Article
Chemistry, Multidisciplinary
Youngjae Song, Kyungmin Kang, Inho Kim, Tae-Jung Kim
Summary: Digital pathology provides powerful tools for biomarker discovery, analysis, and translation. However, the clinical adoption of digital pathology has been slow and requires clinical and methodological validation. Digital pathological biomarkers can be used in conjunction with other diagnostic technologies to select the most appropriate patient treatment.
APPLIED SCIENCES-BASEL
(2022)
Article
Oncology
Linjing Li, Xin Li, Qingyan Zhang, Tao Ye, Shuli Zou, Jing Yan
Summary: The study demonstrated that EIF5A is highly expressed in HCC tissues and significantly correlated with histological grade, clinical stage, and pT stage, indicating it could be a potential biomarker for HCC.
Review
Oncology
Xiao Fu, Erik Sahai, Anna Wilkins
Summary: In recent years, the use of advanced analytics, particularly AI, in digital histological images has started to revolutionize their clinical application. The development of highly multiplexed immunofluorescence platforms has increased the complexity that can be captured in the tumor microenvironment. AI plays a crucial role in recognizing and quantifying image features and their association with clinically important outcomes. Deep-learning algorithms have the potential to make clinically relevant predictions and discover important tumor microenvironment features.
JOURNAL OF PATHOLOGY
(2023)
Article
Oncology
Kazeera Aliar, Henry R. Waterhouse, Foram Vyas, Niklas Krebs, Bowen Zhang, Emily Poulton, Nathan Chan, Ricardo Gonzalez, Gun Ho Jang, Peter Bronsert, Sandra E. Fischer, Steven Gallinger, Barbara T. Grunwald, Rama Khokha
Summary: Hourglass is an open-access analytical framework that streamlines visualization, interrogation, and statistical assessment of multiparametric datasets. It can help users extract hidden insights from heterogeneous tissues and provides unique and widely accessible analytical means for users with or without computational proficiency.
JOURNAL OF PATHOLOGY
(2023)
Article
Chemistry, Analytical
Siqi Qian, Han Wu, Bin Huang, Qi Liu, Yan Chen, Bo Zheng
Summary: This study presents a method for sub-micron resolution patterning of perfluorinated surfaces and its application in digital immunoassays without beads. By using negative microcontact printing and a composite stamp, polydopamine patterns are successfully fabricated on perfluorinated surfaces, enabling the creation of microspot arrays for digital assays. The high-resolution polydopamine patterned perfluorinated substrate offers a highly-sensitive and low-cost approach for digital immunoassays, showing great potential in high-throughput and digital bioassays.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Oncology
Ulf Titze, Torsten Hansen, Christoph Brochhausen, Barbara Titze, Birte Schulz, Alfons Gunnemann, Bernardo Rocco, Karl-Dietrich Sievert
Summary: The study demonstrates that FCM is an effective tool for timely assessment of prostate biopsies, providing reliable real-time diagnosis of prostate cancer in patients requiring therapy. Despite some limitations, FCM shows strong diagnostic performance in prostate biopsies.
Article
Health Care Sciences & Services
L. G. Hutchinson, O. Grimm
Summary: In this study, we developed an approach that integrates digital pathology and mathematical modeling to provide quantitative information for clinical teams in deciding the time point of biopsy sample collection. The validated model can accurately predict the dynamics of simulated biopsies and has applications in clinical trial protocol design and personalized healthcare.
NPJ DIGITAL MEDICINE
(2022)
Article
Oncology
Hadia Munir, Fawad Ahmad, Sajid Ullah, Saeedah Musaed Almutairi, Samra Asghar, Tehmina Siddique, Mostafa A. Abdel-Maksoud, Rabab Ahmed Rasheed, Fatma Alzahraa A. Elkhamisy, Mohammed Aufy, Hamid Yaz
Summary: In this study, six real hub genes were identified from known hub genes using microarray technology, which may be useful in reducing heterogenetic-specific barriers in PRAD patients for diagnosis, prognosis, and treatment. Expression analysis revealed significant up-regulation of these genes in PRAD patients, and valuable correlations were found with other data in PRAD samples. Several important transcription factors, miRNAs, and chemotherapeutic drugs were also discovered, showing great therapeutic potential.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2022)
Editorial Material
Oncology
Amir Safarpoor, Shivam Kalra, Hamid R. Tizhoosh
Summary: Generative models are powerful tools for learning data distribution and have emerged as promising fields in medical imaging, especially in synthesizing high-quality pathology images. Recent research demonstrates the potential of generative models in medical education and training of machine learning models, while addressing privacy and confidentiality concerns.
