4.2 Article

Common genetic variation of β1-and β2-adrenergic receptor and response to four classes of antihypertensive treatment

Journal

PHARMACOGENETICS AND GENOMICS
Volume 20, Issue 5, Pages 342-345

Publisher

LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/FPC.0b013e328338e1b8

Keywords

beta 1-adrenergic receptor; beta 2-adrenergic receptor; bisoprolol; drugs; hypertension; pharmacogenetics; polymorphism

Funding

  1. Academy of Finland
  2. Sigrid Juselius Foundation
  3. Finnish Heart Foundation

Ask authors/readers for more resources

Varying results have been reported on the association of beta-adrenergic receptor polymorphisms with blood pressure (BP) response to beta-blockers. We investigated the influence of ADRB1 Ser49Gly and Arg389Gly, and ADRB2 Gly16Arg and Glu27Gln polymorphisms on ambulatory BP response to bisoprolol and three other antihypertensive drug monotherapies in a placebo-controlled, double-blind, cross-over study with 233 moderately hypertensive men. ADRB1 Ser49Ser homozygotes tended to have a better ambulatory BP response to bisoprolol but the difference was statistically nonsignificant. ADRB1 Arg389Arg homozygotes did not show better BP response to bisoprolol than the other genotypes. There were no significant associations of ADRB2 polymorphisms with BP responses to any of the study drugs. The results from this controlled study in hypertensive men do not support clinical use of common polymorphisms in ADRB1 and ADRB2 in predicting BP responses to beta-blockers or to three other antihypertensive drugs. Pharmacogenetics and Genomics 20: 342-345 (c) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.2
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Article Peripheral Vascular Disease

Genome-wide association study of white-coat effect in hypertensive patients

Jenni M. Rimpela, Teemu Niiranen, Antti Jula, Ilkka H. Porsti, Antti Tikkakoski, Aki Havulinna, Terho Lehtimaki, Veikko Salomaa, Kimmo K. Kontula, Timo P. Hiltunen

BLOOD PRESSURE (2019)

Article Multidisciplinary Sciences

Heme oxygenase-1 repeat polymorphism in septic acute kidney injury

Laura M. Vilander, Suvi T. Vaara, Kati M. Donner, Paivi Lakkisto, Mari A. Kaunisto, Ville Pettila, Raili Laru-Sompa, Anni Pulkkinen, Minna Saarelainen, Mikko Reilama, Sinikka Tolmunen, Ulla Rantalainen, Marja Miettinen, Markku Suvela, Katrine Pesola, Pekka Saastamoinen, Sirpa Kauppinen, Kirsi-Maija Kaukonen, Anna-Maija Korhonen, Sara Nisula, Suvi Vaara, Raili Suojaranta-Ylinen, Leena Mildh, Mikko Haapio, Laura Nurminen, Sari Sutinen, Leena Pettila, Helina Laitinen, Heidi Syrja, Kirsi Henttonen, Elina Lappi, Hillevi Boman, Tero Varpula, Paivi Porkka, Mirka Sivula, Mira Rahkonen, Anne Tsurkka, Taina Nieminen, Niina Prittinen, Ari Alaspaa, Ville Salanto, Hanna Juntunen, Teija Sanisalo, Ilkka Parviainen, Ari Uusaro, Esko Ruokonen, Stepani Bendel, Niina Rissanen, Maarit Lang, Sari Rahikainen, Saija Rissanen, Merja Ahonen, Elina Halonen, Eija Vaskelainen, Meri Poukkanen, Esa Lintula, Sirpa Suominen, Jorma Heikkinen, Timo Lavander, Kirsi Heinonen, Anne-Mari Juopperi, Tadeusz Kaminski, Fiia Gaddnas, Tuija Kuusela, Jane Roiko, Sari Karlsson, Matti Reinikainen, Tero Surakka, Helena Jyrkonen, Tanja Eiserbeck, Jaana Kallinen, Vesa Lund, Paivi Tuominen, Pauliina Perkola, Riikka Tuominen, Marika Hietaranta, Satu Johansson, Seppo Hovilehto, Anne Kirsi, Pekka Tiainen, Tuija Myllarinen, Pirjo Leino, Anne Toropainen, Anne Kuitunen, Ilona Leppanen, Markus Levoranta, Sanna Hoppu, Jukka Sauranen, Jyrki Tenhunen, Atte Kukkurainen, Samuli Kortelainen, Simo Varila, Outi Inkinen, Niina Koivuviita, Jutta Kotamaki, Anu Laine, Tero Ala-Kokko, Jouko Laurila, Sinikka Salkio, Simo-Pekka Koivisto, Raku Hautamaki, Maria Skinnar

PLOS ONE (2019)

Article Multidisciplinary Sciences

Genetic architecture of human plasma lipidome and its link to cardiovascular disease

Rubina Tabassum, Joel T. Ramo, Pietari Ripatti, Jukka T. Koskela, Mitja Kurki, Juha Karjalainen, Priit Palta, Shabbeer Hassan, Javier Nunez-Fontarnau, Tuomo T. J. Kiiskinen, Sanni Soderlund, Niina Matikainen, Mathias J. Gerl, Michal A. Surma, Christian Klose, Nathan O. Stitziel, Hannele Laivuori, Aki S. Havulinna, Susan K. Service, Veikko Salomaa, Matti Pirinen, Matti Jauhiainen, Mark J. Daly, Nelson B. Freimer, Aarno Palotie, Marja-Riitta Taskinen, Kai Simons, Samuli Ripatti, Anu Jalanko, Jaakko Kaprio, Kati Donner, Mari Kaunisto, Nina Mars, Alexander Dada, Anastasia Shcherban, Andrea Ganna, Arto Lehisto, Elina Kilpelainen, Georg Brein, Ghazal Awaisa, Jarmo Harju, Kalle Parr, Pietro Della Briotta Parolo, Risto Kajanne, Susanna Lemmela, Timo P. Sipila, Tuomas Sipila, Ulrike Lyhs, Vincent Llorens, Teemu Niiranen, Kati Kristiansson, Lotta Mannikko, Manuel Gonzalez Jimenez, Markus Perola, Regis Wong, Terhi Kilpi, Tero Hiekkalinna, Elina Jarvensivu, Essi Kaiharju, Hannele Mattsson, Markku Laukkanen, Paivi Laiho, Sini Lahteenmaki, Tuuli Sistonen, Sirpa Soini, Adam Ziemann, Anne Lehtonen, Apinya Lertratanakul, Bob Georgantas, Bridget Riley-Gillis, Danjuma Quarless, Fedik Rahimov, Graham Heap, Howard Jacob, Jeffrey Waring, Justin Wade Davis, Nizar Smaoui, Relja Popovic, Sahar Esmaeeli, Jeff Waring, Athena Matakidou, Ben Challis, David Close, Slave Petrovski, Antti Karlsson, Johanna Schleutker, Kari Pulkki, Petri Virolainen, Lila Kallio, Arto Mannermaa, Sami Heikkinen, Veli-Matti Kosma, Chia-Yen Chen, Heiko Runz, Jimmy Liu, Paola Bronson, Sally John, Sanni Landenpera, Susan Eaton, Wei Zhou, Minna Hendolin, Outi Tuovila, Raimo Pakkanen, Joseph Maranville, Keith Usiskin, Marla Hochfeld, Robert Plenge, Robert Yang, Shameek Biswas, Steven Greenberg, Eija Laakkonen, Juha Kononen, Juha Paloneva, Urho Kujala, Teijo Kuopio, Jari Laukkanen, Eeva Kangasniemi, Kimmo Savinainen, Reijo Laaksonen, Mikko Arvas, Jarmo Ritari, Jukka Partanen, Kati Hyvarinen, Tiina Wahlfors, Andrew Peterson, Danny Oh, Diana Chang, Edmond Teng, Erich Strauss, Geoff Kerchner, Hao Chen, Hubert Chen, Jennifer Schutzman, John Michon, Julie Hunkapiller, Mark McCarthy, Natalie Bowers, Tim Lu, Tushar Bhangale, David Pulford, Dawn Waterworth, Diptee Kulkarni, Fanli Xu, Jo Betts, Jorge Esparza Gordillo, Joshua Hoffman, Kirsi Auro, Linda McCarthy, Soumitra Ghosh, Meg Ehm, Kimmo Pitkanen, Tomi Makela, Anu Loukola, Heikki Joensuu, Juha Sinisalo, Kari Eklund, Lauri Aaltonen, Martti Farkkila, Olli Carpen, Paula Kauppi, Pentti Tienari, Terhi Ollila, Tiinamaija Tuomi, Tuomo Meretoja, Anne Pitkaranta, Joni Turunen, Katariina Hannula-Jouppi, Sampsa Pikkarainen, Sanna Seitsonen, Miika Koskinen, Antti Palomaki, Juha Rinne, Kaj Metsarinne, Klaus Elenius, Laura Pirila, Leena Koulu, Markku Voutilainen, Markus Juonala, Sirkku Peltonen, Vesa Aaltonen, Andrey Loboda, Anna Podgornaia, Aparna Chhibber, Audrey Chu, Caroline Fox, Dorothee Diogo, Emily Holzinger, John Eicher, Padhraig Gormley, Vinay Mehta, Xulong Wang, Johannes Kettunen, Katri Pylkas, Marita Kalaoja, Minna Karjalainen, Reetta Hinttala, Riitta Kaarteenaho, Seppo Vainio, Tuomo Mantere, Anne Remes, Johanna Huhtakangas, Juhani Junttila, Kaisa Tasanen, Laura Huilaja, Marja Luodonpaa, Nina Hautala, Peeter Karihtala, Saila Kauppila, Terttu Harju, Timo Blomster, Hilkka Soininen, Ilkka Harvima, Jussi Pihlajamaki, Kai Kaarniranta, Margit Pelkonen, Markku Laakso, Mikko Hiltunen, Mikko Kiviniemi, Oili Kaipiainen-Seppanen, Paivi Auvinen, Reetta Kalviainen, Valtteri Julkunen, Anders Malarstig, Asa Hedman, Catherine Marshal, Christopher Whelan, Heli Lehtonen, Jaakko Parkkinen, Kari Linden, Kirsi Kalpala, Melissa Miller, Nan Bing, Stefan McDonough, Xing Chen, Xinli Hu, Ying Wu, Annika Auranen, Airi Jussila, Hannele Uusitalo-Jarvinen, Hannu Kankaanranta, Hannu Uusitalo, Jukka Peltola, Mika Kahonen, Pia Isomaki, Tarja Laitinen, Teea Salmi, Anthony Muslin, Clarence Wang, Clement Chatelain, Ethan Xu, Franck Auge, Kathy Call, Kathy Klinger, Marika Crohns, Matthias Gossel, Kimmo Palin, Manuel Rivas, Harri Siirtola, Javier Gracia Tabuenca

