Article
Clinical Neurology
Kate M. Perepezko, Joseph J. Gallo, Gregory M. Pontone, Jared T. Hinkle, Kelly A. Mills
Summary: We aimed to identify caregiver characteristics associated with the trajectory of quality of life (QoL) in Parkinson's disease (PD). We found that lower caregiver strain, better mobility, and better verbal fluency at baseline predicted membership in the favorable QOL class. Worse mobility and younger age predicted membership in the problematic QOL class. The novel finding of an association between caregiver strain and PD QOL trajectory suggests the importance of measuring and addressing caregiver strain in future research and practice.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Audiology & Speech-Language Pathology
Zulina Souza de Lira, Izabela Lara Leite de Lemos, Nathalia Suellen Valeriano Cardoso, Clarissa Evelyn Bandeira Paulino, Ana Claudia Carvalho Vieira, Jonia Alves Lucena, Adriana de Oliveira Camargo Gomes
Summary: This study verified the immediate effect of the Finger Kazoo technique associated with glissandos on the voice of individuals with Parkinson's disease. The results showed that the technique increased the voice range and maximum phonation time of the participants, and they reported satisfaction with the technique and its results.
Article
Psychiatry
Boheng Zhu, Robert Kohn, Amar Patel, Brian B. Koo, Elan D. Louis, John M. de Figueiredo
Summary: This research identified disruptions in health-related quality of life specific to demoralization in patients with Parkinson disease. The prevalence of demoralization in PD patients was 19%. Stigma and perceived difficulty with mobility were associated with demoralization and may indicate the need for psychotherapeutic and behavioral interventions.
PSYCHOTHERAPY AND PSYCHOSOMATICS
(2021)
Article
Physics, Applied
Zachary Engel, Keisuke Motoki, Christopher M. Matthews, W. Alan Doolittle
Summary: By controlling the surface chemistry and temporary metal doses, phase-pure, metal-rich epitaxy of ScAlN was achieved, showing improved structural and electrical characteristics. The catalytic effect of Sc in metal-rich conditions was observed, resulting in varied growth rates and introducing feedback stabilization of surface chemistry.
JOURNAL OF APPLIED PHYSICS
(2022)
Article
Clinical Neurology
Maarten Te Groen, Bastiaan R. Bloem, Samuel S. Wu, Bart Post
Summary: Compared to LOPD patients, YOPD patients had better quality of life, less caregiver strain, fewer falls, and better cognitive functioning after their first follow-up visit, and also a slower decline over time.
JOURNAL OF NEUROLOGY
(2021)
Review
Rehabilitation
Irene Battel, Irene Calvo, Margaret Walshe
Summary: The use of biofeedback in the treatment of dysphagia in patients with PD shows potential positive effects on swallowing-related quality of life. However, existing studies have low methodological quality and high risk of bias, future research should be rigorously designed to determine the optimal types, schedules, and timing of biofeedback treatment.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2021)
Review
Neurosciences
Na Zhao, Yuan Yang, Ling Zhang, Qinge Zhang, Lloyd Balbuena, Gabor S. Ungvari, Yu-Feng Zang, Yu-Tao Xiang
Summary: Studies have shown that Parkinson's disease patients have lower quality of life compared to healthy controls, especially in terms of physical function and mental health. Effective measures should be developed to improve the quality of life in this population, given the negative impact on daily life and functional outcomes.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Rehabilitation
Melike Kahya, Kelly E. Lyons, Rajesh Pahwa, Abiodun E. Akinwuntan, Jianghua He, Hannes Devos
Summary: The study investigated the reliability and validity of pupillary response during dual-task balance conditions in individuals with Parkinson disease (PD). The results showed excellent test-retest reliability and validity of pupillary response in PD patients and healthy controls during dual-task balance. Increased mental demand was significantly correlated with increased pupillary response in individuals with PD.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2021)
Article
Rehabilitation
Tobias Braun, Detlef Marks, Christian Thiel, Alexandra Menig, Christian Grueneberg
Summary: The study examined the measurement properties of the de Morton Mobility Index in hospital patients with Parkinson's disease, including structural validity, unidimensionality, construct validity, internal consistency reliability, and inter-rater reliability. The results showed that the index demonstrated unidimensionality, sufficient internal consistency reliability, and inter-rater reliability in Parkinson's disease patients, indicating good feasibility.
CLINICAL REHABILITATION
(2021)
Article
Rehabilitation
Cira Fundaro, Marco Gazzoni, Gian D. Pinna, Carlo Dallocchio, Alberto Rainoldi, Roberto Casale
Summary: The study aimed to assess if muscles in PD exhibit a different myoelectric fatigue pattern compared to healthy age-matched subjects. Results showed that parkinsonian muscles do not differ in developing peripheral myoelectric fatigue compared to healthy age-matched subjects.
