Article
Clinical Neurology
Song Li, Zhengzhi Wu, Weidong Le
Summary: In Western medicine, dementia affects cognition, mental health, and physical abilities, while Traditional Chinese Medicine explains it from the perspectives of brain dystrophy, Spleen-Kidney weakness, Blood stasis, and Phlegm stagnation. Ancient Chinese physicians believed that dementia manifests not only as cognitive symptoms but also as psychiatric disorders and sleep disturbance, offering various treatment methods.
ALZHEIMERS & DEMENTIA
(2021)
Article
Multidisciplinary Sciences
Xiaohe Xiao, Zhaofang Bai, Jiabo Wang, Haibo Song
Summary: In recent years, there has been an increase in adverse reactions/events associated with TCM due to the passive state of safety and risk management, which has hindered the healthy development of TCM industries. To address this, a pharmacovigilance technology system tailored to TCM characteristics is proposed for active prevention and control of TCM safety risks. This system has been successfully used to formulate strategies for prevention and control of TCM safety risks, supporting the clinical rational and safe use of TCM and contributing to the sustainable development of TCM disciplines and industries.
CHINESE SCIENCE BULLETIN-CHINESE
(2021)
Article
Multidisciplinary Sciences
Hen-Hong Chang, Su-Yin Chiang, Pei-Chun Chen, Chia-Han Tsai, Rong-Chi Yang, Chiu-Lin Tsai, Tsung-Hsiu Wu, Yow-Wen Hsieh, Yu-Chun Lin, Yung-Te Kuo, Kuan-Chung Chen, Hsueh-Ting Chu
Summary: The Taiwan Adverse Drug Reaction Reporting System for Herbal Medicine (TADRRS-HM) has been documenting suspected adverse events from ADR reports since 1998, finding that herbal medicines may cause a wide range of ADRs, with gastrointestinal system disorders and skin issues being the most common.
SCIENTIFIC REPORTS
(2021)
Review
Pharmacology & Pharmacy
Lei Li, Man Wang, Jikuai Chen, Juelin Chen, Yawei Wang, Minghao Zhao, Qing Song, Shuogui Xu
Summary: As global warming continues, heat waves are becoming more frequent and intense, leading to an increase in the incidence of heat stroke. Heat stroke is associated with significant morbidity and mortality, and further research is urgently needed to address this issue. Traditional Chinese medicine offers potential treatment methods, including herbal therapies and external treatments, which may provide clinical benefits and research directions for heat stroke.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Ingrid Laemmle-Ruff, Georgina Lewis, Hazel J. J. Clothier, Gerardo Luis Dimaguila, Michelle Wolthuizen, Jim Buttery, Nigel W. Crawford
Summary: The translation discusses SAEFVIC's response to the COVID-19 vaccine program and lessons learned for vaccine safety. It highlights the streamlined collection of AEFI reports, increased staffing, innovative approaches to manage the increased report volumes, and the importance of communication with government, regulatory bodies, and specialist groups. The translation emphasizes the significance of vaccine safety in supporting public confidence in vaccines and informing evidence-based immunisation policy.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Plant Sciences
Wei Zhuang, Shao-Li Liu, Sheng-Yan Xi, Ying-Nan Feng, Ke Wang, Teliebald Abduwali, Ping Liu, Xiao-Jiang Zhou, Lan Zhang, Xian-Zhe Dong
Summary: This article summarizes the frequently used traditional Chinese medicine decoctions and Chinese patent medicines for treating depression, reviews their clinical therapeutic effects and possible mechanisms, and highlights the importance of traditional Chinese medicine in the management of depression.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Xue Bai, Meng Zhang
Summary: Research has shown that traditional Chinese medicine has a clinical impact on vascular dementia, improving patients' cognitive function and quality of life. The pharmacological mechanisms of TCM for VD treatment include targeting the kidneys, eliminating turbidity, and promoting blood circulation, indicating promising prospects.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Zhi Ge Wen, Qi Qi Zhang, Li Li Zhang, Meng Fei Shen, Yi Shan Huang, Lin Hua Zhao
