Article
Nutrition & Dietetics
Herve Lobbes, Stephane Durupt, Sabine Mainbourg, Bruno Pereira, Raphaele Nove-Josserand, Isabelle Durieu, Quitterie Reynaud
Summary: Iron deficiency prevalence in adult patients with cystic fibrosis is 44.2%, and it is significantly associated with female gender, younger age, lower body mass index, and Pseudomonas aeruginosa colonization.
Article
Genetics & Heredity
Yuelin Shen, Xiaolei Tang, Qionghua Chen, Hui Xu, Hui Liu, Jinrong Liu, Haiming Yang, Huimin Li, Shunying Zhao
Summary: This study characterizes the genotypic features of cystic fibrosis (CF) in Chinese children, revealing significant differences from the Caucasian population. The research also provides the first report on the geographical distribution of the most frequent CF variants among Chinese patients.
JOURNAL OF MEDICAL GENETICS
(2023)
Article
Pediatrics
Sarah Jane Driscoll, Katie Heinz, Philippa Goddard, Maya Desai, Francis J. Gilchrist
Summary: This study reviewed the outcomes of CF newborn bloodspot screening in the West Midlands from November 1, 2006 to October 31, 2021, with 1075161 babies screened. Among them, 268 were diagnosed with CF, 33 with CFSPID, and 17 as CF carriers, giving a CF birth prevalence of 1 in 4012.
ARCHIVES OF DISEASE IN CHILDHOOD
(2023)
Article
Pediatrics
L. Seddon, K. Dick, S. B. Carr, I. M. Balfour-Lynn
Summary: The majority of parents in a survey conducted in a London pediatric center believed that cystic fibrosis newborn screening results should be communicated face to face rather than over the telephone. There were mixed responses regarding whether parents should be informed of the genotype and CF diagnosis before the confirmatory sweat test.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Cell Biology
Melissa S. Phuong, Rafael E. Hernandez, Daniel J. Wolter, Lucas R. Hoffman, Subash Sad
Summary: Pseudomonas aeruginosa induces inflammasome signaling, cell death, and IL-1 beta expression by macrophages in early respiratory isolates, while chronic isolates lead to poor inflammasome signaling and cell death but excessive production of TNF, IL-6, and IL-8. Premature cell death of macrophages caused by virulent bacteria compromises their ability to express cytokines, resulting in increased cytokine induction with chronic isolates compared to early isolates. Contrary to the belief that chronic P. aeruginosa isolates are less pathogenic, infections with chronic isolates result in a relatively intense inflammation due to failure to induce immune cell death.
CELL DEATH & DISEASE
(2021)
Article
Nutrition & Dietetics
Monica Verdoia, Matteo Nardin, Roberta Rolla, Federica Negro, Rocco Gioscia, Arraa Maddalena Saghir Afifeh, Filippo Viglione, Harry Suryapranata, Marco Marcolongo, Giuseppe De Luca
Summary: The study revealed that among patients with cardiovascular disease, vitamin D deficiency is associated with a higher metabolic and clinical risk profile, as well as elevated inflammatory parameters, predicting higher levels of inflammatory indicators in the body.
CLINICAL NUTRITION
(2021)
Article
Infectious Diseases
Mathis Steindor, Sylvia Hafkemeyer, Christian Ruckes, Florian Stehling, Lutz Naehrlich, Felix C. Ringsha
Summary: This study investigated the epidemiology and screening practice of nontuberculous mycobacteria (NTM) among people with cystic fibrosis (pwCF) in Germany. The study found that the burden of NTM remained unchanged in pwCF in Germany from 2016 to 2020, with Mycobacterium abscessus complex (MABC) being the most common species and Mycobacterium avium complex (MAC) infections increasing with time and patient age. NTM infections were also associated with Aspergillus fumigatus infection and allergic bronchopulmonary aspergillosis, highlighting the need for increased awareness of NTM.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Carsten Schwarz, Eliana Wimmer, Frederik Holz, Claudia Grehn, Doris Staab, Patience Ndidi Eschenhagen
Summary: People with cystic fibrosis often experience exacerbations, which can lead to lung damage, decreased lung function, higher mortality rate, and poor quality of life. This study examines the use of antibiotics and the optimal duration of treatment for exacerbations in cystic fibrosis patients. The results show that the modified Fuchs exacerbation score is a reliable indicator of acute exacerbations, regardless of the patient's health status. Home spirometry is a useful tool for managing exacerbations in outpatient settings. Changes in C-reactive protein levels and the modified Fuchs score are strong markers of exacerbation, as they correlate closely with lung function.
Article
Multidisciplinary Sciences
Sameer Desai, Wei Zhang, Jason M. Sutherland, Joel Singer, Bradley S. Quon
Summary: Cystic fibrosis (CF) is a progressive multi-organ disease that places extensive demands on the healthcare system. This study found that individuals with severe lung impairment, lung transplantation, liver cirrhosis with portal hypertension, and female sex were more likely to become frequent high-cost CF users. These high-cost users accounted for more than one-third of the overall healthcare costs, primarily due to inpatient hospitalization and outpatient medication costs.
