Article
Biochemistry & Molecular Biology
Kanyaluck Yangnok, Sukanda Innajak, Ratchawin Sawasjirakij, Wilawan Mahabusarakam, Ramida Watanapokasin
Summary: The study demonstrated that artonin E induced apoptosis in colon cancer cells LoVo and HCT116 through changes in mitochondrial membrane potential and regulation of apoptotic-related proteins.
Article
Oncology
Bustanur Rosidi, Diana Priyatno, Teguh Pribadi Putra, Irawan Yusuf
Summary: The study aimed to investigate the effects of metformin on the proliferation and growth of human colorectal cancer cell lines HCT116 and SW620. The results showed that metformin inhibited the proliferation and growth of HCT116 and SW620 cells in a concentration-dependent manner. Flow cytometric analysis revealed early apoptosis and metformin-induced cell death in both cell lines. However, caspase 3 activity and cleavage of PARP1 and pro-caspase 3 were not observed, suggesting a caspase 3-unrelated mechanism of metformin-induced cell death in these colorectal cancer cell lines.
CANCER MANAGEMENT AND RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Ming Zhang, Jianmei Lai, Qianlong Wu, Jia Lai, Jingyao Su, Bing Zhu, Yinghua Li
Summary: Hepatocarcinoma is a common digestive system tumor worldwide with no effective treatment. Naringenin, isolated from citrus fruits, has shown anticancer effects. This study investigated the molecular mechanisms and oxidative stress implications of naringenin-induced cytotoxicity in HepG2 cells. Naringenin induced apoptosis in HepG2 cells through multiple pathways, enhanced cytotoxic effects, triggered reactive oxygen species, inhibited JAK-2/STAT-3 signaling pathways, and activated caspase-3. These findings suggest that naringenin could be a promising candidate for cancer therapy.
Article
Biochemistry & Molecular Biology
Yin Shi, Shengfeng Xu, Natalie Y. L. Ngoi, Qi Zeng, Zu Ye
Summary: Hypoxia in the tumor microenvironment, causing excessive ROS and genomic instability, is a hallmark of cancer contributing to self-renewal, metastasis, and therapy resistance. PRL-3, an oncoprotein, has been found to regulate apoptosis resistance by negatively affecting p38 MAPK activity in response to hypoxia stress.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Cell Biology
Lujia Feng, Yantao Wei, Yimeng Sun, Linbin Zhou, Shaowei Bi, Weirong Chen, Wu Xiang
Summary: Cataracts are a leading cause of blindness worldwide, with age being a major risk factor. The exact mechanisms of cataractogenesis are still unclear. A recent study found that microRNA-34a (MIR34A) is involved in cataract development, but the underlying pathogenesis is unknown. This study showed that hexokinase 1 (HK1) is a target gene of MIR34A and demonstrated that MIR34A modulates lens epithelial cell apoptosis and cataract development through the HK1/caspase 3 signaling pathway.
Article
Environmental Sciences
Kuang-Chi Lai, Fu-Shin Chueh, Yi-Shih Ma, Yu-Cheng Chou, Jaw-Chyun Chen, Ching-Lung Liao, Yi-Ping Huang, Shu-Fen Peng
Summary: This study aimed to investigate the apoptotic effects of the combination of IRI and PEITC on human colon cancer HCT 116 cells in vitro. The results showed that the combination treatment reduced viable cell number and induced higher levels of cell apoptosis compared to IRI or PEITC alone. The combination treatment also increased levels of reactive oxygen species (ROS) and calcium ions (Ca2+), and higher caspase activities. Additionally, the combination treatment induced higher levels of ER stress, mitochondria, and caspase-associated proteins.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Izabela Buniowska, Norbert Wronski, Malgorzata Insinska-Rak, Marek Sikorski, Agnieszka Wolnicka-Glubisz
Summary: This study compared the effects of 3MeTARF and riboflavin on A431 cancer cells under irradiation. The results showed that 3MeTARF more effectively activated MAPK and induced cell death in skin cancer cells, suggesting its therapeutic potential in photodynamic oxidation processes.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2023)
Article
Cell Biology
Yijing Ren, Cheng Lv, Jing Zhang, Beibei Zhang, Bei Yue, Xiaoping Luo, Zhilun Yu, Hao Wang, Junyu Ren, Zhengtao Wang, Wei Dou
Summary: Alantolactone (ATL) exhibits inhibitory effects on cell activities, induces apoptosis, and inhibits colony formation in colorectal cancer. It also reduces cell migration and invasion capabilities. Furthermore, ATL demonstrates significant anti-tumor effects in vivo models.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Mohammad A. Alfhili, Hosni A. M. Hussein, Youngyong Park, Myon Hee Lee, Shaw M. Akula
Summary: This study investigates the antitumor properties of Triclosan (TCS) in Burkitt's lymphoma (BL) cells, showing that TCS induce cell death through various mechanisms such as membrane phospholipid scrambling, compromised permeability, and activation of caspase and JNK MAPK signaling pathways. This research identifies TCS as a potential antitumor agent with insights into its molecular mechanisms of action in BL cells.