Summary: This review evaluated the effectiveness and safety of traditional Chinese medicine (TCM) for treating overweight/obesity based on randomized controlled trials (RCTs). The results showed that TCM preparations can effectively reduce body weight, body mass index, waist circumference, hip circumference, total cholesterol, triglycerides, and fasting blood glucose levels, while increasing high-density lipoprotein levels and lowering blood pressure. TCM may be a suitable treatment option for overweight/obesity in adults due to its long-term effectiveness and safety.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Chao Mo, Jie Zhao, Jingyan Liang, Huiling Wang, Yu Chen, Guodong Huang
Summary: Exosomes play a crucial role in intercellular communication, and the interaction between exosomes and traditional Chinese medicine (TCM) has beneficial effects on various diseases. TCM formulas and compounds can modulate exosomes to inhibit cell proliferation, reduce inflammation, and attenuate fibrosis. Additionally, exosomes serve as a natural delivery system for TCM compounds, and they may also be potential biomarkers for TCM syndromes.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biology
Qi Zhang, Jianhang Zhou, Bob Zhang
Summary: This study systematically summarizes the development of computational TCM diagnosis, focusing on digital acquisition devices, collected datasets, and computational detection methods. It provides principles, applications, and current progress in computing for computational TCM diagnosis while discussing future development directions and technological trends.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Chien-Yu Ko, Jung Chao, Pei-Yu Chen, Shan-Yu Su, Tomoji Maeda, Chin-Yu Lin, Hung-Che Chiang, Shyh-Shyun Huang
Summary: The study investigated 74 skin whitening prescriptions sold in TCM pharmacies in Taiwan, revealing 90 traditional Chinese medicinal materials mainly sourced from Apiaceae and Leguminosae. Oral prescriptions were mostly warm and sweet, while external prescriptions included cold and bitter medicinal materials, with a focus on tonifying and replenishing effects. Pharmacological analysis indicated potential benefits for wound healing, inflammatory skin diseases, and anti-hyperpigmentation.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Medicine, Research & Experimental
Wang Shao-Mei, Ye Li-Fang, Wang Li-Hong
Summary: Heart failure often stems from various cardiovascular diseases, with an energy metabolism disorder of cardiomyocytes serving as a molecular basis. Current drugs like ARNi and SGLT-2 inhibitors target myocardial metabolism to treat HF. Traditional Chinese medicine, including Danshen yin and Fufang Danshen dripping pill, has gained acceptance for HF treatment, potentially serving as a complementary approach for prevention.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Integrative & Complementary Medicine
Jillian L. Capodice, Barbara M. Chubak
Summary: Traditional Chinese Medicine (TCM) is a comprehensive medical system that has been developed over thousands of years and is utilized in the treatment of COVID-19. This paper highlights the use of TCM in treating COVID-19, discussing concepts and challenges of integrating TCM into medical settings.
Review
Pharmacology & Pharmacy
Mia Aakjaer, Marie Louise De Bruin, Morten Andersen
Summary: This study aims to explore methods for sequential analysis of electronic healthcare data to address the limitations of spontaneous reporting systems. Through literature review and experimentation, it has been demonstrated that the use of sequential analysis can successfully conduct epidemiological surveillance of various exposures and outcomes. However, there is a relative lack of research on analyzing data at multiple time points in realistic settings.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2023)
Review
Pharmacology & Pharmacy
Ming Lyu, Guanwei Fan, Guangxu Xiao, Taiyi Wang, Dong Xu, Jie Gao, Shaoqin Ge, Qingling Li, Yuling Ma, Han Zhang, Jigang Wang, Yuanlu Cui, Junhua Zhang, Yan Zhu, Boli Zhang
