Article
Critical Care Medicine
Markus B. Skrifvars, Nora Luethi, Michael Bailey, Craig French, Alistair Nichol, Tony Trapani, Colin McArthur, Yaseen M. Arabi, Stepani Bendel, David J. Cooper, Rinaldo Bellomo, EPO TBI Investigators, ANZICS Clinical Trials Grp
Summary: Recombinant erythropoietin (EPO) did not decrease overall long-term mortality nor improve functional outcome in moderate or severe traumatic brain injury (TBI) patients treated in the intensive care unit (ICU). The limited sample size makes it difficult to draw final conclusions about the use of EPO in TBI.
INTENSIVE CARE MEDICINE
(2023)
Article
Multidisciplinary Sciences
Insiyah Campwala, Francis X. Guyette, Joshua B. Brown, Mark H. Yazer, Brian J. Daley, Richard S. Miller, Brian G. Harbrecht, Jeffrey A. Claridge, Herbert A. Phelan, Brian Eastridge, Raminder Nirula, Gary A. Vercruysse, Terence O'Keeffe, Bellal Joseph, Matthew D. Neal, Brian S. Zuckerbraun, Jason L. Sperry
Summary: A secondary analysis of data from two large prehospital randomized controlled trials was conducted to study the effects of multiorgan failure (MOF) and nosocomial infection (NI) on delayed mortality and resource utilization in severely injured patients. MOF was found to be an independent predictor of mortality, while NI was associated with higher resource utilization.
SCIENTIFIC REPORTS
(2023)
Article
Critical Care Medicine
Xiang Wu, Li Xie, Jin Lei, Jiemin Yao, Jiarong Li, Lixin Ruan, Jun Hong, Guodong Zheng, Yangyu Cheng, Liansheng Long, Jiancun Wang, Chuanping Huang, Qiuyou Xie, Xuelei Zhang, Jianghong He, Xuebin Yu, Shouhua Lv, Zhaosheng Sun, Dai Liu, Xin Li, Jianxin Zhu, Xiaoliang Yang, Dongdong Wang, Yijun Bao, Andrew I. R. Maas, David Menon, Yajun Xue, Jiyao Jiang, Junfeng Feng, Guoyi Gao, ACES Participants
Summary: This study aimed to determine whether right median nerve electrical stimulation is a safe and effective treatment for accelerating emergence from coma after severe traumatic brain injury. The results showed that the RMNS group had a higher proportion of patients who regained consciousness at 6 months post-injury compared with the control group. Furthermore, the RMNS group showed significant improvements in secondary outcome measures.
INTENSIVE CARE MEDICINE
(2023)
Article
Clinical Neurology
Yuping Li, Jun Zhang, Haili Wang, Lei Zhu, Hengzhu Zhang, Qiang Ma, Xiaoguang Liu, Lun Dong, Guangyu Lu
Summary: This meta-analysis reviewed 10 randomized controlled trials on the efficacy and safety of erythropoietin (EPO) for traumatic brain injury (TBI), finding that EPO can reduce mortality rate in TBI patients without significant impact on good functional outcomes. EPO has potential value for further research and application in TBI treatment.
NEUROLOGICAL SCIENCES
(2022)
Article
Pediatrics
Cydni N. Williams, Cindy T. McEvoy, Miranda M. Lim, Steven A. Shea, Vivek Kumar, Divya Nagarajan, Kurt Drury, Natalia Rich-Wimmer, Trevor A. Hall
Summary: Over 50,000 children are hospitalized annually for traumatic brain injury (TBI) and more than 50% of them develop sleep/wake disturbances (SWDs) after hospital discharge. This study found that SWDs are associated with worse executive function outcomes in children with TBI, suggesting that targeting SWDs may improve outcomes.
Review
Critical Care Medicine
Anders Granholm, Waleed Alhazzani, Lennie P. G. Derde, Derek C. Angus, Fernando G. Zampieri, Naomi E. Hammond, Rob Mac Sweeney, Sheila N. Myatra, Elie Azoulay, Kathryn Rowan, Paul J. Young, Anders Perner, Morten Hylander Moller
Summary: Randomised clinical trials are important in providing unbiased evidence of intervention effects. Current critical care RCTs face challenges such as overly optimistic effect sizes and limited focus on patient-centered outcomes. Novel methods, including research program approaches and alternative outcome choices, may offer solutions to these challenges.
