Article
Physiology
Jeremy A. Bigalke, Huanjia Gao, Qing-Hui Chen, Zhiying Shan
Summary: Salt-sensitivity is a major factor in the development of hypertension, and the role of the brain orexin system in the pathology of salt-sensitive hypertension remains to be explored. This study demonstrated that orexin signaling through the OX1R in the PVN plays a critical role in the onset and maintenance of hypertension in the DOCA-salt model, involving the activation of AVP-producing neurons and subsequent release of AVP into the periphery.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Endocrinology & Metabolism
Danni Mu, Yichen Ma, Jin Cheng, Ling Qiu, Shi Chen, Xinqi Cheng
Summary: Copeptin level measurement is a useful tool for differentiating between DI and PP.
ENDOCRINE PRACTICE
(2023)
Article
Behavioral Sciences
Archana Durairaja, Ceylan-Scarlett Steinecke, Markus Fendt
Summary: The study found that orexin 1 receptor antagonist impairs cognitive flexibility in a sex-dependent manner, affecting females more than males. Consumption of the reward used in the ASST was not affected by the antagonist, indicating a specific impact on cognitive flexibility rather than reward response.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Endocrinology & Metabolism
Julie Refardt, Cihan Atila, Mirjam Christ-Crain
Summary: Arginine vasopressin deficiency (AVP-D) is a form of the polyuria-polydipsia syndrome. New diagnostic tests using copeptin have been introduced to accurately diagnose AVP-D. Treatment focuses on desmopressin substitution and psychopathological factors also play a role in managing AVP-D patients.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2023)
Article
Behavioral Sciences
Wen-Rui Gao, Xiao-Hong Hu, Kai-Yue Yu, Hong-Yan Cai, Zhao-Jun Wang, Lei Wang, Mei-Na Wu
Summary: Cognitive dysfunction is a main clinical manifestation of Alzheimer's disease (AD). Previous research has found a correlation between elevated orexin level and the progression of AD. Orexin-A treatment has been shown to increase amyloid beta protein (A beta) deposition and worsen spatial memory impairment in mice. Dual orexin receptor (OXR) antagonist has been found to affect A beta level and cognitive dysfunction in AD, but the effects of OX1R or OX2R alone have not been reported. This study investigates the role of OX1R in AD cognitive dysfunction and its possible mechanism.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Endocrinology & Metabolism
Lucia Sugawara, Takaaki Nakamura, Yoshitaka Ishizuka, Hiroshi Maegawa
Summary: The case report describes a 40-year-old man diagnosed with familial central diabetes insipidus based on family history, which led to a gene mutation analysis identifying an abnormality in the AVPneurophysin II gene. This mutation causes the AVP to lose its carrier protein function, resulting in the occurrence of central diabetes insipidus.
Article
Endocrinology & Metabolism
Lucia Sugawara, Takaaki Nakamura, Yoshitaka Ishizuka, Hiroshi Maegawa
Summary: This article reports a case of familial central diabetes insipidus. Through gene mutation analysis, it was found that both the patient and his daughter had abnormalities in the AVP-neurophysin II gene, which may be the cause of their development of this disease.
Review
Health Care Sciences & Services
Krishnaraju Venkatesan, Kumarappan Chidambaram, Premalatha Paulsamy, Ramasubbamma Ramaiah, Ali Al-Qahtani, Kumar Venkatesan, Ester Mary Pappiya, Swetha Devidi, Kalpana Krishnaraju
Summary: Dipsogenic diabetes insipidus (DDI) is a subtype of primary polydipsia (PP) that typically occurs in healthy individuals without psychiatric illness. The pathogenesis of DDI is not well understood, and treatment options are limited, but there have been successful case reports of treatment.
