Article
Pharmacology & Pharmacy
Rita Ambrus, Areen Alshweiat, Piroska Szabo-Revesz, Csilla Bartos, Ildiko Csoka
Summary: Nanocrystals of meloxicam (MLX) were prepared using the bead mill method and high-pressure homogenization. Different drying methods and cryoprotectants were applied to obtain dry nanocrystals. The results showed that freeze-dried samples had the smallest particle size, mannitol-based samples had the highest crystallinity index, and trehalose-based samples had the lowest crystallinity index. These factors explained the differences in dissolution among the samples.
Article
Pharmacology & Pharmacy
Oriana Boscolo, Sabrina Flor, Leandro Salvo, Cecilia Dobrecky, Christian Hoecht, Valeria Tripodi, Marcela Moretton, Silvia Lucangioli
Summary: In this study, UDCA nanosuspensions were designed and optimized using the precipitation-ultrasonication method to improve the solubility, dissolution, and oral bioavailability of UDCA.
Article
Biochemistry & Molecular Biology
Emilia Jakubowska, Bartlomiej Milanowski, Janina Lulek
Summary: Nanosizing was successfully achieved by combining liquid antisolvent precipitation with ultrasound, reducing the particle size of cilostazol to nanoscale and improving its dissolution characteristics. The study showed that the combination of precipitation-sonication is a successful bottom-up method in enhancing the dissolution rate of poorly soluble drugs like cilostazol while maintaining stability in nanosuspension.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Areen Alshweiat, Patricia Varga, Ildiko Csoka, Anett Nemeth, Csilla Bartos, Rita Ambrus
Summary: Nanonization is commonly used to improve the bioavailability of poorly water-soluble drugs. In this study, nanocrystals of niflumic acid (NIF) were produced using bead pre-milling and high-pressure homogenization (HPH) to enhance its dissolution rate. Different drying procedures were applied, and the effect on the re-dispersibility of drug nanocrystals was investigated. The results showed that the drying process significantly impacted the size of the nanocrystals after re-dispersion in water. The smartcrystals exhibited a higher drug release rate compared to the raw NIF, indicating their potential as an efficient delivery system.
Article
Chemistry, Applied
Jiajia Wang, Jun Xu, Shiyun Zhu, Qiqi Wu, Jinpeng Li, Yi Gao, Bin Wang, Jun Li, Wenhua Gao, Jinsong Zeng, Kefu Chen
Summary: A time-saving and low-cost chemi-mechanical method was proposed to prepare cellulose nanocrystals and cellulose nanofibers with high yield. The diameter and length distribution of the obtained nanocellulose were 16-45 nm and 150-600 nm, respectively. The approach offers a promising strategy for high yield of nanocellulose due to its easy operation and low pollution.
CARBOHYDRATE POLYMERS
(2021)
Article
Food Science & Technology
Guoyuan Xiong, Xuejuan Jiang, Fei Xie, Yaqi Fan, Xinglian Xu, Min Zhang, Jun Qi, Shanglong Wang, Xi Zhou
Summary: High-pressure homogenization (HPH) has a significant effect on the emulsifying properties and structural changes of chicken liver proteins isolated by isoelectric solubilization/precipitation (ISP). Proper HPH combined with ISP treatments can promote the emulsifying stability of proteins by adjusting their properties through different pressure levels and pH values.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Chemistry, Applied
Xiaosong Zhai, Yamei Xiang, Yaning Tian, Aiyue Wang, Zisong Li, Wentao Wang, Hanxue Hou
Summary: In this study, cellulose nanocrystals (CNCs) were extracted from cotton-derived microcrystalline cellulose (MCC) using enzymatic hydrolysis-assisted high-pressure homogenization. The CNCs showed needle-like shape with a length of 100-250 nm and a width of 5-10 nm, and had a particle size range of 3-80 nm. The extracted CNCs exhibited slightly lower crystallinity and higher thermal stability compared to MCC, making them a promising reinforcing agent in biodegradable packaging materials.
