Article
Physiology
Stephanie L. Daugherty, Jonathan M. Beckel, Kyoungeun A. Kim, Bruce A. Freeman, Jiaxin Liu, Shaoyong Wang, William C. de Groat, Xiulin Zhang
Summary: Experiments conducted on guinea pig bladder activity revealed differential effects of TRPA1, TRPV1, and TRPC agonists, suggesting the modulation of bladder function through activation of different types of afferent nerves and release of neurotransmitters.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Medicine, Research & Experimental
Guanghan Ou, Miki Fujisawa, Ayano Yashiro, Keyue Xu, Kento Yoshioka, Keisuke Obara, Yoshio Tanaka
Summary: The study found that U46619 and other prostanoids can enhance the basal tone and spontaneous contractile activities of UBSM, and this enhancing effect can be suppressed by a TP receptor antagonist. TP receptors and TP-receptor-activated VDCCs/SOCCs are key molecules responsible for these effects.
Article
Multidisciplinary Sciences
Ge Liu, Mizuki Kaneko, Kento Yoshioka, Keisuke Obara, Yoshio Tanaka
Summary: In this study, the effects of platelet-activating factor (PAF) on the contractile activities of guinea pig and mouse urinary bladder smooth muscle tissues were investigated. The results showed that PAF can enhance the basal tone and spontaneous contractile activities of the smooth muscle tissues through its receptor. The mRNA expression of PAF-synthesizing and -degrading enzymes was also detected in the urinary bladder tissues. These findings suggest that PAF plays a role in regulating the contractility of the urinary bladder smooth muscle and may contribute to detrusor overactivity.
SCIENTIFIC REPORTS
(2022)
Editorial Material
Medicine, General & Internal
Chieh-Ying Chang, Ming-Han Hsieh
Summary: This case report presents a 68-year-old male patient with type 2 diabetes who developed dysuria and passed small balls in the urine while being treated with an SGLT2 inhibitor.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Immunology
Hong-Ying Qiu, Na-Na Zhang, Qing-Qing Ma, Rui-Ting Li, Meng-Yue Guan, Li-Li Zhang, Jia Zhou, Rong-Rong Zhang, Xing-Yao Huang, Wen-Hui Yang, Yong-Qiang Deng, Cheng-Feng Qin, Dong-Sheng Zhou
Summary: This study demonstrates that Zika virus can be transmitted via aerosol routes, resulting in systemic infection and inducing immune responses.
EMERGING MICROBES & INFECTIONS
(2022)
Article
Engineering, Biomedical
Runfeng Tian, Julius P. A. Dewald, Nirvik Sinha, Yuan Yang
Summary: Through experiments on muscle responses, we found that the time delay for linear connectivity is less than 35 ms, while that for nonlinear connectivity is between 40-70 ms. This suggests that the estimated linear connectivity is likely generated by the mono-synaptic spinal stretch reflex loop, while the nonlinear connectivity may be associated with multi-synaptic supraspinal stretch reflex loops. These findings provide new evidence on the nature of neural connectivity related to the stretch reflex.
ANNALS OF BIOMEDICAL ENGINEERING
(2021)
Review
Biochemistry & Molecular Biology
Joanna Chorbinska, Wojciech Krajewski, Lukasz Nowak, Bartosz Malkiewicz, Francesco Del Giudice, Tomasz Szydelko
Summary: The urine microbiome, previously thought to be sterile, has been proven to exist and play a role in the pathogenesis of urological diseases. This review aims to summarize the current knowledge on the urinary microbiome in bladder diseases and identify potential directions for further research.
Article
Biochemistry & Molecular Biology
Urszula Mazur, Ewa Lepiarczyk, Pawel Janikiewicz, Agnieszka Bossowska
Summary: The study examined the distribution and chemical coding of somatostatin-immunoreactive (SOMIR) nerve fibers supplying the urinary bladder wall and the paracervical ganglion (PCG) neurons projecting to this organ in female pigs. It was found that somatostatin is extensively expressed in both the nerve fibers supplying the porcine urinary bladder wall and the PCG neurons projecting to this organ, indicating an important regulatory role of SOM in the control of the urinary bladder function.
