Article
Cardiac & Cardiovascular Systems
Charles U. Solomon, David G. McVey, Catherine Andreadi, Peng Gong, Lenka Turner, Paulina J. Stanczyk, Sonja Khemiri, Julie C. Chamberlain, Wei Yang, Tom R. Webb, Christopher P. Nelson, Nilesh J. Samani, Shu Ye
Summary: This comprehensive analysis shows that a large percentage of CAD loci can modulate gene expression in VSMCs and influence VSMC behavior. Several candidate causal genes identified are likely to be druggable and thus represent potential therapeutic targets.
Article
Biochemistry & Molecular Biology
Fan Yang, Matthew J. Smith, Alexander Griffiths, Alexander Morrell, Sarah J. Chapple, Richard C. M. Siow, Theodora Stewart, Wolfgang Maret, Giovanni E. Mann
Summary: Zinc has various beneficial effects on human coronary artery smooth muscle cells, including antioxidant, anti-inflammatory, and anti-proliferative actions. The supplementation of zinc increases the total intracellular zinc content and enhances the NRF2 signaling pathway, providing protection against oxidative stress. These effects are more pronounced under high oxygen tension compared to normal oxygen conditions.
Article
Multidisciplinary Sciences
Hyun-Jung Kim, Paul Cheng, Stanislao Travisano, Chad Weldy, Joao P. Monteiro, Ramendra Kundu, Trieu Nguyen, Disha Sharma, Huitong Shi, Yi Lin, Boxiang Liu, Saptarsi Haldar, Simon Jackson, Thomas Quertermous
Summary: Genes encoding risk for coronary disease are crucial for developing new therapies. A particular gene, PDGFD, has been identified as a culprit gene and it promotes disease risk. Mechanistic studies confirm that rs2019090 and PDGFD represent the functional genetic variant and gene responsible for coronary artery disease. PDGFD mediates CAD risk by promoting deleterious phenotypic changes in smooth muscle cells and an inflammatory response primarily focused in the adventitia.
NATURE COMMUNICATIONS
(2023)
Review
Biochemistry & Molecular Biology
Kenichi Goto, Takanari Kitazono
Summary: Blood pressure is determined by cardiac output and systemic vascular resistance. The upregulation of Ca2+-activated Cl- channel TMEM16A and the increased activity of NKCC1 in hypertension can increase vascular contractility and elevate blood pressure.
Article
Physiology
Li Zhang, Xi-Xi Zeng, Yu-Mei Li, Shao-Kun Chen, Li-Yu Tang, Nan Wang, Xi Yang, Mo-Jun Lin
Summary: The study suggests that keratin 1 regulates PASMC expansion and has a preventive effect on PAH.
Article
Physiology
Julie M. M. Lade, Manuella R. R. Andrade, Clark Undem, Jasmine Walker, Haiyang Jiang, Xin Yun, Larissa A. A. Shimoda
Summary: Exposure to hypoxia leads to structural changes in pulmonary vascular wall, including hyperplasia and migration of pulmonary arterial smooth muscle cells (PASMCs). In this study, the interaction between ezrin and NHE1 was found to increase under hypoxic conditions, promoting SMA binding and enhancing PASMC migration and proliferation.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Run-Sheng Jiang, Li Zhang, Hui Yang, Meng-Yuan Zhou, Chun-Yu Deng, Wei Wu
Summary: The experiments showed that U46619 induced a concentration-dependent contraction in the coronary artery, which was completely blocked by a specific TXA2 receptor blocker, GR32191. Inhibitors of PI-PLC, Rho-Kinase, and Pan-PKC also were able to block the U46619-induced coronary artery contraction in a dose-dependent manner.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Wenwen Zhuang, Seo-Yeong Mun, Minju Park, Junsu Jeong, Hongzoo Park, Sunghun Na, Se Jin Lee, Won-Kyo Jung, Il-Whan Choi, Hongliang Li, Won Sun Park
Summary: Lurasidone, a second-generation antipsychotic drug, inhibits vascular Kv channels in a concentration- and use (state)-dependent manner by affecting the voltage sensors and the steady-state inactivation curve of the channels.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Mi Seon Seo, Jin Ryeol An, Hee Seok Jung, Minji Kang, Ryeon Heo, Eun-Taek Han, Se-Ran Yang, Hongzoo Park, Won-Kyo Jung, Il-Whan Choi, Young Min Bae, Sung Hun Na, Won Sun Park
Summary: Darifenacin inhibits Kv currents in rabbit coronary arteries, leading to vasocontraction and decreased coronary blood flow. This inhibition is concentration- and use-dependent and associated with the Kv1.5 subtype.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Christine Veith, Ipek Varturk-Ozcan, Magdalena Wujak, Stefan Hadzic, Cheng-Yu Wu, Fenja Knoepp, Simone Kraut, Aleksandar Petrovic, Marija Gredic, Oleg Pak, Monika Brosien, Marie Heimbrodt, Jochen Wilhelm, Friederike C. Weisel, Kathrin Malkmus, Katharina Schaefer, Henning Gall, Khodr Tello, Djuro Kosanovic, Akylbek Sydykov, Akpay Sarybaev, Andreas Guenther, Ralf P. Brandes, Werner Seeger, Friedrich Grimminger, Hossein A. Ghofrani, Ralph T. Schermuly, Grazyna Kwapiszewska, Natascha Sommer, Norbert Weissmann
Summary: This study provides evidence for the involvement of SPARC in the pathogenesis of human PH and chronic hypoxia-induced PH in mice, most likely by affecting vascular cell function.
