Computational Prediction of Drug Solubility in Fasted Simulated and Aspirated Human Intestinal Fluid

A review of drug solubility in human intestinal fluids: Implications for the prediction of oral absorption

(2013) Patrick Augustijns et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Early pharmaceutical profiling to predict oral drug absorption: Current status and unmet needs

(2013) Christel A.S. Bergström et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Solubility Profiling of HIV Protease Inhibitors in Human Intestinal Fluids

(2013) Benjamin Wuyts et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Glyceride Lipid Formulations: Molecular Dynamics Modeling of Phase Behavior During Dispersion and Molecular Interactions Between Drugs and Excipients

(2013) Dallas B. Warren et al.   PHARMACEUTICAL RESEARCH

Computational Prediction of Drug Solubility in Lipid Based Formulation Excipients

(2013) Linda C. Persson et al.   PHARMACEUTICAL RESEARCH

Ethanol Effects on Apparent Solubility of Poorly Soluble Drugs in Simulated Intestinal Fluid

(2012) Jonas H. Fagerberg et al.   MOLECULAR PHARMACEUTICS

Computational Prediction of CNS Drug Exposure Based on a Novel In Vivo Dataset

(2012) Christel A. S. Bergström et al.   PHARMACEUTICAL RESEARCH

Target promiscuity and physicochemical properties contribute to pharmacologically induced ER-stress

(2012) E. Koslov-Davino et al.   TOXICOLOGY IN VITRO

Recent Advances on Aqueous Solubility Prediction

(2011) Junmei Wang et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Getting physical in drug discovery II: the impact of chromatographic hydrophobicity measurements and aromaticity

(2011) Robert J. Young et al.   DRUG DISCOVERY TODAY

Intestinal drug solubility estimation based on simulated intestinal fluids: Comparison with solubility in human intestinal fluids

(2011) Sarah Clarysse et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Revisiting the General Solubility Equation: In Silico Prediction of Aqueous Solubility Incorporating the Effect of Topographical Polar Surface Area

(2011) Jogoth Ali et al.   Journal of Chemical Information and Modeling

Molecular obesity, potency and other addictions in drug discovery

(2011) Michael M. Hann   MedChemComm

Profiling and Trend Analysis of Food Effects on Oral Drug Absorption Considering Micelle Interaction and Solubilization by Bile Micelles

(2010) Yukinori Kawai et al.   Drug Metabolism and Pharmacokinetics

What is modulating solubility in simulated intestinal fluids?

(2010) Giorgio Ottaviani et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Prediction of food effect by bile micelles on oral drug absorption considering free fraction in intestinal fluid

(2010) Kiyohiko Sugano et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Dissolution Rate and Apparent Solubility of Poorly Soluble Drugs in Biorelevant Dissolution Media

(2010) Jonas H. Fagerberg et al.   MOLECULAR PHARMACEUTICS

A Modified Physiological BCS for Prediction of Intestinal Absorption in Drug Discovery

(2010) Noha M. Zaki et al.   MOLECULAR PHARMACEUTICS

Simulating Fasted Human Intestinal Fluids: Understanding the Roles of Lecithin and Bile Acids

(2010) Erik Söderlind et al.   MOLECULAR PHARMACEUTICS

Physiochemical drug properties associated with in vivo toxicological outcomes

(2008) Jason D. Hughes et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Molecular Dynamics Simulations of Functional Group Effects on Solvation Thermodynamics of Model Solutes in Decane and Tricaprylin

(2008) Sagar S. Rane et al.   MOLECULAR PHARMACEUTICS

Rate-Limiting Steps of Oral Absorption for Poorly Water-Soluble Drugs in Dogs; Prediction from a Miniscale Dissolution Test and a Physiologically-Based Computer Simulation

(2008) Ryusuke Takano et al.   PHARMACEUTICAL RESEARCH

Dissolution Media Simulating Conditions in the Proximal Human Gastrointestinal Tract: An Update

(2008) Ekarat Jantratid et al.   PHARMACEUTICAL RESEARCH