Review
Plant Sciences
Maike Cosse, Thorsten Seidel
Summary: This article discusses the main proton pumps in plant cells and their role in regulating cytosolic pH, emphasizing the coordination of pump activity through 14-3-3 proteins, phosphorylation events, ion concentrations, and redox conditions to maintain cellular homeostasis.
FRONTIERS IN PLANT SCIENCE
(2021)
Review
Agriculture, Dairy & Animal Science
Marta Borobia, Sergio Villanueva-Saz, Marta Ruiz de Arcaute, Antonio Fernandez, Maria Teresa Verde, Jose Maria Gonzalez, Teresa Navarro, Alfredo A. Benito, Jose Luis Arnal, Marcelo De las Heras, Aurora Ortin
Summary: Sheep are highly susceptible to copper intoxication, which is a deadly disease causing significant economic losses worldwide. Depending on the duration of exposure, two types of copper poisoning can occur in sheep. Chronic toxicosis is the most common form and develops after a long subclinical period of copper accumulation in the liver. Acute copper poisoning, although less frequent, results from accidental administration or ingestion of toxic amounts of copper.
Article
Ophthalmology
Marina Yasvoina, Qian Yang, Sasha M. Woods, Tjebo Heeren, Grant M. Comer, Catherine A. Egan, Marcus Fruttiger
Summary: This study found that RPE cells invading the retina in retinal degenerative diseases undergo dedifferentiation and can be pigmented or unpigmented. As a result, the number of these cells may be underestimated through funduscopy.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Neurosciences
Iori Ohmori, Mamoru Ouchida, Hirohiko Imai, Saeko Ishida, Shinya Toyokuni, Tomoji Mashimo
Summary: Thioredoxin plays a critical role in reducing oxidative stress in the central nervous system (CNS). Mutations in the Txn1 gene were found to be associated with CNS degeneration and decreased insulin activity. Txn1 was shown to be involved in regulating oxidative stress in the midbrain with high energy metabolism, and neuronal death was observed in mutant rats.
NEUROBIOLOGY OF DISEASE
(2022)
Review
Biochemistry & Molecular Biology
Karolina Wleklik, Slawomir Borek
Summary: Vacuolar processing enzymes (VPEs) are plant cysteine proteases that are activated at an acidic pH and play a role in controlling tonoplast rupture during programmed cell death (PCD). VPEs are also involved in various types of plant PCD related to development, senescence, and environmental stress responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Sonja Michele Schmidtpott, Thorsten Seidel
Summary: This study presents a simple and reliable protocol for FRET measurements, including procedures for protein expression estimation and adjustment of laser and detector settings. Data evaluation will be conducted through calibration with a fluorescent fusion protein of known FRET efficiency.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Review
Immunology
Kristina Ritter, Jasmin Rousseau, Christoph Hoelscher
Summary: This review discusses the importance of cytokine IL-27 in tuberculosis (TB) for protective inflammatory immune responses and the pathological sequelae of chronic inflammation. The timely restricted blockade of IL-27 signalling may promote better control of Mycobacterium tuberculosis (Mtb) infection but also lead to chronic hyperinflammation and immunopathology. IL-27 administration may be a potential treatment option for the immunopathological consequences of chronic TB.
FRONTIERS IN IMMUNOLOGY
(2022)
Editorial Material
Plant Sciences
Wim Van den Ende
Summary: Researchers have discovered a novel fructan 1-exohydrolase (1-FEH) in onions, which belongs to the vacuolar invertase subgroup and suggests that plant fructan exohydrolases could have originated from different ancestral invertases. This finding will contribute to further understanding the evolution and functions of plant FEHs in fructan-accumulating and non-fructan-accumulating plants.
JOURNAL OF EXPERIMENTAL BOTANY
(2022)
Article
Biology
Aleksandra Wilk, Dagmara Szypulska-Koziarska, Dorota Oszutowska-Mazurek, Alexander Baraniskin, Joanna Kabat-Koperska, Przemyslaw Mazurek, Barbara Wiszniewska
Summary: Immunosuppressive drugs used for transplant recipients have both advantages in prolonging graft function and adverse effects on liver morphology and function. This study compared the effects of prenatal exposure to different immunosuppressants on vacuolar degeneration in rat livers. The results showed that tacrolimus, mycophenolate mofetil, glucocorticoids, cyclosporine A, and everolimus with glucocorticoids had the highest incidence and severity of vacuolar degeneration in hepatocytes. This study provides valuable insights into the influence of multidrug immunosuppression on hepatic tissue in offspring.
