The Photolysis of Disulfide Bonds in IgG1 and IgG2 Leads to Selective Intramolecular Hydrogen Transfer Reactions of Cysteine Thiyl Radicals, Probed by Covalent H/D Exchange and RPLC-MS/MS analysis

Title
The Photolysis of Disulfide Bonds in IgG1 and IgG2 Leads to Selective Intramolecular Hydrogen Transfer Reactions of Cysteine Thiyl Radicals, Probed by Covalent H/D Exchange and RPLC-MS/MS analysis
Authors
Keywords
carbon-centered radical, covalent hydrogen/deuterium (H/D) exchange, cysteine thiyl radical (CysS•), intramolecular hydrogen transfer, photo-degradation
Journal
PHARMACEUTICAL RESEARCH
Volume 30, Issue 5, Pages 1291-1299
Publisher
Springer Nature
Online
2013-01-11
DOI
10.1007/s11095-012-0968-1

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