Article
Medicine, General & Internal
Luca Koechlin, Brigitta Gahl, Jules Miazza, Urs Zenklusen, Bejtush Rrahmani, Ion Vasiloi, David Santer, Denis Berdajs, Friedrich S. Eckstein, Oliver Reuthebuch
Summary: This study aimed to analyze the performance of minimal invasive extracorporeal circulation (MiECC) with Microplegia in patients with recent myocardial infarction (MI) undergoing urgent coronary artery bypass grafting (CABG) surgery. The results showed that the use of MiECC with Microplegia in urgent CABG surgery is feasible and safe, providing a straightforward intraoperative setting.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Alistair G. Royse, Rinaldo Bellomo, Colin F. Royse, Sandy Clarke-Errey, Stuart Boggett, Thomas Kelly, Hugh S. Paterson
Summary: Two different surgical methods for total arterial coronary revascularization of three coronary territory disease showed no significant difference in survival rates among younger patients.
ANNALS OF THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Jacek Kwiecinski, Evangelos Tzolos, Alexander J. Fletcher, Jennifer Nash, Mohammed N. Meah, Sebastien Cadet, Philip D. Adamson, Kajetan Grodecki, Nikhil Joshi, Michelle C. Williams, Edwin J. R. van Beek, Chi Lai, Adriana A. S. Tavares, Mark G. MacAskill, Damini Dey, Andrew H. Baker, Jonathon Leipsic, Daniel S. Berman, Stephanie L. Sellers, David E. Newby, Marc R. Dweck, Piotr J. Slomka
Summary: This study aimed to investigate the potential of F-18-sodium fluoride (F-18-NaF) positron emission tomography (PET) in identifying graft vasculopathy and to examine the impact of coronary artery bypass graft (CABG) surgery on the activity and progression of native coronary artery disease.
JACC-CARDIOVASCULAR IMAGING
(2022)
Review
Cardiac & Cardiovascular Systems
Lauren Kari Dixon, Umme Akberali, Ettorino Di Tommaso, Sarah J. George, Thomas W. Johnson, Vito Domenico Bruno
Summary: Compared with coronary artery bypass grafting (CABG), hybrid coronary revascularization (HCR) has a slightly higher short-term mortality but the difference is not significant in patients with multi-vessel coronary artery disease (MCAD). Similar rates of mid-term survival and other short-term post-operative complications were found between the two groups. HCR has shorter intensive care unit stays and reduced requirement for blood transfusion.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Donald S. Likosky, Raymond J. Strobel, Xiaoting Wu, Robert S. Kramer, Baron L. Hamman, James K. Brevig, Michael P. Thompson, Amir A. Ghaferi, Min Zhang, Eric J. Lehr
Summary: This study evaluated whether interhospital variation in mortality rates for coronary artery bypass grafting was driven by complications and failure to rescue. The study found a positive correlation between hospital failure to rescue rates and complications, suggesting that early recognition and management of complications are important factors in improving the success of coronary artery bypass grafting.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Flemming Javier Olsen, Soren Lindberg, Sune Pedersen, Allan Iversen, Filip Soeskov Davidovski, Soren Galatius, Thomas Fritz-Hansen, Gunnar Hilmar Gislason, Peter Sogaard, Rasmus Mogelvang, Tor Biering-Sorensen
Summary: The study found that GLS is an independent predictor of long-term outcomes after coronary artery bypass grafting, especially among patients with preserved left ventricular ejection fraction.
Article
Cardiac & Cardiovascular Systems
Jason M. Ali, Maksym Kovzel, Eve McPhilimey, Simon Colah, Ravi De Silva, Narain Moorjani
Summary: The study showed that using minimally invasive extracorporeal circulation for coronary artery bypass grafting can reduce operative times, blood loss, blood transfusion requirements, incidence of acute kidney injury, and result in significant cost savings.
