Article
Clinical Neurology
Palmiero Monteleone, Giammarco Cascino, Alessio Maria Monteleone, Paola Rocca, Alessandro Rossi, Alessandro Bertolino, Eugenio Aguglia, Mario Amore, Enrico Collantoni, Giulio Corrivetti, Alessandro Cuomo, Antonello Bellomo, Enrico D'Ambrosio, Liliana Dell'Osso, Marianna Frascarelli, Giulia Maria Giordano, Luigi Giuliani, Carlo Marchesi, Cristiana Montemagni, Lucio Oldani, Federica Pinna, Maurizio Pompili, Rita Roncone, Rodolfo Rossi, Alberto Siracusano, Antonio Vita, Patrizia Zeppegno, Silvana Galderisi, Mario Maj
Summary: The study assessed the prevalence of EPS in schizophrenia patients treated with FGAs and SGAs, and found associations between EPS and the severity of the illness, neurocognitive impairments, and social cognition deficits. EPS were shown to impact patients' neurocognitive functions, but did not directly affect their social cognition abilities.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Clinical Neurology
Alejandra Zazueta, Tito Castillo, Alvaro Cavieres, Rene Gonzalez, Maximiliano Abarca, Rodrigo R. Nieto, Javier Deneken, Cristian Araneda, Pablo R. Moya, M. Leonor Bustamante
Summary: The response to conventional antipsychotic drugs and clozapine treatment is associated with genetic variations, but more research is needed for personalized prescriptions.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Giammarco Cascino, Rossella Ceres, Alessio Maria Monteleone, Paola Bucci, Giulia Maria Giordano, Silvana Galderisi, Palmiero Monteleone
Summary: This study aimed to investigate the switching of antipsychotic medications in people with schizophrenia and analyze potential predictors. Over a four-year period, 34.9% of the participants switched their medication. The use of first-generation antipsychotics and the presence of extrapyramidal symptoms at baseline were associated with switching antipsychotic classes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Psychiatry
Yuta Kawakita, Masahiro Takeshima, Tomonari Komatsu, Aya Imanishi, Dai Fujiwara, Yu Itoh, Kazuo Mishima
Summary: This study retrospectively compared the incidence of appendicitis in patients with schizophrenia with and without a history of clozapine exposure, finding a relationship between clozapine exposure and appendicitis onset.
Article
Pharmacology & Pharmacy
Konstantina Bampali, Filip Koniuszewski, Luca L. Silva, Sabah Rehman, Florian D. Vogel, Thomas Seidel, Petra Scholze, Florian Zirpel, Arthur Garon, Thierry Langer, Matthaeus Willeit, Margot Ernst
Summary: The study investigates the effects of tricyclic compounds on alpha 5 subunit-containing receptor subtypes. The results show that the antipsychotic drugs clozapine and chlorpromazine exert functional inhibition on multiple GABA(A) receptor subtypes, including those containing alpha 5-subunits. A novel binding site in alpha 5 GABA(A) receptor subunits was identified, and differential usage of this site and the orthosteric sites by these ligands was demonstrated.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Psychiatry
Markku Laehteenvuo, Jurjen J. Luykx, Heidi Taipale, Ellenor Mittendorfer-Rutz, Antti Tanskanen, Albert Batalla, Jari Tiihonen
Summary: This study compared the effects of different antipsychotic medications on the risk of developing substance use disorder (SUD) and hospital admissions in patients with schizophrenia. The results showed that clozapine and antipsychotic polytherapy were most strongly associated with a reduced risk of developing SUD and lower relapse rates.
BRITISH JOURNAL OF PSYCHIATRY
(2022)
Article
Clinical Neurology
Juan Duque-Yemail, Juan Carlos Avila
Summary: Despite the availability of various treatments for schizophrenia, the response rate to first-line antipsychotics remains low. Clozapine, despite its efficacy, is limited by side effects and the need for routine blood tests. Cariprazine, on the other hand, has shown effectiveness and good tolerability in treating patients with schizophrenia.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2022)
Article
Multidisciplinary Sciences
Xiuru Su, Limin Qiao, Qing Liu, Yujie Shang, Xiaoni Guan, Meihong Xiu, Xiangyang Zhang
Summary: The study found that BDNF gene polymorphisms are related to cognitive function at different stages of schizophrenia, especially in language performance in drug-naive first-episode patients. Different genotypes showed significant differences in language performance between drug-naive first-episode patients and chronic patients, but not in cognitive functioning.
