Inhibiting the clathrin-mediated endocytosis pathway rescues KIR2.1 downregulation by pentamidine

Beat-to-beat variability of repolarization as a new biomarker for proarrhythmia in vivo

(2012) Rosanne Varkevisser et al.   HEART RHYTHM

Experimental Mapping of the Canine KCNJ2 and KCNJ12 Gene Structures and Functional Analysis of the Canine KIR2.2 ion Channel

(2012) Marien J. C. Houtman et al.   Frontiers in Physiology

Cholesterol Sensitivity of KIR2.1 Is Controlled by a Belt of Residues around the Cytosolic Pore

(2011) Avia Rosenhouse-Dantsker et al.   BIOPHYSICAL JOURNAL

A novel gain-of-function KCNJ2 mutation associated with short-QT syndrome impairs inward rectification of Kir2.1 currents

(2011) T. Hattori et al.   CARDIOVASCULAR RESEARCH

Golgi Export of the Kir2.1 Channel Is Driven by a Trafficking Signal Located within Its Tertiary Structure

(2011) Donghui Ma et al.   CELL

Toward specific cardiac IK1 modulators for in vivo application: Old drugs point the way

(2011) Marcel A.G. van der Heyden et al.   HEART RHYTHM

Phosphatidylinositol-(4,5)-bisphosphate regulates clathrin-coated pit initiation, stabilization, and size

(2011) Costin N. Antonescu et al.   MOLECULAR BIOLOGY OF THE CELL

Endocytosis Promotes Rapid Dopaminergic Signaling

(2011) Sarah J. Kotowski et al.   NEURON

The Dynamin Chemical Inhibitor Dynasore Impairs Cholesterol Trafficking and Sterol-Sensitive Genes Transcription in Human HeLa Cells and Macrophages

(2011) Emmanuelle Girard et al.   PLoS One

Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809

(2011) F. Van Goor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Results of a phase IIa study of VX-809, an investigational CFTR corrector compound, in subjects with cystic fibrosis homozygous for theF508del-CFTRmutation

(2011) J P Clancy et al.   THORAX

Role of calpain in the regulation of CFTR (cystic fibrosis transmembrane conductance regulator) turnover

(2010) Monica Averna et al.   BIOCHEMICAL JOURNAL

The anti-protozoal drug pentamidine blocks KIR2.x-mediated inward rectifier current by entering the cytoplasmic pore region of the channel

(2010) TP De Boer et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inhibition of lysosomal degradation rescues pentamidine-mediated decreases of KIR2.1 ion channel expression but not that of Kv11.1

(2010) Lukas Nalos et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Protein Kinase A-Dependent Biophysical Phenotype for V227F-KCNJ2 Mutation in Catecholaminergic Polymorphic Ventricular Tachycardia

(2009) Amanda L. Vega et al.   Circulation-Arrhythmia and Electrophysiology

A clathrin-dependent pathway leads to KRas signaling on late endosomes en route to lysosomes

(2009) Albert Lu et al.   JOURNAL OF CELL BIOLOGY

Calpain Mediates Proteolysis of the Voltage-Gated Sodium Channel  -Subunit

(2009) C. R. von Reyn et al.   JOURNAL OF NEUROSCIENCE

Blockade of the IKs potassium channel: An overlooked cardiovascular liability in drug safety screening?

(2009) Rob Towart et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Dynasore, a Dynamin Inhibitor, Induces PAI-1 Expression in MeT-5A Human Pleural Mesothelial Cells

(2008) Chi-Li Chung et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Lysosome mediated Kir2.1 breakdown directly influences inward rectifier current density

(2008) John A. Jansen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

AP-2-dependent Internalization of Potassium Channel Kir2.3 Is Driven by a Novel Di-hydrophobic Signal

(2008) Amanda K. Mason et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Kir2.1 channels by the Rho-GTPase, Rac1

(2008) Stephanie B. Boyer et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Postsynaptic Density-95 (PSD-95) and Calcineurin Control the Sensitivity of N-Methyl-D-aspartate Receptors to Calpain Cleavage in Cortical Neurons

(2008) E. Y. Yuen et al.   MOLECULAR PHARMACOLOGY

Drugs and trafficking of ion channels: a new pro-arrhythmic threat on the horizon?

(2007) M A G Heyden et al.   BRITISH JOURNAL OF PHARMACOLOGY