JOURNAL OF CHEMICAL NEUROANATOMY
(2021)
Article
Biochemical Research Methods
Jung Hun Lee, Yu-Jung Hwang, Hui Li, Hyeyoon Kim, Myung-Whan Suh, Dohyun Han, Seung-Ha Oh
Summary: This study successfully identified 1413 proteins in guinea pig perilymph samples, expanding the previous understanding of the guinea pig perilymph proteome and providing a comprehensive proteomic resource for the research community.
Article
Agriculture, Dairy & Animal Science
Petr Tejml, Vojtech Navratil, Lubos Zabransky, Miloslav Soch
Summary: Cases of newborn conjoined twins in guinea pigs are extremely rare, with this report detailing the fourth described case in which two male twins were connected in the upper body. The twins had separate hearts and livers, but shared lungs. The anomaly of this type of conjoined twins in guinea pigs has not yet been fully explained.
Article
Virology
Keisuke Satoh, Keita Takahashi, Kazuma Noguchi, Yuhki Kobayashi, Ryuichi Majima, Yoshihiko Iwase, Keisuke Yamaguchi, Yukina Masuda, Tetsuo Koshizuka, Naoki Inoue
Summary: This study identified a second apoptosis inhibitor from guinea pig cytomegalovirus (GPCMV) that interacts with BAK, a Bcl-2 family proapoptotic protein. The findings suggest the potential development of BH3 mimetics that can regulate inhibition or induction of apoptosis based on short peptide molecules.
JOURNAL OF VIROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Miao Zhao, Xian Zou, Shenping Zhou, Jilong Liu, Chong Wang
Summary: In this study, the gene expression profiles of the receptive uterus in guinea pigs were analyzed and compared to the pre-receptive uterus. The results highlighted the importance of the inflammatory response in uterine receptivity and identified several hub genes involved in regulating endometrial receptivity. A cross-species comparison revealed that guinea pigs have a gene expression pattern of uterine receptivity more similar to humans than mice.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Veterinary Sciences
Navid Ahmadi, Nodir Saidov, Julia Clara Gausterer, Anne-Margarethe Kramer, Clemens Honeder, Christoph Arnoldner
Summary: Cisplatin, an effective antineoplastic agent used in cancer treatment, can cause progressive and irreversible hearing loss as a serious side effect. Animal models that mimic cisplatin-induced hearing loss are essential for the development of protective therapies. However, establishing such models is challenging due to the high toxicity of cisplatin. This manuscript introduces a detailed protocol for a guinea pig model that successfully induces permanent hearing loss with cisplatin, providing guidance for future model development and increasing reproducibility of results.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
Chuang Tang, Jideng Ma, Fanli Kong, Bo Li, Qinjiao Du, Yali Zhang, Haoming Wang, Qianzi Tang, Silu Hu, Lingyan Liu, Xuewei Li, Mingzhou Li
Summary: Previous studies have demonstrated functional differences between segments of the intestine as well as differences in the intestines between species. Guinea pigs are commonly used in intestinal research, so it is important to study their intestinal tract for the rational use of guinea pig models. In this study, we collected and analyzed the gene expression profiles and microbial composition of different segments of the intestine in guinea pigs. The results showed functional regionalization of the intestine, changes in gene expression between segments, an association between microbes and gene expression, and differences in gene expression between species. This study provides a reference for future intestinal research.
Article
Multidisciplinary Sciences
Dania Giaddui, Danielle S. Porreca, Ekta Tiwari, Nagat A. Frara, Lucas J. Hobson, Mary F. Barbe, Alan S. Braverman, Justin M. Brown, Michel A. Pontari, Michael R. Ruggieri Sr
Summary: This study aimed to identify potential lateralization of bladder function through electrical stimulation in female dogs. The results showed that innervation of the female dog bladder could be lateralized with similar rates of left-and right-sided dominance, which varied at different spinal cord levels within the same animal.
