Article
Medicine, General & Internal
Jia-Lin Chen, Yung-Chi Hsu, Go-Shine Huang, Chih-Yuan Lin, Hung-Yen Ke, Po-Shun Hsu, Chi-Hsiang Chung, Chien-Sung Tsai, Tso-Chou Lin
Summary: The purpose of this study was to investigate the effects of nitroglycerin on tissue perfusion during cardiac surgery. The results showed that nitroglycerin use may cause transient profound hypotension, but does not improve cerebral oxygenation, tissue perfusion, and coagulation.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
William L. Holman, Joseph Timpa, James K. Kirklin
Summary: In the mid-20th century, the development of safe cardiopulmonary bypass techniques revolutionized cardiac surgery. Advances in pump and oxygenator designs, along with successful repairs of cardiac malformations, led to the establishment of direct open-heart operations. This historical progression demonstrates the brilliance of engineering and surgical innovation in the field.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Review
Critical Care Medicine
Mathias J. Holmberg, Asger Granfeldt, Anne-Marie Guerguerian, Claudio Sandroni, Cindy H. Hsu, Ryan M. Gardner, Peter C. Lind, Mark A. Eggertsen, Cecilie M. Johannsen, Lars W. Andersen
Summary: This article is a systematic review that compares the use of extracorporeal cardiopulmonary resuscitation (ECPR) with manual or mechanical cardiopulmonary resuscitation during cardiac arrest. The recent randomized trials suggest a potential benefit of ECPR, but the certainty of evidence remains low, and it is unclear which patients might benefit from ECPR.
Article
Pediatrics
Daniel D. Reiff, Randy Q. Cron
Summary: Cytokine storm syndrome (CSS) is a serious condition caused by severe systemic inflammation and immune activation. The use of cytokine-directed therapies, such as interleukin-1 receptor antagonist, has shown promising results in treating CSS in ECMO patients.
Article
Cardiac & Cardiovascular Systems
Cheng Zhao, Xing Hao, Chao Xue, Yichen Zhao, Jie Han, Yixin Jia, Xiaotong Hou, Jiangang Wang
Summary: Acute right ventricular failure is a common and challenging condition in heart transplant recipients. While extracorporeal membrane oxygenation (ECMO) is an effective strategy for its treatment, the outcomes after weaning and during follow up need further investigation. This study aimed to evaluate the right-sided heart function in ECMO survivors following HTx.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Henrik Arthursson, Gunilla Kjellberg, Thomas Tovedal, Fredrik Lennmyr
Summary: The study found that increasing the pump flow during the rewarming phase of cardiopulmonary bypass did not have a significant effect on cerebral autoregulation. However, there were significant individual variations in cerebral autoregulation.
Article
Anesthesiology
Luca Cioccari, Laurent Bitker, Lisa Toh, Douglas Hacking, Salvatore L. Cutuli, Eduardo A. Osawa, Fumitaka Yanase, Thummaporn Naorungroj, Nora Luethi, Adrian Michalopoulos, Shanan Woo, Judy Wang, Glenn M. Eastwood, Laurence Weinberg, Rinaldo Bellomo
Summary: The study revealed that most patients undergoing cardiac surgery on CPB experience prolonged cerebral desaturation after surgery, which remained unresolved even 7 days postoperatively. Further investigation is needed to understand the underlying mechanisms and time to resolution of such cerebral desaturations.
EUROPEAN JOURNAL OF ANAESTHESIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Jawad Salman, Beeke-Alina Bernhard, Fabio Ius, Reza Poyanmehr, Wiebke Sommer, Khalil Aburahma, Hani Alhadidi, Thierry Siemeni, Christian Kuehn, Murat Avsar, Axel Haverich, Gregor Warnecke, Igor Tudorache
Summary: This study aimed to identify risk factors for the need of intra-operative ECMO use in lung transplant patients with pulmonary fibrosis. Factors such as preoperative proof of pulmonary hypertension, mean pulmonary arterial pressure, and pulmonary vascular resistance were identified as risk factors, while increased recipient body surface area and higher cardiac output were protective factors. The post-operative course was found to be more complicated in the ECMO+ group, although long-term survival did not differ significantly among groups.
