Article
Endocrinology & Metabolism
Jonathan Yap, Kamalesh Anbalakan, Wan Ting Tay, Daniel Ting, Carol Yim Cheung, Charumathi Sabanayagam, Ching-Yu Cheng, Tien-Yin Wong, Khung Keong Yeo
Summary: Diabetes mellitus is a significant predictor of mortality and cardiovascular morbidity in Asian patients without prior cardiovascular disease. Among patients with type 2 diabetes, poorer glycemic control is associated with increased major adverse cardiovascular events (MACE) but not mortality rates. A greater burden of microvascular complications identifies a subset of patients with poorer outcomes.
BMJ OPEN DIABETES RESEARCH & CARE
(2021)
Article
Endocrinology & Metabolism
Filippo Luca Gurgoglione, Dario Pitocco, Rocco A. Montone, Riccardo Rinaldi, Riccardo C. Bonadonna, Giulia Magnani, Camilla Calvieri, Emilia Solinas, Alessandro Rizzi, Linda Tartaglione, Andrea Flex, Luca Viti, Carlo Trani, Diego Ardissino, Filippo Crea, Giampaolo Niccoli
Summary: The study aimed to investigate the influence of diabetic microvascular complications (DMC) on coronary collateral (CC) vessel development in patients with coronary chronic total occlusion (CTO). Results showed that patients with DMC had a higher prevalence of CC and high-grade CC compared with those without DMC. Furthermore, there was a positive association between the number of DMC in each patient and the prevalence of high-grade CC.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Endocrinology & Metabolism
Xinyang Guo, Yiqiao Xing, Wei Jin
Summary: Diabetic microangiopathy is a common and severe problem in diabetics, and it includes diabetic retinopathy, nephropathy, neuropathy, and cardiomyopathy. Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase (NOS), is significantly elevated in patients with type 2 diabetes and microvascular complications. ADMA promotes the occurrence and progression of microvascular complications in type 2 diabetes through influencing endothelial cell function, oxidative stress damage, inflammation, and fibrosis. This review paper explores the association between ADMA and microvascular complications of diabetes, and provides new insights and potential treatment options.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Ancuta Cutas, Cristina Drugan, Gabriela Roman, Adriana Rusu, Cristina Sorina Catana, Andrei Achimas-Cadariu, Tudor Drugan
Summary: The study found a link between the inflammatory status and the occurrence of microvascular complications in patients with type 1 DM, especially diabetic neuropathy and retinopathy. Chitotriosidase enzymatic activity increased over time, with a faster progression observed in non-smokers. Increased chitotriosidase activity may be a predictor of endothelial dysfunction in type 1 DM.
Article
Cardiac & Cardiovascular Systems
Rocco A. Montone, Dario Pitocco, Filippo Luca Gurgoglione, Riccardo Rinaldi, Marco Giuseppe Del Buono, Massimiliano Camilli, Alessandro Rizzi, Linda Tartaglione, Gaetano Emanuele Rizzo, Mauro Di Leo, Andrea Flex, Michele Russo, Giovanna Liuzzo, Giulia Magnani, Riccardo C. Bonadonna, Diego Ardissino, Filippo Crea, Giampaolo Niccoli
Summary: This study aimed to investigate the impact of diabetic microvascular complications (DMC) on the features of coronary plaques. The results showed that the presence of DMC could identify a distinct diabetic population with more severe coronary artery disease (CAD), but a more stable pattern of coronary plaques.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Medicine, General & Internal
David M. Nathan, GRADE Study Res Grp, John M. Lachin, Ionut Bebu, Henry B. Burch, John B. Buse, Andrea L. Cherrington, Stephen P. Fortmann, Jennifer B. Green, Steven E. Kahn, M. Sue Kirkman, Heidi Krause-Steinrauf, Mary E. Larkin, Lawrence S. Phillips, Rodica Pop-Busui, Michael Steffes, Margaret Tiktin, Mark Tripputi, Deborah J. Wexle, Naji Younes
Summary: There were no material differences among the four commonly used glucose-lowering medications when added to metformin in terms of microvascular complications and death in participants with type 2 diabetes, but possible differences were indicated in the incidence of any cardiovascular disease.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Endocrinology & Metabolism
Mohammed Abdu Seid, Yonas Akalu, Yibeltal Yismaw Gela, Yitayeh Belsti, Mengistie Diress, Sofonias Addis Fekadu, Baye Dagnew, Mihret Getnet
Summary: This study found a high prevalence of microvascular complications among type 2 diabetes mellitus patients in Ethiopia. Increasing age, longer duration of diabetes, and co-morbid hypertension were identified as independent predictors.