NATURE COMMUNICATIONS (2019)

Article Multidisciplinary Sciences

Effect of four classes of antihypertensive drugs on cardiac repolarization heterogeneity: A double-blind rotational study

Heini Sanez Tahtisalo, Timo P. Hiltunen, Tuomas Kentt, Juhani Junttila, Lasse Oikarinen, Juha Virolainen, Kimmo K. Kontula, Kimmo Porthan

PLOS ONE (2020)

Article Multidisciplinary Sciences

Human essential hypertension: no significant association of polygenic risk scores with antihypertensive drug responses

Heini Sanez Tahtisalo, Sanni Ruotsalainen, Nina Mars, Kimmo Porthan, Lasse Oikarinen, Juha Virolainen, Frej Fyhrquist, Samuli Ripatti, Kimmo K. Kontula, Timo P. Hiltunen

SCIENTIFIC REPORTS (2020)

Article Pharmacology & Pharmacy

Adverse Cardiovascular Outcomes and Antihypertensive Treatment: A Genome-Wide Interaction Meta-Analysis in the International Consortium for Antihypertensive Pharmacogenomics Studies

Caitrin W. McDonough, Helen R. Warren, John R. Jack, Alison A. Motsinger-Reif, Nicole D. Armstrong, Joshua C. Bis, John S. House, Sonal Singh, Nihal M. El Rouby, Yan Gong, Joesyf C. Mychaleckyj, Daniel M. Rotroff, Oscar R. Benavente, Mark J. Caulfield, Alessandrio Doria, Carl J. Pepine, Bruce M. Psaty, Valeria Glorioso, Nicola Glorioso, Timo P. Hiltunen, Kimmo K. Kontula, Donna K. Arnett, John B. Buse, Marguerite R. Irvin, Julie A. Johnson, Patricia B. Munroe, Michael J. Wagner, Rhonda M. Cooper-DeHoff

Summary: The study aimed to identify genome-wide variants influencing antihypertensive drug response and adverse cardiovascular outcomes in European ancestry hypertensive patients. A genetic variant (rs139945292) was found to be associated with beta-blocker response and adverse cardiovascular risk, suggesting further investigation into this region is warranted.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2021)