Article
Medicine, Research & Experimental
Chuanlin Zhang, MeiJuan Xiao, Nan Cao, Lei Zhang, Qiong He, Jianing Wang, Rui Wang, Lu Wang, Lei Zhao, Junqiang Si
Summary: The study aimed to investigate the mechanical and electrophysiological effects of emodin on BK channels in rat interlobar renal artery smooth muscle cells (IRASMCs). The results showed that emodin induced vasorelaxation and enhanced outward currents in a concentration-dependent manner. These effects were mediated through the activation of BK channels.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Cardiac & Cardiovascular Systems
Rajkumar Dorajoo, Mario Octavianus Ihsan, Wenting Liu, Hwee Ying Lim, Veronique Angeli, Sung-Jin Park, Joyce M. S. Chan, Xiao Yun Lin, Mei Shan Ong, Umamaheswari Muniasamy, Rijan Gurung, Hee Hwa Ho, Roger Foo, Jianjun Liu, Theo Kofidis, Chuen Neng Lee, Vitaly A. Sorokin
Summary: The study found that IL1B plays a significant role in patients with low SYNTAX score (LSS) coronary artery disease and may influence the pathogenesis of the disease, providing a potential anti-inflammatory treatment option for this patient group.
Article
Biochemistry & Molecular Biology
Martin O. O. Sundqvist, Jonatan Warme, Robin Hofmann, Sven-Christian Pawelzik, Magnus Back
Summary: This study investigated the role of CagA in vascular calcification and found that CagA can induce calcification in coronary artery smooth muscle cells (CASMC) through upregulating bone morphogenic protein 2 (BMP-2) and induce a pro-inflammatory response. These findings suggest that H. pylori may contribute to vascular calcification through CagA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Jihui Lee, Hara Kang
Summary: Hypoxia-induced downregulation of the RNA-binding protein nucleolin (NCL) was found to regulate miRNA expression in pulmonary artery smooth muscle cells (PASMCs). The downregulation of miR-24-3p and miR-409-3p under hypoxic conditions promoted PASMC proliferation. These findings highlight the significance of NCL-miRNA interactions in hypoxia-induced vascular diseases and provide insights into potential therapeutic strategies involving RNA-binding proteins.
Article
Toxicology
Minji Kang, Jin Ryeol An, Hongliang Li, Wenwen Zhuang, Ryeon Heo, Seojin Park, Seo-Yeong Mun, Minju Park, Mi Seon Seo, Eun-Taek Han, Jin-Hee Han, Wanjoo Chun, Won Sun Park
Summary: This study investigated the impact of the acetylcholine muscarinic receptor inhibitor benztropine on Kv channels in rabbit coronary arterial smooth muscle cells. It was found that benztropine inhibited Kv currents in a concentration- and use (state)-dependent manner. The inhibition primarily involved the Kv1.5 subtype.
