Article
Pediatrics
Abdullah Al-Shamrani, Saleh Alharbi, Sumayyah Kobeisy, Suzan A. AlKhater, Haleimah Alalkami, Turki Alahmadi, Aisha Almutairi, Adel S. Alharbi, Abdullah A. Yousef
Summary: This article studied the safety profile of montelukast in children and found that adverse neuropsychiatric and sleep-related drug reactions were more prevalent. Sleep disturbance, agitation, pain, and hyperactivity were the most common adverse reactions. Pediatricians need to be aware of these adverse reactions and conduct research on risk management.
Article
Pediatrics
Sandip Ray, Anju Seth, Sarita Singh, Garima Sharma, Neha Gaur, Yukti Shah, Praveen Kumar, Jagdish Chandra
Summary: This study aimed to actively monitor adverse drug reactions (ADRs) in HIV-infected children newly initiated on antiretroviral therapy (ART), and assess their impact on ART adherence. The results showed that ADRs were frequent but mostly mild and self-limiting. Gastrointestinal symptoms were the most common ADR, and different treatment regimens were significantly associated with different types of ADRs. Children with immunological suppression were at a higher risk of developing ADRs compared to those without it.
INDIAN JOURNAL OF PEDIATRICS
(2023)
Review
Plant Sciences
Rui Zheng, Yang Sun, Xiaoyu Zhang, Chen Zhao, Pengqian Wang, Shiqi Chen, Zhao Chen, Ruijin Qiu, Aihua Liang, Hongcai Shang
Summary: This comprehensive review examines the clinical features of adverse events (AEs) associated with the combination of XYP and RB. The review analyzes data from randomized controlled trials, cohort studies, case-control studies, case reports, case series, and the National Adverse Drug Reaction Monitoring Information System. The most common AE reported is skin and appendage reactions, with a majority of cases being pseudo-allergic reactions. The study recommends increased awareness of the safety of the XYP-RB combination treatment, especially in children, and the standardization of medication protocols.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Allergy
Cagla Karavaizoglu, Ayse Suleyman, Roza Yavuz Alic, Kazim Okan Dolu, Esra Yucel, Zeynep Hizli Demirkale, Sevgi Sipahi Cimen, Cevdet Ozdemir, Zeynep Ulker Tamay
Summary: This study aimed to investigate the adverse reactions after drug skin tests in children. The results showed that although adverse reactions were rare, severe allergic reactions may still occur. Therefore, performing skin tests in experienced clinical centers is necessary.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Abdelbaset A. Elzagallaai, Michael J. Rieder
Summary: In most cases, drug use in children is based on data extrapolated from trials in adult populations, which increases the risk of adverse drug reactions. Drug hypersensitivity reactions, a major type of ADR, are largely unpredictable and problematic due to a lack of understanding of their pathophysiology. The lack of clear clinical guidelines for children makes modeling a desirable approach to address this issue.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Jiahao Zhu, Jieluan Lu, Yaodong He, Xianhuan Shen, Hanbing Xia, Wenzhou Li, Jianping Zhang, Xiaomei Fan
Summary: This study found that the polymorphisms of the ABCB1 gene are associated with the treatment outcomes of valproic acid in Chinese children with epilepsy. The TT genotype of rs1128503 is more likely to lead to persistent seizures after treatment, while the CC genotype of rs3789243 may be protective against gastrointestinal adverse drug reactions but increase the risk of cutaneous adverse drug reactions. However, the CT genotype of rs3789243 is associated with a lower risk of cutaneous adverse drug reactions. Additionally, carriers of the CC haplotype tend to respond better to valproic acid treatment.
Article
Allergy
Veronica Sansing-Foster, Nicole Haug, Andrew Mosholder, Noelle M. Cocoros, Marie Bradley, Yong Ma, Dinci Pennap, Elizabeth C. Dee, Sengwee Toh, Ella Pestine, Andrew B. Petrone, Ivone Kim, Jennifer G. Lyons, Efe Eworuke
Summary: The study found no associations between montelukast use and hospitalizations for depression or self-harm events compared to ICS use. Most psychiatric adverse events occurred in patients with a past psychiatric history.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Pediatrics
Lisa Marie Kiesel, Astrid Bertsche, Wieland Kiess, Manuela Siekmeyer, Thilo Bertsche, Martina Patrizia Neininger
Summary: In a pediatric intensive care unit, critically ill children frequently experience hemodynamic alterations due to the complex treatment and administration of drugs. The majority of these alterations are temporally related to drug therapy, and a high percentage of administered drugs have potential adverse effects on hemodynamic parameters.