SCIENTIFIC REPORTS
(2021)
Article
Psychiatry
Mi Yang, Qiwen Li, Chunzhi Wang, Li Li, Min Xu, Fei Yan, Wei Chen, Ying Wan
Summary: Hospital-acquired pneumonia (HAP) in hospitalized middle-aged and elderly patients with schizophrenia is associated with older age, male gender, and longer hospitalization duration. Specific antipsychotic drugs such as quetiapine, clozapine, and olanzapine, as well as combination with aceglutamide, are risk factors for HAP infection. Minimizing the types and dosages of antipsychotic drugs while monitoring mental symptoms is important in preventing HAP in this population.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Psychiatry
Annarita Barone, Michele De Prisco, Benedetta Altavilla, Camilla Avagliano, Raffaele Balletta, Elisabetta Filomena Buonaguro, Mariateresa Ciccarelli, Luigi D'Ambrosio, Sara Giordano, Gianmarco Latte, Marta Matrone, Federica Milandri, Danilo Notar Francesco, Licia Vellucci, Andrea de Bartolomeis
Summary: This study used a machine learning approach to explore the relationship between Treatment Resistant Schizophrenia (TRS) and the five-factor model of the Positive and Negative Syndrome Scale (PANSS). Through the random forest algorithm, it was found that patients with higher scores in disorganization, positive, and excitement symptoms were more likely to be classified as TRS. A multivariate logistic regression model further confirmed that only the disorganization factor was significantly associated with TRS.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Clinical Neurology
Shimeng Dong, Johannes Schneider-Thoma, Irene Bighelli, Spyridon Siafis, Dongfang Wang, Angelika Burschinski, Kristina Schestag, Myrto Samara, Stefan Leucht
Summary: In this network meta-analysis, the efficacy and adverse events of different antipsychotics in treatment-resistant schizophrenia were examined. The results showed that clozapine and olanzapine were more effective in relieving symptoms compared to other drugs. Clozapine remains the gold standard for patients with treatment-resistant schizophrenia, while olanzapine can be considered as an alternative option.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2023)
Article
Psychiatry
Antonio F. Pardinas, Sophie E. Smart, Isabella R. Willcocks, Peter A. Holmans, Charlotte A. Dennison, Amy J. Lynham, Sophie E. Legge, Bernhard T. Baune, Tim B. Bigdeli, Murray J. Cairns, Aiden Corvin, Ayman H. Fanous, Josef Frank, Brian Kelly, Andrew McQuillin, Ingrid Melle, Preben B. Mortensen, Bryan J. Mowry, Carlos N. Pato, Sathish Periyasamy, Marcella Rietschel, Dan Rujescu, Carmen Simonsen, David St Clair, Paul Tooney, Jing Qin Wu, Ole A. Andreassen, Kaarina Kowalec, Patrick F. Sullivan, Robin M. Murray, Michael J. Owen, James H. MacCabe, Michael C. O'Donovan, James T. R. Walters
Summary: This study examined the genetic architecture of treatment-resistant schizophrenia (TRS) by reassessing genetic data from schizophrenia studies and validating it in carefully ascertained clinical samples. The results showed that TRS is a polygenic trait with detectable heritability, and it is genetically correlated with traits related to intelligence and cognition. The study also found associations between TRS and a history of taking clozapine.