Review
Cardiac & Cardiovascular Systems
Nicholas W. S. Chew, Jin Hean Koh, Cheng Han Ng, Darren Jun Hao Tan, Jie Ning Yong, Chaoxing Lin, Oliver Zi-Hern Lim, Yip Han Chin, Denzel Ming Wei Lim, Koo Hui Chan, Poay-Huan Loh, Adrian Low, Chi-Hang Lee, Huay-Cheem Tan, Mark Chan
Summary: This study conducted a two-stage meta-analysis using reconstructed individual patient data to compare long-term mortality between coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI) for patients with multivessel disease (MVD) without left main (LM) involvement. The results showed that CABG had a lower cumulative all-cause mortality compared to PCI for MVD patients without LM involvement. However, in patients with moderate to high SYNTAX score, PCI had a significantly higher 10-year all-cause mortality compared to CABG.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Ho Young Hwang, Jin Chul Paeng, Jeehoon Kang, Myoung-jin Jang, Ki-Bong Kim
Summary: The study found that graft occlusion during the 5 years after coronary artery bypass grafting was associated with the functional significance of coronary artery stenosis, particularly when the stenosis degree was not severe.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Geriatrics & Gerontology
Ajar Kochar, Salil V. Deo, Brian Charest, Fanny Peterman-Rocha, Yakov Elgudin, Danny Chu, Robert W. Yeh, Sunil V. Rao, Dae H. Kim, Jane A. Driver, Daniel E. Hall, Ariela R. Orkaby
Summary: Frailty is prevalent among US veterans undergoing coronary artery bypass grafting (CABG) and is associated with worse mid-term outcomes. There may be an opportunity to improve outcomes by identifying and mitigating frailty before surgery.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Clinical Neurology
Kok Wai Giang, Anders Jeppsson, Martin Karlsson, Emma C. Hansson, Aldina Pivodic, Ingmar Skoog, Martin Lindgren, Susanne J. Nielsen
Summary: Overall, the long-term risk for all-cause dementia does not differ significantly between CABG patients and the general population. Younger patients have a higher risk compared to controls, while older patients have a lower risk.
ALZHEIMERS & DEMENTIA
(2021)
Article
Cardiac & Cardiovascular Systems
Zhuoming Zhou, Jiantao Chen, Guangguo Fu, Xiaodong Zhuang, Jian Hou, Sida Chen, Suiqing Huang, Yuan Yue, Liqun Shang, Keke Wang, Linhua Lv, Mengya Liang, Zhongkai Wu
Summary: The study found that among patients undergoing CABG, those with higher post-operative systolic blood pressure variability (BPV) were at increased risk of early mortality, while the association with late mortality was not significant. Post-operative BPV can assist clinicians in identifying patients with potential hemodynamic instability and guiding timely clinical decisions.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
William B. Keeling, Jose Binongo, Jane Wei, Bradley G. Leshnower, Woodrow Farrington, Michael E. Halkos
Summary: This study examines the national trends in emergency CABG and finds that the volume of these surgeries has declined over time, while the rates of postoperative complications have also decreased.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Oliver J. Liakopoulos, Elmar W. Kuhn, Martin Hellmich, Markus Schloemicher, Justus Strauch, Wilko Reents, Anno Diegeler, Matthias Thielmann, Daniel Wendt, Jochen Boergermann, Jan F. Gummert, Christian Stoppe, Andreas Goetzenich, Sven Martens, Hermann Reichenspurner, Jens Wippermann, Hannes Reuter, Yeong-Hoon Choi, Thorsten Wahlers
Summary: This study aimed to analyze the effects of high-dose statin therapy before surgical revascularization. The results showed that additional statin loading before surgery did not reduce the rate of major adverse cardiac and cerebrovascular events (MACCE) occurring within 30 days.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Francesca Colo, Federico Cammertoni, Marialisa Nesta, Pietro Caliandro, Piergiorgio Bruno, Massimo Massetti, Aldobrando Broccolini
Summary: This study reports two cases of extensive infarction in the corpus callosum and other brain watershed areas following coronary artery bypass grafting (CABG) on extracorporeal circulation (ECC). These cases diverge from classical brain watershed infarcts and highlight the need for further research on the complex response of brain circulation and metabolism during heart surgery with ECC.