Review
Psychiatry
Thomas H. Havens, Gaetano Innamorato, Eric C. Nemec
Summary: This systematic review assessed the therapeutic effect of non-antipsychotic medications on patients with stable psychotic illness and concurrent psychogenic polydipsia (PPD). The results showed that some medications were effective in improving PPD outcomes, but no single drug appeared to be the most efficacious. Further research and guidance are needed to provide better treatment options for PPD.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2022)
Article
Cell & Tissue Engineering
Wei Wen, Xiang Chen, Xin-Yi Shen, Hua-Yu Li, Feng Zhang, Feng-Qi Fang, Xiao-Bing Zhang
Summary: This study optimized the efficiency of NK cell differentiation from HSPCs by modulating osmotic pressure. The optimized protocol not only improved the proliferation capacity and functional characteristics of NK cells, but also yielded a higher cell count compared to conventional methods. Furthermore, this method was also suitable for generating high-yield CAR-NK cells.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Veterinary Sciences
Emily A. Barrell
Summary: Polyuria and polydipsia are rare clinical signs with multiple potential causes. The most common causes in horses are chronic kidney disease, pituitary pars intermedia dysfunction (PPID), and psychogenic polydipsia. Investigating these symptoms should start with a thorough examination and specific tests. Overhydration and certain medications can also cause polyuria. Distinguishing psychogenic polydipsia from diabetes insipidus requires specific tests.
VETERINARY CLINICS OF NORTH AMERICA-EQUINE PRACTICE
(2022)
Article
Multidisciplinary Sciences
Jo B. Henningsen, Rana Soylu-Kucharz, Maria Bjorkqvist, Asa Petersen
Summary: Huntington disease is a fatal neurodegenerative movement disorder caused by a mutant huntingtin protein. Despite certain brain regions being affected, the role of excitotoxicity in the loss of hypothalamic neuronal populations in HD remains unclear. Further research is needed to understand the underlying mechanisms of selective vulnerability of certain neurons in HD.
Article
Behavioral Sciences
Naghmeh Saadati, Maryam Bananej, Fatemeh Khakpai, Mohammad -Reza Zarrindast, Hengameh Alibeik
Summary: This study evaluated the effects of co-treatment of orexin agents and citalopram on depression-like behavior and BDNF expression in the prefrontal cortex (PFC) of sleep-deprived male mice. It was found that sleep deprivation increased depression-like behavior while decreasing BDNF expression. Citalopram showed an antidepressant effect, which was potentiated by an orexin antagonist and reversed by orexin-1. The study suggests that the orexin system interacts with citalopram to modulate depression-like behavior in sleep-deprived mice.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2022)
Editorial Material
Medicine, General & Internal
Daniel H. Geschwind
Summary: Autism spectrum disorder is characterized by deficits in social functioning and repetitive-restrictive behaviors, with current pharmacologic interventions limited to symptom treatment instead of targeting social deficits. Behavioral treatments have shown effectiveness in some individuals, but there is a need for drug development to improve social functioning. The potential use of oxytocin as a pro-social hormone for autism treatment has gained attention.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Pilar Marcos, Rafael Covenas
Summary: Understanding the dysregulation of hypothalamic neuropeptides is crucial in studying feeding behavior and obesity. Current pharmacological strategies for obesity treatment are ineffective, highlighting the need for new therapeutic approaches. This review focuses on the involvement of the orexinergic system in feeding behavior, discussing animal models, human studies, and the connection to other substances. Promising research on orexinergic signaling pathways, heterogeneity of hypothalamic orexinergic neurons, receptor-receptor interaction, and sex differences are highlighted. The development of combination therapies and more specific orexin receptor antagonists is important for successful anti-obesity treatments.