INTENSIVE CARE MEDICINE
(2022)
Article
Geriatrics & Gerontology
Y. Launey, A. Coquet, S. Lasocki, C. Dahyot-Fizelier, O. Huet, E. Le Pabic, A. Roquilly, P. Seguin
Summary: This study evaluated the outcomes of ICU patients over 65 years of age with TBI. The results showed that age, sex, baseline Glasgow coma scale score, injury severity score, and use of osmotherapy were predictors of unfavourable neurological outcome.
Article
Clinical Neurology
Kirill Shumilov, Sophia Xiao, Allen Ni, Marta Celorrio, Stuart H. Friess
Summary: Traumatic brain injury (TBI) can cause damage to the white matter through axonal loss and demyelination. The proliferation of oligodendrocyte progenitor cells (OPCs) plays a crucial role in the process of remyelination. However, current treatments for TBI are unable to effectively stimulate OPC proliferation. This study demonstrates the potential of recombinant human erythropoietin (rhEPO) in promoting myelination by increasing the proliferation of oligodendrocyte lineage cells after TBI.
Review
Neurosciences
Qiujing Du, Yuwei Liu, Xinrong Chen, Ka Li
Summary: Hypothermia therapy may improve the outcome scores of children with traumatic brain injury (TBI), but it does not significantly improve the incidence of complications, intracranial pressure, mortality rate, and length of stay.
Review
Critical Care Medicine
Kumait Al Lawati, Sameer Sharif, Said Al Maqbali, Hussein Al Rimawi, Andrew Petrosoniak, Emilie P. Belley-Cote, Sunjay V. Sharma, Justin Morgenstern, Shannon M. Fernando, Julian J. Owen, Michelle Zeller, David Quinlan, Waleed Alhazzani, Bram Rochwerg
Summary: The study suggests that tranexamic acid (TXA) may not have an impact on mortality or disability in patients with acute traumatic brain injury (TBI), but could potentially reduce hematoma expansion on subsequent imaging. The use of TXA may not increase the risk of adverse events.
INTENSIVE CARE MEDICINE
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Cyrus Ayubcha, Mona-Elisabeth Revheim, Andrew Newberg, Mateen Moghbel, Chaitanya Rojulpote, Thomas J. Werner, Abass Alavi
Summary: PET has been widely used in the study of traumatic brain injury (TBI) for decades, with recent focus on imaging biomarkers related to TBI and chronic traumatic encephalopathy (CTE). This review critically assesses the use of glycolysis, beta-amyloid, and tau protein radiotracers in the context of TBI, weighing their strengths and weaknesses. Despite the ongoing debate, PET remains a powerful modality in diagnosing TBI-related conditions.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Clinical Neurology
Xing Wang, Xiaolong Li, Lu Ma, Hui Chen, Chao You
Summary: The authors conducted a Bayesian network meta-analysis to evaluate the safety and efficacy of different medications with neuroprotective properties in patients with traumatic brain injury. The results showed that erythropoietin and propranolol were associated with reduced mortality and improved functional recovery.
NEUROLOGICAL SCIENCES
(2023)
Article
Critical Care Medicine
Jeffrey E. Max, Nicholas Judd, Erin D. Bigler, Elisabeth A. Wilde, Jo Ellen Patterson, Todd M. Edwards, Ainara Calahorra, Bianca G. De La Garza, Florin Vaida
Summary: The study found that mild traumatic brain injury had a significantly greater negative impact on psychiatric outcomes in children during the first 3 months post-injury compared to orthopedic injury. Other factors such as family psychiatric history and socioeconomic status were also significantly associated with the frequency of novel psychiatric disorders.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Rehabilitation
Mari S. Rasmussen, Nada Andelic, Are H. Pripp, Tonje H. Nordenmark, Helene L. Soberg
Summary: This study aimed to evaluate the effectiveness of a family-centred intervention for patients with traumatic brain injury and their family members. The results showed that patients who received the intervention showed significant improvement in mental health, family cohesion, and caregiver burden during the treatment period.