WORLD JOURNAL OF PEDIATRICS
(2023)
Article
Pharmacology & Pharmacy
Ryogo Umetsu, Mizuki Tanaka, Yoko Nakayama, Yamato Kato, Natsumi Ueda, Yuri Nishibata, Shiori Hasegawa, Kiyoka Matsumoto, Noriaki Takeyama, Kazuhiro Iguchi, Hiroyuki Tanaka, Eiichi Hinoi, Naoki Inagaki, Masatoshi Inden, Yoshinori Muto, Mitsuhiro Nakamura
Summary: This study investigated the association between montelukast and neuropsychiatric adverse events, finding significant reporting odds ratios for suicidal ideation and depression. Functional enrichment analysis revealed multiple genes interacting with montelukast and involved in neuroactive ligand-receptor interactions. The study suggests a need for further research on the pharmacological mechanisms underlying montelukast-associated neuropsychiatric symptoms.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Chemistry, Medicinal
Diane Merino, Arnaud Fernandez, Alexandre O. Gerard, Nouha Ben Othman, Fanny Rocher, Florence Askenazy, Celine Verstuyft, Milou-Daniel Drici, Susanne Thummler
Summary: Children and youth treated with antipsychotic drugs may experience adverse drug reactions and poor treatment response, which could be related to genetic variations in drug metabolism. The most frequent adverse reactions observed were weight gain and metabolic syndrome, followed by lack of therapeutic effect and neurological issues. Studies on the pharmacogenetic profiles associated with these drugs have yielded conflicting results, but some cases have shown significant clinical improvement through genotyping. Further research, especially on the key enzyme CYP1A2, is needed to improve the risk-benefit assessment of prescribing olanzapine, clozapine, and/or loxapine for children and youth.
Article
Pharmacology & Pharmacy
Mahmathi Karuppannan, Nur Azzrin Nisha Mohamad Rizal, Kok-Thong Wong, Salmiah Mohd Ali, Kang-Nee Ting, Helen Boardman
Summary: Adverse drug reactions (ADR) are a major public health concern with a high mortality rate, and pharmacists play a significant role in monitoring and preventing ADRs. However, many pharmacists, especially community pharmacists, have a misconception about reporting ADRs.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Francesca Filippi-Arriaga, Cristina Aguilera, Elena Guillen, Lucia Bellas, Eulalia Perez, Lourdes Vendrell, Antonia Agusti, Gloria Cereza
Summary: A study showed that approximately 15.2% of spontaneous ADR reports contained unknown drug-ADR pairs. These unknown ADRs have significant impact on the severity and outcome of patients, and contribute to the development of pharmacovigilance regulatory actions.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Seunghee Lee, Hyekyung Woo, Chung Chun Lee, Gyeongmin Kim, Jong-Yeup Kim, Suehyun Lee
Summary: As society ages, it is crucial to monitor drug use in the elderly. This study explores the usefulness of social network studies (SNS) in providing drug side effects information. By analyzing social media data, the researchers were able to obtain well-known side effects and propose a pharmacovigilance pipeline for unknown side effects. The proposed Drug_SNSMiner analysis pipeline proved effective in monitoring side effects and served as a drug prescription platform for the elderly.
SCIENTIFIC REPORTS
(2023)
Article
Pharmacology & Pharmacy
Louis Letinier, Amandine Ferreira, Alexandre Marceron, Marina Babin, Joelle Micallef, Ghada Miremont-Salame, Antoine Pariente
Summary: The study found that hemorrhage was the most common clinical manifestation of serious adverse drug reactions resulting from drug-drug interactions reported in France, followed by renal failure, pharmacokinetic alteration, and cardiac arrhythmias. More than one-third of serious adverse drug reactions involved at least three drugs.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Health Care Sciences & Services
Elisangela da Costa Lima, Thais de Barros Fernandes, Adair Freitas, Juliana Freire de Lima Sias, Marcelo Gerardin Poirot Land, Mariana Tschoepke Aires, Louise Bracken, Matthew Peak
Summary: This study involved the translation and transcultural adaptation of two tools for analyzing ADRs in Brazilian children, showing reliable and valid results. The Brazilian-Portuguese versions of LCAT and LAAT provide a quick and efficient method for causality and avoidability assessment of ADRs in children.
