Article
Chemistry, Multidisciplinary
Wenzhao Han, Fanwei Meng, Hao Gan, Feng Guo, Junfeng Ke, Liping Wang
Summary: ATN-FFPFF-ATN, a new targeted antitumor drug carrier designed in this study, polymerized from phenylalanine dipeptide (FF), ATN-161 peptide, and Pluronic (R) F-127, can smartly unravel in acidic environment to achieve specific drug accumulation, effectively inhibiting cell proliferation.
Article
Biochemistry & Molecular Biology
Daniel Braatz, Mathias Dimde, Guoxin Ma, Yinan Zhong, Michael Tully, Carsten Groetzinger, Yuanyuan Zhang, Alexandros Mavroskoufis, Michael Schirner, Zhiyuan Zhong, Matthias Ballauff, Rainer Haag
Summary: Six well-defined amphiphilic block copolymers were synthesized and characterized for their excellent drug delivery capabilities, showing monodispersed size distributions, strong negative charges, and low critical micelle concentrations. These micelles exhibited high serum stability and efficient drug-loading efficiency, with selective release triggered by specific stimuli. In vitro and in vivo studies demonstrated sustained release of the drug, high cell compatibility, and improved antitumor efficacy at a lower dosage. Targetability to tumor tissue was confirmed through fluorescence imaging studies. The system showed good biocompatibility with no observed toxicity.
Review
Pharmacology & Pharmacy
Rahul Rimal, Prachi Desai, Rasika Daware, Aisa Hosseinnejad, Jai Prakash, Twan Lammers, Smriti Singh
Summary: The tumor microenvironment, specifically cancer-associated fibroblasts (CAF), plays a critical role in tumor progression and drug resistance. This review presents imaging techniques for visualizing CAF and CAF-induced fibrosis, as well as compounds known to modulate CAF activity. Additionally, CAF-targeted therapies and CAF-modulating nanocarriers are discussed, along with the challenges and prospects for these treatments.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Pharmacology & Pharmacy
Leila Farhoudi, Prashant Kesharwani, Muhammed Majeed, Thomas P. Johnston, Amirhossein Sahebkar
Summary: Natural compounds, such as curcumin, have potential benefits in cancer therapy, but their low bioavailability limits their application. Nanotechnology-based drug delivery systems have shown promise in improving the delivery and efficacy of curcumin.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Materials Science, Biomaterials
Zhicheng Pan, Guangxuan Yang, Jian Liu, Jinfeng Yuan, Mingwang Pan, Jiehua Li, Hong Tan
Summary: This study investigates the effect of negative charges in the polymer chains on the properties of cationic surfactant Gemini quaternary ammonium (GQA) in polymer micelles. It is found that interchain electrostatic interaction undermines the function of GQA and hinders the self-assembly and stabilization of polyurethane micelles. By regulating the ratio of oppositely charged moieties, micelles exhibit tunable biological properties. The study provides rational guidance for the design and fabrication of GQA polymer micelles.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Polymer Science
Rakshita Grover, Sahil Drall, Neelam Poonia, Gaurav Kumar Jain, Geeta Aggarwal, Viney Lather, Prashant Kesharwani, Deepti Pandita, Ramesh K. Goyal
Summary: Cancer stem cells (CSCs) contribute to tumor onset, progression, chemotherapy resistance, and relapse. CD44 and CD133 are commonly expressed markers used to identify aggressive CSCs. Targeting these markers with aptamers conjugated nanocarriers can overcome the limitations of antibodies and has proven to be beneficial in targeting CSCs. This article reviews the recent advancements in aptamers and their conjugation with nanocarriers for specific targeting of CSCs and improved cancer therapy efficacy.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Nanoscience & Nanotechnology
June Yong Park, Yuseon Shin, Woong Roeck Won, Chaemin Lim, Jae Chang Kim, Kioh Kang, Patihul Husni, Eun Seong Lee, Yu Seok Youn, Kyung Taek Oh
Summary: An AE147 peptide-conjugated nanocarrier system was developed to target metastatic tumors, displaying potential and effective accumulation at tumor metastatic sites.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Multidisciplinary Sciences
Shima Shahrad, Mohammad Rajabi, Hamidreza Javadi, Ali Akbar Karimi Zarchi, Mohammad Hasan Darvishi
Summary: MUC1 aptamer-functionalized PLA-PEG nanocarriers were prepared at various w/w ratios and evaluated for their physiochemical properties, drug release kinetics, cytotoxicity, and antitumor activity. Targeted nanocarriers at a w/w ratio of 10:1 demonstrated significantly higher apoptosis rates in MUC1-overexpressing cancer cells compared to non-targeted and free drug forms, suggesting their potential as a promising drug delivery system for targeted therapy.