ANNALS OF THORACIC SURGERY
(2021)
Article
Medicine, Research & Experimental
Patrick Bernhard, Berit Amelie Bretthauer, Sam Joe Brixius, Hannah Buegener, Johannes Elias Groh, Christian Scherer, Domagoj Damjanovic, Joerg Haberstroh, Georg Trummer, Christoph Benk, Friedhelm Beyersdorf, Oliver Schilling, Jan-Steffen Pooth
Summary: This study investigated the effects of cardiac arrest (CA), conventional cardiopulmonary resuscitation (CPR), and extracorporeal cardiopulmonary resuscitation (ECPR) on the serum proteome profiles in a pig model. The results showed significant changes in the serum proteome during resuscitation, including haemolysis, coagulation, inflammation, and cell-death processes. These findings contribute to a better understanding of the underlying mechanisms and may help improve therapeutic options for CA and resuscitation.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Physiology
A. Valerianova, M. Mlcek, O. Kittnar, T. Grus, L. Tejkl, V. Lejsek, J. Malik
Summary: This study investigated the impact of large arteriovenous fistulas on organ perfusion during partial and full Veno-arterial ECMO support. The results showed that opening a large arteriovenous fistula resulted in a decrease in effective systemic blood flow, particularly affecting carotid artery flow and cerebral tissue oxygenation.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Multidisciplinary Sciences
Elise L. Huppert, Sam Parnia
Summary: Cerebral oximetry, which measures regional cerebral oxygen saturation during CPR, has emerged as a potentially beneficial marker of cerebral ischemia. Studies have shown that higher rSO(2) during CPR is associated with improved survival and neurologic outcomes after cardiac arrest.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Tae Wan Kim, Joonghyun Ahn, Jeong-Am Ryu
Summary: In this study, machine learning methods were used to investigate the predictors of poor neurological outcomes in ECPR patients. The results showed that machine learning algorithms demonstrated excellent predictive accuracy for neurological outcomes in ECPR patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Engineering, Biomedical
Mousa Kharnaf, Spencer Hogue, Zachariah Wilkes, James A. A. Reagor, Daniel G. G. Leino, Benjamin Gourley, Leah Rosenfeldt, Qing Ma, Prasad Devarajan, Joseph S. S. Palumbo, James S. S. Tweddell, Farhan Zafar
Summary: This study developed a novel blood-primed murine model of veno-arterial ECMO and demonstrated its good functionality in maintaining oxygenation and perfusion. The model showed stable hemodynamic parameters and adequate blood oxygenation during ECMO. The study also revealed a significant increase in plasma-free hemoglobin and proinflammatory cytokines, as well as early signs of kidney and liver dysfunction during ECMO.
Article
Hematology
Alejandro V. Garcia, Ana Karen Velez, Victoria Surma, Leah R. Jager, Melania M. Bembea
Summary: Low cerebral regional tissue oxygenation (crSO2) is associated with unfavorable neurological outcomes in children requiring extracorporeal membrane oxygenation (ECMO) support. Red blood cell (RBC) transfusion can improve brain oxygenation and crSO2 has been proposed as a noninvasive monitoring tool that could aid in RBC transfusion decision-making. However, how crSO2 responds to RBC transfusion is largely unknown.
Review
Critical Care Medicine
Abdelaziz Farhat, Ryan Ruiyang Ling, Christopher L. Jenks, Wynne Hsing Poon, Isabelle Xiaorui Yang, Xilong Li, Yulun Liu, Cindy Darnell-Bowens, Kollengode Ramanathan, Ravi R. Thiagarajan, Lakshmi Raman
Summary: The study revealed a rapid expansion in the use of extracorporeal cardiopulmonary resuscitation in pediatric patients, with an overall survival rate of 46% and a 30% rate of favorable neurologic outcomes.
