Article
Endocrinology & Metabolism
Hitomi Tsuchida, Narumi Kawai, Koki Yamada, Marina Takizawa, Naoko Inoue, Yoshihisa Uenoyama, Hiroko Tsukamura
Summary: Energetic status can impact reproductive function, glucose homeostasis, and feeding in mammals. Central beta-endorphin-MOR signaling may play a role in suppressing pulsatile LH release and increasing gluconeogenesis/feeding during malnutrition.
Article
Neurosciences
Naoko Inoue, Safiullah Hazim, Hitomi Tsuchida, Yuri Dohi, Ren Ishigaki, Ai Takahashi, Yuki Otsuka, Koki Yamada, Yoshihisa Uenoyama, Hiroko Tsukamura
Summary: Ovulation in female rodents is triggered by ATP-purinergic signaling, which activates kisspeptin neurons in the AVPV. The administration of an ATP receptor antagonist blocks the LH surge and reduces ovulation rate. ATP also increases intracellular Ca2+ levels in kisspeptin neurons, indicating its role in mediating ovulation.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Chemistry, Medicinal
Liang Ye, Yifei yang, Chunmei Li, Jianzhao Zhang, Wenyan Wang, Mingxu Ma, Hengwei Xu, Wenjing Zhang, Fangxia Zou, Zhengping Hu, Hongbo Wang, Jingwei Tian
Summary: The study found that pharmacological blockade of neurokinin B (NKB) signaling with an oral NK3R antagonist significantly improved hot flash symptoms, suggesting NK3R as a viable drug target. A series of novel imidazolepiperazine derivatives were designed and synthesized, among which compound 16x showed promising inhibitory activity against NK3R. In vivo studies demonstrated that 16x was orally active, efficacious, and well-tolerated in a specific model, indicating its potential for further development.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Cheng-Yung Lin, Hsiang-Chien Tseng, Yu-Rong Chu, Chia-Lun Wu, Po-Hsiang Zhang, Huai-Jen Tsai
Summary: Pgk1 promotes the survival of dopamine-producing cells and improves locomotion, and its effects are time- and dose-dependent, independent of the energy-supplying function of intracellular Pgk1.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Chenhao Li, Yang Li, Wenwen Zhang, Zhenjie Ma, Shaobo Xiao, Wei Xie, Shuai Miao, Bozhi Li, Guangshuang Lu, Yingyuan Liu, Wenhao Bai, Shengyuan Yu
Summary: Clinical imaging studies have shown that the hypothalamus is activated in migraine patients before and during headache, and has increased functional connectivity with the spinal trigeminal nucleus. The dopaminergic system in the hypothalamus, particularly the A11 nucleus, may play a crucial role in the pathogenesis of migraine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agriculture, Dairy & Animal Science
Hitomi Tsuchida, Marina Takizawa, Miku Nonogaki, Naoko Inoue, Yoshihisa Uenoyama, Hiroko Tsukamura
Summary: Gonadal function is often suppressed during lactation, and kisspeptin neurons in the ARC play a critical role in this process. This study examined the role of central enkephalin-d-opioid receptor signaling in the suppression of LH release in lactating rats. The results suggest that central DOR signaling mediates the suppression of LH release induced by suckling stimuli in lactating rats, potentially through inhibition of ARC kisspeptin neurons.