Article
Clinical Neurology
Marta Jorge-Oliva, Jasper F. M. Smits, Vera I. Wiersma, Jeroen J. M. Hoozemans, Wiep Scheper
Summary: This study investigates the connection between pathological protein accumulations and GVBs in neurons. The researchers found that GVBs are closely associated with cytosolic pathological tau in tauopathy, but can also be present in the absence of cytosolic tau accumulation in Parkinson's disease. GVBs in both tauopathy and alpha-synuclein pathology show similar immunoreactivity for phosphorylated tau epitopes, suggesting a common mechanism. The emergence of GVBs is identified as a generalized response to cytosolic protein pathology.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Clinical Neurology
Lucia A. A. Giannini, Daniel T. Ohm, Annemieke J. M. Rozemuller, Laynie Dratch, EunRan Suh, Vivianna M. van Deerlin, John Q. Trojanowski, Edward B. Lee, John C. van Swieten, Murray Grossman, Harro Seelaar, David J. Irwin
Summary: FTLD-MAPT cases with different tau isoform groups show distinctive features of tau burden and neuronal degeneration, but all exhibit pronounced anterior temporal neuronal degeneration. These data suggest that genetic tauopathies with distinct isoform-related mechanisms may share similar regional vulnerability to neurodegeneration within the frontotemporal paralimbic networks.
ACTA NEUROPATHOLOGICA
(2022)
Editorial Material
Cell Biology
Meng Yang, Yan Wang, Dawei Li, Yule Liu
Summary: This article discusses how plant viruses promote infection by interfering with vacuolar acidification and the degradation of autophagic bodies.
Article
Plant Sciences
Junzhe Wang, Xiaolong Guo, Qiang Xiao, Jianchu Zhu, Alice Y. Cheung, Li Yuan, Elizabeth Vierling, Shengbao Xu
Summary: The nucellus tissue plays a crucial role in plant reproduction by influencing the degeneration of the nucellus and the expansion of the female gametophyte through the regulation of auxin. Auxin efflux is essential for controlling the precise distribution of auxin around the nucellus and the female gametophyte. Maternal tissues control auxin concentration and efflux, serving as a key communication between maternal and filial tissues during development.
Review
Agriculture, Dairy & Animal Science
Snorre Stuen, Cecilie Ersdal
Summary: Fasciolosis caused by Fasciola hepatica is a serious disease and a huge challenge in the sheep industry. Climate change and increasing drug resistance have made the control of fasciolosis difficult. However, with diagnostic improvements, targeted treatment and vaccine development, there is hope for improving animal health and welfare in fluke-infested pastures.
Article
Biochemistry & Molecular Biology
Viktor A. Anashkin, Alexander A. Baykov
Summary: The study revealed that membrane-integral inorganic pyrophosphatases exhibit structural symmetry, but asymmetry increased upon substrate binding, opening water channel exit. This asymmetrical change may have a regulatory function in the vacuole.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Veterinary Sciences
Luis Armando C. Brust, Ana Paula Aragao, Pedro S. Bezerra, Alexandre Galvao, Ticiana N. Franca, Flavio A. S. Graca, Paulo V. Peixoto
PESQUISA VETERINARIA BRASILEIRA
(2015)
Article
Veterinary Sciences
Andre M. Santos, Paulo V. Peixoto, Mariana S. D'Avila, Tiago C. Peixoto, Ticiana N. Franca, Samay Z. R. Costa, Gabriela C. Cid, Vivian A. Nogueira
