritis (RA) are at a higher risk of COVID-19, including increased risk of hospitalization and in-hospital death. Systemic therapies do not further increase the risk, except for non-TNFi biologics.
JOURNAL OF RHEUMATOLOGY
(2022)
Article
Pharmacology & Pharmacy
Alexander Vugler, James O'Connell, Mai Anh Nguyen, Dietmar Weitz, Thomas Leeuw, Elizabeth Hickford, Alexander Verbitsky, Xiaoyou Ying, Markus Rehberg, Bruce Carrington, Mark Merriman, Andrew Moss, Jean-Marie Nicholas, Phil Stanley, Sara Wright, Tim Bourne, Yann Foricher, Daniel Brookings, Helen Horsley, Matthias Herrmann, Srinivas Rao, Markus Kohlmann, Peter Florian
Summary: This article reports the discovery and development of a potent small molecule inhibitor of TNF, SAR441566, which has shown potential as a treatment option for chronic autoimmune diseases. By stabilizing an asymmetrical form of TNF and compromising its functions, SAR441566 offers a promising alternative to established biologic drugs targeting TNF.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Kana Shiraishi, Shinya Furukawa, Sen Yagi, Kenichirou Mori, Tomoyuki Ninomiya, Keitarou Kawasaki, Yuji Mizukami, Seiyuu Suzuki, Masayoshi Uraoka, Naozumi Shibata, Sanae Nakamura, Satoshi Imamine, Hidehiro Murakami, Katsuhisa Ohashi, Masamoto Torisu, Makoto Yano, Aki Hasebe, Harumi Yano, Masato Murakami, Eiji Takeshita, Yoshio Ikeda, Yoichi Hiasa
Summary: In patients with ulcerative colitis, serum globulin showed a significant positive association with endoscopic activity and a significant inverse association with mucosal healing, especially in the low C-reactive protein group.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Alexandra E. Livanos, Alexandra Dunn, Jeremy Fischer, Ryan C. Ungaro, Williams Turpin, Sun -Ho Lee, Shumin Rui, Diane Marie Del Valle, Julia J. Jougon, Gustavo Martinez-Delgado, Mark S. Riddle, Joseph A. Murray, Renee M. Laird, Joana Torres, Manasi Agrawal, Jared S. Magee, Thierry Dervieux, Sacha Gnjatic, Dean Sheppard, Bruce E. Sands, Chad K. Poster, Kenneth Croitoru, Francesca Petralia, Jean-Frederic Colombel, Saurabh Mehandru
Summary: This study found that anti-integrin avfi6 autoantibodies are present in patients with ulcerative colitis (UC) and are associated with disease development and outcomes before diagnosis. These findings suggest that anti-avfi6 antibodies may be a useful biomarker for prediction and prognosis of UC.
Article
Gastroenterology & Hepatology
Filippos Koutroumpakis, Anna Evans Phillips, Dhiraj Yadav, Jorge D. Machicado, Maaz Ahsan, Claudia Ramos Rivers, Xiaoqing Tan, Marc Schwartz, Siobhan Proksell, Elyse Johnston, Jeffrey Dueker, Jana G. Hashash, Arthur Barrie, Janet Harrison, Michael A. Dunn, Liza Konnikova, Douglas J. Hartman, Hasieb Din, Dmitriy Babichenko, Gong Tang, David G. Binion
Summary: The study identified that IgG4 subclass deficiency is common in patients with IBD and associated with markers of disease severity. Treatment with intravenous Ig replacement therapy was beneficial in patients with IgG4-deficient severe IBD. Further research is needed to understand the mechanistic role of IgG4 deficiency in this subset of severe IBD patients.
INFLAMMATORY BOWEL DISEASES
(2021)
Article
Dermatology
K. A. Bain, E. McDonald, F. Moffat, M. Tutino, M. Castelino, A. Barton, J. Cavanagh, U. Z. Ijaz, S. Siebert, I. B. McInnes, A. Astrand, S. Holmes, S. W. F. Milling
BRITISH JOURNAL OF DERMATOLOGY
(2020)
Review
Immunology
Megan Sutcliffe, Gemma Radley, Anne Barton
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
(2020)
Article
Rheumatology
Anne Barton, Meghna Jani, Christine Bundy, James Bluett, Stephen McDonald, Brian Keevil, Faraz Dastagir, Melissa Aris, Ian Bruce, Pauline Ho, Eoghan McCarthy, Ellen Bruce, Ben Parker, Kimme Hyrich, Rachel Gorodkin
Summary: This study successfully reduced self-reported non-adherence to MTX from 24.7% to 7.4% through a series of interventions. Key factors for improvement included motivational interviewing and consistency in information delivery.
Review
Rheumatology
Chenfu Shi, Magnus Rattray, Anne Barton, John Bowes, Gisela Orozco
Article
Rheumatology
Sizheng Steven Zhao, Eftychia Bellou, Suzanne M. M. Verstappen, Michael J. Cook, Jamie C. Sergeant, Richard B. Warren, Anne Barton, John Bowes
Summary: Observational and genetic evidence suggest that BMI and glycemic control are associated with increased risk of psoriatic disease, while psoriatic disease is associated with increased risk of coronary artery disease.