Article Multidisciplinary Sciences

Mapping the human genetic architecture of COVID-19

Mari E. K. Niemi, Juha Karjalainen, Mark Daly, Andrea Ganna, Juha Mehtonen, Mattia Cordioli, Mari Kaunisto, Sara Pigazzini, Kati Donner, Katja Kivinen, Aarno Palotie, Mark J. Daly, Rachel G. Liao, Masahiro Kanai, Kumar Veerapen, Camelia Minica, Amy Trankiem, Mary K. Balaconis, Huy Nguyen, Matthew Solomonson, Laurent Francioli, Qingbo Wang, Robert C. Green, Sam Bryant, Hilary Finucane, Alicia R. Martin, Wei Zhou, Lindokuhle Nkambule, Konrad J. Karczewski, Elizabeth G. Atkinson, Kristin Tsuo, Nikolas Baya, Patrick Turley, Rahul Gupta, Raymond K. Walters, Duncan S. Palmer, Gopal Sarma, Nathan Cheng, Wenhan Lu, Claire Churchhouse, Jacqueline Goldstein, Daniel King, Cotton Seed, Benjamin M. Neale, F. Kyle Satterstrom, Gita A. Pathak, Frank R. Wendt, Renato Polimanti, Shea J. Andrews, Laura Sloofman, Stuart C. Sealfon, Israel Fernandez-Cadenas, Eva C. Schulte, Ulrike Protzer, Pasquale Striano, Domenico A. Coviello, Federico Zara, Vincenzo Salpietro, Michele Iacomino, Paolo Scudieri, Renata Bocciardi, Carlo Minetti, Maria Stella Vari, Francesca Madia, Eirini Marouli, Stavroula Kanoni, Loukas Moutsianas, Mohd Anisul Karim, Maya Ghoussaini, Jeremy Schwartzentruber, Ian Dunham, Jeanne Savage, Danielle Posthuma, Elleke Tissink, Emil Uffelmann, Guillaume Butler-Laporte, J. Brent Richards, Tomoko Nakanishi, David R. Morrison, Vincenzo Forgetta, Biswarup Ghosh, Laetitia Laurent, Danielle Henry, Tala Abdullah, Olumide Adeleye, Noor Mamlouk, Nofar Kimchi, Zaman Afrasiabi, Nardin Rezk, Branka Vulesevic, Meriem Bouab, Charlotte Guzman, Louis Petitjean, Chris Tselios, Xiaoqing Xue, Jonathan Afilalo, Darin Adra, Han-Na Kim, Yukinori Okada, Jinyoung Byun, Younghun Han, Mohammed Jashim Uddin, George Davey Smith, Cristen J. Willer, Joseph D. Buxbaum, Laura G. Sloofman, Brett L. Collins, Tess Levy, Slayton J. Underwood, Bari Britvan, Katherine Keller, Lara Tang, Michael Peruggia, Liam L. Hiester, Kristi Niblo, Alexandra Aksentijevich, Alexander Labkowsky, Avromie Karp, Menachem Zlatopolsky, Jatin Arora, Soumya Raychaudhuri, Josep Mercader, Caroline Cusick, Bogdan Pasaniuc, Hanna Julienne, Hugues Aschard, Huwenbo Shi, Loic Yengo, Karolina Chwialkowska, Margherita Francescatto, Lea Davis, V. Eric Kerchberger, Sulggi Lee, James Priest, Nirmal Vadgama, Yosuke Tanigawa, Alessandra Renieri, Vijay G. Sankaran, David van Heel, Adolfo de Salazar, David A. van Heel, Karen A. Hunt, Bhavi Trivedi, Patrick Deelen, Lude Franke, Annique Claringbould, Esteban Lopera, Robert Warmerdam, Irene van Blokland, Pauline Lanting, Vincent Mooser, Rui Li, Alexandre Belisle, Pierre Lepage, Jiannis Ragoussis, Daniel Auld, G. Mark Lathrop, Les Biesecker, J. Kenneth Baillie, Sara Clohisey, Max Head Fourman, James Furniss, Chris Haley, Andy Law, Jonathan Millar, Erola Pairo-Castineira, Nicholas Parkinson, Konrad Rawlik, Clark D. Russell, Barbara Shih, Albert Tenesa, Bo Wang, Marie Zechner, Andrew Law, Ross Hendry, Ruth Armstrong, Ceilia Boz, Adam Brown, Louise Cullum, Nicky Day, Esther Duncan, Paul Finernan, Ailsa Golightly, Dawn Law, Rachel Law, Sarah Law, Hanning Mal, Ellie Mcmaster, Jen Meikle, Wilna Oosthuyzen, Trevor Paterson, Andrew Stenhouse, Maaike Swets, Helen Szoor-McElhinney, Filip Taneski, Tony Wackett, Mairi Ward, Jane Weaver, Judy Coyle, Bernadette Gallagher, Rebecca Lidstone-Scott, Debbie Hamilton, Fiona Griffiths, Sean Keating, Timothy Walsh, Andrew D. Bretherick, Graeme Grimes, Caroline Hayward, Lucija Klaric, Alison M. Meynert, Chris P. Ponting, Anne Richmond, Veronique Vitart, James F. Wilson, Francesca Mari, Mirjam Lista, Valentina Perticaroli, Chiara Fallerini, Sergio Daga, Margherita Baldassarri, Francesca Fava, Elisa Frullanti, Floriana Valentino, Gabriella Doddato, Annarita Giliberti, Mirella Bruttini, Susanna Croci, Ilaria Meloni, Giada Beligni, Andrea Tommasi, Laura Di Sarno, Maria Palmieri, Miriam Lucia Carriero, Diana Alaverdian, Nicola Iuso, Gabriele Inchingolo, Rossella Tita, Sara Amitrano, Maria Antonietta Mencarelli, Caterina Lo Rizzo, Anna Maria Pinto, Francesca Montagnani, Mario Tumbarello, Simone Furini, Elisa Benetti, Kristina Zguro, Katia Capitani, Giacomo Zanelli, Francesco Bianchi, Anna Bernasconi, Stefano Ceri, Pietro Pinoli, Stefano Ceri Baillie, Arif Canakoglu, Brooke Wolford, Annika Faucon, Atanu Kumar Dutta, Sanjay Patel, Claudia Schurmann, Emi Harry, Ewan Birney, Jamal Nasir, Minttu Marttila, Nicole Dueker, Sophie Limou, Souad Rahmouni, Hamdi Mbarek, Dima Darwish, Said I. Ismail, Chadi Saad, Yaser Al-Sarraj, Radja Messai Badji, Wadha Al-Muftah, Asma Al Thani, Md Mesbah Uddin, Raquel Albertos, Ricard Ferrer, Jordi Perez-Tur, Ruolin Li, Carolina Medina-Gomez, Bahar Sedaghati-Khayat, Costanza Vallerga, Cindy Boer, Ingrid Kennis-Szilagyi, Vid Prijatelj, Lasse Folkersen, Ida Moltke, Nils Koelling, Chris A. Spencer, Alexander Teumer, Athanasios Kousathanas, Dorota Pasko, Mark J. Caulfield, Richard H. Scott, Susan Walker, Alex Stuckey, Christopher A. Odhams, Daniel Rhodes, Tom Fowler, Augusto Rendon, Georgia Chan, Prabhu Arumugam, Alicia Utrilla, Ricardo A. Verdugo, Ruth Zarate, David Gomez-Cabrero, Elena Carnero-Montoro, Marta E. Alarcon-Riquelme, Manuel Martinez-Bueno, Carmen L. Cadilla, Andres Moreno-Estrada, Adriana Garmendia, Leire Moya, Palwende Romuald Boua, Marie-Julie Fave, Audrey Lemacon, Isabelle Migeotte, Reka Varnai, Jozsef L. Szentpeteri, Csilla Sipeky, Francesca Colombo, Kathrin von Hohenstaufen, Pietro Lio, Hogune Im, Chulho Han, Han Song, Jiwoo Lim, Younhe Lee, Sugyeong Kim, Biljana Atanasovska, Hajar Fauzan Ahmad, Philip Jansen, Jouke Jan Hottenga, Meike Bartels, Eco J. C. de Geus, Michel G. Nivard, Sergey A. Kornilov, Ilangkumaran Sivanadhan, Sarala Perumal, Sahar Esmaeeli, Nathaniel M. Pearson, Adam Auton, Janie F. Shelton, Anjali J. Shastri, Teresa Filshtein-Sonmez, Daniella Coker, Antony Symons, Stella Aslibekyan, Jared O'Connell, Chelsea Ye, Catherine H. Weldon, Jorge Esparza-Gordillo, Minoli Perera, Guang Yang, Cristina Alarcon, Stefanie Herrmann, Paula Friedman, Kevin O'Leary, Sophia Mazurek, Matthew Tuck, Jeff Banagan, Zacharia Hamidi, Travis O'Brien, David Meltzer, Noora