Article
Health Care Sciences & Services
Diana Z. Paderina, Anastasiia S. Boiko, Ivan V. Pozhidaev, Anna V. Bocharova, Irina A. Mednova, Olga Yu. Fedorenko, Elena G. Kornetova, Anton J. M. Loonen, Arkadiy V. Semke, Nikolay A. Bokhan, Svetlana A. Ivanova
Summary: The study investigated the association of nine polymorphisms in serotonergic system genes with MetS in patients with schizophrenia. Results suggested that allelic variants of HTR2C genes may affect metabolic parameters, and MetS is too complex to be studied without dissecting it into individual components.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Nicolas Hoertel, Marina Sanchez-Rico, Erich Gulbins, Johannes Kornhuber, Alexander Carpinteiro, Eric J. Lenze, Angela M. Reiersen, Miriam Abellan, Pedro de la Muela, Raphael Vernet, Carlos Blanco, Celine Cougoule, Nathanael Beeker, Antoine Neuraz, Philip Gorwood, Jesus M. Alvarado, Pierre Meneton, Frederic Limosin
Summary: The use of FIASMA medication in COVID-19 patients may reduce the risk of intubation or death, with this association remaining significant in multiple sensitivity analyses and not specific to a particular FIASMA class or medication. Double-blind controlled randomized clinical trials are needed to further investigate the potential benefits of these medications for COVID-19.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Behavioral Sciences
Jivago Ropke, Talita H. Ferreira-Vieira, Lia P. Iglesias, Laila Asth, Fabiola M. Ribeiro, Fabricio A. Moreira
Summary: The study demonstrated that increasing endocannabinoid levels can protect rats against haloperidol-induced TD through CB1 receptor mediation. High-VCM rats showed increased CB1 receptor expression, which was positively correlated with the number of VCMs.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2021)
Article
Neurosciences
Jinjing Song, Xiujuan Yang, Ying Zhou, Lei Chen, Xu Zhang, Zhuxi Liu, Weibo Niu, Nengpeng Zhan, Xuelian Fan, Abdul Aziz Khan, Yifang Kuang, Lulu Song, Guang He, Weidong Li
Article
Pharmacology & Pharmacy
Meixing Zhang, Dong Zhang, Jingbo Dai, Yong Cao, Wangjie Xu, Guang He, Zhaoxia Wang, Lianyu Wang, Runsheng Li, Zhongdong Qiao
Article
Cell Biology
Jiaying Chen, Xinzhi Zhao, Li Cui, Guang He, Xinhui Wang, Fudi Wang, Shiwei Duan, Lin He, Qiang Li, Xiaodan Yu, Fuquan Zhang, Mingqing Xu
Article
Multidisciplinary Sciences
Binyin Hou, Lei Ji, Zhixuan Chen, Lin An, Naixin Zhang, Decheng Ren, Fan Yuan, Liangjie Liu, Yan Bi, Zhenming Guo, Gaini Ma, Fei Xu, Fengping Yang, Shunying Yu, Zhenghui Yi, Yifeng Xu, Lin He, Chuanxin Liu, Bo Bai, Shaochang Wu, Longyou Zhao, Changqun Cai, Tao Yu, Guang He, Yi Shi, Xingwang Li
SCIENTIFIC REPORTS
(2020)
Article
Clinical Neurology
Binyin Hou, Lei Ji, Zhixuan Chen, Lin An, Naixin Zhang, Decheng Ren, Fan Yuan, Liangjie Liu, Yan Bi, Zhenming Guo, Gaini Ma, Fei Xu, Fengping Yang, Shunying Yu, Zhenghui Yi, Yifeng Xu, Lin He, Chuanxin Liu, Bo Bai, Tao Yu, Shaochang Wu, Longyou Zhao, Changqun Cai, Xi Wu, Xingwang Li, Guang He
Summary: The study found that the CEND1 gene may be associated with depressive symptoms, especially under negative life events. Two SNPs (rs7946354 and rs6597982) have significant impacts on DSs and negative life events. The AG genotype of rs6597982 and GT genotype of rs7946354 contribute to the maximum risk of DSs under high negative life events.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Clinical Neurology
Na Wu, Liangjie Liu, Decheng Ren, Fan Yuan, Yan Bi, Zhenming Guo, Binyin Hou, Lei Ji, Ke Han, Mofan Feng, Kai Su, Tao Yu, Xingwang Li, Fengping Yang, Xueli Sun, Zaiquan Dong, Shunying Yu, Zhenghui Yi, Yifeng Xu, Lin He, Shaochang Wu, Longyou Zhao, Cai Changqun, Yi Shi, Guang He
Summary: The study found no significant association between two SNPs (rs6354 and rs1487971) in the SLC6A4 gene and remission after venlafaxine treatment in patients with major depressive disorder.