CLINICAL REHABILITATION
(2021)
Review
Biochemistry & Molecular Biology
Wiley Gillam, Nikhil Godbole, Shourya Sangam, Alyssa Detommaso, Marco Foreman, Brandon Lucke-Wold
Summary: This review aimed to explore how neurologic injury can lead to Post-Traumatic Stress Disorder (PTSD), focusing on traumatic brain injury, subarachnoid hemorrhage, and stroke as common neurologic injuries. The altered activity in the limbic system may be associated with characteristic symptoms of PTSD. However, early diagnosis and appropriate treatment are lacking in these patients.
Article
Critical Care Medicine
Colman B. Taylor, Kelly J. Thompson, Carol Hodgson, Cheelim Liew, Edward Litton, Forbes McGain, Alistair Nichol, Rashmi Rauniyar, Emma Ridley, Alisa Higgins
Summary: This article provides best practice recommendations for conducting economic evaluations alongside intensive care unit (ICU) randomized controlled trials (RCTs). The recommendations cover various aspects of economic evaluations, including study design, measurement of health outcomes and quality of life, estimation of resources and costs, analytical methods, and future research directions to improve the quality of data and costing methods for the ICU.
AUSTRALIAN CRITICAL CARE
(2023)
Article
Critical Care Medicine
Yahya Shehabi, Ary Serpa Neto, Rinaldo Bellomo, Belinda D. Howe, Yaseen M. Arabi, Michael Bailey, Frances E. Bass, Suhaini Bin Kadiman, Colin J. McArthur, Michael C. Reade, Ian M. Seppelt, Jukka Takala, Matt P. Wise, Steve A. Webb
Summary: The study aimed to evaluate the association between different infusion rates of dexmedetomidine and propofol in combination and mortality, taking age into account. The results showed that increasing the dose of propofol was associated with decreased mortality in patients aged 65 years or below, while increasing the dose of dexmedetomidine may be associated with increased mortality.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Hematology
Matteo Marcello, Anna Lorenzin, Massimo De Cal, Michela Zorzi, Marco Salvatore La Malfa, Valentina Fin, Alessandra Sandini, Francesco Fiorin, Rinaldo Bellomo, Silvia De Rosa, Claudio Ronco, Monica Zanella
Summary: We conducted an ex vivo study to assess the quantitative capacity of a novel adsorptive cartridge to remove bilirubin from plasma. The results showed that the device has good adsorption capacity for bilirubin and can guide the frequency and duration of clinical treatment.
BLOOD PURIFICATION
(2023)
Editorial Material
Hematology
Thiago Reis, Francisco de Assis Rocha Neves, Antonio Fagundes Jr., Emily See, Rogerio da Hora Passos, Bruno Zawadzki, Rinaldo Bellomo, Claudio Ronco
BLOOD PURIFICATION
(2023)
Article
Medicine, General & Internal
Alisa M. Higgins, Lindsay R. Berry, Elizabeth Lorenzi, Srinivas Murthy, Zoe McQuilten, Paul R. Mouncey, Farah Al-Beidh, Djillali Annane, Yaseen M. Arabi, Abi Beane, Wilma Van Bentum-Puijk, Zahra Bhimani, Marc J. M. Bonten, Charlotte A. Bradbury, Frank M. Brunkhorst, Aiden Burrell, Adrian Buzgau, Meredith Buxton, Walton N. Charles, Matthew Cove, Michelle A. Detry, Lise J. Estcourt, Elizabeth O. Fagbodun, Mark Fitzgerald, Timothy D. Girard, Ewan C. Goligher, Herman Goossens, Rashan Haniffa, Thomas Hills, Christopher M. Horvat, David T. Huang, Nao Ichihara, Francois Lamontagne, John C. Marshall, Daniel F. McAuley, Anna McGlothlin, Shay P. McGuinness, Bryan J. McVerry, Matthew D. Neal, Alistair D. Nichol, Rachael L. Parke, Jane C. Parker, Karen Parry-Billings, Sam E. C. Peters, Luis F. Reyes, Kathryn M. Rowan, Hiroki Saito, Marlene S. Santos, Christina T. Saunders, Ary Serpa-Neto, Christopher W. Seymour, Manu Shankar-Hari, Lucy M. Stronach, Alexis F. Turgeon, Anne M. Turner, Frank L. van de Veerdonk, Ryan Zarychanski, Cameron Green, Roger J. Lewis, Derek C. Angus, Colin J. McArthur, Scott Berry, Lennie P. G. Derde, Anthony C. Gordon, Steve A. Webb, Patrick R. Lawler