Raffat, Carmen de la Horra, Peter O'Donnell, Edith Nutescu, Diana Moreno, April Barbour, Rocio Gallego-Duran, Bart Ferwerda, Diederik van de Beek, Matthijs C. Brouwer, Martijn Beudel, Rutger Koning, Alexander P. J. Vlaar, Anne Geke Algera, Frank van Baarle, Lieuwe Bos, Michela Botta, Sanne de Bruin, Esther Bulle, Dave Dongelmans, Paul Elbers, Lucas Fleuren, Armand Girbes, Laura Hagens, Leo Heunks, Janneke Horn, Niels van Mourik, Frederique Paulus, Jorinde Raasveld, Marcus J. Schultz, Marry Smit, Charlotte Teunissen, Patrick Thoral, Heder de Vries, W. Joost Wiersinga, Michiel van Agtmael, Marije Bomers, Justin de Brabander, Godelieve de Bree, Osoul Chouchane, Suzanne Geerlings, Bram Goorhuis, Martin P. Grobusch, Vanessa Harris, Sabine M. Hermans, Joppe W. Hovius, Jeannine Nellen, Edgar Peters, Tom van der Poll, Jan M. Prins, Tom Reijnders, Michiel Schinkel, Alex Schuurman, Kim Sigaloff, Cornelis S. Stijnis, Anissa Tsonas, Marc van der Valk, Michele van Vugt, A. H. Koos Zwinderman, Diane Bax, Alex Cloherty, Theo Geijtenbeek, Florianne Hafkamp, Bennedikt Preckel, Harm Jan Bogaard, Peter Bonta, Esther J. Nossent, Marianna Bugiani, Bart Geerts, Markus Hollmann, Denise Veelo, Jorg Hamann, Robert Hemke, Menno D. de Jong, Willemke Stilma, Dorien Wouters, Rene P. Minnaar, Adrie Kromhout, Kees W. J. van Uffelen, Ruud A. Wolterman, Genevieve Roberts, Danny Park, Catherine A. Ball, Marie Coignet, Shannon McCurdy, Spencer Knight, Raghavendran Partha, Brooke Rhead, Miao Zhang, Nathan Berkowitz, Michael Gaddis, Keith Noto, Luong Ruiz, Milos Pavlovic, Eurie L. Hong, Kristin Rand, Ahna Girshick, Harendra Guturu, Asher Haug Baltzell, Michel Georges, Sofia Melo, Nicolas Jacques, Emmanuel Di Valentin, Francois Giroule, Alice Collignon, Coraline Radermecker, Marielle Lebrun, Helene Peree, Samuel Latour, Olivia Barada, Judit Sanchez, Margot Meunier, Emeline Mariavelle, Sandy Anania, Helene Gazon, Myriam Mni, Marie Wery, Yasmine Belhaj, Julien Guntz, Laurent Jadot, Sabine Claassen, Yves Beguin, Stephanie Gofflot, Kamilia El Kandoussi, Raphael Thonon, Youssef Bouysran, Adeline Busson, Xavier Peyrassol, Francoise Wilkin, Bruno Pichon, Guillaume Smits, Isabelle Vandernoot, Jean-Christophe Goffard, Michel Moutschen, Benoit Misset, Gilles Darcis, Julien Guiot, Samira Azarzar, Patricia Dellot, Axelle Bertrand, Gilles Parzibut, Mathilde Clarinval, Catherine Moermans, Olivier Malaise, Pascale Huynen, Alyssia Mesdagh, Claire Josse, Bouchra Boujemla, Danusia Juszczak, Marjorie Fadeur, Severine Camby, Christelle Meuris, Marie Thys, Jessica Jacques, Monique Henket, Philippe Leonard, Frederic Frippiat, Jean-Baptiste Giot, Anne-Sophie Sauvage, Christian Von Frenckell, Alicia Staderoli, Bernard Lambermont, Edouad Louis, Marc Afilalo, Maureen Oliveira, Bluma Brenner, Nathalie Brassard, Madeleine Durand, Michael Chasse, Daniel E. Kaufmann, Erwin Schurr, Lea K. Davis, Nancy J. Cox, Jennifer E. Below, Julia M. Sealock, Annika B. Faucon, Megan M. Shuey, Hannah G. Polikowsky, Lauren E. Petty, Douglas M. Shaw, Hung-Hsin Chen, Wanying Zhu, Kerstin U. Ludwig, Julia Schroeder, Selina Rolker, Markus M. Nothen, Julia Fazaal, Carlo Maj, Verena Keitel, Bjorn-Erik Ole Jensen, Torsten Feldt, Lisa Knopp, Ingo Kurth, Thomas Eggermann, Nikolaus Marx, Michael Dreher, Isabell Pink, Markus Cornberg, Thomas Illig, Sonja Volland, Clara Lehmann, Philipp Schommers, Max Augustin, Jan Rybniker, Philipp Koehler, Oliver A. Cornely, Janine Altmuller, Marc M. Berger, Thorsten Brenner, Anke Hinney, Oliver Witzke, Robert Bals, Christian Herr, Nicole Ludwig, Jorn Walter, Christian Fuchsberger, Cristian Pattaro, Alessandro De Grandi, Peter Pramstaller, David Emmert, Roberto Melotti, Luisa Foco, Deborah Mascalzoni, Martin Gogele, Francisco Domingues, Andrew Hicks, Christopher R. Gignoux, Stephen J. Wicks, Kristy Crooks, Kathleen C. Barnes, Michelle Daya, Jonathan Shortt, Nicholas Rafaels, Sameer Chavan, David B. Goldstein, Krzysztof Kiryluk, Soumitra Sengupta, Amritha Menon, Yat S. So, Wendy Chung, Muredach P. Reilly, Atlas Khan, Chen Wang, Ali G. Gharavi, Ning Shang, Sheila M. O'Byrne, Renu Nandakumar, Gundula Povysil, Nitin Bhardwaj, Iuliana Ionita-Laza, Eldad Hod, Danielle Pendrick, Soo-Kyung Park, Hyung-Lae Kim, Chang Kyung Kang, Wan Beom Park, Hyo-Jung Lee, Kyoung-Ho Song, Sin Young Ham, Jongtak Jung, Eu Suk Kim, Hong Bin Kim, Kyung Jae Yoon, Nam-Jong Paik, Woojin Seok, Heejun Yoon, Eun-Jeong Joo, Yoosoo Chang, Seungho Ryu, Jeong Su Park, Kyoung Un Park, David Ellinghaus, Frauke Degenhardt, Simonas Juzenas, Florian Tran, Philip Rosenstiel, Stefan Schreiber, Andre Franke, Eike Matthias Wacker, Florian Uellendahl-Werth, Hesham ElAbd, Lars Wienbrandt, Malte Christoph Ruhlemann, Mareike Wendorff, Anja Tanck, Christoph Gassner, Georg Hemmrich-Stanisak, Jan Kassens, Maria E. Figuera Basso, Martin Schulzky, Michael Wittig, Nicole Braun, Tanja Wesse, Wolfgang Albrecht, Xiaoli Yi, Almut Nebel, Anna Peschuck, Sandra May, Banasik Karina, Soren Brunak, Mario Caceres, Jon Lerga-Jaso, Tobias L. Lenz, Ana Teles, Clinton Azuure, Onur Ozer, Agustin Albillos, Beatriz Mateos, Francisco Mesonero, Luis Tellez, Miguel Rodriguez-Gandia, Luis Bujanda, Jesus M. Banales, Manuel Romero-Gomez, Maria Buti, Douglas Maya-Miles, Koldo Garcia-Etxebarria, Laura Izquierdo-Sanchez, Pedro M. Rodrigues, Francisco Rodriguez-Frias, Mar Riveiro-Barciela, Antonio Julia, Adriana Palom, Sara Marsal, Bettina Heidecker, Florian Kurth, Leif Erik Sander, Alena Mayer, Alice Braun, Carsten Skurk, Charlotte Thibeault, Elisa T. Helbig, Julia Kraft, Lena J. Lippert, Phillip Suwalski, Stephan Ripke, Wolfgang Poller, Xiaomin Wang, Zehra Karadeniz, Federico Garcia, Jose Hernandez Quero, Natalia Chueca, Trinidad Gonzalez Cejudo, Frank Hanses, Sibylle Wilfling, Heinz Zoller, Benedikt Schaefer, Jan C. Holter, Johannes R. Hov, Tom H. Karlsen, Trine Folseraas, Aleksander Rygh Holten, Anne Ma Dyrhol-Riise, Kristian Tonby, Andreas Lind, Fredrik Muller, Susanne Dudman, Marit M. Grimsrud, Javier Fernandez, Carlos Ferrando, Enric Reverter, Joan Ramon Badia, Maria Hernandez-Tejero, Pedro Castro, Rafael de Cid, Anna Carreras Nolla, Beatriz Cortes, Ivan Galvan-Femenia, Natalia Blay, Xavier Farre, Rosanna