DIABETOLOGY & METABOLIC SYNDROME
(2021)
Article
Endocrinology & Metabolism
Afnan Mansour, Mira Mousa, Dima Abdelmannan, Guan Tay, Ahmed Hassoun, Habiba Alsafar
Summary: This study conducted an Exome-Wide Association Study (EWAS) on Emirati individuals with type 2 diabetes mellitus (T2DM) to identify susceptibility loci associated with T2DM-related complications. The results showed associations between various genes and each complication category. The study also highlighted the limitations of the current genotyping arrays in representing diverse populations, emphasizing the need for better representation in future studies.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Veterinary Sciences
Charles Sharchil, Amulya Vijay, Vinu Ramachandran, Sambhavi Bhagavatheeswaran, Reena Devarajan, Bhupendra Koul, Dhananjay Yadav, Anandan Balakrishnan
Summary: Diabetes is a chronic metabolic disease with a global impact. Zebrafish is an ideal model for studying diabetes due to its small size, quick growth, transparency, large offspring numbers, and gene similarity with humans. The use of zebrafish allows for gene editing and drug therapy to establish diabetes models. This review emphasizes the physiological and pathological processes of microvascular problems in zebrafish, as well as the models used to study diabetic nephropathy (DN) and the observed mechanisms.
VETERINARY SCIENCES
(2022)
Review
Endocrinology & Metabolism
William B. Horton, Eugene J. Barrett
Summary: This review discusses the microvascular dysfunction in diabetes mellitus and cardiometabolic disease, suggesting that dysfunction can be an early marker of change. The study also found that familiar complications of diabetes can be late-stage manifestations of microvascular injury that begins years earlier. Advances in understanding normal microvascular function and early dysfunction are leading to novel preventative interventions at early stages of microvascular injury.
Article
Medicine, General & Internal
Naba Al-Sari, Svetlana Kutuzova, Tommi Suvitaival, Peter Henriksen, Flemming Pociot, Peter Rossing, Douglas McCloskey, Cristina Legido-Quigley
Summary: Using blood small molecule profiling and machine learning, the risk of developing complications, such as kidney disease and retinopathy, in diabetes patients can be predicted. This precision diagnostic approach has the potential to be implemented in clinical settings to screen patients early and prevent complications.
Article
Endocrinology & Metabolism
Jaejin An, Gregory A. Nichols, Lei Qian, Mercedes A. Munis, Teresa N. Harrison, Zhuoxin Li, Rong Wei, Tracey Weiss, Swapnil Rajpathak, Kristi Reynolds
Summary: In a US integrated healthcare system, the prevalence of chronic kidney disease (CKD) was highest among patients newly diagnosed with T2D, while the prevalence of cardiovascular disease (CVD) was lower. Factors such as older age, sex, A1C levels, smoking, and hypertension were associated with increased incidence of CKD and CVD in T2D patients. Despite lower incidence rates of T2D complications in more recent years, a significant number of patients had complications at diagnosis, emphasizing the importance of early preventive therapies and managing modifiable factors to delay development and progression of T2D complications.
BMJ OPEN DIABETES RESEARCH & CARE
(2021)
Article
Gastroenterology & Hepatology
Xinrong Zhang, Terry Cheuk-Fung Yip, Yee-Kit Tse, Vicki Wing-Ki Hui, Guanlin Li, Huapeng Lin, Lilian Yan Liang, Jimmy Che-To Lai, Henry Lik-Yuen Chan, Stephen Lam Chan, Alice Pik-Shan Kong, Grace Lai-Hung Wong, Vincent Wai-Sun Wong
Summary: This study found that a longer duration of type 2 diabetes (T2D) is associated with a higher risk of liver-related events and all-cause mortality in patients with non-alcoholic fatty liver disease (NAFLD).