EUROPEAN JOURNAL OF PHYSICAL AND REHABILITATION MEDICINE
(2021)
Article
Clinical Neurology
Connie Marras, Kelly A. Mills, Shirley Eberly, David Oakes, Kelvin L. Chou, Matthew Halverson, Sotirios A. Parashos, Christopher G. Tarolli, Jin-Shei Lai, Cindy J. Nowinsky, Oksana Suchowersky, Eric S. Farbman, Lisa M. Shulman, Tanya Simuni
Summary: The Neuro-QoL item banks showed limited utility as outcome measures in clinical trials for Parkinson's disease, indicating the need for more sensitive tools.
MOVEMENT DISORDERS
(2021)
Article
Rehabilitation
Valerie Shuman, Jennifer S. Brach, Jonathan F. Bean, Janet K. Freburger
Summary: The study aimed to determine the frequency of mobility limitation documentation during visits with older adults, as well as the patient, physician, and practice characteristics associated with such documentation. It was found that the documentation of mobility limitations is generally inadequate and primarily occurs when there are significant changes in function.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2023)
Article
Medicine, General & Internal
Seong-Min Choi, Soo Hyun Cho, Youngshik Choe, Byeong C. C. Kim
Summary: This study investigated the clinical determinants and impact of apathy on health-related quality of life in patients with early Parkinson disease (PD). Apathy was found to be an independent predictor of HRQoL, emphasizing the importance of identifying and managing apathy in patients with early PD.
Review
Clinical Neurology
Bradley McDaniels, Gregory M. Pontone, Soania Mathur, Indu Subramanian
Summary: This article discusses the issue of stigma faced by Parkinson's disease patients and highlights the negative impact of stigma on quality of life. The researchers present proactive practical suggestions to help patients effectively combat the negative effects of stigma.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Medicine, General & Internal
Qiaohong Wang, Yiping Chen, Linbo Li, Chao Li, Li Li, Huili Cao, Hui Yang
Summary: This study aimed to explore the barriers to home exercise for patients with Parkinson's disease (PwPDs) and provide guidelines for healthcare providers. The findings identified five themes including psychosomatic stress and low activity, lack of early rehabilitation authorisation, poor 'flow' state of home exercise, inaccessibility of continued service, and sociocultural impact on family coping. By addressing these challenges through multidisciplinary management, early rehabilitation authorisation, exercise experience, continuous service mode, and family coping strategies, the home exercise behavior of PwPDs can be gradually improved.
Article
Psychology, Clinical
Adrianna M. Ratajska, Francesca Lopez, Lauren Kenney, Charles Jacobson, Kelly D. Foote, Michael S. Okun, Dawn Bowers
Summary: The study identified three cognitive subtypes of ET patients undergoing DBS, with 27.4% meeting criteria for MCI. The majority of MCI cases were in the Low Executive or Low Memory Multi-Domain groups, with the latter having a higher percentage of members classified as MCI. Future work should focus on examining these subgroups for progression to dementia.
CLINICAL NEUROPSYCHOLOGIST
(2022)
Article
Education, Scientific Disciplines
P. Izbicki, E. L. Stegemoller, J. Compton, J. Thompson
Summary: The first year of college is crucial for students, especially those in STEM fields, as it is a time when many students leave due to disconnection from faculty and peers. The Freshman Research Initiative (FRI) has shown positive outcomes for student success and retention in STEM. This pilot study found that FRI not only increased social connectedness and assurance among students in a neurophysiology course, but also led to the majority of students being retained in STEM fields. Future studies will focus on gathering longitudinal data to further understand the reasons behind these positive outcomes.
CBE-LIFE SCIENCES EDUCATION
(2021)
Article
Neurosciences
Elizabeth L. Stegemoller, Andrew Zaman, Mack Shelley, Bhavana Patel, Ahmad El Kouzi, Elizabeth A. Shirtcliff
Summary: This study investigated the acute effects of group therapeutic singing on physiological and clinical motor symptoms in persons with Parkinson's disease. Results indicated that participants in the singing group reported feeling less sad after the session, with an increase in heart rate compared to the control group. This suggests that group therapeutic singing may be beneficial for persons with PD without causing undue stress.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Behavioral Sciences
Elizabeth L. Stegemoller, Thomas D. Ferguson, Andrew Zaman, Paul Hibbing, Patricia Izbicki, Olave E. Krigolson
Summary: This study used time-frequency analysis (wavelet) of EEG data to investigate differences in motor and auditory cortical activity when moving to music at different rates. Results showed little difference in cortical oscillations between moving to music versus a tone, but distinct responses were observed between different music styles and movement rates, especially at slower speeds. These findings suggest the importance of considering music style and movement rate in therapeutic applications aiming to improve motor performance.
BRAIN AND BEHAVIOR
(2021)
Article
Psychology, Multidisciplinary
Adrianna M. Ratajska, Anne N. Nisenzon, Francesca Lopez, Alexandra L. Clark, Didem Gokcay, Michael S. Okun, Dawn Bowers
Summary: The study found that patients with left-sided symptom onset in Parkinson's disease were slower to initiate anger and happiness facial expressions compared to patients with right-sided symptom onset and healthy controls.
