Article
Neurosciences
Alexandre Caux-Dedeystere, Etienne Allart, Pierre Morel, Alexandre Kreisler, Philippe Derambure, Herve Devanne
Summary: In patients with writer's cramp (WC), alterations in GABAergic inhibitory mechanisms result in longer duration of LICI and delayed LCD, affecting the activity of primary motor cortex inhibitory and excitatory circuits controlling hand muscles. This study highlights the impact of these changes on involuntary muscle contractions while writing and the potential therapeutic targets for WC.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Review
Clinical Neurology
Wen-Juan Fang, Fei Zheng, Lin-Zhi Zhang, Wen-Hui Wang, Cheng-Chen Yu, Juan Shao, Yi-Jin Wu
Summary: This article reviews the effects of current main clinical treatment methods and nutritional interventions on the treatment and rehabilitation of post-stroke dysphagia patients. It emphasizes the importance of developing an individualized care plan for these patients.
NEUROLOGICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Shane M. Fresnoza, Giorgi Batsikadze, Lynn Elena Mueller, Constanze Rost, Michael Chamoun, Walter Paulus, Min-Fang Kuo, Michael A. Nitsche
Summary: Dopamine plays a crucial role in neuroplasticity and has dosage-dependent effects on motor cortex plasticity. Different dosages of dopamine precursor such as L-DOPA can either impair, abolish, preserve, or reverse plasticity in healthy individuals. Similarly, selective D1-like and D2-like receptor activation has excitatory and inhibitory effects on plasticity. However, the effects of nonselective dopamine agonists like apomorphine on plasticity have not been extensively explored in humans.
Review
Clinical Neurology
Jordan Morrison-Ham, Gillian M. Clark, Elizabeth G. Ellis, Andris Cerins, Juho Joutsa, Peter G. Enticott, Daniel T. Corp
Summary: This study evaluated the effects of non-invasive brain stimulation (NIBS) on dystonia symptoms through a meta-analysis. The results showed that NIBS had a small effect in reducing dystonia symptoms, with effect sizes depending on methodological characteristics. More sessions of stimulation resulted in a larger response.
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
(2022)
Article
Neurosciences
Zonghao Xin, Akihiro Kuwahata, Shuang Liu, Masaki Sekino
Summary: The integration of temporal interference stimulation and magnetic stimulation in a four-coil configuration was shown to stimulate deeper brain regions while maintaining a relatively narrow spread of the electric field. Controlling the geometry of the coil array allowed for adjustment of the relationship between field depth and focality.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Neurosciences
Xiao-Hua Zhang, Ping Han, Yuan-Yuan Zeng, Yu-Long Wang, Hui-Lan Lv
Summary: The study showed that combining repetitive transcranial magnetic stimulation (rTMS) with conventional rehabilitation significantly assists in the recovery of consciousness in patients in a persistent vegetative state (PVS).
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Clinical Neurology
Jodi D. Edwards, Adan Ulises Dominguez-Vargas, Charlotte Rosso, Meret Branscheidt, Lisa Sheehy, Fanny Quandt, Simon A. Zamora, Melanie K. Fleming, Valentina Azzollini, Ronan A. Mooney, Charlotte J. Stagg, Chiristian Gerloff, Simone Rossi, Leonardo G. Cohen, Pablo Celnik, Michael A. Nitsche, Cathrin M. Buetefisch, Numa Dancause
Summary: The purpose of this study was to address the translation barriers in stroke rehabilitation research using non-invasive brain stimulation techniques, and to provide consensus recommendations to overcome these barriers. The study identified five key barriers and formulated five core consensus recommendations, including increased understanding of NIBS mechanisms, improved methodological rigor, standardization of outcome measures, increased clinical relevance in preclinical animal models, and optimization and individualization of NIBS protocols.
NEUROREHABILITATION AND NEURAL REPAIR
(2023)
Article
Clinical Neurology
Anna Latorre, Lorenzo Rocchi, Amit Batla, Alfredo Berardelli, John C. Rothwell, Kailash P. Bhatia
Summary: The study found that primary writing tremor and dystonic tremor syndrome share similar patterns of electrophysiological abnormalities, supporting the hypothesis of a common pathophysiology between them.
MOVEMENT DISORDERS
(2021)
Review
Rehabilitation
Ellen E. R. Williams, Sabrina Sghirripa, Nigel C. Rogasch, Brenton Hordacre, Stacie Attrill
Summary: This review summarized the existing literature on non-invasive brain stimulation (NIBS) as a treatment for post-stroke aphasia and provided recommendations for future research. Quantitative analysis showed that ipsilesional anodal transcranial direct current stimulation and contralesional 1-Hz repetitive transcranial magnetic stimulation were the most commonly used forms of NIBS. Qualitative analysis revealed four key themes. The results highlighted systemic challenges in the field.