Summary: The COVID-19 pandemic poses a significant threat to global public health and safety, with the crucial role and potential mechanisms of Traditional Chinese Medicine (TCM) in combination with Western medicine highlighted and discussed. A comprehensive review of the clinical effects and potential mechanisms of TCM on COVID-19 is presented, aiming to provide reference for healthcare professionals and the public, and facilitate understanding of the true scientific value of TCM.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Neuroimaging
Tengfei Zhou, Tingyu Yi, Tianxiao Li, Liangfu Zhu, Yucheng Li, Zhaoshuo Li, Meiyun Wang, Qiang Li, Yingkun He, Pengfei Yang, Yongwei Zhang, Zifu Li, Yongxin Zhang, Xiaofei Ye, Wenhuo Chen, Shouchun Wang, Jianmin Liu
Summary: Through analyzing the predictors of futile recanalization in AIS patients who received endovascular treatment, it was found that older age, higher baseline systolic blood pressure, incomplete reperfusion defined by eTICI, and larger final infarct volume are independent predictors of futile recanalization.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2022)
Article
Pharmacology & Pharmacy
Xiao Chen, Lianhui Wei, Lijie Chi, Xiaojing Guo, Chenxin Chen, Zhijian Guo, Jizhou Liang, Yi Zheng, Jia He, Xiaofei Ye
Summary: This study explored and described the adverse reaction signals in safety reporting for alpelisib by performing a disproportionality analysis on the World Health Organization's VigiBase database, identifying a comprehensive list of potentially associated adverse events.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Rheumatology
Geyao Qi, Hao Wang, Yufeng Guo, Chi Peng, Chenxu Zhang, Ting Chen, Jia He, Zhichao Jin
Summary: This study investigated the clinical outcomes of patients with rheumatic diseases infected with COVID-19. The results showed that rheumatic diseases seemed to aggravate the course of COVID-19 infection, but the poor outcomes of COVID-19 seemed to be unrelated to rheumatic diseases.
CLINICAL RHEUMATOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yi Zheng, Wenli Zhou, Xiaojing Guo, Lijie Chi, Chenxin Chen, Zhijian Guo, Jizhou Liang, Lianhui Wei, Xiao Chen, Xiaofei Ye, Jia He
Summary: This study aimed to identify drugs causing SJS and found 295 drugs with signals, where allopurinol, phenytoin, and carbamazepine were the strongest. However, further research is needed to verify the signals from garenoxaci, carbocisteine, and dimetindene due to lack of reported cases.
EXPERT OPINION ON DRUG SAFETY
(2022)
Article
Neuroimaging
Pengfei Xing, Xiaoxi Zhang, Hongjian Shen, Fang Shen, Lei Zhang, Zifu Li, Yongxin Zhang, Bo Hong, Huaizhang Shi, Hongxing Han, Xiaofei Ye, Yongwei Zhang, Pengfei Yang, Jianmin Liu
Summary: This study evaluated the efficacy and safety of different treatment strategies based on stroke etiology in patients with large vessel occlusion. The results showed that there were no significant differences in efficacy and safety between different stroke etiology groups.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2022)
Article
Clinical Neurology
Yu Zhou, Pengfei Xing, Zifu Li, Xiaoxi Zhang, Lei Zhang, Yongxin Zhang, Yongwei Zhang, Bo Hong, Yi Xu, Qinghai Huang, Qiang Li, Kaijun Zhao, Chao Zou, Ying Yu, Qiao Zuo, Shen Liu, Liyong Zhang, Charles B. L. M. Majoie, Yvo B. W. E. M. Roos, K. M. Treurniet, Xiaofei Ye, Ya Peng, Pengfei Yang, Jianmin Liu
Summary: In this study, there was no evidence found that occlusion location could influence decisions on intravenous alteplase in endovascular treatment-eligible patients presenting directly at endovascular treatment-capable centers. Further research is needed to validate these findings.
Article
Behavioral Sciences
Liwei Shen, Xiaoli Yang, Wenmei Lu, Weijie Chen, Xiaofei Ye, Danhong Wu
Summary: Abnormal blood pressure regulation is a common feature of autonomic dysfunction in Parkinson's disease patients. This study found significant differences in circadian blood pressure rhythm between different disease stages and subtypes of PD patients, with reverse dipping being more common in advanced PD patients. 24-hour ambulatory blood pressure monitoring is crucial for evaluating blood pressure alterations in PD patients and clinicians should be vigilant about reverse dipping to prevent serious clinical events.