Asselta, Stefano Duga, Alberto Mantovani, Alessandro Protti, Alessio Aghemo, Ana Lleo, Antonio Voza, Elena Azzolini, Elvezia Maria Paraboschi, Ilaria My, Maurizio Cecconi, Paolo Tentorio, Salvatore Badalamenti, Sara Bombace, Claudio Cappadona, Valeria Rimoldi, Siegfried Goerg, Ute Hehr, Emma F. Perez, Ole Bernt Lenning, May Sissel Vadla, Ronny Myhre, Aaron Blandino Ortiz, Raul de Pablo, Adolfo Garrido Chercoles, Beatriz Nafria-Jimenez, Agustin Ruiz, Isabel Hernandez, Itziar de Rojas, Marta Marquie, Merce Boada, Daniele Prati, Guido Baselli, Luca Valenti, Alessandro Cherubini, Antonio Muscatello, Cinzia Hu, Cristiana Bianco, Daniela Galimberti, Elio Scarpini, Ferruccio Ceriotti, Giuseppe Lamorte, Leonardo Terranova, Mahnoosh Ostadreza, Alberto Zanella, Alessandra Bandera, Andrea Gori, Anna Ludovica Fracanzani, Antonio Pesenti, Cinzia Paccapelo, Filippo Martinelli-Boneschi, Flora Peyvandi, Francesco Blasi, Giacomo Grasselli, Giorgio Costantino, Luigi Santoro, Luigia Scudeller, Maria Carrabba, Marina Baldini, Monica Miozzo, Nicola Montano, Roberta Gualtierotti, Serena Pelusi, Silvano Bosari, Stefano Aliberti, Valter Monzani, Pietro Invernizzi, Alessio Gerussi, Chiara Milani, Alfredo Ramirez, Victor Andrade, Ana Barreira, Anders Benjamin Kildal, Andreas Gluck, Thomas Bahmer, Anna Latiano, Orazio Palmieri, Ariadna Rando-Segura, Luisa Roade, Aurora Solier, David Jimenez, Rosa Nieto, Carla Bellinghausen, Carmen Quereda, Enrique Navas, Christoph D. Spinner, Jochen Schneider, Christoph Lange, Jan Heyckendorf, Cristina Sancho, Maider Intxausti, Dag Arne Lihaug Hoff, Jan Egil Afset, Sammra Haider, David Pestana, David Toapanta, Eloisa Urrechaga, Pedro P. Espana, Emanuele Pontali, Lucia Garbarino, Michela Mazzocco, Eunate Arana, Natale Imaz Ayo, Felix Garcia Sanchez, Francesco Malvestiti, Gianni Pezzoli, Holger Neb, Mauro D'Amato, Josune Goikoetxea, Karl Erik Muller, Lars Heggelund, Karoline Gaede, Lauro Sumoy, Manolis Kogevinas, Judith Garcia-Aymerich, Gemma Castano-Vinyals, Carlota Dobano, Victor Moreno, Maria A. Gutierrez-Stampa, Maria J. G. T. Vehreschild, Yascha Khodamoradi, Massimo Castoldi, Tenghao Zheng, Michael J. Seilmaier, Nilda Martinez, Per Hoffmann, Stefanie Heilmann-Heimbach, Petra Bacher, Sandra Ciesek, Ulf Landmesser, Vegard Skogen, Enrique J. Calderon, Francisco J. Medrano, Juan Delgado, Ruben Morilla, Vicente Friaza, Daniel F. Gudbjartsson, Kari Stefansson, Patrick Sulem, Gardar Sveinbjornsson, Pall Melsted, Gudmundur Norddahl, Kristjan Helgi Swerford Moore, Unnur Thorsteinsdottir, Hilma Holm, David Bernardo, Javier Ampuero, Silvia Rojo Rello, Reedik Magi, Lili Milani, Andres Metspalu, Triin Laisk, Kristi Lall, Maarja Lepamets, Tonu Esko, Ene Reimann, Helene Alavere, Kristjan Metsalu, Mairo Puusepp, Paul Naaber, Edward Laane, Jaana Pesukova, Part Peterson, Kai Kisand, Jekaterina Tabri, Raili Allos, Kati Hensen, Joel Starkopf, Inge Ringmets, Anu Tamm, Anne Kallaste, Kati Kristiansson, Sami Koskelainen, Markus Perola, Carlo Rivolta, Mathieu Quinodoz, Dhryata Kamdar, Pierre-Yves Bochud, Stephanie Bibert, Noemie Boillat, Semira Gonseth Nussle, Werner Albrich, Noemie Suh, Dionysios Neofytos, Veronique Erard, Cathy Voide, P. Y. Bochud, C. Rivolta, S. Bibert, M. Quinodoz, D. Kamdar, D. Neofytos, V Erard, C. Voide, R. Friolet, P. Vollenweider, J. L. Pagani, M. Oddo, F. Meyer zu Bentrup, A. Conen, O. Clerc, O. Marchetti, A. Guillet, C. Guyat-Jacques, S. Foucras, M. Rime, J. Chassot, M. Jaquet, R. Merlet Viollet, Y. Lannepoudenx, L. Portopena, F. Desgranges, P. Filippidis, B. Guery, D. Haefliger, E. E. Kampouri, O. Manuel, A. Munting, M. Papadimitriou-Olivgeris, J. Regina, L. Rochat-Stettler, V Suttels, E. Tadini, J. Tschopp, M. Van Singer, B. Viala, N. Boillat-Blanco, T. Brahier, O. Hugli, J. Y. Meuwly, O. Pantet, Tomas Pumarola, S. Gonseth Nussle, M. Bochud, V D'Acremont, S. Estoppey Younes, W. C. Albrich, N. Suh, A. Cerny, L. O'Mahony, M. Frischknecht, G-R Kleger, M. Filipovic, C. R. Kahlert, H. Wozniak, T. Rochat Negro, J. Pugin, K. Bouras, C. Knapp, T. Egger, A. Perret, P. Montillier, C. di Bartolomeo, B. Barda, Anna Carreras, Josep Maria Mercader, Marta Guindo-Martinez, David Torrents, Marco Gori, Nicola Picchiotti, Mario Umberto Mondelli, Raffaele Bruno, Serena Ludovisi, Francesco Castelli, Eugenia Quiros-Roldan, Melania Degli Antoni, Massimo Vaghi, Stefano Rusconi, Agostino Riva, Matteo Siano, Arianna Gabrieli, Massimiliano Fabbiani, Barbara Rossetti, Ilaria Rancan, Elena Bargagli, Laura Bergantini, Miriana D'Alessandro, Paolo Cameli, David Bennet, Federico Franchi, Federico Anedda, Simona Marcantonio, Sabino Scolletta, Maria Antonietta Mazzei, Susanna Guerrini, Luca Cantarini, Edoardo Conticini, Bruno Frediani, Danilo Tacconi, Chiara Spertilli, Marco Feri, Alice Donati, Raffaele Scala, Luca Guidelli, Genni Spargi, Marta Corridi, Cesira Nencioni, Leonardo Croci, Maria Bandini, Maurizio Spagnesi, Paolo Piacentini, Elena Desanctis, Silvia Cappelli, Gian Piero Caldarelli, Anna Canaccini, Agnese Verzuri, Valentina Anemoli, Agostino Ognibene, Alessandro Pancrazi, Maria Lorubbio, Antonella D'Arminio Monforte, Esther Merlini, Federica Gaia Miraglia, Massimo Girardis, Stefano Busani, Sophie Venturelli, Andrea Antinori, Arianna Emiliozzi, Alessandra Vergori, Daniela Francisci, Elisabetta Schiaroli, Francesco Paciosi, Pier Giorgio Scotton, Francesca Andretta, Sandro Panese, Renzo Scaggiante, Francesca Gatti, Matteo Della Monica, Carmelo Piscopo, Mario Capasso, Roberta Russo, Immacolata Andolfo, Achille Iolascon, Giuseppe Merla, Giuseppe Fiorentino, Marco Castori, Massimo Carella, Filippo Aucella, Antonio Di Biagio, Matteo Bassetti, Luca Masucci, Alessandra Guarnaccia, Maurizio Sanguinetti, Serafina Valente, Oreste De Vivo, Marco Mandala, Alessia Giorli, Lorenzo Salerni, Patrizia Zucchi, Pierpaolo Parravicini, Ferdinando Giannattasio, Tullio Trotta, Gabriella Coiro, Cristina Mussini, Giancarlo Bosio, Enrico Martinelli, Luisa Tavecchia, Mary Ann Belli, Sandro Mancarella, Lia Crotti, Gianfranco Parati, Marco Rizzi, Franco Maggiolo, Diego Ripamonti, Maria Teresa La Rovere, Simona Sarzi-Braga, Maurizio Bussotti, Sabrina Ravaglia, Ravaglia Sabrina, Rosangela Artuso, Antonio