JOURNAL OF PATHOLOGY
(2021)
Article
Oncology
Zhilong Yu, ZeYin Rong, Jinxin Sheng, Zai Luo, Jianming Zhang, Tengfei Li, Zhonglin Zhu, Zhongmao Fu, Zhengjun Qiu, Chen Huang
Summary: Recent studies have shown that non-coding RNAs (ncRNAs) may serve as novel biomarkers for predicting the occurrence and prognosis of gastric cancer. By analyzing the expression profiles of miRNA, lncRNA, and cirRNA in gastric cancer patients, it was found that these ncRNAs could potentially be promising molecular markers for the diagnosis and prognosis of gastric cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Zheng Fang, Hong-yu Shen, Qi Xu, Hong-lei Zhou, Lei Li, Si-Yuan Yang, Zhen Zhu, Jin-hai Tang
Summary: Breast cancer patients with high expression of PUS1 have poor prognosis and shorter survival time. Knockdown of PUS1 suppresses the proliferation, colony formation, and invasion abilities of breast cancer cells. PUS1 may serve as a promising biomarker and treatment target for breast cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Health Care Sciences & Services
Samar Betmouni
Summary: Digital Pathology is the process of producing digital images from tissue sections on glass slides, which can now be viewed on computer monitors, allowing pathologists to work remotely and collaborate with colleagues. Despite its potential benefits in clinical practice, the adoption of digital pathology as a diagnostic tool remains low, posing a challenge for scaling up its use. Early adopters have shown the way, but the healthcare sector still lacks theoretical frameworks for planning digital pathology deployment effectively.
Article
Medicine, General & Internal
Uwe Bieri, Lorenz Buser, Marian Severin Wettstein, Daniel Eberli, Karim Saba, Holger Moch, Thomas Hermanns, Cedric Poyet
Summary: This study evaluated the prognostic value of a modified Immunoscore (mIS) in bladder cancer patients undergoing radical cystectomy. The results showed that patients with high mIS had better outcomes in terms of progression free survival and cancer specific survival.
Article
Oncology
Qiurong Xie, Liya Liu, Xiaoping Chen, Ying Cheng, Jiapeng Li, Xiuli Zhang, Nanhui Xu, Yuying Han, Huixin Liu, Lihui Wei, Jun Peng, Aling Shen
Summary: The study identified higher expression of CST1 and CST2 in CRC tissues compared to noncancerous adjacent tissues, with CST2 levels correlated with advanced stages and disease-free survival. Further exploration into the role of CST2 in CRC is encouraged. Additionally, upregulation of CST2 in multiple cancer tissues suggests its potential as a diagnostic and prognostic biomarker for CRC.
Article
Biochemistry & Molecular Biology
Anne Menz, Timo Weitbrecht, Natalia Gorbokon, Franziska Buescheck, Andreas M. Luebke, Martina Kluth, Claudia Hube-Magg, Andrea Hinsch, Doris Hoeflmayer, Soren Weidemann, Christoph Fraune, Katharina Moeller, Christian Bernreuther, Patrick Lebok, Till Clauditz, Guido Sauter, Ria Uhlig, Waldemar Wilczak, Stefan Steurer, Sarah Minner, Eike Burandt, Rainer Krech, David Dum, Till Krech, Andreas Marx, Ronald Simon
Summary: CK18 is consistently expressed in various epithelial cancers, especially adenocarcinomas. Down-regulation or loss of CK18 expression in cancers arising from CK18 positive tissues as well as CK18 neo-expression in cancers originating from CK18 negative tissues is linked to cancer progression and may reflect tumor dedifferentiation. Up-regulation of CK18 in squamous cell carcinomas was linked to high grade and lymph node metastasis.