PESQUISA VETERINARIA BRASILEIRA
(2016)
Article
Veterinary Sciences
Samay Z. R. Costa, Paulo V. Peixoto, Luiz Armando C. Brust, Mariana S. d'Avila, Andre M. Santos, David Driemeier, Vivian de A. Nogueira, Ticiana N. Franca
PESQUISA VETERINARIA BRASILEIRA
(2016)
Article
Veterinary Sciences
Ileana C. Miranda, Gabriela Riet-Correa, Carlos A. Oliveira Junior, Beatriz Riet-Correa, Paulo V. Peixoto, Samay Z. R. Costa, Mariana S. d'Avila, Gabriela C. Cid, Ticiana N. Franca
PESQUISA VETERINARIA BRASILEIRA
(2016)
Article
Veterinary Sciences
Saulo A. Caldas, Gabriela C. Cid, Vivian A. Nogueira, Ticiana N. Franca, Flavio A. S. Graca, Gabriel A. Dutra, Julio C. F. Jacob, Paulo V. Peixoto
PESQUISA VETERINARIA BRASILEIRA
(2016)
Article
Veterinary Sciences
Andre M. Santos, Paulo V. Peixoto, Mariana S. D'Avila, Tiago C. Peixoto, Ticiana N. Franca, Samay Z. R. Costa, Gabriela C. Cid, Vivian A. Nogueira
PESQUISA VETERINARIA BRASILEIRA
(2016)
Article
Veterinary Sciences
Samay Z. R. Costa, Paulo V. Peixoto, Luiz Armando C. Brust, Mariana S. d'Avila, Andre M. Santos, David Driemeier, Vivian de A. Nogueira, Ticiana N. Franca
PESQUISA VETERINARIA BRASILEIRA
(2016)
Article
Veterinary Sciences
Ileana C. Miranda, Gabriela Riet-Correa, Carlos A. Oliveira Junior, Beatriz Riet-Correa, Paulo V. Peixoto, Samay Z. R. Costa, Mariana S. d'Avila, Gabriela C. Cid, Ticiana N. Franca
PESQUISA VETERINARIA BRASILEIRA
(2016)
Article
Veterinary Sciences
Saulo A. Caldas, Gabriela C. Cid, Vivian A. Nogueira, Ticiana N. Franca, Flavio A. S. Graca, Gabriel A. Dutra, Julio C. F. Jacob, Paulo V. Peixoto
PESQUISA VETERINARIA BRASILEIRA
(2016)
Article
Veterinary Sciences
Mariana B. Mascarenhas, Paulo V. Peixoto, Regina R. Ramadinha, Anibal G. Armien, Samay Z. Costa, Ileana C. Miranda, Vivian A. Nogueira, Ticiana N. Franca
PESQUISA VETERINARIA BRASILEIRA
(2017)
Article
Veterinary Sciences
Paulo V. Peixoto, Krishna D. Oliveira, Ticiana N. Franca, David Driemeier, Marcos D. Duarte, Pedro S. Bezerra, Valiria D. Cerqueira, Anibal G. Armien
PESQUISA VETERINARIA BRASILEIRA
(2017)
Article
Veterinary Sciences
Mariana B. Mascarenhas, Paulo V. Peixoto, Regina R. Ramadinha, Anibal G. Armien, Samay Z. Costa, Ileana C. Miranda, Vivian A. Nogueira, Ticiana N. Franca
PESQUISA VETERINARIA BRASILEIRA
(2017)
Article
Veterinary Sciences
Paulo V. Peixoto, Krishna D. Oliveira, Ticiana N. Franca, David Driemeier, Marcos D. Duarte, Pedro S. Bezerra, Valiria D. Cerqueira, Anibal G. Armien
PESQUISA VETERINARIA BRASILEIRA
(2017)
Article
Veterinary Sciences
Juliana F. Rocha, Bartolomeu B. N. Santos, Alexandre Galvao, Tayson O. Marques, Leonardo R. L. Silva, Ticiana N. Franca, Paulo V. Peixoto
Summary: The occurrence of enzootic hematuria in buffaloes in Brazil caused by ingestion of bracken fern has been reported. This is the first report of this disease in buffaloes in Brazil. The disease has a significant economic impact on the buffalo industry in Brazil. Initial observations indicated that buffaloes are less sensitive to the toxic principle of bracken fern compared to cattle, but cases of hematuria in buffaloes have been reported.
PESQUISA VETERINARIA BRASILEIRA
(2022)
Article
Veterinary Sciences
Bruno L. Anjos, Paulo V. Peixoto, Flavio A. S. Graca, Saulo A. Caldas, Daniel Bhaltazar, Ticiana N. Franca, Anibal G. Armien
JOURNAL OF ZOO AND WILDLIFE MEDICINE
(2016)