Summary: The longer-term effects of therapies for critically ill COVID-19 patients are unknown. In this study, 4869 patients were randomized to receive different interventions, and it was found that treatment with IL-6 receptor antagonists and antiplatelet agents significantly improved survival rates after 180 days. These findings suggest that most therapies have consistent effects over a 6-month period.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Critical Care Medicine
Mark Dennis, Timothy J. Southwood, Matthew Oliver, Alistair Nichol, Aidan Burrell, Carol Hodgson
Summary: This study conducted a survey among clinicians in Australia and New Zealand and found strong support for further research on optimizing the use of ECMO and ECPR. The results provide a framework for prioritizing future clinical trials and research agendas.
AUSTRALIAN CRITICAL CARE
(2023)
Article
Critical Care Medicine
Emma J. Ridley, Lee-anne S. Chapple, Kate Ainscough, Aidan Burrell, Lewis Campbell, Claire Dux, Suzie Ferrie, Kate Fetterplace, Matin Jamei, Victoria King, Ary Serpa Neto, Alistair Nichol, Emma Osland, Eldho Paul, Matthew Summers, Andrea P. Marshall, Andrew Udy
Summary: This study aimed to describe nutrition-related service delivery practices in critically ill patients with COVID-19 admitted to Australian ICUs during the initial pandemic phase. Results showed that approximately half of the patients were seen by a dietitian, with increased malnutrition screening in the ICU associated with higher risk scores and higher likelihood of dietetic consult.
AUSTRALIAN CRITICAL CARE
(2023)
Article
Critical Care Medicine
Tai Pham, Leo Heunks, Giacomo Bellani, Fabiana Madotto, Irene Aragao, Gaetan Beduneau, Ewan C. Goligher, Giacomo Grasselli, Jon Henrik Laake, Jordi Mancebo, Oscar Penuelas, Lise Piquilloud, Antonio Pesenti, Hannah Wunsch, Frank van Haren, Laurent Brochard, John G. Laffey
Summary: This study investigated the management and outcomes of weaning from invasive mechanical ventilation in patients requiring at least 2 days of ventilation. The results showed that only 65% of patients were successfully weaned at 90 days. Factors such as delayed initiation of weaning and excessive sedation levels were associated with weaning failure. Understanding these factors could improve the success rate of weaning.
LANCET RESPIRATORY MEDICINE
(2023)
Review
Anesthesiology
Angela A. Frentiu, Kevin Mao, Carla Borg Caruana, Dev Raveendran, Luke A. Perry, Jahan C. Penny-Dimri, Dhruvesh M. Ramson, Reny Segal, Rinaldo Bellomo, Julian A. Smith, Zhengyang Liu
Summary: RED CELL DISTRIBUTION WIDTH (RDW) is a biomarker that can predict erythropoietic dysfunction and adverse outcomes after cardiac surgery. This systematic review and meta-analysis aimed to determine the prognostic value of RDW in cardiac surgery patients. The authors included 26 studies involving 48,092 patients and found that elevated preoperative RDW was associated with increased short- and long-term mortality, postoperative atrial fibrillation (POAF), and acute kidney injury (AKI). However, more research is needed to investigate the role of RDW in risk stratification of patients undergoing cardiac surgery.
