Journal
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
Volume 17, Issue 6, Pages 705-711Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/10837450.2011.572895
Keywords
Boundary layer; diffusion; diffusion cell; in vitro methodology; permeation
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Funding
- National Institute for Occupational Safety and Health
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The unstirred aqueous boundary layer (ABL) thickness was determined for modified Franz diffusion cells using three test compounds-parathion, 4-hexylresorcinol, and 2,4-dinitrochlorobenzene (DNCB). Steady-state fluxes through one, two, and three dialysis membranes in series were achieved in donor-saturated, infinite-dose permeation experiments. These results were then used to calculate the total diffusive resistance for each case, as well as an extrapolated zero membrane value which was used in conjunction with an estimate of the aqueous diffusivities to calculate the ABL thickness. The resulting value (mean +/- SE) was 0.070 +/- 0.004 cm.
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