Perrella, Davide Romani, Paola Bergomi, Emanuele Catena, Riccardo Colombo, Simona Dei, Marco Tanfoni, Maurizio Sanarico, Francesco Raimondi, Filippo Biscarini, Alessandra Stella, Mattia Bergomi, Marco Vecchia, Stefania Mantovani, Isabella Zanella, Andrea Cossarizza, Saverio Giuseppe Parisi, Stefano Baratti, Gabriella Maria Squeo, Pamela Raggi, Carmen Marciano, Rita Perna, Elisabetta Menatti, Fabio Lena, Chiara Gabbi, Tiziana Bachetti, Claudia Suardi, Giordano Botta, Paolo Di Domenico, Richard C. Trembath, Qin Qin Huang, Hilary C. Martin, Dan Mason, John Wright, Sarah Finer, Shaheen Akhtar, Mohammad Anwar, Elena Arciero, Samina Ashraf, Gerome Breen, Raymond Chung, Charles J. Curtis, Maharun Chowdhury, Grainne Colligan, Panos Deloukas, Ceri Durham, Chris Griffiths, Matt Hurles, Shapna Hussain, Kamrul Islam, Ahsan Khan, Amara Khan, Cath Lavery, Sang Hyuck Lee, Robin Lerner, Daniel MacArthur, Bev MacLaughlin, Hilary Martin, Shefa Miah, Bill Newman, Nishat Safa, Farah Tahmasebi, Christopher J. Griffiths, Albert Smith, Andrew P. Boughton, Kevin W. Li, Jonathon LeFaive, Aubrey Annis, Sebastian Zollner, Jiongming Wang, Andrew Beck, Cinthia E. Jannes, Jose E. Krieger, Alexandre C. Pereira, Mariliza Velho, Emanuelle Marques, Isabella Ramos Lima, Mauricio Teruo Tada, Karina Valino, Mark McCarthy, Carrie Rosenberger, Diana Chang, Christian Hammer, Julie Hunkapiller, Anubha Mahajan, Sarah Pendergrass, Lara Sucheston-Campbell, Brian Yaspan, Jong Eun Lee, Hyun Soo Lee, Eunsoon Shin, Hye Yoon Jang, Sunmie Kim, Sungmin Kym, Yeon-Sook Kim, Hyeongseok Jeong, Ana Alegria, Ki Tae Kwon, Shin-Woo Kim, Jin Yong Kim, Young Rock Jang, Hyun Ah Kim, Ji Yeon Lee, Jeong Eun Lee, Shinwon Lee, Kang-Won Choe, Yu Min Kang, Sun Ha Jee, Keum Ji Jung, Victoria Parikh, Matthew Wheeler, Karen Dalton, Jeff Christle, John Gorzynski, Hannah de Jong, Shirley Sutton, Nathan Youlton, Ruchi Joshi, David Jimenez-Morales, Christopher Hughes, David Amar, Steve Hershman, Anna Kirillova, Kinya Seo, Yong Huang, Archana Raja, Jimmy Zhen, Euan Ashley, Carlos Bustamante, Manuel Rivas, Alex Ioannidis, Benjamin Pinksy, Massa Shoura, Nathan Hammond, Nathaniel Watson, ChunHong Huang, Malaya Sahoo, Hannah Wang, Phillip Febbo, Kyle Farh, Gary P. Schroth, Francis DeSouza, Christopher Deboever, Sandor Szalma, Simone Rubinacci, Olivier Delaneau, Peter J. McGuigan, Christopher Wasson, Stephanie Finn, Jackie Green, Erin Collins, Bernadette King, Luke Stephen Prockter Moore, Marcela Paola Vizcaychipi, Laura Gomes de Almeida Martins, Jaime Carungcong, Kathryn Hall, Isheunesu Mapfunde, Andy Campbell, Sara Smuts, Joseph Duffield, Oliver Smith, Lewis Mallon, Watkins Claire, Ailstair Nichol, Kathy Brickell, Michelle Smyth, Lorna Murphy, Geraldine Ward, Pamela Bremmer, Valerie Joan Page, Siobhain Carmody, Malcolm G. Semple, Tom Solomon, Lance C. W. Turtle, Hayley Hardwick, Kayode Adeniji, Daniel Agranoff, Chi Eziefula, Ken Agwuh, Dhiraj Ail, Erin L. Aldera, Louise Allen, Eva Beranova, Nikki Crisp, Joanne Deery, Tracy Hazelton, Alicia Knight, Carly Price, Sorrell Tilbey, Salah Turki, Sharon Turney, Brian Angus, Abdul Ashish, Dougal Atkinson, Shahedal Bari, Gavin Barlow, Stella Barnass, Nicholas Barrett, Sam Douthwaite, Marlies Ostermann, Manu Shankar-Hari, Christopher Bassford, Sneha Basude, David Baxter, Michael Beadsworth, Ingeborg Welters, Jolanta Bernatoniene, John Berridge, Nicola Best, Pieter Bothma, Darell Tupper-Carey, David Chadwick, Robin Brittain-Long, Naomi Bulteel, Lee Murphy, Nicola Wrobel, Sarah McCafferty, Kirstie Morrice, Alan MacLean, Tom Burden, Andrew Burtenshaw, Vikki Caruth, Duncan Chambler, Nigel Chee, Jenny Child, Srikanth Chukkambotla, Tom Clark, Paul Collini, Cariad Evans, Gary H. Mills, Norfaizan Ahmad, Joann Barker, Kris Bauchmuller, Sarah Bird, Kay Cawthron, Kate Harrington, Yvonne Jackson, Faith Kibutu, Becky Lenagh, Shamiso Masuko, Ajay Raithatha, Matthew Wiles, Jayne Willson, Helen Newell, Alison Lye, Lorenza Nwafor, Claire Jarman, Sarah Rowland-Jones, David Foote, Joby Cole, Roger Thompson, James Watson, Lisa Hesseldon, Irene Macharia, Luke Chetam, Jacqui Smith, Amber Ford, Samantha Anderson, Kathryn Birchall, Kay Housley, Sara Walker, Leanne Milner, Helena Hanratty, Helen Trower, Patrick Phillips, Simon Oxspring, Ben Donne, Catherine Cosgrove, Jason Cupitt, Maria-Teresa Cutino-Moguel, Paul Dark, Chris Dawson, Samir Dervisevic, Andrew Drummond, Andrew Ustianowski, Ingrid DuRand, Ahilanadan Dushianthan, Tristan Dyer, Christopher Fegan, Adam Finn, Duncan Fullerton, Elijah Matovu, Sanjeev Garg, Atul Garg, Effrossyni Gkrania-Klotsas, Elinoor Moore, Jo Godden, Arthur Goldsmith, Clive Graham, Elaine Hardy, Stuart Hartshorn, Daniel Harvey, Peter Havalda, Andrew Workman, Daniel B. Hawcutt, Maria Hobrok, Luke Hodgson, Anil Hormis, Michael Jacobs, Susan Jain, Paul Jennings, Agilan Kaliappan, Vidya Kasipandian, Stephen Kegg, Michael Kelsey, Caroline Kerrison, Ian Kerslake, Oliver Koch, Rosie Baruah, Sheila Morris, Susie Ferguson, Amy Shepherd, Gouri Koduri, George Koshy, Tamas Leiner, Katherine Mortimore, Shondipon Laha, Steven Laird, Susan Larkin, Patrick Lillie, James Limb, Vanessa Linnett, Jeff Little, Mark Lyttle, Emily MacNaughton, Ravish Mankregod, Huw Masson, Katherine McCullough, Ruth McEwen, Lawrence Wilson, Manjula Meda, Jane Minton, Karl Ward, Mariyam Mirfenderesky, Kavya Mohandas, Quen Mok, James Moon, Nigel Capps, Sanal Jose, Patrick Morgan, Craig Morris, Samuel Moses, Mbiye Mpenge, Rohinton Mulla, Michael Murphy, Megan Nagel, Thapas Nagarajan, Mark Nelson, Matthew K. O'Shea, Christoper A. Green, Igor Otahal, Mark Pais, Selva Panchatsharam, Danai Papakonstantinou, Hollie Bancroft, Mary Bellamy, Margaret Carmody, Jacqueline Daglish, Faye Moore, Joanne Rhodes, Mirriam Sangombe, Salma Kadiri, James Scriven, Hassan Paraiso, Brij Patel, Natalie Pattison, Justin Pepperell, Mandeep Phull, Stefania Pintus, Jagtur Singh Pooni, Frank Post, Anna Cavazza, Maeve Cockrell, Eleanor Corcoran, Maria Depante, Clare Finney, Ellen Jerome, Mark McPhail, Monalisa Nayak, Harriet Noble, Kevin O'Reilly, Evita Pappa, Rohit Saha, Sian Saha, John Smith, Abigail Knighton, David Price, Rachel Prout, Nikolas Rae, Henrik Reschreiter, Tim