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2023)
Article
Infectious Diseases
Rahul Costa-Pinto, Sarah Klink, Hannah Rotherham, Padeepa Perera, Liam Finlay, Karen Urbancic, Karl Vaz, Jason Trubiano, Rinaldo Bellomo
Summary: Our study found no significant liver or cardiac side effects associated with the use of voriconazole in critically ill patients with suspected COVID-19-associated pulmonary aspergillosis. These findings provide reassurance for clinicians when initiating therapy for such patients.
Article
Urology & Nephrology
Thomas Larsen, Emily J. See, Natasha E. Holmes, Rinaldo Bellomo
Summary: A novel equation was developed to estimate baseline creatinine in patients with acute kidney injury (AKI) on chronic kidney disease (CKD). By adjusting the most recent creatinine value for drift over time, the equation provides more accurate baseline creatinine estimation, reducing false-positive AKI detection and improving patient care.
Article
Urology & Nephrology
Marina Wainstein, Nicholas Spyrison, Danyang Dai, Moji Ghadimi, Jonathan S. Chavez-Iniguez, Lilia Rizo-Topete, Barbara Wanjiru Citarella, Laura Merson, Jason D. Pole, Rolando Claure-Del Granado, David W. Johnson, S. Shrapnel
Summary: There is a lack of research on the relationship between COVID-19 and acute kidney injury (AKI) in low- and low-middle income countries. This study found that AKI incidence was highest in LLMIC, with lower rates of dialysis and poorer patient outcomes.
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Public, Environmental & Occupational Health
Tanya Symons, Janelle Bowden, Anne McKenzie, Julia M. Fallon-Ferguson, Leanne Y. Weekes, James Ansell, Rinki Murphy, Shilpa Jesudason, Manoj Saxena, Alistair Nichol, Nicola Straiton
Summary: This manuscript describes the development of a toolkit to support meaningful consumer involvement in clinical trials in Australia and guide others in creating similar resources. The toolkit aims to enhance consumer participation in prioritizing, designing, and conducting clinical research, and is a comprehensive digital resource derived from best practice literature and international standards.
PUBLIC HEALTH RESEARCH & PRACTICE
(2023)
Article
Critical Care Medicine
Peter J. McGuigan, Elisa Giallongo, Bronagh Blackwood, James Doidge, David A. Harrison, Alistair D. Nichol, Kathryn M. Rowan, Manu Shankar-Hari, Markus B. Skrifvars, Karen Thomas, Danny F. McAuley, Peter J. McGuigan
Summary: This retrospective analysis found an association between hypotension and hypertension in the first 24 h in ICU and mortality following OHCA. Patients with a lowest recorded MAP in the range 60-63 mmHg and a highest recorded MAP in the range 95-104 mmHg had the lowest associated mortality. Research into individualized blood pressure targets for survivors following OHCA is needed.
Article
Medicine, General & Internal
G. Eastwood, A. D. Nichol, C. Hodgson, R. L. Parke, S. McGuinness, N. Nielsen, S. Bernard, M. B. Skrifvars, D. Stub, F. S. Taccone, J. Archer, D. Kutsogiannis, J. Dankiewicz, G. Lilja, T. Cronberg, H. Kirkegaard, G. Capellier, G. Landoni, J. Horn, T. Olasveengen, Y. Arabi, Y. W. Chia, A. Markota, M. Haenggi, M. P. Wise, A. M. Grejs, S. Christensen, H. Munk-Andersen, A. Granfeldt, G. O. Andersen, E. Qvigstad, A. Flaa, M. Thomas, K. Sweet, J. Bewley, M. Backlund, M. Tiainen, M. Iten, A. Levis, L. Peck, J. Walsham, A. Deane, A. Ghosh, F. Annoni, Y. Chen, D. Knight, E. Lesona, H. Tlayjeh, F. Svensek, P. J. McGuigan, J. Cole, D. Pogson, M. P. Hilty, J. P. During, M. J. Bailey, E. Paul, B. Ady, K. Ainscough, A. Hunt, S. Monahan, T. Trapani, C. Fahey, R. Bellomo
Summary: In patients with coma who were resuscitated after out-of-hospital cardiac arrest, targeted mild hypercapnia did not lead to better neurologic outcomes at 6 months than targeted normocapnia. There were no significant differences in the incidence of death or adverse events between the two groups.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