Article
Cardiac & Cardiovascular Systems
Gianni D. Angelini, Barnaby C. Reeves, Jonathan Evans, Lucy A. Culliford, Laura Collett, Chris A. Rogers, Elizabeth Stokes, Kyriakos Anastasiadis, Polychronis Antonitsis, Thierry Carrel, Dorothee Keller, Andreas Liebold, Fatma Ashkanani, Aschraf El-Essawi, Ingo Breitenbach, Clinton Lloyd, Mark Bennett, Alex Cale, Lindsay Mclean, Serdar Gunaydin, Eren Gunertem, Farouk Oueida, Ibrahim Yassin, Cyril Serrick, Vivek Rao, Marco Moscarelli, Ignazzo Condello, Prakash Punjabi, Cha Rajakaruna, Daniel Bone, William Lansdown, Narain Moorjani, Sarah Dennis
Summary: The COMICS trial is a multi-center, international study comparing different types of minimally invasive extracorporeal circulation with conventional extracorporeal circulation in cardiac surgery patients in terms of post-operative complications. With 603 patients randomized, the recruitment for the trial is progressing well.
Expression of Concern
Cardiac & Cardiovascular Systems
Kyriakos Anastasiadis, Polychronis Antonitsis, Stephen Westaby, Ajan Reginald, Sabena Sultan, Argirios Doumas, George Efthimiadis, Martin John Evans
Summary: The Editor-in-Chief has expressed concern about this article.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Helena Argiriadou, Polychronis Antonitsis, Anna Gkiouliava, Evangelia Papapostolou, Apostolos Deliopoulos, Kyriakos Anastasiadis
Summary: The study investigated the effect of contemporary minimal invasive extracorporeal circulation (MiECC) on coagulation parameters during cardiac surgery. The results showed that MiECC preserves clot quality throughout surgery, leading to minimal postoperative bleeding and restricted use of blood products and coagulation factors.
Letter
Cardiac & Cardiovascular Systems
Kyriakos Anastasiadis, Polychronis Antonitsis, Apostolos Deliopoulos, Helena Argiriadou
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2021)
Review
Respiratory System
Kyriakos Anastasiadis, Polychronis Antonitsis, Apostolos Deliopoulos, Helena Argiriadou
Summary: The development of minimally invasive cardiac surgery aims to reduce surgical stress triggered by full median sternotomy, minimize surgical trauma, improve recovery, and lower morbidity. Extracorporeal circulation is fundamental to most MICS procedures, with advancements in perfusion techniques enabling the development of MICS. Less invasive cardiopulmonary bypass techniques focus on facilitating demanding surgical maneuvers rather than minimizing invasiveness, leading to increased CPB duration for MICS procedures. Minimal invasive Extracorporeal Circulation (MiECC) represents a major breakthrough in perfusion, translating to improved clinical outcomes and end-organ protection. Integration of MiECC can advance MICS towards a more physiologic approach to cardiac surgery.
JOURNAL OF THORACIC DISEASE
(2021)
Review
Cardiac & Cardiovascular Systems
Kyriakos Anastasiadis, Polychronis Antonitsis, Christos Asteriou, Apostolos Deliopoulos, Helena Argiriadou
Summary: Despite concerns about air handling and volume management, the study demonstrates the safety and technical feasibility of using modular MiECC in all cardiac surgical procedures. The results showed a high technical success rate and a low conversion rate to an open circuit, with no clinical adverse events related to MiECC identified.