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
Laurent M. Willems, Maja Hochbaum, Johann Philipp Zoellner, Juliane Schulz, Katja Menzler, Lisa Langenbruch, Stjepana Kovac, Susanne Knake, Felix von Podewils, Mario Hamacher, Hajo M. Hamer, Jens-Peter Reese, Katharina Frey, Felix Rosenow, Adam Strzelczyk
Summary: This study aimed to calculate epilepsy-related costs in adult patients in Germany and compare them to previous studies. The findings showed that the costs remained constant, but indirect costs increased, leading to an overall increase in total costs.
Article
Obstetrics & Gynecology
Rita F. Padoan, Serena Quattrucci, Annalisa Amato, Marco Salvatore, Donatello Salvatore, Giuseppe Campagna
Summary: The study found that preconceptional respiratory function of women with cystic fibrosis (CF) is associated with the duration of pregnancy and birthweight of newborns, and cesarean deliveries are common among young CF women with normal respiratory function.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Article
Economics
Sarah Acaster, Clara Mukuria, Donna Rowen, John E. Brazier, Claire E. Wainwright, Bradley S. Quon, Jamie Duckers, Alexandra L. Quittner, Yiyue Lou, Patrick R. Sosnay, Lisa J. McGarry
Summary: This study developed a preference-based utility measure for cystic fibrosis (CF) based on the CFQ-R questionnaire, which is the first disease-specific scoring algorithm for CF. It allows for estimation of disease-specific utilities and can be used in cost-effectiveness analysis.
Article
Radiology, Nuclear Medicine & Medical Imaging
Maxime Ronot, Giovanna Ferraioli, Hans-Peter Mueller, Mireen Friedrich-Rust, Carlo Filice, Valerie Vilgrain, David Cosgrove, Adrian K. Lim
Summary: The study compared liver stiffness measurement provided by Canon 2D-shear wave elastography (2D-SWE) and transient elastography (TE), and found that there was good correlation between the two methods. However, 2D-SWE tended to underestimate higher stages of liver fibrosis while correctly classifying the majority of patients. It may be used in TE-derived algorithms to manage patients.
EUROPEAN RADIOLOGY
(2021)
Article
Pediatrics
Pia Bonde Nielsen, Hanne Vebert Olesen, Claus Sixtus Jensen
Summary: This study aimed to explore parents' everyday life experiences from the time of diagnosis and in the following months for children with cystic fibrosis. The results showed that the way the diagnosis was communicated and the relationship with the cystic fibrosis team had a profound impact on parents' experiences. Parents valued the knowledge and calmness exhibited by the doctors and nurses. After the diagnosis, parents expressed anxiety and concern for their child's future. The study highlights the importance of implementing essential elements to optimize patient care pathway.
Article
Clinical Neurology
Till Wagner, Nele Assmann, Sandra Koehne, Anja Schaich, Daniel Alvarez-Fischer, Stefan Borgwardt, Arnoud Arntz, Ulrich Schweiger, Eva Fassbinder
Summary: This study focuses on the high cost-of-illness associated with borderline personality disorder (BPD), finding that in Germany, each BPD patient incurred costs of euro 31,130 per year before receiving disorder-specific outpatient treatment. Direct costs, mainly related to hospital treatment, accounted for 54.8%, while indirect costs, with work disability as a key driver, made up 45.2% of the total costs. The study emphasizes the significant economic burden of BPD and highlights the importance of addressing both direct and indirect costs for societal impact.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2022)
Article
Economics
Elena A. Phillips, Sebastian F. Himmler, Jonas Schreyogg
Summary: The study found that patients have a clear preference for blended care that includes face-to-face contact with a psychotherapist, emphasizing personal contact, proven effectiveness, and low price. Preferences for components of e-mental health interventions varied among patients, with differences in preferences for training methods and peer support.
Article
Health Care Sciences & Services
Stefan Rabbe, Carl R. Blankart, Wolfgang-Michael Franz, Lutz Hager, Jonas Schreyoegg
Summary: This study aims to evaluate the effects of a non-invasive telemonitoring intervention on patients with chronic heart failure (CHF) in Germany. The results show that telemonitoring intervention significantly reduces mortality and leads to a shift in costs from inpatient care to ambulatory care after 36 months.
JOURNAL OF TELEMEDICINE AND TELECARE
(2023)
Article
Health Care Sciences & Services
Henrike Schmidt, Eva-Maria Wild, Jonas Schreyoegg
Summary: The study investigates factors influencing people's health information seeking behavior and finds that sociodemographic and health-related characteristics such as age, gender, immigration status, education, employment status, marital status and general health condition significantly impact the choice of health information sources. Immigrants and individuals with low educational attainment are more likely to use emergency departments for health information, suggesting targeted policy interventions to address disparities in health information access.