CLINICAL NEUROPHARMACOLOGY
(2021)
Article
Neurosciences
Zhuxi Liu, Caiqin Li, Xuelian Fan, Yifang Kuang, Xu Zhang, Lei Chen, Jinjing Song, Ying Zhou, Eiki Takahashi, Guang He, Weidong Li
Article
Cell Biology
Song Xiaozhen, Yuan Fan, Yuan Fang, Lan Xiaoping, Jia Jia, Xu Wuhen, Tang Xiaojun, Shen Jun, Chen Yucai, Zhang Hong, He Guang, Wu Shengnan
Summary: Two variants of the SEMA6B gene, occurring de novo in two patients, underlie early-onset epilepsy with different severity and treatment responses. One variant results in increased expression of a truncated protein, while the other affects a functional domain of SEMA6B. Both variants influence protein binding and suggest the potential mechanism of the SEMA6B-related disease.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zhenming Guo, Mengxia Chen, Yiming Chao, Chunhai Cai, Liangjie Liu, Li Zhao, Linbo Li, Qing-Ran Bai, Yanxin Xu, Weibo Niu, Lei Shi, Yan Bi, Decheng Ren, Fan Yuan, Shuyue Shi, Qian Zeng, Ke Han, Yi Shi, Shan Bian, Guang He
Summary: RGCC regulates NSC self-renewal and neuronal differentiation by affecting cell cycle regulation and spindle orientation, with deficiency leading to decreased NSC population and brain developmental malformation. This study suggests that RGCC plays a crucial role in maintaining the NSC pool during cortical development and potential etiological roles in human brain malformations.
Article
Toxicology
Dong Zhang, Jingbo Dai, Meixing Zhang, Yilin Xie, Yong Cao, Guang He, Wangjie Xu, Lianyun Wang, Zhiguang Qiao, Zhongdong Qiao
Summary: Paternal nicotine exposure can induce hepatic fibrosis in offspring by down-regulating mmu-miR-15b expression via hyper-methylation, activating the Wnt pathway, leading to increased activation and proliferation of hepatic stellate cells. Additionally, nicotine can promote the activation of the TGF-beta pathway, cooperatively enhancing the transcription of extracellular matrix genes, ultimately contributing to liver fibrosis in offspring.
TOXICOLOGY LETTERS
(2021)
Article
Multidisciplinary Sciences
Lei Ji, Changfeng Chen, Binyin Hou, Decheng Ren, Fan Yuan, Liangjie Liu, Yan Bi, Zhenming Guo, Fengping Yang, Xi Wu, Xingwang Li, Chuanxin Liu, Zhen Zuo, Rong Zhang, Zhenghui Yi, Yifeng Xu, Lin He, Yi Shi, Tao Yu, Guang He
Summary: Negative life events can undermine academic engagement through depressive symptoms, but social supports can mitigate this negative impact among college students in the Chinese cultural context.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Xin Yi, Minzhe Li, Guang He, Huihui Du, Xingwang Li, Dongmei Cao, Lu Wang, Xi Wu, Fengping Yang, Xu Chen, Lin He, Yong Ping, Daizhan Zhou
Summary: This study identified possible pathogenic mutations in the TENM4 gene and demonstrated its association with impaired neural circuits and behaviors observed in schizophrenia through aberrant expression leading to lower learning ability, reduced sleep, and increased aggressiveness in animal models.
Article
Biochemistry & Molecular Biology
Na Wu, Fan Yuan, Siran Yue, Fengyan Jiang, Decheng Ren, Liangjie Liu, Yan Bi, Zhenming Guo, Lei Ji, Ke Han, Xiao Yang, Mofan Fend, Kai Su, Fengping Yang, Xi Wu, Qing Lu, Xingwang Li, Ruirui Wang, Baocheng Liu, Shenglong Le, Yi Shi, Guang He
Summary: The study found that exercise and diet intervention can affect DNA methylation of GAB2 in NAFLD and NASH patients, protecting them from disease progression. It also demonstrated that DNA methylation variations in blood can reflect epigenetic signatures in target tissues such as liver and adipose tissue.
CELL AND BIOSCIENCE
(2021)
Article
Cell Biology
Qiao Wang, Decheng Ren, Yan Bi, Ruixue Yuan, Dong Li, Jianying Wang, Ruirui Wang, Lei Zhang, Guang He, Baocheng Liu
Article
Geriatrics & Gerontology
Zhan Gu, Yan Bi, Fan Yuan, Ruirui Wang, Dong Li, Jianying Wang, Xiaojuan Hu, Guang He, Lei Zhang, Bao-cheng Liu
CLINICAL INTERVENTIONS IN AGING
(2020)