SCIENTIFIC REPORTS
(2022)
Article
Polymer Science
Sicheng Tang, Ruhui Yang, Yuhan Gao, Limeng Zhu, Shengwu Zheng, Xingjie Zan
Summary: In this study, ClO--sensitive amphiphilic brush polymers were synthesized, which can self-assemble into nano-sized particles in a neutral buffer, allowing for rapid cellular uptake. These polymers have a low critical micellization concentration and can encapsulate hydrophobic drug molecules up to 19% wt. The micelles disassemble in a ClO--rich environment and exhibit a faster drug release rate compared to previous systems, ensuring quick ROS elimination in vitro and in vivo.
Article
Pharmacology & Pharmacy
S. Salido, A. Alejo-Armijo, A. J. Parola, V Sebastian, T. Alejo, S. Irusta, M. Arruebo, J. Altarejos
Summary: In this study, two nanocarriers based on chitosan conjugates were designed and synthesized to selectively transport hLDHA inhibitors into hepatocytes and disrupt them once they reach the cytosol. The redox-sensitive nanocarrier showed high drug loadings and encapsulation efficiencies for the hLDHA inhibitors tested, and it disassembled under the reducing conditions present inside hepatocytes, releasing the encapsulated inhibitor.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Chemistry, Multidisciplinary
Wen Xie, Feiya Zhou, Xiang Li, Zhichen Liu, Manyu Zhang, Zhihui Zong, Lili Liang
Summary: A multifunctional nano-sized drug-delivery material MIL-101(Fe)@FU@FA with a uniform particle size was successfully synthesized for targeting therapeutic purposes. The nanoparticles showed good biocompatibility, significantly inhibited cell proliferation, and had anti-metastasis ability to tumor cells.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Biophysics
Yamini Bobde, Tarun Patel, Milan Paul, Swati Biswas, Balaram Ghosh
Summary: Polymeric micelles composed of mPEG-b-HPMA copolymer were studied for delivering DOX effectively. The optimized micelle P6-M1 showed small particle size, high drug loading, and promising anticancer effects in breast cancer cell lines. This study demonstrated the potential of mPEG-b-HPMA micelles as a nanomedicine for breast cancer treatment.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Review
Nanoscience & Nanotechnology
Rui Yang, Leilei Wang, Zhifeng Wu, Yongxiang Yin, Shi-Wen Jiang
Summary: This review summarizes the general features of GlcNAcylation and its alterations in cancers, and discusses the advantages and challenges of using nanocarriers for targeted therapy of O-GlcNAcylation.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Veronica Almeida-Marrero, Fleur Bethlehem, Sara Longo, M. Candelaria Bertolino, Tomas Torres, Jurriaan Huskens, Andres de la Escosura
Summary: Modifying surfaces with multiple ligands allows for the study of multivalency, which has been successfully demonstrated in the efficient binding of a photosensitizer-nanocarrier system to siglec10. This approach represents a potential method for targeting siglec-expressing cells with photosensitizing nanocarriers.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Physical
Mengyi Li, Shuai Jiang, Adelina Haller, Sebastian Wirsching, Michael Fichter, Johanna Simon, Manfred Wagner, Volker Mailander, Stephan Gehring, Daniel Crespy, Katharina Landfester
Summary: This study developed a DXM-phosphate-based polyprodrug encapsulated in silica nanocontainers, showing enhanced control of inflammatory responses in liver cells, highlighting the advantage of combining the polyprodrug strategy with nanocarrier-mediated delivery for water-soluble low molecular weight drugs.
NANOSCALE HORIZONS
(2021)