JOURNAL OF VINYL & ADDITIVE TECHNOLOGY
(2021)
Article
Polymer Science
Franciene Almeida Villanova, Amy Hui-Mei Lin
Summary: This study applied high-pressure homogenization to modify the structure of pea starch, resulting in the formation of high-level complexes and reduced starch digestibility. Additionally, the functionality of the starch was improved with a slower degradation rate.
Article
Food Science & Technology
Ricardo Henrique Belmiro, Ludmilla de Carvalho Oliveira, Alline Artigiani Lima Tribst, Marcelo Cristianini
Summary: The study found that incorporating coffee by-products into cookies can increase total reducing power and fiber content, with minimal impact on the dimensions, physical properties, and sensory attributes of the cookies.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Physical
Zhao Yang, Taiki Nakata, Chao Xu, Gang Wang, Lin Geng, Shigeharu Kamado
Summary: A high-performance Mg-8Gd-4Y-0.5Mn-0.2Sc alloy was fabricated using homogenization, hot extrusion, and ageing. The microstructure evolution during homogenization was studied, and an optimum time of 18 h was determined to minimize the volume fraction of second phase particles and maintain a fine grain structure. The alloy exhibited excellent age-hardening ability and strength after peak-aged treatment, with a tensile yield stress of 441 MPa and an ultimate tensile strength of 506 MPa. The high yield strength was attributed to the co-existing bimodal microstructure, fine dynamically recrystallized grains, dense precipitated particles, and nano-scale precipitates. Precipitation strengthening was revealed as the dominant strengthening mechanism.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Article
Biochemistry & Molecular Biology
Yan Liu, Yuwan Li, Lei Rao, Yongtao Wang, Xiaojun Liao
Summary: This study investigated the effects of high pressure homogenization (HPH) on the interaction between corn starch and cyanidin-3-O-glucoside. The results showed that the interaction was strongest at low temperatures and low pressures. HPH opened the entry channels, increased contact area, and preserved steric hindrance, which increased hydrogen bonding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Medicinal
Biswadip Sinha, Rainer H. Mueller, Jan P. Moeschwitzer
Summary: The study demonstrates that Cavi-precipitation technology can be used to generate drug nanocrystals of the model compound resveratrol (RVT) with crystallites of 30-50 nm size. The combination of DMSO alone or in combination with acetone in the solvent phase produced the smallest size RVT nanocrystals.
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2021)
Article
Chemistry, Physical
Minwoo Lee, Minhaeng Heo, Hyunho Lee, Jihoon Shin
Summary: The isolation degree of cellulose nanocrystals (CNCs) suspensions can be estimated through turbidimetry, surface charge, and dispersion analysis. Different raw cellulosic materials show significant changes in CNCs isolation degree and turbidity after the same treatment, indicating a direct correlation between yield, turbidity, surface charge, and sedimentation of CNCs suspensions.
Article
Biochemistry & Molecular Biology
Dan Luo, Qiang Xie, Chen Chen, Kaiyu Mu, Zhaomin Wang, Shimin Gu, Wentong Xue
Summary: The pea starch-gallic acid (PS-GA) complexes were prepared using high pressure homogenization (HPH), and the effect and mechanism of pressure on the multi-scale structure and digestibility of the complexes were investigated. High pressure homogenization promoted the formation of PS-GA complexes, with the maximum complex index achieved at 90 MPa. The mechanism of pressure involved hydrophobic interactions and hydrogen bonding. The resulting complexes had a dense hierarchical structure, which increased gelatinization temperature and changed the digestibility of the complexes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Food Science & Technology
Atiyeh Heidary, Nafiseh Soltanizadeh
Summary: The aim of this study was to investigate the effects of high-pressure homogenization (HPH) on the functional, physicochemical, and structural properties of gelatin. The results showed that HPH could destroy hydrogen bonds and lead to protein unfolding. The microstructure of gelatin gel was altered, and the emulsifying and foaming properties of gelatin were improved after HPH treatment.
FOOD AND BIOPROCESS TECHNOLOGY
(2023)