Review
Health Care Sciences & Services
Kai Svane Blume, Karina Dietermann, Uta Kirchner-Heklau, Vera Winter, Steffen Fleischer, Lisa Maria Kreidl, Gabriele Meyer, Jonas Schreyoegg
Summary: This study derived a comprehensive list of nursing-sensitive patient outcomes (NSPOs) from published research on nurse staffing levels and expert opinion, indicating strong evidence for a significant association between nurse staffing levels and these outcomes, providing guidance for future studies.
HEALTH SERVICES RESEARCH
(2021)
Article
Multidisciplinary Sciences
Nirosha Elsem Varghese, Iryna Sabat, Sebastian Neumann-Bohme, Jonas Schreyoegg, Tom Stargardt, Aleksandra Torbica, Job van Exel, Pedro Pita Barros, Werner Brouwer
Summary: The study found that during the COVID-19 pandemic, the public had high levels of trust and adherence to information from the WHO, especially in social distancing recommendations. Familiarity and adherence also increased with age, gender, and level of education.
Article
Hematology
Torsten Chandler, Sebastian Neumann-Boehme, Iryna Sabat, Pedro Pita Barros, Werner Brouwer, Job van Exel, Jonas Schreyoegg, Aleksandra Torbica, Tom Stargardt
Summary: This study aimed to investigate the impact of COVID-19 on blood donors and their motivation to donate, finding that during the pandemic about half of donors reduced their donation frequency. Most donors made extra efforts to donate in response to COVID-19, yet awareness of blood testing for COVID-19 antibodies was low. Perceived risk of infection during blood donation was generally low, but those anticipating high risk or adhering to COVID guidelines were less likely to donate.
Article
Psychiatry
Elena A. Phillips, Sebastian Himmler, Jonas Schreyoegg
Summary: This study examined the attitudes and preferences of licensed psychotherapists in Germany towards blended care (BC) applications. The survey results showed that psychotherapists had positive attitudes towards BC and expressed a strong intention to use BC formats. The choice experiment revealed that a recommendation from a professional society for a BC online component was the most important characteristic.
Article
Clinical Neurology
Andre Hajek, Iryna Sabat, Sebastian Neumann-Boehme, Jonas Schreyoegg, Pedro Pita Barros, Tom Stargardt, Hans-Helmut Koenig
Summary: The study highlights the prevalence of probable depression and anxiety during the COVID-19 pandemic in European countries, showing significant differences between countries and higher rates among individuals aged 18 to 29. Factors associated with probable depression and anxiety include increasing age, income difficulties, and lower health-related quality of life.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Medicine, General & Internal
Vera Winter, Karina Dietermann, Udo Schneider, Jonas Schreyoegg
Summary: The study examines the impact of nurse staffing on patient-perceived quality of nursing care, finding that a decrease in nurse staffing levels and an increase in the proportion of assistant nurses lead to decreased quality. The findings suggest that both nurse staffing levels and nursing skill mix are crucial factors to consider in improving the quality of nursing care in hospitals.
Article
Economics
Stefan Rabbe, Meilin Moellenkamp, Benedetta Pongiglione, Hedwig Blommestein, Pim Wetzelaer, Renaud Heine, Jonas Schreyoegg
Summary: Variation in healthcare utilization is mainly attributed to hospital level factors, with regional characteristics explaining only a small part of the variation. Effective care category shows less variation compared to preference- and supply-sensitive categories.
Letter
Health Care Sciences & Services
Esra E. Bayindir, Jonas Schreyoegg
Article
Multidisciplinary Sciences
Florian Hofer, Jonas Schreyogg, Tom Stargardt
Summary: This study evaluated the effects of a structured home telemonitoring program implemented by a statutory health insurer in Germany on COPD patients. The results showed that the telemonitoring program was associated with higher healthcare expenditures, particularly in the first year. However, participants in the program had significantly improved survival rates compared to non-participants.
Article
Economics
Karina Dietermann, Vera Winter, Udo Schneider, Jonas Schreyoegg
Summary: This study aims to provide empirical evidence of the impact of nurse staffing levels on nursing-sensitive patient outcomes at the hospital unit level. The analysis of a large dataset reveals significant results, showing that differentiating between unit types and using multilevel regression approaches can provide important insights into this relationship. By categorizing inpatient cases based on clinical complexity, hidden effects beyond unit types can be ruled out.
EUROPEAN JOURNAL OF HEALTH ECONOMICS
(2021)
Correction
Economics
Dmitrij Achelrod, Jonas Schreyoegg, Tom Stargardt
Summary: Incorrect specification of observation period in the original article led to increased hospital costs and inpatient utilization in the control group.
EUROPEAN JOURNAL OF HEALTH ECONOMICS
(2021)
Article
Economics
Esra Eren Bayindir, Jonas Schreyoegg
Summary: This study examines the impact of ownership types, system membership, patient insurance status, and hospital competition on treatment choices in US hospitals. Findings suggest that system member not-for-profit hospitals and not-for-profits facing high for-profit competition act similarly to for-profit hospitals. These results underscore the importance of considering system membership in addition to market competitiveness when evaluating not-for-profit tax exemptions.
HEALTH ECONOMICS REVIEW
(2021)