JOURNAL OF REPRODUCTION AND DEVELOPMENT
(2023)
Article
Multidisciplinary Sciences
Stephanie Constantin, Daniel Reynolds, Andrew Oh, Katherine Pizano, Susan Wray
Summary: Researchers have found that the long-lasting impact of KP on GnRH neurons is regulated by the interaction with nitric oxide signaling, which affects the activity of GnRH neurons and their pulse generation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Endocrinology & Metabolism
Bin Wang, Kaijie Wang, Zhenfang Tian, Aijun Cui, Xin Liu, Zhixin Jin, Xuezhou Liu, Yan Jiang, Yongjiang Xu
Summary: This study evaluated the effects of endogenous SPX2 peptide on the expression levels of key reproductive genes in the brain-pituitary axis of half-smooth tongue sole. The results showed that SPX2 has inhibitory effects and can induce an increase in pituitary fsh beta expression.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Developmental Biology
Marcella Birtele, Petter Storm, Yogita Sharma, Janko Kajtez, Jenny Nelander Wahlestedt, Edoardo Sozzi, Fredrik Nilsson, Simon Stott, Xiaoling L. He, Bengt Mattsson, Daniella Rylander Ottosson, Roger A. Barker, Alessandro Fiorenzano, Malin Parmar
Summary: This study used single-cell RNA sequencing to analyze the transcriptional profile of human fetal VM during the generation and differentiation of dopamine neurons, revealing that 3D culture conditions are superior to monolayer conditions. These findings can guide stem cell-based therapies and disease modeling in Parkinson's disease.
Article
Endocrinology & Metabolism
Frederick Wasinski, Fernanda M. Chaves, Joao A. B. Pedroso, Naira S. Mansano, Joao Paulo Camporez, Daniela O. Gusmao, Edward O. List, John J. Kopchick, Renata Frazao, Raphael E. Szawka, Jose Donato
Summary: Deletion of GHR in DAT- or TH-expressing cells does not affect various physiological aspects in male and female mice, but impairs restraint stress-induced prolactin release in male mice, suggesting sex differences in the regulation of GHR signaling on prolactin secretion. The mechanism behind this regulation requires further investigation.
JOURNAL OF NEUROENDOCRINOLOGY
(2021)
Article
Fisheries
Bin Wang, Kaijie Wang, Aijun Cui, Weixin Wang, Lu Fang, Yongjiang Xu, Yan Jiang, Xuezhou Liu
Summary: The study analyzed the effects of piscine GnIH ortholog LPXRFa peptides on the expression of reproduction-related genes in the brain of yellowtail kingfish, revealing inhibitory effects on multiple gene expressions. This suggests that these peptides may have negative impacts on the reproductive system of yellowtail kingfish.
Article
Agriculture, Dairy & Animal Science
Hira Zubair, Muhammad Saqib, Muhammad Noman Khan, Shazia Shamas, Shahzad Irfan, Muhammad Shahab
Summary: This study examined the developmental changes in the GnIH neuronal system and its relationship with GnRH and Kiss1 gene expression during puberty. The findings suggest that GnIH plays a role in the prepubertal suppression of the reproductive axis and may be a potential target for the development of therapeutics and contraceptives for humans. Further research is needed to fully understand the mechanisms underlying these findings.
Article
Endocrinology & Metabolism
Siew Hoong Yip, Pauline Campos, Xinhuai Liu, Robert Porteous, Allan E. Herbison
Summary: Studies in mice have shown that GnRH neurons extend dendron-like projections to the median eminence and respond to kisspeptin, indicating a potential dendron-like arrangement in rats as well.
Review
Cell Biology
Eun Bee Lee, Iman Dilower, Courtney A. Marsh, Michael W. Wolfe, Saeed Masumi, Sameer Upadhyaya, Mohammad A. Karim Rumi
Summary: Kisspeptin (KP) and kisspeptin receptor (KPR) play essential roles in the development and function of gonads. There is sexual dimorphism in the expression and function of KP and KPR in the hypothalamus and other tissues. Gonadal hormones regulate KP neurons and affect reproductive function through pulsatile gonadotropin secretion. KP and KPR are also expressed in extrahypothalamic tissues. While the sexual dimorphism of hypothalamic KP is well characterized, little is known about extrahypothalamic KP.
Review
Cell Biology
Virginia Delli, Mauro S. B. Silva, Vincent Prevot, Konstantina Chachlaki
Summary: Kisspeptin and nitric oxide play opposing roles in regulating GnRH secretion, with kisspeptin promoting release and NO inhibiting secretion, creating a dynamic interplay that is fine-tuned by the gonadal steroid environment.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)