MOLECULAR MEDICINE
(2021)
Article
Oncology
Kim R. M. Blenman, Michal Marczyk, Thomas Karn, Tao Qing, Xiaotong Li, Vignesh Gunasekharan, Vesal Yaghoobi, Yalai Bai, Eiman Y. Ibrahim, Tristen Park, Andrea Silber, Denise M. Wolf, Emily Reisenbichler, Carsten Denkert, Bruno V. Sinn, Mariya Rozenblit, Julia Foldi, David L. Rimm, Sibylle Loibl, Lajos Pusztai
Summary: This study examined gene expression, germline variant, and somatic mutation features associated with pathologic response to neoadjuvant durvalumab plus chemotherapy in basal-like triple-negative breast cancer. The results showed differences in gene expression and pathway enrichment between cases with different pathologic responses, with immune-rich cases being associated with macrophages, activated B cells, and T cells, while immune-poor cases were associated with other signaling pathways. The findings contribute to a better understanding and prediction of the efficacy of this treatment regimen.
CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Xiaojia Guo, Shlomit Jessel, Rihao Qu, Yuval Kluger, Tian-Min Chen, Lindsay Hollander, Robert Safirstein, Bryce Nelson, Charles Cha, Marcus Bosenberg, Lucia B. Jilaveanu, David Rimm, Carla Rothlin, Harriet M. Kluger, Gary Desir
Summary: This study found that RNLS inhibition leads to tumor regression in melanoma and that anti-RNLS antibody treatment enhances the activity of anti-PD-1, improving the treatment of melanoma.
EUROPEAN JOURNAL OF CANCER
(2022)
Letter
Dermatology
Matthew Vesely, Sandra Martinez-Morilla, Jeff R. Gehlhausen, Jennifer M. McNiff, Peter G. Whang, David Rimm, Christine J. Ko
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Article
Oncology
Myrto Moutafi, Sandra Martinez-Morilla, Prajan Divakar, Ioannis Vathiotis, Niki Gavrielatou, Thazin Nwe Aung, Vesal Yaghoobi, Aileen Fernandez, Jon Zugazagoitia, Roy S. Herbst, Kurt A. Schalper, David L. Rimm
Summary: Using digital spatial profiling, the study identified CD66b expression as an indicator of resistance to immune checkpoint inhibitors (ICIs) therapy in patients with non-small cell lung cancer (NSCLC). Further investigations are needed to understand the role of neutrophils in ICI resistance.
JOURNAL OF THORACIC ONCOLOGY
(2022)
Article
Oncology
Brian S. Henick, Franz Villarroel-Espindola, Ila Datar, Miguel F. Sanmamed, Jovian Yu, Shruti Desai, Alice Li, Adam Aguirre-Ducler, Konstantinos Syrigos, David L. Rimm, Lieping Chen, Roy S. Herbst, Kurt A. Schalper
Summary: QIF was used to measure the distribution and clinical significance of major myeloid cell subsets in human NSCLC. M1-like macrophages were lower and MDSC-like cells were higher in tumor tissues. Stromal CD11b was higher in SCC than in ADC.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Michal Marczyk, Tao Qing, Tess O'Meara, Vesal Yagahoobi, Vasiliki Pelekanou, Yalai Bai, Emily Reisenbichler, Kimberly S. Cole, Xiaotong Li, Vignesh Gunasekharan, Eiman Ibrahim, Kristina Fanucci, Wei Wei, David L. Rimm, Lajos Pusztai, Kim R. M. Blenman
Summary: Differences in the tumor immune microenvironment may exist between African American and NonAA breast cancer patients, which may impact treatment response and prognosis.