Review
Genetics & Heredity
Philippa D. K. Curry, Andrew P. Morris, Anne Barton, James Bluett
Summary: Psoriatic arthritis is a chronic musculoskeletal disease that affects a significant proportion of psoriasis patients. The response to targeted therapies, such as TNF inhibitors, varies among patients. Researchers have been investigating potential genetic biomarkers for predicting drug response. Although several genetic variants have been reported to correlate with TNF inhibitor response, further validation and implementation into clinical practice are needed.
PHARMACOGENOMICS JOURNAL
(2023)
Article
Rheumatology
Ryan M. Hum, Pauline Ho, Nisha Nair, Meghna Jani, Ann W. Morgan, John D. Isaacs, Anthony G. Wilson, Kimme L. Hyrich, Darren Plant, Anne Barton
Summary: This study suggests that higher levels of TNF-a inhibitor serum drug levels (SDLs) are associated with good treatment response in fully adherent patients. Interventions to improve SDLs, such as encouraging adherence, may improve treatment response. The identified SDL cut-offs for adalimumab and certolizumab may be useful in clinical practice.
Review
Biochemistry & Molecular Biology
Robert Gurke, Annika Bendes, John Bowes, Michaela Koehm, Richard M. Twyman, Anne Barton, Dirk Elewaut, Carl Goodyear, Lisa Hahnefeld, Rainer Hillenbrand, Ewan Hunter, Mark Ibberson, Vassilios Ioannidis, Sabine Kugler, Rik J. Lories, Eduard Resch, Stefan Rueping, Klaus Scholich, Jochen M. Schwenk, James C. Waddington, Phil Whitfield, Gerd Geisslinger, Oliver FitzGerald, Frank Behrens, Stephen R. Pennington
Summary: The definitive diagnosis and early treatment of immune-mediated inflammatory diseases (IMIDs) are challenging due to variable clinical manifestations. Psoriatic arthritis (PsA) is an example of such a disease. The detection of molecular biomarkers offers hope for the early diagnosis and treatment of PsA, but specific biomarkers are not yet available. By analyzing multi-omics data and integrating them with clinical assessment, it is possible to develop molecular profiles that improve the diagnosis and treatment outcomes of PsA patients.
Letter
Rheumatology
Sizheng Steven Zhao, Anne Barton, John Bowes
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Biochemical Research Methods
Elena Vigorito, Anne Barton, Costantino Pitzalis, Myles J. Lewis, Chris Wallace
Summary: In this study, a Bayesian beta-binomial mixture model (BBmix) is proposed for calling genotypes using RNA-Seq data, which can model specific biases in RNA-Seq. The benchmarking results show that BBmix generally outperforms competitors in genotype calling, with an increase of up to 1.4% in the accuracy of heterozygous calls. BBmix can be easily incorporated into standard genotype calling pipelines and the model parameters are generally transferable within datasets, making it possible to call genotypes in a large number of samples with less than 1 hour of learning.
Letter
Rheumatology
Philippa D. K. Curry, Hector Chinoy, Meghna Jani, Darren Plant, Kimmie L. Hyrich, Ann W. Morgan, A. G. Wilson, John D. Isaacs, Andrew P. Morris, Anne Barton, James Bluett
JOURNAL OF RHEUMATOLOGY
(2023)
Letter
Rheumatology
Chuan Fu Yap, Nisha Nair, Annick de Vries, Floris C. Loeff, Ann W. Morgan, John D. Isaacs, Anthony G. Wilson, Kimme L. Hyrich, Anne Barton, Darren Plant
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Stephanie F. Ling, Chuan Fu Yap, Nisha Nair, James Bluett, Ann W. Morgan, John D. Isaacs, Anthony G. Wilson, Kimme L. Hyrich, Anne Barton, Darren Plant
Summary: This study aimed to identify proteomic biomarkers associated with clinical outcome measures in patients with rheumatoid arthritis (RA) starting biologic disease-modifying antirheumatic drugs (bDMARDs). Through SWATH-MS analysis of serum samples from RA patients before and after 3 months of treatment, ten proteins were found to be significantly associated with clinical outcome measures, and one of them was validated in an independent cohort.
Article
Rheumatology
Katriona Goldmann, Athina Spiliopoulou, Andrii Iakovliev, Darren Plant, Nisha Nair, Cankut Cubuk, Paul McKeigue, Michael R. Barnes, Anne Barton, Costantino Pitzalis, Myles J. Lewis
Summary: This study conducted expression quantitative trait locus (eQTL) analysis using RNA-Sequencing to explore the link between genetic variants and gene expression in rheumatoid arthritis (RA) patients. The analysis identified 898 eQTL genes in synovium and blood, with 232 genes in common. A specific eQTL at HLA-DPB2 was found to be associated with clinical severity and the lympho-myeloid pathotype.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Pharmacology & Pharmacy
Syed S. A. Gilani, Nisha Nair, Darren Plant, Kimme Hyrich, Ann W. Morgan, Andrew P. Morris, Anthony G. Wilson, John D. Isaacs, Anne Barton, James Bluett