Journal
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
Volume 100, Issue 2, Pages 187-192Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.pestbp.2011.03.009
Keywords
Garlic; Lindane; Testes; Oxidative stress; Brain
Categories
Funding
- Laboratory of Physiology, Faculty of Sciences at Sfax
- department of Biology, Faculty of Sciences at Gafsa
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The purpose of this study, carried out on male Wistar rats, was to evaluate the beneficial effects of garlic (Allium sativum) extract injections upon lindane-induced damages in testes, brain and thyroid function. Under our experimental conditions, lindane poisoning (in drinking water for 30 days, supplying about 50 mg/kg body weight per day) resulted in a decreased weight of testes, epididymides, prostate gland and seminal vesicles (-52%, -42%, -50% and -5%, respectively), a decrease of spermatozoa count and motility (-56%, -37%, respectively), an increased level of free thyroxin (+84%) and decreased levels of TSH and FSH in serum (-74%, -77%, respectively). In addition, lindane treatment triggered an oxidative stress in testes and brain as revealed by an increased level of lipids peroxidation (TBARS) (+96%,+92%), an increase of superoxide-dismutase activity in testes (+69%) and a decrease of glutathione-peroxidase and catalase activities in testes and brain (-52%, -34% and -49%, -45%, respectively). These lindane-induced changes were almost reversed to normal in animals injected with a garlic extract (an amount corresponding to 300 mg fresh garlic/kg/day), what confirms a beneficial effect of this vegetal source of antioxidants. (C) 2011 Elsevier Inc. All rights reserved.
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