BRAIN AND BEHAVIOR
(2022)
Article
Clinical Neurology
Ping Zhang, Hong-jian Shen, Lei Chen, Xuan Zhu, Min-min Zhang, Yi Jiang, Peng-fei Yang, Lei Zhang, Peng-fei Xing, Xiao-fei Ye, Min Lou, Cong-guo Yin, Ben-qiang Deng, Tao Wu, Yong-wei Zhang, Jian-min Liu
Summary: This study aimed to analyze the impact of endovascular thrombectomy (EVT) alone versus EVT after intravenous alteplase on patient-reported anxiety/depression, as well as to identify predictors of anxiety/depression after ischemic stroke. The results indicated that intravenous alteplase treatment may have a beneficial effect on anxiety/depression, suggesting that it may be better to provide intravenous alteplase before EVT rather than EVT alone.
FRONTIERS IN NEUROLOGY
(2022)
Article
Endocrinology & Metabolism
Yinghong Zhai, Xiaofei Ye, Fangyuan Hu, Jinfang Xu, Xiaojing Guo, Xiang Zhou, Yi Zheng, Xinxin Zhao, Xiao Xu, Yang Cao, Jia He
Summary: We provided a comprehensive overview of metabolic and nutritional toxicities after the initiation of immune checkpoint inhibitors (ICIs) through an integrated big database. The results showed a significant association between ICIs usage and metabolic and nutritional disorders (MNDs), especially with monotherapy using anti-PD-1 ICIs. Combination therapy was associated with a higher reporting frequency of these toxicities.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medical Informatics
Qi Chen, Bihan Tang, Jiaqi Song, Ying Jiang, Xinxin Zhao, Yiming Ruan, Fangjie Zhao, Guosheng Wu, Tao Chen, Jia He
Summary: A real-time prediction model based on Dynamic Bayesian Networks (DBNs) was developed and validated for predicting physiological changes, organ dysfunctions, and mortality risk in critical trauma patients. The model demonstrated high accuracy in both datasets and showed promising results for real-life ICU scenarios.
BMC MEDICAL INFORMATICS AND DECISION MAKING
(2022)
Article
Pharmacology & Pharmacy
Ziwei Dong, Xiaofei Ye, Chenxin Chen, Rui Wang, Dongxu Liu, Xiao Xu, Xiang Zhou, Jia He
Summary: This study analyzed the association between the use of JAKinibs and thromboembolic events and found several safety signals. However, some of these signals still require more medical evidence.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Clinical Neurology
Yu Zhou, Lei Zhang, Johanna Ospel, Mayank Goyal, Rosalie McDonough, Pengfei Xing, Zifu Li, Xiaoxi Zhang, Yongxin Zhang, Yongwei Zhang, Bo Hong, Yi Xu, Qinghai Huang, Qiang Li, Ying Yu, Qiao Zuo, Xiaofei Ye, Pengfei Yang, Jianmin Liu
Summary: This study found that intravenous alteplase increases early reperfusion for patients with large vessel occlusion directly presenting to an endovascular treatment-capable hospital, especially when endovascular treatment gets delayed more than approximately half an hour.
Article
Medicine, General & Internal
Hao Li, Jinbo Huang, Shisheng Ye, Hai Chen, Li Yuan, Geng Liao, Weijie Du, Chaomao Li, Ling Fang, Sheng Liu, Pengfei Yang, Yongwei Zhang, Pengfei Xing, Xiaoxi Zhang, Xiaofei Ye, Ya Peng, Jie Cao, Liyong Zhang, Zhi Yang, Jianmin Liu
Summary: This study aimed to identify predictors of 90-day mortality in acute ischemic stroke patients treated with mechanical thrombectomy. The results showed that symptomatic intracranial hemorrhage, high post-thrombectomy NIHSS score, high NIHSS score on admission, and high glucose level at hospital arrival were significant independent predictors of mortality. Smoking may also be associated with mortality, but further research is needed to confirm this.
Article
Cardiac & Cardiovascular Systems
Yinghong Zhai, Xiaofei Ye, Fangyuan Hu, Jinfang Xu, Xiaojing Guo, Zhen Lin, Xiang Zhou, Zhijian Guo, Yang Cao, Jia He
Summary: This study aims to investigate the safety of PPIs and summarize their potential cardiac and vascular risks. By analyzing the FDA Adverse Event Reporting System database, it is found that PPIs may cause various cardiac and vascular events, with a more significant impact on the vascular system.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
