Article
Polymer Science
Alexandra Grigoreva, Kseniia Tarankova, Olga Zamyshlyayeva, Sergey Zaitsev
Summary: The formation of monolayers of PFA-b-PAA amphiphilic copolymers at the air/water interface was characterized using Langmuir film balance technique and atomic force microscopy. Both internal and external effects on the aggregation behavior of the copolymers were considered. The study found that the structure of the copolymer and the pH and salt concentration of the subphase have significant impacts on the surface behavior of the copolymers.
JOURNAL OF POLYMER RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Justyna Srebro, Witold Brniak, Aleksander Mendyk
Summary: This review discusses the discovery and development of proton pump inhibitors (PPIs), formulation issues, and contemporary solutions, possibilities, and challenges in formulation development. It outlines the physicochemical characteristics of PPIs, their pharmacokinetic and pharmacodynamic properties, and stability, as well as qualitative and quantitative analysis methods. The review also characterizes commercial preparations with PPIs and focuses on the state of the art in the development of novel formulations with PPIs, covering various approaches employed in this process.
Article
Polymer Science
Xiang-Yue Cheng, Qi-Kun Feng, Zhi-Min Dang, Fu-Sheng Du, Zi-Chen Li
Summary: This paper reports the synthesis and molar mass control of three alternating [1.1.1]propellane-(meth)acrylate copolymers. The copolymers exhibit high thermal stability and semi-crystalline properties. The introduction of the rigid bicyclo[1.1.1]pentane unit into the polymer backbone enhances the dielectric constants and ensures high breakdown strength, resulting in extraordinary energy storage performance.
MACROMOLECULAR RAPID COMMUNICATIONS
(2023)
Article
Polymer Science
Rachel L. Atkinson, Olivia R. Monaghan, Matthew T. Elsmore, Paul D. Topham, Daniel T. W. Toolan, Matthew J. Derry, Vincenzo Taresco, Robert A. Stockman, Davide S. A. De Focatiis, Derek J. Irvine, Steven M. Howdle
Summary: Terpenes are considered ideal candidates for sustainable polymer feedstocks due to their natural abundance and availability from existing waste streams. By using RAFT control, well-defined polymers and precise di- and multiblock copolymer architectures can be synthesized. A wide range of T-g values are observed for terpene (meth)acrylate homopolymers, which can be utilized to create renewably-sourced hard-soft block copolymers.
Article
Polymer Science
Roberto Lopez-Munoz, Raul Guillermo Lopez, Hened Saade, Angel Licea-Claverie, Francisco Javier Enriquez-Medrano, Graciela Morales, Daniel Grande
Summary: A drug-loaded electrospun mat has been found to have potential for cancer treatment after surgery. Using a semi-continuous heterophase polymerization method, a methacrylic copolymer called P(MMA-co-MAA) was synthesized as a carrier for the anticancer drug doxorubicin hydrochloride (DOX). Confocal microscopy images indicated that the copolymer was more effective at incorporating the drug than the ES100 nanofibers. The in-vitro release profiles showed that the synthesized copolymer had a lower release rate compared to the ES100 copolymer, suggesting its potential for sustained and prolonged drug release.
Article
Polymer Science
Liang Xu, Yu Takagi, Xiangming Fu, Yanqiu Wang, Atsushi Narumi, Shin-ichiro Sato, Xiande Shen, Toyoji Kakuchi
Summary: The hydrosilylation-promoted group transfer polymerization (GTP) was used to investigate the polymerization method, preparation of well-defined (co)polymers, and the controlled/living property of ethyl sorbate (ES). The two methods, single catalyst and catalyst switch, were employed to produce well-defined poly(ethyl sorbate) (PES). The kinetic experiments showed that the propagation rate kp for t-Bu-P4-catalyzed GTP is higher than that for B(C6F5)3. Alpha-end-functionalized PES was synthesized via the hydrosilylation-promoted GTP using a sorbate ester with a functional group as the moisture-stable latent initiator. Furthermore, the controlled/living property enabled the GTP of ES with MMA and nBA to produce AB-diblock copolymers and ABA-and ABC-triblock copolymers composed of PES, PMMA, and PnBA.
Proceedings Paper
Materials Science, Multidisciplinary
R. B. Sharma, V Arora, S. Arora, A. Kapila, R. Sharma
Summary: The aim of this study was to investigate the role of biomaterials cross carmellose sodium and Eudragit S100 in controlling drug release to the colon. Nine formulations with different polymer concentrations were prepared, and coating process using Eudragit S100 and various excipients was performed. One formulation showed a release of 99.4% of the drug in the colon within 36 hours, indicating excellent release performance.