Article
Oncology
Myrto K. Moutafi, Magdalena Molero, Sandra Martinez Morilla, Javier Baena, Ioannis A. Vathiotis, Niki Gavrielatou, Laura Castro-Labrador, Gorka Ruiz de Garibay, Vera Adradas, Daniel Orive, Karmele Valencia, Alfonso Calvo, Luis M. Montuenga, S. Ponce Aix, Kurt A. Schalper, Roy S. Herbst, Luis Paz-Ares, David L. Rimm, Jon Zugazagoitia
Summary: This study identifies CD44 as a novel biomarker for predicting sensitivity to PD-1 axis blockade in NSCLC, and validates its correlation with prolonged progression-free survival and overall survival.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
David A. Schoenfeld, Ross D. Merkin, Myrto Moutafi, Sandra Martinez, Adebowale Adeniran, Deepika Kumar, Lucia Jilaveanu, Michael Hurwitz, David L. Rimm, Harriet M. Kluger
Summary: The study found that LAG3 protein levels are lower at metastatic sites compared to primary tumors in advanced renal cell carcinoma patients, and this difference is more pronounced in patients with high-risk clinical characteristics. Additionally, the prognostic value of LAG3 levels varies depending on the tissue site, with higher LAG3 levels at metastatic sites predicting a better response to immunotherapy and longer overall survival.
FRONTIERS IN ONCOLOGY
(2022)
Editorial Material
Medical Laboratory Technology
David L. Rimm, Sanja Dacic, Stuart J. Schnitt
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2023)
Article
Pathology
Charles J. Robbins, Aileen I. Fernandez, Gang Han, Serena Wong, Malini Harigopal, Mirna Podoll, Kamaljeet Singh, Amy Ly, M. Gabriela Kuba, Hannah Wen, Mary Ann Sanders, Jane Brock, Shi Wei, Oluwole Fadare, Krisztina Hanley, Julie Jorns, Olivia L. Snir, Esther Yoon, Kim Rabe, T. Rinda Soong, Emily S. Reisenbichler, David L. Rimm
Summary: This study evaluated the concordance and interrater reliability of scoring HER2 IHC in breast cancer biopsies by 18 breast cancer-specialized pathologists. The results showed poor concordance within the intermediate categories and for the IHC 0 cases. The use of a 3-category system partially reduced the discordance. The study also revealed the optimal number of raters for determining HER2 IHC scores of 0 and 3+.
Editorial Material
Oncology
David L. Rimm
Article
Oncology
Katherine M. Bates, Ioannis Vathiotis, Tyler MacNeil, Fahad Shabbir Ahmed, Thazin Nwe Aung, Yuliya Katlinskaya, Sabyasachi Bhattacharya, Amanda Psyrri, Steven Yea, Amanda Parkes, Nooshin Hashemi Sadraei, Siddhartha Roychoudhury, David L. Rimm, Niki Gavrielatou
Summary: This study used quantitative immunofluorescence to evaluate CD40 expression on solid tumors, including lung, ovarian, and pancreatic cancers. The results showed a high percentage of tumor cells expressing CD40, but no significant impact on overall survival.
Article
Pathology
Aileen I. Fernandez, Patricia Gaule, David L. Rimm
Summary: This study found that the antigenicity of PD-L1 antibody 22C3 may change over time due to the degradation of the glycan part of the epitope. This should be taken into consideration when evaluating archival tissue for diagnostic or research purposes.
Article
Oncology
Taja Lozar, Israa Laklouk, Athena E. Golfinos, Niki Gavrielatou, Jin Xu, Christopher Flynn, Aysenur Keske, Menggang Yu, Justine Y. Bruce, Wei Wang, Cvetka Grasic Kuhar, Howard H. Bailey, Paul M. Harari, Huy Q. Dinh, David L. Rimm, Rong Hu, Paul F. Lambert, Megan B. Fitzpatrick
Summary: This study suggests that cytokeratin 17 may be an independent predictive biomarker for poor response to immune check-point blockade therapy in head and neck cancer patients.
Article
Oncology
Amelia A. Trant, Anees Chagpar, Wei Wei, Veronique Neumeister, David Rimm, Karen Stavris, Bonnie Lurie, Courtney Frederick, Liva Andrejeva, Madhavi Raghu, Brigid Killelea, Nina Horowitz, Donald Lannin, Elspeth Knill-Selby, Tracy Sturrock, Erin Hofstatter
Summary: This study found that the use of black cohosh had no significant impact on cellular proliferation, tumor volume, or invasive disease upgrade rates in ductal carcinoma in situ (DCIS) patients. Black cohosh was well-tolerated with no observed significant toxicities.
INTEGRATIVE CANCER THERAPIES
(2022)