APPLIED SCIENCES-BASEL
(2022)
Article
Neurosciences
Csaba Varga, Gabor Tamas, Pal Barzo, Szabolcs Olah, Peter Somogyi
Letter
Cardiac & Cardiovascular Systems
Aniko Posa, Imre Pavo, Csaba Varga
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2015)
Article
Cell Biology
Aniko Posa, Renata Szabo, Anett Csonka, Medea Veszelka, Aniko Magyarine Berko, Zoltan Barath, Rudolf Menesi, Imre Pavo, Mariann Gyongyosi, Ferenc Laszlo, Krisztina Kupai, Csaba Varga
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2015)
Article
Cell Biology
Aniko Posa, Renata Szabo, Krisztina Kupai, Anett Csonka, Zita Szalai, Medea Veszelka, Szilvia Toeroek, Lejla Daruka, Csaba Varga
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2015)
Article
Cell Biology
Aniko Posa, Renata Szabo, Krisztina Kupai, Zoltan Barath, Zita Szalai, Anett Csonka, Medea Veszelka, Mariann Gyoengyoesi, Zsolt Radak, Rudolf Menesi, Imre Pavo, Aniko Magyarine Berko, Csaba Varga
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2015)
Article
Biochemistry & Molecular Biology
Eviatar Natan, Tamaki Endoh, Liora Haim-Vilmovsky, Tilman Flock, Guilhem Chalancon, Jonathan T. S. Hopper, Bilint Kintses, Peter Horvath, Lejla Daruka, Gergely Fekete, Csaba Pal, Balazs Papp, Erika Oszi, Zoltan Magyar, Joseph A. Marsh, Adrian H. Elcock, M. Madan Babu, Carol V. Robinson, Naoki Sugimoto, Sarah A. Teichmann
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Eviatar Natan, Tamaki Endoh, Liora Haim-Vilmovsky, Tilman Flock, Guilhem Chalancon, Jonathan T. S. Hopper, Bilint Kintses, Peter Horvath, Lejla Daruka, Gergely Fekete, Csaba Pal, Balazs Papp, Erika Oszi, Zoltan Magyar, Joseph A. Marsh, Adrian H. Elcock, M. Madan Babu, Carol V. Robinson, Naoki Sugimoto, Sarah A. Teichmann
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2018)
Article
Microbiology
Viktoria Lazar, Ana Martins, Reka Spohn, Lejla Daruka, Gabor Grezal, Gergely Fekete, Monika Szamel, Pramod K. Jangir, Balint Kintses, Balint Csorgo, Akos Nyerges, Adam Gyorkei, Andras Kincses, Andras Der, Fruzsina R. Walter, Maria A. Deli, Edit Urban, Zsofia Hegedus, Gabor Olajos, Orsolya Mehi, Balazs Balint, Istvan Nagy, Tamas A. Martinek, Balazs Papp, Csaba Pal
NATURE MICROBIOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Renata Szabo, Rudolf Menesi, Andor H. Molnar, Zita Szalai, Lejla Daruka, Gabor Toth, Janos Gardi, Marta Galfi, Denise Borzsei, Krisztina Kupai, Anna Juhasz, Marianna Radacs, Ferenc A. Laszlo, Csaba Varga, Aniko Posa
Article
Pharmacology & Pharmacy
Alexandra Bocsik, Ilona Grof, Lorand Kiss, Ferenc Otvos, Otto Zsiros, Lejla Daruka, Livia Fulop, Monika Vastag, Agnes Kittel, Norbert Imre, Tamas A. Martinek, Csaba Pal, Piroska Szabo-Revesz, Maria A. Deli
Article
Microbiology
Petra Szili, Gabor Draskovits, Tamas Revesz, Ferenc Bogar, David Balogh, Tamas Martinek, Lejla Daruka, Reka Spohn, Balint Mark Vasarhelyi, Marton Czikkely, Balint Kintses, Gabor Grezal, Gyorgyi Ferenc, Csaba Pal, Akos Nyerges
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2019)
Article
Multidisciplinary Sciences
Reka Spohn, Lejla Daruka, Viktoria Lazar, Ana Martins, Fanni Vidovics, Gabor Grezal, Orsolya Mehi, Balint Kintses, Monika Szamel, Pramod K. Jangir, Balint Csorgo, Adam Gyorkei, Zoltan Bodi, Aniko Farago, Laszlo Bodai, Imre Foldesi, Diana Kata, Gergely Maroti, Bernadett Pap, Roland Wirth, Balazs Papp, Csaba Pal
NATURE COMMUNICATIONS
(2019)
Article
Multidisciplinary Sciences
Balint Kintses, Pramod K. Jangir, Gergely Fekete, Monika Szamel, Orsolya Mehi, Reka Spohn, Lejla Daruka, Ana Martins, Ali Hosseinnia, Alla Gagarinova, Sunyoung Kim, Sadhna Phanse, Balint Csorgo, Adam Gyorkei, Eszter Ari, Viktoria Lazar, Istvan Nagy, Mohan Babu, Csaba Pal, Balazs Papp
NATURE COMMUNICATIONS
(2019)
Article
Biochemistry & Molecular Biology
Akos Nyerges, Tihomir Tomasic, Martina Durcik, Tamas Revesz, Petra Szili, Gabor Draskovits, Ferenc Bogar, Ziga Skok, Nace Zidar, Janez Ilas, Anamarija Zega, Danijel Kikelj, Lejla Daruka, Balint Kintses, Balint Vasarhelyi, Imre Foldesi, Diana Kata, Martin Welin, Raymond Kimbung, Dorota Focht, Lucija Peterlin Masic, Csaba Pal