Editorial Material
Cardiac & Cardiovascular Systems
John M. Murkin, Cyril Serrick, Polychronis Antonitsis, Kyriakos Anastasiadis, Prakash P. Punjabi
Editorial Material
Cardiac & Cardiovascular Systems
Kyriakos Anastasiadis, Polychronis Antonitsis, Apostolos Deliopoulos, Helena Argiriadou
Article
Cardiac & Cardiovascular Systems
Theo M. M. H. de By, Felix Schoenrath, Kevin M. Veen, Paul Mohacsi, Julia Stein, Khalid M. M. Alkhamees, Kyriakos Anastasiadis, Alexander Berhnardt, Friedhelm Beyersdorf, Kadir Caliskan, David Reineke, Kevin Damman, Arnt Fiane, Angeliki Gkouziouta, Can Gollmann-Tepekoeylue, Gustafsson Finn, Michal Hulman, Attilio Iacovoni, Antonio Loforte, Bela Merkely, Francesco Musumeci, Petr Nemec, Ivan Netuka, Mustafa Ozbaran, Evgenij Potapov, Yuri Pya, Gregorio Rabago, Faiz Ramjankhan, Hermann Reichenspurner, Diyar Saeed, Elena Sandoval, Bernard Stockman, Marc Vanderheyden, Laurens Tops, Thorsten Wahlers, Michael Zembala, Daniel Zimpfer, Thierry Carrel, Jan Gummert, Bart Meyns
Summary: The study reviewed outcomes of patients receiving mechanical circulatory support in different implant eras, finding changes in patient characteristics and outcomes between periods. Overall, mortality, transplant rates, and probability of weaning at 5 years post-implant were 55%, 25%, and 2% respectively. Major infections mainly occurred in the early phase post-implant.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Review
Anatomy & Morphology
Christos Tsiouris, Nikolaos Lazaridis, Maria Piagkou, Fabrice Duparc, Ioannis Antonopoulos, Polychronis Antonitsis, Konstantinos Natsis
Summary: The prevalence of left-sided aortic arch (LSAA) variants and their detection are influenced by the subjects' geographical region and the technology of multidetector computed tomography (MDCT) scanners. Further research is required due to heterogeneity among studies.
SURGICAL AND RADIOLOGIC ANATOMY
(2022)
Review
Cardiac & Cardiovascular Systems
Kyriakos Anastasiadis, Polychronis Antonitsis, John Murkin, Cyril Serrick, Serdar Gunaydin, Aschraf El-Essawi, Mark Bennett, Gabor Erdoes, Andreas Liebold, Prakash Punjabi, Konstantinos C. Theodoropoulos, Bob Kiaii, Alexander Wahba, Filip de Somer, Adrian Bauer, Alexander Kadner, Wim van Boven, Helena Argiriadou, Apostolos Deliopoulos, Robert A. Baker, Ingo Breitenbach, Can Ince, Pascal Starinieri, Hansjoerg Jenni, Vadim Popov, Narain Moorjani, Marco Moscarelli, Marco Di Eusanio, Alex Cale, Oz Shapira, Christophe Baufreton, Ignazio Condello, Frank Merkle, Marco Stehouwer, Christof Schmid, Marco Ranucci, Gianni Angelini, Thierry Carrel
Summary: The 2016 MiECTiS position paper laid the groundwork for minimal invasive perfusion and related technologies by promoting a common language between cardiac surgeons, anesthesiologists, and perfusionists. The current expert consensus document provides updates in areas with new evidence, recognizing modular minimal invasive extracorporeal circulation (MiECC) as a safe and effective perfusion technique. MiECC increases biocompatibility and ensures perfusion safety in all adult cardiac surgical procedures. MiECC strategies, combining reduced surgical trauma with minimal physiological derangements, advance minimal invasive cardiac surgery (MICS) and offer evidence-based clinical benefits.
Article
Cardiac & Cardiovascular Systems
Anna Gkiouliava, Helena Argiriadou, Polychronis Antonitsis, Antonis Goulas, Evangelia Papapostolou, Despoina Sarridou, Georgios T. Karapanagiotidis, Kyriakos Anastasiadis
Summary: Individualized heparin monitoring and management can reduce the protamine dose used in cardiac surgery with a reduced anticoagulation strategy, thereby reducing the risk of coagulation complications.
