Elucidation of Degradants in Acidic Peak of Cation Exchange Chromatography in an IgG1 Monoclonal Antibody Formed on Long-Term Storage in a Liquid Formulation

Investigation of degradation processes in IgG1 monoclonal antibodies by limited proteolysis coupled with weak cation-exchange HPLC

(2010) Hollis Lau et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

An improved trypsin digestion method minimizes digestion-induced modifications on proteins

(2009) Da Ren et al.   ANALYTICAL BIOCHEMISTRY

Identification and characterization of asparagine deamidation in the light chain CDR1 of a humanized IgG1 antibody

(2009) Josef Vlasak et al.   ANALYTICAL BIOCHEMISTRY

Large-Scale Identification and Quantification of Covalent Modifications in Therapeutic Proteins

(2009) Zhongqi Zhang   ANALYTICAL CHEMISTRY

Detection and Quantitation of IgG 1 Hinge Aspartate Isomerization: A Rapid Degradation in Stressed Stability Studies

(2009) David M. Hambly et al.   ANALYTICAL CHEMISTRY

Identification and measurement of isoaspartic acid formation in the complementarity determining region of a fully human monoclonal antibody

(2009) Lawrence W. Dick et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Engineering Human IgG1 Affinity to Human Neonatal Fc Receptor: Impact of Affinity Improvement on Pharmacokinetics in Primates

(2009) Y. A. Yeung et al.   JOURNAL OF IMMUNOLOGY

Succinimide formation at Asn 55 in the complementarity determining region of a recombinant monoclonal antibody IgG1 heavy chain

(2009) Boxu Yan et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

The effects of alpha-helix on the stability of Asn residues: Deamidation rates in peptides of varying helicity

(2009) Andrew A. Kosky et al.   PROTEIN SCIENCE

Hydrophobic Interaction Chromatography of Soluble Interleukin I Receptor Type II To Reveal Chemical Degradations Resulting in Loss of Potency

(2008) Yuling Zhang et al.   ANALYTICAL CHEMISTRY

Isomerization of a Single Aspartyl Residue of Anti-Epidermal Growth Factor Receptor Immunoglobulin γ2 Antibody Highlights the Role Avidity Plays in Antibody Activity

(2008) Douglas S. Rehder et al.   BIOCHEMISTRY

Heterogeneity of Monoclonal Antibodies Revealed by Charge-Sensitive Methods

(2008) J. Vlasak et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

A study in glycation of a therapeutic recombinant humanized monoclonal antibody: Where it is, how it got there, and how it affects charge-based behavior

(2007) Cynthia Quan et al.   ANALYTICAL BIOCHEMISTRY

Heterogeneity of Monoclonal Antibodies

(2007) Hongcheng Liu et al.   JOURNAL OF PHARMACEUTICAL SCIENCES