DISABILITY AND REHABILITATION
(2023)
Review
Immunology
Rongjun Sheng, Changchun Chen, Huan Chen, Peipei Yu
Summary: Stroke is a major cause of death and disability globally, and survivors often experience various dysfunctions. Repetitive transcranial magnetic stimulation (rTMS), as a noninvasive brain stimulation technique, has been shown to have positive effects on the recovery of motor, sensory, and cognitive functions in stroke patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Neurosciences
Jing Luo, Yuan Feng, Mingyue Li, Mingyu Yin, Feng Qin, Xiquan Hu
Summary: The study shows that long-term rTMS stimulation can promote neurogenesis, inhibit apoptosis, and control inflammation. rTMS modulates microglia with anti-inflammatory polarization variation and improves neural function recovery. It may be a promising therapeutic approach for ischemic stroke.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Clinical Neurology
Freek Nieuwhof, Ivan Toni, Arthur W. G. Buijink, Bart P. C. van de Warrenburg, Rick C. Helmich
Summary: This study aimed to investigate the causal role of the cerebellum and motor cortex in dystonic tremor syndromes and explore the therapeutic efficacy of phase-locked transcranial alternating current stimulation (TACS). The findings show that the cerebellum plays a causal role in the generation of (non-jerky) dystonic tremor syndrome, and tremor phenotype may guide optimal intervention targets.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Clinical Neurology
Giovanni Fabbrini, Antonella Conte, Gina Ferrazzano, Marcello Esposito, Alberto Albanese, Roberta Pellicciari, Francesca Di Biasio, Francesco Bono, Roberto Eleopra, Tommaso Ercoli, Maria Concetta Altavista, Alfredo Berardelli, Giovanni Defazio
Summary: Italian neurologists tend to use MRI to assist in the diagnosis of idiopathic adult-onset focal dystonia, especially in patients with cervical dystonia, spasmodic dysphonia, or non-task-specific upper limb dystonia. However, MRI may be less likely to be used in patients with blepharospasm or task-specific upper limb dystonia.
NEUROLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Renata Proa, Joana Balardin, Danilo D. de Faria, Artur M. Paulo, Joao R. Sato, Carlos A. Baltazar, Vanderci Borges, Sonia M. C. Azevedo Silva, Henrique B. Ferraz, Patricia de Carvalho Aguiar
Summary: Using fNIRS, this study compared cortical brain activation between patients with focal upper-limb dystonia and controls during a writing task under naturalistic conditions. The results suggest that patients with dystonia exhibit increased activation in contralateral M1 and S1 cortices, as well as ipsilateral M1 cortex, indicating reduced specificity of task-related cortical areas.
NEUROREHABILITATION AND NEURAL REPAIR
(2021)
Review
Neurosciences
Shoogo Ueno, Masaki Sekino
Summary: This article reviews the evolution and recent developments of transcranial magnetic brain stimulation using figure-eight coils, discussing their geometric variations, characteristics, and applications in neuroscience and medicine. Recent topics such as focality, tradeoff between depth and focality, and approaches for extending depth are also explored.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Letter
Clinical Neurology
Teresa J. Kimberley, Jesse Dawson
Review
Neurosciences
Navzer D. Engineer, Teresa J. Kimberley, Cecilia N. Prudente, Jesse Dawson, W. Brent Tarver, Seth A. Hays
FRONTIERS IN NEUROSCIENCE
(2019)
Article
Multidisciplinary Sciences
David Alexander Dickie, Teresa Jacobson Kimberley, David Pierce, Navzer Engineer, W. Brent Tarver, Jesse Dawson
SCIENTIFIC REPORTS
(2019)
Article
Clinical Neurology
Mo Chen, Rebekah L. S. Summers, Cecilia N. Prudente, George S. Goding, Sharyl Samargia-Grivette, Christy L. Ludlow, Teresa J. Kimberley
Article
Clinical Neurology
Rebekah L. S. Summers, Mo Chen, Colum D. MacKinnon, Teresa J. Kimberley
CLINICAL NEUROPHYSIOLOGY
(2020)
Review
Clinical Neurology
Mitchell G. Miglis, Charles H. Adler, Elena Antelmi, Dario Arnaldi, Luca Baldelli, Bradley F. Boeve, Matteo Cesari, Irene Dall'Antonia, Nico J. Diederich, Kathrin Doppler, Petr Dusek, Raffaele Ferri, Jean-Francois Gagnon, Ziv Gan-Or, Wiebke Hermann, Birgit Hoegl, Michele T. Hu, Alex Iranzo, Annette Janzen, Anastasia Kuzkina, Jee-Young Lee, Klaus L. Leenders, Simon J. G. Lewis, Claudio Liguori, Jun Liu, Christine Lo, Kaylena A. Ehgoetz Martens, Jiri Nepozitek, Giuseppe Plazzi, Federica Provini, Monica Puligheddu, Michal Rolinski, Jan Rusz, Ambra Stefani, Rebekah L. S. Summers, Dallah Yoo, Jennifer Zitser, Wolfgang H. Oertel
Summary: Patients with isolated rapid-eye-movement sleep behavior disorder (RBD) are considered to be in the early stages of progressive neurodegenerative diseases involving alpha-synuclein pathology, such as Parkinson's disease or multiple system atrophy. Developing reliable biomarkers is crucial for predicting disease progression, monitoring treatment response, and predicting the subtype of alpha-synucleinopathy patients with isolated RBD.
