Journal
PHARMACOGENOMICS
Volume 9, Issue 11, Pages 1605-1616Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/14622416.9.11.1605
Keywords
mu-opioid receptor; OPRM1 gene; analgesic; association study; haplotype analysis; pain; SNP
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Funding
- Japanese ministry of Health, Labour and Welfare [H17-pharmaco-001]
- Japanese ministry of Education, Culture, Sports, Science, and Technology
- Naito Foundation
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The association between SNPs of the human OPRM1 gene encoding the P-opioid receptor and postoperative analgesic requirements in surgical patients remains controversial. Here, we evaluate whether any of the five tag SNPs (A118G, IVS2+G691C, IVS3+G5953A, IVS3+A8449G and TAA+A2109G) representing the four linkage disequilibrium blocks of the OPRM1 gene influences postoperative analgesic requirements. Materials & methods: We studied 138 adult Japanese patients who underwent major open abdominal surgery under combined general and epidural anesthesia and received continuous postoperative epidural analgesia with opioids. Results: The 118G homozygous (GG) patients required 24-h postoperative analgesics more than 118A homozygous (AA) and heterozygous (AG) patients. Tag SNP haplotypes also were associated with 24-h postoperative analgesic requirements. Conclusions: These results suggest that OPRM1 gene tag SNP genotypes and haplotypes can primarily contribute to prediction of postoperative analgesic requirements in individual patients undergoing major open abdominal surgery.
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