Reynolds, Neil Richardson, Mark Roberts, Devender Roberts, Alistair Rose, Guy Rousseau, Brendan Ryan, Taranprit Saluja, Aarti Shah, Prad Shanmuga, Anil Sharma, Anna Shawcross, Jeremy Sizer, Victoria Bastion, Daphene Clarke, Beena David, Harriet Kent, Rachel Lorusso, Gamu Lubimbi, Sophie Murdoch, Melchizedek Penacerrada, Alastair Thomas, Jennifer Valentine, Ana Vochin, Retno Wulandari, Brice Djeugam, Richard Smith, Catherine Snelson, Tony Whitehouse, Nick Spittle, Nikki Staines, Shico Visuvanathan, Tom Stambach, Richard Stewart, Pradeep Subudhi, Tamas Szakmany, Kate Tatham, Jo Thomas, Chris Thompson, Ascanio Tridente, Mary Twagira, Nick Vallotton, Lisa Vincent-Smith, Alan Vuylsteke, Sam Waddy, Rachel Wake, Andrew Walden, Paul Whittaker, Ashley Whittington, Padmasayee Papineni, Meme Wijesinghe, Stephen Winchester, Martin Wiselka, Adam Wolverson, Daniel G. Wooton, Bryan Yates, Peter Young, Rupert Beale, Charles Hinds, Elvina Gountouna, David J. Porteous, David Harrison, Kathy Rowan, Gavin Band, Paul Klenerman, Julian Knight, Debby Bogaert, Xia Shen, Zhijian Yang, Ranran Zhai, Chenqing Zheng, Cynthia M. Bulik, Mikael Landen, Bengt Fundin, Yang Wu, Jian Yang, Lisa Norman, Riinu Pius, Thomas M. Drake, Cameron J. Fairfield, Stephen R. Knight, Kenneth A. Mclean, Derek Murphy, Catherine A. Shaw, Annemarie B. Docherty, Ewen M. Harrison, Jo Dalton, Michelle Girvan, Egle Saviciute, Stephanie Roberts, Janet Harrison, Laura Marsh, Marie Connor, Sophie Halpin, Clare Jackson, Carrol Gamble, Chloe Donohue, Gary Leeming, Murray Wham, James Scott-Brown, Beatrice Alex, Benjamin Bach, Colin Begg, Antonia Ying Wai Ho, Peter W. Horby, Lowell Ling, David Maslove, Danny McAuley, Hugh Montgomery, Alistair Nichol, Peter J. M. Openshaw, Ryan S. Thwaites, Shona C. Moore, Charlotte Summers, Lisa Armstrong, Hayley Bates, Emma Dooks, Fiona Farquhar, Brigid Hairsine, C. McParland, Sophie Packham, Zoe Alldis, Raine Astin-Chamberlain, Fatima Bibi, Jack Biddle, Sarah Blow, Matthew Bolton, Catherine Borra, Ruth Bowles, Maudrian Burton, Yasmin Choudhury, David Collier, Amber Cox, Amy Easthope, Patrizia Ebano, Stavros Fotiadis, Jana Gurasashvili, Rosslyn Halls, Pippa Hartridge, Delordson Kallon, Jamila Kassam, Ivone Lancoma-Malcolm, Maninderpal Matharu, Peter May, Oliver Mitchelmore, Tabitha Newman, Mital Patel, Jane Pheby, Irene Pinzuti, Zoe Prime, Oleksandra Prysyazhna, Julian Shiel, Melanie Taylor, Carey Tierney, Suzanne Wood, Anne Zak, Olivier Zongo, Miranda Forsey, Anne Nicholson, Joanne Riches, Mark Vertue, Lina Grauslyte, Musarat Hussain, Tatiana Pogreban, Lace Rosaroso, Erika Salciute, George Franke, Joanna Wong, Aparna George, Louise Akeroyd, Shereen Bano, Matt Bromley, Lucy Gurr, Tom Lawton, James Morgan, Kirsten Sellick, Deborah Warren, Brian Wilkinson, Janet McGowan, Camilla Ledgard, Amelia Stacey, Kate Pye, Ruth Bellwood, Michael Bentley, Ronda Loosley, Heather McGuinness, Helen Tench, Rebecca Wolf-Roberts, Sian Gibson, Amanda Lyle, Fiona McNeela, Jayachandran Radhakrishnan, Alistair Hughes, Asifa Ali, Megan Brady, Sam Dale, Annalisa Dance, Lisa Gledhill, Jill Greig, Kathryn Hanson, Kelly Holdroyd, Marie Home, Diane Kelly, Ross Kitson, Lear Matapure, Deborah Melia, Samantha Mellor, Tonicha Nortcliffe, Jez Pinnell, Matthew Robinson, Lisa Shaw, Ryan Shaw, Lesley Thomis, Alison Wilson, Tracy Wood, Lee-Ann Bayo, Ekta Merwaha, Tahira Ishaq, Sarah Hanley, David Antcliffe, Dorota Banach, Stephen Brett, Phoebe Coghlan, Ziortza Fernandez, Anthony Gordon, Roceld Rojo, Sonia Sousa Arias, Maie Templeton, Rajeev Jha, Vinodh Krishnamurthy, Lai Lim, Li Lim, Rehana Bi, Barney Scholefield, Lydia Ashton, Alison Williams, Claire Cheyne, Anne Saunderson, Sam Moultrie, M. Odam, Angela Allan, Felicity Anderson, Callum Kaye, Jade Liew, Jasmine Medhora, Teresa Scott, Erin Trumper, Adriana Botello, Petra Polgarova, Katerina Stroud, Eoghan Meaney, Megan Jones, Anthony Ng, Shruti Agrawal, Nazima Pathan, Deborah White, Esther Daubney, Kay Elston, Robert Parker, Amie Reddy, Ian Turner-Bone, Laura Wilding, Peter Harding, Reni Jacob, Cathy Jones, Craig Denmade, Maria Croft, Ian White, Denise Griffin, Nycola Muchenje, Mcdonald Mupudzi, Richard Partridge, Jo-Anna Conyngham, Rachel Thomas, Mary Wright, Maria Alvarez Corral, Joy Dawson, Sweyn Garrioch, Melanie Tolson, Jonathan Aldridge, Sarah Beavis, Katie Dale, Rachel Gascoyne, Joanne Hawes, Kelly Pritchard, Lesley Stevenson, Amanda Whileman, Anne Cowley, Judith Highgate, Rikki Crawley, Abigail Crew, Mishell Cunningham, Allison Daniels, Laura Harrison, Susan Hope, Ken Inweregbu, Sian Jones, Nicola Lancaster, Jamie Matthews, Alice Nicholson, Gemma Wray, Leonie Benham, Zena Bradshaw, Joanna Brown, Melanie Caswell, Sarah Melling, Stephen Preston, Nicola Slawson, Emma Stoddard, Scott Warden, Edward Combes, Teishel Joefield, Sonja Monnery, Valerie Beech, Sallyanne Trotman, Bridget Hopkins, Laura Thrasyvoulou, Heather Willis, Susan Anderson, Janine Birch, Emma Collins, Kate Hammerton, Ryan O'Leary, Eleanor Andrews, Caroline Abernathy, Louise Foster, Andrew Gratrix, Vicky Martinson, Priyai Parkinson, Elizabeth Stones, Llucia Carbral-Ortega, Ritoo Kapoor, David Loader, Karen Castle, Craig Brandwood, Lara Smith, Richard Clark, Katie Birchall, Laurel Kolakaluri, Deborah Baines, Anila Sukumaran, Megan Meredith, Lucy Morris, Lucy Ryan, Amy Clark, Julia Sampson, Cecilia Peters, Martin Dent, Margaret Langley, Saima Ashraf, Shuying Wei, Angela Andrew, Manish Chablani, Amy Kirkby, Kimberley Netherton, Michelle Bates, Jo Dasgin, Jaspret Gill, Annette Nilsson, Elena Apetri, Cathrine Basikolo, Bethan Blackledge, Laura Catlow, Bethan Charles, Reece Doonan, Jade Harris, Alice Harvey, Daniel Horner, Karen Knowles, Stephanie Lee, Diane Lomas, Chloe Lyons, Tracy Marsden, Danielle McLaughlan, Liam McMorrow, Jessica Pendlebury, Jane Perez, Maria Poulaka, Nicola Proudfoot, Melanie Slaughter, Kathryn Slevin, Vicky Thomas, Danielle Walker, Angiy Michael, Matthew Collis, Martyn Clark, Martina Coulding, Edward Jude, Jacqueline McCormick, Oliver Mercer, Darsh Potla, Hafiz Rehman, Heather Savill, Victoria Turner, Miriam Davey, David Golden, Rebecca Seaman, Jodie Hunt, Joy Dearden, Emma Dobson, Michelle Mulcahy, ,

