Small Amounts of Sub-Visible Aggregates Enhance the Immunogenic Potential of Monoclonal Antibody Therapeutics

Aggregation of Human Recombinant Monoclonal Antibodies Influences the Capacity of Dendritic Cells to Stimulate Adaptive T-Cell Responses In Vitro

(2014) Verena Rombach-Riegraf et al.   PLoS One

Immunogenicity of Subcutaneously Administered Therapeutic Proteins—a Mechanistic Perspective

(2013) Anas M. Fathallah et al.   AAPS Journal

Preclinical Models Used for Immunogenicity Prediction of Therapeutic Proteins

(2013) Vera Brinks et al.   PHARMACEUTICAL RESEARCH

Oxidation of Therapeutic Proteins and Peptides: Structural and Biological Consequences

(2013) Riccardo Torosantucci et al.   PHARMACEUTICAL RESEARCH

Highly Aggregated Antibody Therapeutics Can Enhance thein VitroInnate and Late-stage T-cell Immune Responses

(2012) Marisa K. Joubert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Immunogenicity of different stressed IgG monoclonal antibody formulations in immune tolerant transgenic mice

(2012) Vasco Filipe et al.   mAbs

Detection and Characterization of Subvisible Aggregates of Monoclonal IgG in Serum

(2012) Vasco Filipe et al.   PHARMACEUTICAL RESEARCH

Inhibition of Aberrant Circulating Tfh Cell Proportions by Corticosteroids in Patients with Systemic Lupus Erythematosus

(2012) Xuebing Feng et al.   PLoS One

Classification and Characterization of Therapeutic Antibody Aggregates

(2011) Marisa K. Joubert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glass particles as an adjuvant: A model for adverse immunogenicity of therapeutic proteins

(2011) Amber Haynes Fradkin et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Fluorescence Single Particle Tracking for the Characterization of Submicron Protein Aggregates in Biological Fluids and Complex Formulations

(2011) Vasco Filipe et al.   PHARMACEUTICAL RESEARCH

Prediction of Immunogenicity of Therapeutic Proteins

(2010) Christine J. Bryson et al.   BIODRUGS

IL-21 regulates germinal center B cell differentiation and proliferation through a B cell–intrinsic mechanism

(2010) Dimitra Zotos et al.   JOURNAL OF EXPERIMENTAL MEDICINE

An Industry Perspective on the Monitoring of Subvisible Particles as a Quality Attribute for Protein Therapeutics

(2010) Satish K. Singh et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Longterm Safety of Patients Receiving Rituximab in Rheumatoid Arthritis Clinical Trials

(2010) R. F. van VOLLENHOVEN et al.   JOURNAL OF RHEUMATOLOGY

Immunogenicity of different brands of human insulin and rapid-acting insulin analogs in insulin-naïve children with type 1 diabetes

(2010) B Mianowska et al.   PEDIATRIC DIABETES

Stability of Protein Pharmaceuticals: An Update

(2010) Mark Cornell Manning et al.   PHARMACEUTICAL RESEARCH

Response of a concentrated monoclonal antibody formulation to high shear

(2009) Jared S. Bee et al.   BIOTECHNOLOGY AND BIOENGINEERING

Structural properties of monoclonal antibody aggregates induced by freeze–thawing and thermal stress

(2009) Andrea Hawe et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Prevention of Both Direct and Cross-Priming of Antitumor CD8+ T-Cell Responses following Overproduction of Prostaglandin E2 by Tumor Cells In vivo

(2008) M. Ahmadi et al.   CANCER RESEARCH

Protein aggregation: Pathways, induction factors and analysis

(2008) Hanns-Christian Mahler et al.   JOURNAL OF PHARMACEUTICAL SCIENCES