TOXICOLOGICAL SCIENCES
(2022)
Review
Biophysics
Olivier Mignen, Bruno Constantin, Marie Potier-Cartereau, Aubin Penna, Mathieu Gautier, Maxime Gueguinou, Yves Renaudineau, Kenji F. Shoji, Romain Felix, Elsa Bayet, Paul Buscaglia, Marjolaine Debant, Aurelie Chantome, Christophe Vandier
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2017)
Article
Oncology
Pierre Rybarczyk, Alison Vanlaeys, Bertrand Brassart, Isabelle Dhennin-Duthille, Denis Chatelain, Henri Sevestre, Halima Ouadid-Ahidouch, Mathieu Gautier
Article
Nutrition & Dietetics
Francesca Luongo, Giuseppe Pietropaolo, Mathieu Gautier, Isabelle Dhennin-Duthille, Halima Ouadid-Ahidouch, Federica I. Wolf, Valentina Trapani
Review
Oncology
Philippe Kischel, Alban Girault, Lise Rodat-Despoix, Mohamed Chamlali, Silviya Radoslavova, Hiba Abou Daya, Thibaut Lefebvre, Arthur Foulon, Pierre Rybarczyk, Frederic Hague, Isabelle Dhennin-Duthille, Mathieu Gautier, Halima Ouadid-Ahidouch
Editorial Material
Cell Biology
Mathieu Gautier, Mohamed Trebak, Andrea Fleig, Christophe Vandier, Halima Ouadid-Ahidouch
Article
Toxicology
Alison Vanlaeys, Gregory Fouquet, Philippe Kischel, Frederic Hague, Sylvie Pasco-Brassart, Thibaut Lefebvre, Pierre Rybarczyk, Isabelle Dhennin-Duthille, Bertrand Brassart, Halima Ouadid-Ahidouch, Mathieu Gautier
ARCHIVES OF TOXICOLOGY
(2020)
Editorial Material
Cell Biology
Mathieu Gautier, Mohamed Trebak, Andrea Fleig, Christophe Vandier, Halima Ouadid-Ahidouch
Article
Cell Biology
Thibaut Lefebvre, Pierre Rybarczyk, Clara Bretaudeau, Alison Vanlaeys, Remi Cousin, Sylvie Brassart-Pasco, Denis Chatelain, Isabelle Dhennin-Duthille, Halima Ouadid-Ahidouch, Bertrand Brassart, Mathieu Gautier
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2020)
Review
Nutrition & Dietetics
Julie Auwercx, Pierre Rybarczyk, Philippe Kischel, Isabelle Dhennin-Duthille, Denis Chatelain, Henri Sevestre, Isabelle Van Seuningen, Halima Ouadid-Ahidouch, Nicolas Jonckheere, Mathieu Gautier
Summary: This study investigates the expression of Mg2+ transporters in digestive cancers and their impact on patient survival. The findings suggest that these Mg2+ transporters may affect various cancer cell characteristics and play a crucial role in regulating cancer cell fates and oncogenic signaling pathways.
Article
Oncology
Silviya Radoslavova, Antoine Folcher, Thibaut Lefebvre, Kateryna Kondratska, Stephanie Guenin, Isabelle Dhennin-Duthille, Mathieu Gautier, Natalia Prevarskaya, Halima Ouadid-Ahidouch
Summary: This study investigated the role of the Orai1 Ca2+ channel in activated pancreatic stellate cells, revealing its involvement in cell proliferation and TGFβ1 secretion through the AKT signaling pathway. The findings suggest a TGFβ1-induced autocrine positive feedback loop that promotes proliferation through Orai1/AKT-dependent mechanisms.
Editorial Material
Cell Biology
Mathieu Gautier, Christophe Vandier
Article
Pharmacology & Pharmacy
Riadh Hmaidi, Ayoub Ksouri, Rahma Benabderrazek, Viviane Antonietti, Pascal Sonnet, Mathieu Gautier, Balkiss Bouhaouala-Zahar, Halima Ouadid-Ahidouch
Summary: Scorpion alpha-toxins, such as AahII, slow the fast inactivation mechanism of voltage-gated sodium channels and can have toxic effects on the nervous and cardiovascular systems. The anti-AahII nanobody, NbAahII10 (Nb10), has been found to effectively neutralize the effects of AahII by reversing the inactivation of Na(V)1.5 channels. Nb10 also prevents the enhancement of breast cancer cell invasion induced by AahII.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Julie Auwercx, Philippe Kischel, Thibaut Lefebvre, Nicolas Jonckheere, Alison Vanlaeys, Stephanie Guenin, Silviya Radoslavova, Isabelle Van Seuningen, Halima Ouadid-Ahidouch, Hemant M. Kocher, Isabelle Dhennin-Duthille, Mathieu Gautier
Summary: Pancreatic diseases are characterized by activated pancreatic stellate cells (PSCs), which play important roles in tumor stroma. TRPM7 channels have been found to regulate the activation and proliferation of PSCs, and the expression of TRPM7 is associated with the activation status of PSCs.
Article
Biochemistry & Molecular Biology
Marie Potier-Cartereau, Mathieu Gautier, Noemie Ravalet, Elfi Ducrocq, Sophie Hamard, Jean-Yves LeGuennec, Christophe Vandier, Olivier Herault
Summary: This study demonstrated the presence of sodium-calcium exchangers in AFT024 cells and the effect of KB-R7943 on the membrane potential of these stromal cells. This provides potential clues for the differentiation or hematopoietic support of MSCs.
Article
Oncology
Nicolas Jonckheere, Julie Auwercx, Elsa Hadj Bachir, Lucie Coppin, Nihad Boukrout, Audrey Vincent, Bernadette Neve, Mathieu Gautier, Victor Trevino, Isabelle Van Seuningen