Article
Biochemistry & Molecular Biology
Gulcin Yavuz Turel, Nilufer Sahin Calapoglu, Dilek Bayram, Meltem Ozgocmen, Vehbi Atahan Togay, Eda Evgen Tuluceoglu
Summary: The study demonstrated that curcumin has inhibitory effects on cell proliferation and induces apoptosis in colon carcinoma cells. It suggests that curcumin could be a potential protective or treatment agent against colon cancer, but further research on curcumin-rich diets and bioavailability is needed.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Environmental Sciences
Zhuanxu Ouyang, Bijing Yang, Jiangnan Yi, Shanshan Zhu, Suge Lu, Yingwei Liu, Yangwei Li, Yuanliang Li, Khalid Mehmood, Riaz Hussain, Muhammad Ijaz, Jianying Guo, Zhaoxin Tang, Ying Li, Hui Zhang
Summary: This study revealed the harmful effects of sodium fluoride on liver tissues of ducks, including promoting apoptosis and altering the expression levels of key genes.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Review
Neurosciences
Aziz Unnisa, Nigel H. H. Greig, Mohammad Amjad Kamal
Summary: Traumatic brain injury (TBI) is a major cause of death and morbidity, and is the focus of translational research. Apoptosis is important in the pathophysiology of TBI, and inhibiting it may improve functional recovery. Caspases, such as Caspase-3 and Caspase-9, are key mediators of cell death due to apoptosis in TBI. Understanding these apoptotic pathways and finding ways to inhibit Caspases may have significant treatment implications for TBI.
CURRENT NEUROPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Vera Belousova, Oxana Svitich, Elena Timokhina, Irina Ignatko, Irina Bogomazova, Svetlana Pesegova, Tatiana Silaeva, Tatiana Kuzmina, Oxana Skorobogatova
Summary: This article presents the hypothesis that premature placenta apoptosis could be a potential cause of preterm birth, supported by evaluating gene expression. The study found that during pregnancy, the expression of apoptosis-related genes in the placenta is low, but the expression of the apoptosis inhibitor XIAP is high. However, at the onset of preterm labor, the expression of apoptosis-related genes increases significantly, potentially initiating preterm birth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yu-Kai Huang, Kun-Che Chang, Chia-Yang Li, Ann-Shung Lieu, Chih-Lung Lin
Summary: This study investigated the role of AKR1B1 in glioma cell proliferation and apoptosis signaling. AKR1B1 expression was measured in different cell lines and tissues. The effects of AKR1B1 overexpression or knockdown, as well as p38 MAPK activation and inhibition, were evaluated. AKR1B1 was found to regulate glioma cell proliferation through the activation of p38 MAPK and apoptosis signaling. Therefore, AKR1B1 may be a potential therapeutic target for glioma therapy.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Lijie Gong, Chen Chen, Xiaoqin Liu, Xiutao Wu, Ling Zhu, Jianguang Luo, Lingyi Kong
Summary: Hainanolide (HN), a compound extracted from Cephalotaxus fortunei, has been proven to possess potent anti-tumor activities. This study demonstrated that HN inhibits colon cancer cell progression by blocking the cell cycle, inducing apoptosis, and activating the MAPK pathway.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Microbiology
Liyan Yu, Zhifei Hu, Zhijuan Hu, Zhongjun Ma
CURRENT MICROBIOLOGY
(2015)
Article
Agriculture, Multidisciplinary
Wanjing Ding, Zhijuan Hu, Zhewen Zhang, Qiaoqiao Ma, Huifang Tang, Zhongjun Ma
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2015)
Article
Chemistry, Applied
Haibing He, Zhongjun Ma, Qianqian Wang, Yu Liu, Hualin Xu
NATURAL PRODUCT RESEARCH
(2016)
Article
Microbiology
Yue Su, Ruijun Wang, Cong Sun, Shuaibo Han, Jing Hu, Dildar Wu, Zhongjun Ma, Jiawang Chen, Min Wu
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Ling Liu, Qiuping Yao, Zhongjun Ma, Haruo Ikeda, Shinya Fushinobu, Lian-Hua Xu
JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC
(2016)
Article
Biochemical Research Methods
Liyan Yu, Haibing He, Zhifei Hu, Zhongjun Ma
JOURNAL OF PROTEOMICS
(2016)
Article
Chemistry, Applied
Zhi-Fei Hu, Le-Le Qin, Wan-Jing Ding, Yu Liu, Zhong-Jun Ma
NATURAL PRODUCT RESEARCH
(2016)
Article
Chemistry, Applied
Zhijuan Hu, Lele Qin, Qianqian Wang, Wanjing Ding, Zhen Chen, Zhongjun Ma
NATURAL PRODUCT RESEARCH
(2016)
Article
Chemistry, Applied
Liyan Yu, Wanjing Ding, Zhongjun Ma
NATURAL PRODUCT RESEARCH
(2016)
Article
Oncology
Fanfan Zhu, Chunyan Dai, Yufei Fu, Jacky F. C. Loo, Dajin Xia, Sizhi P. Gao, Zhongjun Ma, Zhe Chen
Article
Chemistry, Medicinal
Hui Ding, Wanjing Ding, Zhongjun Ma
Article
Chemistry, Medicinal
Hui Ding, Dashan Zhang, Biao Zhou, Zhongjun Ma
Article
Chemistry, Applied
Qiaoqiao Ma, Wanjing Ding, Zhe Chen, Zhongjun Ma
NATURAL PRODUCT RESEARCH
(2018)
Article
Chemistry, Organic
Liyan Yu, Wanjing Ding, Qianqian Wang, Zhongjun Ma, Xiaowu Xu, Xiaofeng Zhao, Zhe Chen
Article
Biochemistry & Molecular Biology
Jian Xu, Yihua Wu, Guang Lu, Shujun Xie, Zhongjun Ma, Zhe Chen, Han-Ming Shen, Dajing Xia