Article
Neurosciences
Takashi Tsuboi, Yuki Satake, Keita Hiraga, Katsunori Yokoi, Makoto Hattori, Masashi Suzuki, Kazuhiro Hara, Adolfo Ramirez-Zamora, Michael S. Okun, Masahisa Katsuno
Summary: Selegiline, rasagiline, and safinamide, three MAO-BIs drugs, have different effects on the quality of life and non-motor symptoms of patients with Parkinson's disease. However, the understanding of these effects is still unclear and further high-quality studies are needed to verify them.
NPJ PARKINSONS DISEASE
(2022)
Article
Sport Sciences
D. E. Cash, T. M. Mendoza, M. E. Meier, E. L. Stegemoller
Summary: Previous literature has focused on the physiological effects of concussions, but there is limited research on the impact of concussion education on athletes' reporting tendencies and its effect on diagnosis and treatment. This study aimed to determine the effectiveness of preseason concussion education on athletes' likelihood and confidence in reporting concussions. The results showed that the concussion education significantly improved athletes' ability to recognize and report possible concussions, and this effect was maintained during the competition season.
Article
Psychology, Clinical
Adrianna M. Ratajska, Bonnie M. Scott, Francesca V. Lopez, Lauren E. Kenney, Kelly D. Foote, Michael S. Okun, Catherine Price, Dawn Bowers
Summary: This study compared the severity of mood symptoms in PD, ET, and HC groups and examined the relationship between mood and cognition. The results showed that both PD and ET groups reported more mood symptoms and lower cognitive scores compared to the HC group. The relationship between mood and cognition differed between PD and ET groups.
JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY
(2022)
Article
Clinical Neurology
Bonnie M. Scott, Robert S. Eisinger, Amtul-noor Rana, Jared F. Benge, Robin C. Hilsabeck, Michael S. Okun, Aysegul Gunduz, Dawn Bowers
Summary: Patients with both apathy and ICD exhibit significantly greater symptoms of positive and negative urgency, consummatory anhedonia, lack of premeditation and perseverance. Patients with apathy only showed significantly greater anticipatory anhedonia than those with ICD only or neither.
APPLIED NEUROPSYCHOLOGY-ADULT
(2022)
Article
Neurosciences
Bradley J. Wilkes, Emily R. Tobin, David J. Arpin, Wei-en Wang, Michael S. Okun, Michael S. Jaffee, Nikolaus R. McFarland, Daniel M. Corcos, David E. Vaillancourt
Summary: Objective measures of disease progression using the Purdue Pegboard Test (PPT) were conducted in patients with Parkinson's disease (PD), atypical Parkinsonism, and healthy controls. The decline in PPT performance in PD patients correlated with motor symptom progression, while no such decline was seen in controls. Neuroimaging measures from the basal ganglia were significant predictors of PPT performance in PD, and cortical, basal ganglia, and cerebellar regions were predictors for atypical Parkinsonism. Accelerometry in PD patients showed diminished acceleration range and irregular patterns, which correlated with PPT scores.
NPJ PARKINSONS DISEASE
(2023)
Article
Clinical Neurology
Robert S. Eisinger, Michael S. Okun, Stephanie Cernera, Jackson Cagle, Matthew Beke, Adolfo Ramirez-Zamora, B. Hope Kim, Daniel A. N. Barbosa, Liming Qiu, Pavan Vaswani, Whitley W. Aamodt, Casey H. Halpern, Kelly D. Foote, Aysegul Gunduz, Leonardo Almeida
Summary: Weight loss in Parkinson's disease patients accelerates before death. Patients who underwent deep brain stimulation surgery gained weight, and higher post-operative weight correlates with longer survival.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Music
Patricia Izbicki, Courtney Elkin, Emma Gettes, Ella Gustafson, Allison Meyer, Molly Norman, Elizabeth L. Stegemoller
Summary: This study analyzed the effect of listening to music on cognitive inhibition in healthy young and older adults. The results showed that older adults were slower and more accurate than young adults in terms of accuracy and reaction time, regardless of the music condition.
Article
Clinical Neurology
Elizabeth Stegemoller, Emily Forsyth, Bhavana Patel, Ahmad Elkouzi
Summary: Group therapeutic singing (GTS) may have a positive effect on motor symptoms in persons with Parkinson's disease (PD), especially in terms of gait, posture, and tremor.
BMJ NEUROLOGY OPEN
(2022)
Article
Clinical Neurology
Yoon Jin Choi, Basma Yacoubi, Agostina Casamento-Moran, Stefan Delmas, Bradley J. Wilkes, Christopher W. Hess, Aparna Wagle Shukla, Kelly D. Foote, David E. Vaillancourt, Michael S. Okun, Evangelos A. Christou
Summary: The study found that VIM DBS was effective in improving gait and balance in ET DBS patients. The improvements in gait and postural balance were associated with a reduction in axial tremor during the tasks.
TREMOR AND OTHER HYPERKINETIC MOVEMENTS
(2022)
Meeting Abstract
Clinical Neurology
E. L. Stegemoller, K. Diaz, M. L. Kohut
MOVEMENT DISORDERS
(2022)