Article
Neurosciences
Kaila L. Stipancic, Yi-Ling Kuo, Amanda Miller, Hayden M. Ventresca, Dagmar Sternad, Teresa J. Kimberley, Jordan R. Green
Summary: This exploratory study aimed at examining the effects of continuous oromotor activity on subsequent speech learning, revealing improved speech performance following 10 minutes of chewing but degraded performance following 10 minutes of continuous speech. There was no change in the cortical silent period (cSP) as a result of either oromotor activity. These findings have important clinical implications for speech rehabilitation and neuromodulation.
EXPERIMENTAL BRAIN RESEARCH
(2021)
Editorial Material
Clinical Neurology
Yi-Ling Kuo, David J. Lin, Isha Vora, Julie A. DiCarlo, Dylan J. Edwards, Teresa J. Kimberley
Editorial Material
Orthopedics
Lesley E. Smith, Janine E. Annis-Young, Teresa Jacobson Kimberley
Article
Neurosciences
Cecilia N. Prudente, Mo Chen, Kaila L. Stipancic, Katherine L. Marks, Sharyl Samargia-Grivette, George S. Goding, Jordan R. Green, Teresa J. Kimberley
Summary: The study aimed to investigate the safety, feasibility, and effects of a single session 1 Hz rTMS in individuals with adductor laryngeal dystonia. Results showed potential benefits on voice quality and phonatory function in the treatment group.
EXPERIMENTAL BRAIN RESEARCH
(2022)
Article
Clinical Neurology
Yi-Ling Kuo, Mo Chen, Teresa J. Kimberley
Summary: The pathophysiology of adductor laryngeal dystonia remains unknown, but there is evidence of disruptions in the inhibitory regulation of sensorimotor cortical areas. Using functional MRI and transcranial magnetic stimulation, an overly activated laryngeal motor cortex was found in dystonia-related tasks. In a dystonia-unrelated task, there was more broadly dispersed activation and reduced intracortical inhibition in adductor laryngeal dystonia compared to controls.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Clinical Neurology
Baothy P. P. Huynh, Julie A. A. DiCarlo, Isha Vora, Jessica Ranford, Perman Gochyyev, David J. J. Lin, Teresa J. J. Kimberley
Summary: The study aimed to determine the responsiveness and sensitivity to change of FMA-UE in the subacute phase of stroke recovery. The results showed that FMA-UE was highly sensitive to change, with an estimated minimum clinically important difference of 13 points for individuals with moderate to severe motor impairment from 1 to 6 weeks after stroke.
NEUROREHABILITATION AND NEURAL REPAIR
(2023)
Article
Clinical Neurology
Rebekah L. S. Summers, Miriam R. Rafferty, Michael J. Howell, Colum D. MacKinnon
Summary: This work aims to review peripheral signs of early motor deficits in iRBD patients and propose a framework for early protective or preventive therapies using iRBD as a predictive marker. Research suggests that motor deficits such as bradykinesia, daily living activity deficits, and abnormalities in speech, gait, and posture can appear up to 12 years before a diagnosis of synucleinopathy in iRBD patients. The suggested rehabilitation framework includes early exercise-based interventions and consultations to address exercise prescription, progression, and monitoring.
NEUROREHABILITATION AND NEURAL REPAIR
(2021)
Article
Clinical Neurology
Teresa J. Kimberley, Cecilia N. Prudente, Navzer D. Engineer, David Pierce, Brent Tarver, Steven C. Cramer, David Alexander Dickie, Jesse Dawson
EUROPEAN STROKE JOURNAL
(2019)