CRITICAL CARE MEDICINE
(2021)
Letter
Anesthesiology
M. J. Bennett, C. Brodie, N. M. Idris, A. El-Kheir, S. Asopa, P. Robbins
BRITISH JOURNAL OF ANAESTHESIA
(2016)
Letter
Anesthesiology
J. M. A. Vassallo, M. J. Bennett
Letter
Anesthesiology
M. J. Bennett, J. M. A. Vassallo
Editorial Material
Cardiac & Cardiovascular Systems
Samer Bazerbashi, Jaime Villaquiran, Mark Bennett, Michael Jonathan Unsworth-White, Joe Rahamim
ANNALS OF THORACIC SURGERY
(2008)
Article
Critical Care Medicine
Matthew M. Ward, Andrew M. McEwen, Peter M. Robbins, Mark J. Bennett
INTENSIVE CARE MEDICINE
(2009)
Article
Cardiac & Cardiovascular Systems
Anil John, Mark Bennett, Clinton Lloyd, Simon Allen
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2010)
Article
Cardiac & Cardiovascular Systems
Mark J. Bennett, Cha Rajakaruna, Samer Bazerbashi, Gerry Webb, Mayam Gomez-Cano, Clinton Lloyd
INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
(2013)
Article
Engineering, Biomedical
Mark J. Bennett, Sian Hodgkiss, Clinton T. Lloyd, Gerry Webb
INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS
(2019)
Article
Cardiac & Cardiovascular Systems
Gianni D. Angelini, Barnaby C. Reeves, Jonathan Evans, Lucy A. Culliford, Laura Collett, Chris A. Rogers, Elizabeth Stokes, Kyriakos Anastasiadis, Polychronis Antonitsis, Thierry Carrel, Dorothee Keller, Andreas Liebold, Fatma Ashkanani, Aschraf El-Essawi, Ingo Breitenbach, Clinton Lloyd, Mark Bennett, Alex Cale, Lindsay Mclean, Serdar Gunaydin, Eren Gunertem, Farouk Oueida, Ibrahim Yassin, Cyril Serrick, Vivek Rao, Marco Moscarelli, Ignazzo Condello, Prakash Punjabi, Cha Rajakaruna, Daniel Bone, William Lansdown, Narain Moorjani, Sarah Dennis
Summary: The COMICS trial is a multi-center, international study comparing different types of minimally invasive extracorporeal circulation with conventional extracorporeal circulation in cardiac surgery patients in terms of post-operative complications. With 603 patients randomized, the recruitment for the trial is progressing well.
Review
Cardiac & Cardiovascular Systems
Kyriakos Anastasiadis, Polychronis Antonitsis, John Murkin, Cyril Serrick, Serdar Gunaydin, Aschraf El-Essawi, Mark Bennett, Gabor Erdoes, Andreas Liebold, Prakash Punjabi, Konstantinos C. Theodoropoulos, Bob Kiaii, Alexander Wahba, Filip de Somer, Adrian Bauer, Alexander Kadner, Wim van Boven, Helena Argiriadou, Apostolos Deliopoulos, Robert A. Baker, Ingo Breitenbach, Can Ince, Pascal Starinieri, Hansjoerg Jenni, Vadim Popov, Narain Moorjani, Marco Moscarelli, Marco Di Eusanio, Alex Cale, Oz Shapira, Christophe Baufreton, Ignazio Condello, Frank Merkle, Marco Stehouwer, Christof Schmid, Marco Ranucci, Gianni Angelini, Thierry Carrel
Summary: The 2016 MiECTiS position paper laid the groundwork for minimal invasive perfusion and related technologies by promoting a common language between cardiac surgeons, anesthesiologists, and perfusionists. The current expert consensus document provides updates in areas with new evidence, recognizing modular minimal invasive extracorporeal circulation (MiECC) as a safe and effective perfusion technique. MiECC increases biocompatibility and ensures perfusion safety in all adult cardiac surgical procedures. MiECC strategies, combining reduced surgical trauma with minimal physiological derangements, advance minimal invasive cardiac surgery (MICS) and offer evidence-based clinical benefits.
Article
Critical Care Medicine
Stuart Gallacher, Doyo Enki, Sian Stevens, Mark J. Bennett
INTENSIVE CARE MEDICINE EXPERIMENTAL
(2017)
Review
Anesthesiology
Mark Bennett
ANAESTHESIA AND INTENSIVE CARE MEDICINE
(2007)
Article
Critical Care Medicine
AJ Lee, R Eve, MJ Bennett
INTENSIVE CARE MEDICINE
(2006)
Meeting Abstract
Critical Care Medicine
SF Dudnikov, RD Walker, MJ Bennett
INTENSIVE CARE MEDICINE
(2003)