MATERIALS TODAY-PROCEEDINGS
(2022)
Article
Polymer Science
Annalisa Dalmoro, Alexander Y. Sitenkov, Gaetano Lamberti, Anna Angela Barba, Rouslan I. Moustafine
JOURNAL OF APPLIED POLYMER SCIENCE
(2016)
Article
Chemistry, Medicinal
R. I. Mustafin, I. I. Semina, V. R. Garipova, A. V. Bukhovets, A. Yu. Sitenkov, A. R. Salakhova, C. G. M. Gennari, F. Cilurzo
PHARMACEUTICAL CHEMISTRY JOURNAL
(2015)
Article
Pharmacology & Pharmacy
Rouslan I. Moustafine, Alexander Y. Sitenkov, Alexandra V. Bukhovets, Shamil F. Nasibullin, Bernard Appeltans, Tatiana V. Kabanova, Vitaliy V. Khutoryanskiy, Guy Van den Mooter
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2017)
Article
Pharmacology & Pharmacy
Annalisa Dalmoro, Alexander Y. Sitenkov, Sara Cascone, Gaetano Lamberti, Anna Angela Barba, Rouslan I. Moustafine
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2017)
Article
Pharmacology & Pharmacy
Rouslan I. Moustafine, Andrey V. Bodrov, Vera A. Kemenova, Patrick Rombaut, Guy Van den Mooter
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2012)
Article
Chemistry, Medicinal
Rouslan I. Moustafine, Valerija L. Bobyleva, Aleksandra V. Bukhovets, Venera R. Garipova, Tatyana V. Kabanova, Vera A. Kemenova, Guy van den Mooter
JOURNAL OF PHARMACEUTICAL SCIENCES
(2011)
Article
Medicine, Research & Experimental
R. I. Moustafine, A. V. Bukhovets, A. Y. Sitenkov, V. A. Kemenova, P. Rombaut, G. Van den Mooter
MOLECULAR PHARMACEUTICS
(2013)
Article
Chemistry, Medicinal
R. I. Mustafin, T. V. Kabanova, I. I. Semina, A. V. Bukhovets, V. R. Garipova, E. V. Shilovskaya, Sh. F. Nasibullin, A. Yu. Sitenkov, R. R. Kazakova, V. A. Kemenova
PHARMACEUTICAL CHEMISTRY JOURNAL
(2011)
Article
Chemistry, Medicinal
R. I. Moustafine, A. V. Bukhovets, V. R. Garipova, A. Y. Sitenkov, A. R. Shamsutdinova, V. A. Kemenova, P. Rombaut, G. Van den Mooter
PHARMACEUTICAL CHEMISTRY JOURNAL
(2012)
Article
Chemistry, Medicinal
R. I. Mustafin, A. V. Bodrov, V. A. Kemenova, P. Rombaut, G. Van den Mooter
PHARMACEUTICAL CHEMISTRY JOURNAL
(2012)
Article
Chemistry, Medicinal
I. P. Pashina, I. I. Semina, S. A. Sidullina, R. I. Tarasova, M. B. Gazizov, R. I. Mustafin
PHARMACEUTICAL CHEMISTRY JOURNAL
(2013)
Article
Chemistry, Medicinal
R. I. Mustafin, I. I. Semina, A. V. Bukhovets, A. Yu. Sitenkov, V. R. Garipova, A. R. Salakhova, V. A. Kemenova
PHARMACEUTICAL CHEMISTRY JOURNAL
(2014)
Article
Chemistry, Multidisciplinary
R. I. Moustafine
RUSSIAN JOURNAL OF GENERAL CHEMISTRY
(2014)
Article
Polymer Science
Sergey K. Filippov, Ramil R. Khusnutdinov, Wali Inham, Chang Liu, Dmitry O. Nikitin, Irina I. Semina, Christopher J. Garvey, Shamil F. Nasibullin, Vitaliy V. Khutoryanskiy, Hongbo Zhang, Rouslan I. Moustafine
Summary: The choice of drug delivery carrier significantly impacts the fate of drugs in the human body. This study demonstrates the superior efficiency and stability of hybrid Eudragit L100-55/Brij98 nanoparticles in loading haloperidol compared to mesoporous silica (MSN) and metal-organic framework (MOF) platforms. Further optimization could enhance haloperidol loading efficiency up to 40% with high stability.
Article
Pharmacology & Pharmacy
Nadezda E. Kashapova, Ruslan R. Kashapov, Albina Y. Ziganshina, Dmitry O. Nikitin, Irina I. Semina, Vadim V. Salnikov, Vitaliy V. Khutoryanskiy, Rouslan I. Moustafine, Lucia Y. Zakharova
Summary: A water-soluble form of haloperidol was obtained by coaggregation with calix[4]resorcinol to form vesicular nanoparticles. The nanoparticles showed mucoadhesive and thermosensitive properties, making them potentially effective drug delivery systems. In pharmacological studies, haloperidol formulated with calix[4]resorcinol exhibited a cataleptogenic effect in rats both when administered intranasally and intraperitoneally.