Journal
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
Volume 19, Issue 6, Pages 717-727Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/10837450.2013.823994
Keywords
Dexibuprofen; healthy human volunteers; pharmacokinetic study; pluronics; polymeric micelles
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This work aimed to incorporate Dexibuprofen (DXI), the pharmacologically active and more potent form of ibuprofen, into polymeric micelles based tablets with enhanced oral bioavailability. Thin film hydration technique was employed to prepare DXI polymeric micelles using Pluronic (R) F127 and/or P123 solutions in different ratios (ranging from 1: 1 up to 1: 10). Prepared micelles were characterized regarding particle size, drug loading and entrapment efficiency. Selected formulae were lyophilized in presence of cryoprotectants and subjected to solid-state characterization as well as scanning and transmission electron microscopy. Subsequently, tablets were prepared and evaluated in-vitro regarding physical properties and drug release. An in-vivo pharmacokinetic study was performed in six healthy human volunteers in comparison to the commercially available tablet of DXI. Solid-state characterization proved that DXI was homogenously dispersed in Pluronic micelles' matrices. Formula TF5 tablets comprising lyophilized micelles (F5; DXI: Pluronic F127 in 1: 1 ratio and 0.25% mannitol) showed higher C-max and earlier t(max) values than those of the commercial formula, where the relative bioavailability was calculated to be 160.15%. The experimental evidence in this research leads to the conclusion that polymeric micelles present enabling properties for oral delivery of drugs with low solubility.
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