BMC MEDICAL RESEARCH METHODOLOGY
(2021)
Review
Pharmacology & Pharmacy
Susanna M. Wallerstedt, Mikael Hoffmann, Johan Lonnbro
Summary: This study investigated methodological aspects potentially related to the diverging scientific literature on the prevalence of drug-related hospitalisations, focusing on causality assessments. The findings suggest that methodological issues significantly contribute to the diversity in the literature on drug-related admissions, and recommendations were made to harmonize research by explicitly assessing the drug-problem-admission relationships from a medical perspective, focusing on problems where the drug treatment is the probable culprit.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Rickard Zeijlon, Victor Hantelius, Susanna M. Wallerstedt, Lina Holmqvist
Summary: This meta-epidemiological study reviewed case reports on sports nutrition supplements and adverse events, finding that essential factors for causality assessment were often overlooked. Clinical reasoning was common, while systematic causality assessment methods were applied in only a minority of cases. Factors important for causality assessment were more likely to be reported in cases with clinical reasoning, and the systematic method captured additional important aspects.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Niklas Bergh, Anna Myredal, Per Nivedahl, Max Petzold, Sultan Zarin, Constanze Wartenberg, Susanna M. Wallerstedt
Summary: This review compares the efficacy and safety of clopidogrel and ticagrelor as part of dual antiplatelet therapy in patients with acute coronary syndrome and older patients. The results show that there is little or no difference in all-cause mortality between the two drugs. Although not evident in older patients, it cannot be excluded that clopidogrel may be slightly less efficient in reducing the risk of cardiovascular mortality and myocardial infarction, whereas ticagrelor is probably more efficacious in reducing the risk of stent thrombosis. Clopidogrel results in a reduced risk of dyspnea and clinically significant bleeding, and in older people probably in a reduced risk of major bleeding.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Carina Tukukino, Naldy Parodi Lopez, Staffan A. Svensson, Susanna M. Wallerstedt
Summary: This study described the interaction alerts in older patients and evaluated whether these alerts required further medical action or had already been addressed. The results showed that most alerts had already been addressed or were not relevant in the clinical setting, but some patients still needed medical action.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Naldy Parodi Lopez, Staffan A. Svensson, Susanna M. Wallerstedt
Summary: This study investigates the clinical relevance of potentially inappropriate medications (PIMs) and potential prescribing omissions (PPOs), and finds that a fraction of them are clinically relevant. The study shows that the number of PIMs/PPOs and the number of drugs are associated with inadequate drug treatment.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Helena Sundvall, Sigurd Vitols, Susanna M. Wallerstedt, Johan Fastbom
Summary: The prevalence and initiation of statin therapy are increasing among the oldest old, despite the lack of randomized controlled trials focusing on this age group and the difficulty in detecting safety signals.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Naldy Parodi Lopez, Bjorn Belfrage, Anders Koldestam, Johan Lonnbro, Staffan A. Svensson, Susanna M. Wallerstedt
Summary: This study aimed to revisit the inter-rater reliability of drug treatment assessments according to the STOPP/START criteria. The findings showed issues with reliability and highlighted methodological factors that may contribute to inconsistency.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Susanna M. Wallerstedt, Staffan A. Svensson, Johan Lonnbro, Fredrik Hieronymus, Johan Fastbom, Mikael Hoffmann, Naldy Parodi Lopez
Summary: In this diagnostic study, the evaluated PIM/PPO sets had poor to fair performance as diagnostic tools to identify inadequate drug treatment, suggesting the need for reconsideration of using PIMs/PPOs as indicators of drug treatment quality.
Article
Pharmacology & Pharmacy
Carina Tukukino, Anna L. Eriksson, Walaa Hamdan, Frida Wallin Hybelius, Susanna M. Wallerstedt
Summary: Classifications of drug interaction alerts vary between knowledge resources, but there is limited exploration of agreement in recommendations for clinical management. A study analyzed medication lists of 274 older patients and found that while many drug pairs triggered alerts of similar significance in different resources, the recommendations provided varied considerably. The findings highlight the need for medical and pharmaceutical reflection on prescribing decisions as the recommendations cannot be considered definitive.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
Pia Seidel, Bo Rolander, Anna L. Eriksson, Ulf Lindahl, Susanna M. Wallerstedt, Staffan Haegg, Anders Kling
Summary: This study aimed to investigate the use of drug information by physicians in their professional work, particularly those working in primary care. A web-based questionnaire was distributed to physicians in Sweden, addressing drug-related queries, sources used, and factors influencing source choice. The study found that physicians frequently use drug information sources, especially those in primary care. Credibility and easy access were key factors influencing source choice, and personal characteristics also influenced the choice of drug information sources in primary care.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Clinical Neurology
Daniel von Below, Susanna M. Wallerstedt, Filip Bergquist
Summary: This study aimed to validate the Patient-Reported Outcomes in Parkinson's Disease (PRO-PD) scale for monitoring symptoms in PD patients. The results showed that PRO-PD exhibited good reliability and validity in monitoring symptoms in a representative sample of outpatients with PD.
MOVEMENT DISORDERS
(2023)
Meeting Abstract
Public, Environmental & Occupational Health
Susanna M. Wallerstedt, Johan Lonnbro, Staffan A. Svensson, Fredrik Hieronymus, Johan Fastbom, Mikael Hoffmann, Naldy Parodi Lopez
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2022)
Meeting Abstract
Public, Environmental & Occupational Health
Johan Lonnbro, Lina Holmqvist, Elisabeth Persson, Per Thyzell, N. David Aberg, Susanna M. Wallerstedt
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2022)
Meeting Abstract
Public, Environmental & Occupational Health
Naldy Parodi Lopez, Staffan A. Svensson, Susanna M. Wallerstedt
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2022)
Meeting Abstract
Public, Environmental & Occupational Health
Naldy Parodi Lopez, Staffan A. Svensson, Susanna M. Wallerstedt
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2022)