Summary: The genetic make-up of an individual plays a role in susceptibility and response to viral infections. A global network of researchers identified 13 significant genetic loci associated with SARS-CoV-2 infection and severe COVID-19 cases. Mendelian randomization analyses suggest a causal role for smoking and body-mass index in severe COVID-19. Collaboration among human genetics researchers has allowed for the discovery of novel host genetic factors linked to COVID-19.

NATURE (2021)

Article Genetics & Heredity

Dominant Distal Myopathy 3 (MPD3) Caused by a Deletion in the HNRNPA1 Gene

Peter Hackman, Salla M. Rusanen, Mridul Johari, Anna Vihola, Per Harald Jonson, Jaakko Sarparanta, Kati Donner, Paivi Lahermo, Sampo Koivunen, Helena Luque, Merja Soininen, Ibrahim Mahjneh, Mari Auranen, Meharji Arumilli, Marco Savarese, Bjarne Udd

Summary: The study aimed to determine the genetic cause of adult-onset autosomal dominant distal myopathy in a previously reported family. By using clinical evaluation, genetic analysis, and RNA sequencing, a small heterozygous deletion in the HNRNPA1 gene was identified as the cause of the disease, confirming the new phenotype and highlighting the complexities of gene identification in this family.

NEUROLOGY-GENETICS (2021)

Article Biochemistry & Molecular Biology

Pharmacoepigenetics of hypertension: genome-wide methylation analysis of responsiveness to four classes of antihypertensive drugs using a double-blind crossover study design

Marja-Liisa Nuotio, Heini Sanez Tahtisalo, Alexandra Lahtinen, Kati Donner, Frej Fyhrquist, Markus Perola, Kimmo K. Kontula, Timo P. Hiltunen

Summary: Essential hypertension remains a leading factor in global disease burden, with treatment goals often unmet. Research on DNA methylation and antihypertensive drug responses identified potential associations, particularly near the ACY3 TSS. However, robust associations between DNA methylation and BP responses to different antihypertensive drugs were not found, suggesting a need for further exploration.

EPIGENETICS (2022)

Article Pharmacology & Pharmacy

Chromosomal Region 11p14.1 is Associated with Pharmacokinetics and Pharmacodynamics of Bisoprolol

Vanessa Fontana, Richard Myles Turner, Ben Francis, Peng Yin, Benno Puetz, Timo P. Hiltunen, Sanni Ruotsalainen, Kimmo K. Kontula, Bertam Mueller-Myhsok, Munir Pirmohamed

Summary: A novel locus on the chromosomal region 11p14.1 was associated with bisoprolol clearance in a real-world cohort of patients and was validated in an independent cohort with a pharmacodynamic association.

PHARMACOGENOMICS & PERSONALIZED MEDICINE (2022)

Article Multidisciplinary Sciences

L-type calcium channel blocker increases VEGF concentrations in retinal cells and human serum

Anmol Kumar, Stefan Mutter, Erika B. Parente, Valma Harjutsalo, Raija Lithovius, Sinnakaruppan Mathavan, Markku Lehto, Timo P. Hiltunen, Kimmo K. Kontula, Per-Henrik Groop

Summary: This study investigated the effect of L-type calcium channel blockers (LTCCBs) on VEGF concentrations in retinal cells and human serum, and evaluated the association between LTCCB usage and risk of severe diabetic eye disease (SDED). The results showed that LTCCBs increase VEGF concentrations in retinal cells and human serum, but they are not associated with the risk of SDED in adults with type 1 diabetes.

PLOS ONE (2023)

Meeting Abstract Peripheral Vascular Disease

GENOME-WIDE ASSOCIATION STUDY FOR PHARMACOGENETIC RESPONSE OF BLOOD PRESURE TO BETA BLOCKER AND CALCIUM CHANNEL BLOCKER DRUGS

Helen Warren, Tatiana Garofalidou, Sonal Singh, Olle Melander, Timo Hiltunen, Nicola Glorioso, Rhonda Cooper-Dehoff, Anna Dominiczak, Mark Caulfield, Sandosh Padmanabhan, Patricia Munroe

JOURNAL OF HYPERTENSION (2021)

Review Allergy

Genomics of asthma, allergy and chronic rhinosinusitis: novel concepts and relevance in airway mucosa

Anu Laulajainen-Hongisto, Annina Lyly, Tanzeela Hanif, Kishor Dhaygude, Matti Kankainen, Risto Renkonen, Kati Donner, Pirkko Mattila, Tuomas Jartti, Jean Bousquet, Paula Kauppi, Sanna Toppila-Salmi

CLINICAL AND TRANSLATIONAL ALLERGY (2020)

Meeting Abstract Pharmacology & Pharmacy

GENOME WIDE META-ANALYSIS OF BLOOD PRESSURE RESPONSE TO B-BLOCKERS: RESULTS FROM INTERNATIONAL CONSORTIUNI OF ANTIHYPERTENSIVE PHARMACOGENOMICS STUDIES.

S. Singh, H. R. Warren, T. P. Hiltunen, E. Salvi, N. El Rouby, T. Garofalidou, F. Fyhrquist, K. K. Kontula, V. Glorioso, R. Zaninello, N. Glorioso, C. J. Pepine, P. B. Munroe, A. L. Beitelshees, S. T. Turner, A. B. Chapman, E. Boerwinkle, J. A. Johnson, Y. Gong, R. M. Cooper-DeHoff

CLINICAL PHARMACOLOGY & THERAPEUTICS (2019)

Meeting Abstract Pharmacology & Pharmacy

GENOME WIDE META-ANALYSIS OF BLOOD PRESSURE RESPONSE TO B-BLOCKERS: RESULTS FROM INTERNATIONAL CONSORTIUM OF ANTIHYPERTENSIVE PHARMACOGENOMICS STUDIES.

S. Singh, H. R. Warren, T. P. Hiltunen, E. Salvi, N. El Rouby, T. Garofalidou, F. Fyhrquist, K. K. Kontula, V. Glorioso, R. Zaninello, N. Glorioso, C. J. Pepine, P. B. Munroe, A. L. Beitelshees, S. T. Turner, A. B. Chapman, E. Boerwinkle, J. A. Johnson, Y. Gong, R. M. Cooper-DeHoff

CLINICAL PHARMACOLOGY & THERAPEUTICS (2019)

No Data Available