Article
Neurosciences
Dongsheng Zhang, Yang Huang, Jie Gao, Yumeng Lei, Kai Ai, Min Tang, Xuejiao Yan, Xiaoyan Lei, Zhen Yang, Zhirong Shao, Xiaoling Zhang
Summary: This study found that patients with type 2 diabetes mellitus (T2DM) and microvascular complications displayed more extensive changes in different network topology scales, with the visual network and cerebellar being potentially central vulnerable regions for these patients.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Medicine, General & Internal
Alexios S. Antonopoulos, Gerasimos Siasos, Evangelos Oikonomou, Nikolaos Gouliopoulos, Theodosia Konsola, Vasiliki Tsigkou, Marilita Moschos, Nikolaos Tentolouris, Eva Kassi, Stavroula A. Paschou, Anastasia Thanopoulou, Manolis Vavuranakis, Peter Stone, Charalambos Antoniades, Dimitris Tousoulis
Summary: This study found that in patients with T2D, MD and PWV are independently associated with clinical outcomes, with the subgroup of MD and high PWV showing higher incidence of adverse cardiovascular events. Screening for arterial stiffness and MD may improve prognostication and cardiovascular risk reclassification in patients with T2D.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Economics
J. Jaime Caro
Review
Cardiac & Cardiovascular Systems
Stefan D. Anker, Stefan Agewall, Martin Borggrefe, Melanie Calvert, J. Jaime Caro, Martin R. Cowie, Ian Ford, Jean A. Paty, Jillian P. Riley, Karl Swedberg, Luigi Tavazzi, Ingela Wiklund, Paulus Kirchhof
EUROPEAN HEART JOURNAL
(2014)
Article
Economics
Bjoern Stollenwerk, Stefan K. Lhachimi, Andrew Briggs, Elisabeth Fenwick, Jaime J. Caro, Uwe Siebert, Marion Danner, Andreas Gerber-Grote
Letter
Peripheral Vascular Disease
Morales Enrique, Caro Jara
JOURNAL OF CLINICAL HYPERTENSION
(2013)
Article
Chemistry, Multidisciplinary
Ulrike Boehme, Benjamin Barth, Carolin Paula, Andreas Kuhnt, Wilhelm Schwieger, Alexander Mundstock, Juergen Caro, Martin Hartmann
Article
Economics
Kit N. Simpson, Pamela P. Pei, Joergen Moeller, Robert W. Baran, Birgitta Dietz, William Woodward, Kristen Migliaccio-Walle, J. Jaime Caro
Article
Economics
J. Jaime Caro, Jorgen Moller
Review
Economics
Kevin Marsh, Tereza Lanitis, David Neasham, Panagiotis Orfanos, Jaime Caro
Article
Biochemistry & Molecular Biology
Julien Roche, Jose A. Caro, Mariano Dellarole, Ewelina Guca, Catherine A. Royer, Bertrand Garcia-Moreno E., Angel E. Garcia, Christian Roumestand
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
(2013)
Article
Economics
Sean D. Sullivan, Josephine A. Mauskopf, Federico Augustovski, J. Jaime Caro, Karen M. Lee, Mark Minchin, Ewa Orlewska, Pete Penna, Jose-Manuel Rodriguez Barrios, Wen-Yi Shau
Article
Economics
J. Jaime Caro, David M. Eddy, Hong Kan, Cheryl Kaltz, Bimal Patel, Randa Eldessouki, Andrew H. Briggs
Editorial Material
Economics
Paul Tappenden, J. Jaime Caro
Article
Clinical Neurology
Asmir Vodencarevic, Michael Weingaertner, J. Jaime Caro, Dubravka Ukalovic, Marcus Zimmermann-Rittereiser, Stefan Schwab, Peter Kolominsky-Rabas
Summary: This study developed accurate individual risk prediction models for recurrent ischemic stroke based on data easily obtained from patients at home. These models can be applied in a home setting to provide an initial risk assessment and identify high-risk patients early.
Editorial Material
Economics
J. Jaime Caro
Article
Oncology
Brandon Chua, Li Min Lim, Joseph Soon Yau Ng, Yan Ma, Hwee Lin Wee, J. Jaime Caro
Summary: Extended genotyping (XGT) for cervical cancer screening, which identifies human papillomavirus (HPV) genotypes beyond HPV16 and HPV18, can provide risk stratification for clinical management. A study in Singapore compared the resource use, cost, and quality-adjusted life years (QALY) of XGT to partial genotyping (PGT). The results showed that XGT was cost-effective, utilized fewer resources, and provided a risk-based approach compared to PGT. This analysis, conducted in an Asian context, could guide the use of XGT in Asia.