4.4 Meeting Abstract

Using the UK renal registry for a clinical trial in dialysis patients: the example of SIMPLIFIED

Journal

TRIALS
Volume 16, Issue -, Pages -

Publisher

BIOMED CENTRAL LTD
DOI: 10.1186/1745-6215-16-S2-O15

Keywords

-

Ask authors/readers for more resources

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.4
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Article Medicine, General & Internal

High water vs. ad libitum water intake for autosomal dominant polycystic kidney disease: a randomized controlled feasibility trial

R. El-Damanawi, M. Lee, T. Harris, L. B. Cowley, S. Bond, H. Pavey, R. N. Sandford, I. B. Wilkinson, F. E. Karet Frankl, T. F. Hiemstra

QJM-AN INTERNATIONAL JOURNAL OF MEDICINE (2020)

Article Rheumatology

Rituximab as therapy to induce remission after relapse in ANCA-associated vasculitis

Rona M. Smith, Rachel Bronwen Jones, Ulrich Specks, Simon Bond, Marianna Nodale, Reem Aljayyousi, Jacqueline Andrews, Annette Bruchfeld, Brian Camilleri, Simon Carette, Chee Kay Cheung, Vimal Derebail, Tim Doulton, Lindsy Forbess, Shouichi Fujimoto, Shunsuke Furuta, Ora Gewurz-Singer, Lorraine Harper, Toshiko Ito-Ihara, Nader Khalidi, Rainer Klocke, Curry Koening, Yoshinori Komagata, Carol Langford, Peter Lanyon, Raashid Ahmed Luqmani, Hirofumi Makino, Carole McAlear, Paul Monach, Larry W. Moreland, Kim Mynard, Patrick Nachman, Christian Pagnoux, Fiona Pearce, Chen Au Peh, Charles Pusey, Dwarakanathan Ranganathan, Rennie L. Rhee, Robert Spiera, Antoine G. Sreih, Vladimir Tesar, Giles Walters, Michael H. Weisman, Caroline Wroe, Peter Merkel, David Jayne

ANNALS OF THE RHEUMATIC DISEASES (2020)

Article Medicine, Research & Experimental

muLTi-Arm Therapeutic study in pre-ICu patients admitted with Covid-19-Experimental drugs and mechanisms (TACTIC-E): A structured summary of a study protocol for a randomized controlled trial

Ing Ni Lu, Spoorthy Kulkarni, Marie Fisk, Michalis Kostapanos, Edward Banham-Hall, Sonakshi Kadyan, Simon Bond, Sam Norton, Andrew Cope, James Galloway, Frances Hall, David Jayne, Ian B. Wilkinson, Joseph Cheriyan

TRIALS (2020)

Letter Medicine, Research & Experimental

Repurposed immunomodulatory drugs for Covid-19 in pre-ICu patients - mulTi-Arm Therapeutic study in pre-ICu patients admitted with Covid-19-Repurposed Drugs (TACTIC-R): A structured summary of a study protocol for a randomised controlled trial

Spoorthy Kulkarni, Marie Fisk, Michalis Kostapanos, Edward Banham-Hall, Simon Bond, Elena Hernan-Sancho, Sam Norton, Joseph Cheriyan, Andrew Cope, James Galloway, Frances Hall, David Jayne, Ian B. Wilkinson

TRIALS (2020)

Article Radiology, Nuclear Medicine & Medical Imaging

A meta-analysis comparing the diagnostic performance of abbreviated MRI and a full diagnostic protocol in breast cancer

G. C. Baxter, A. Selamoglu, J. W. Mackay, S. Bond, E. Gray, F. J. Gilbert

Summary: The study aimed to compare the diagnostic performance of abbreviated magnetic resonance imaging (ABB-MRI) and full diagnostic protocol MRI (FDP-MRI) in breast cancer. Results showed comparable diagnostic performance of ABB-MRI and FDP-MRI in both screening and enriched cohorts, with no significant differences in sensitivity or specificity.

CLINICAL RADIOLOGY (2021)

Article Medicine, General & Internal

Trial of Dexamethasone for Chronic Subdural Hematoma

Peter J. Hutchinson, Ellie Edlmann, Diederik Bulters, Ardalan Zolnourian, Patrick Holton, Nigel Suttner, Kevin Agyemang, Simon Thomson, Ian A. Anderson, Yahia Z. Al-Tamimi, Duncan Henderson, Peter C. Whitfield, Monica Gherle, Paul M. Brennan, Annabel Allison, Eric P. Thelin, Silvia Tarantino, Beatrice Pantaleo, Karen Caldwell, Carol Davis-Wilkie, Harry Mee, Elizabeth A. Warburton, Garry Barton, Aswin Chari, Hani J. Marcus, Andrew T. King, Antonio Belli, Phyo K. Myint, Ian Wilkinson, Thomas Santarius, Carole Turner, Simon Bond, Angelos G. Kolias

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Urology & Nephrology

Developing a patient-centred tool for pain measurement and evaluation in autosomal dominant polycystic kidney disease

Ragada El-Damanawi, Michael Lee, Tess Harris, Laura B. Cowley, Ingrid Scholtes, Simon Bond, Richard N. Sandford, Ian B. Wilkinson, Niek F. Casteleijn, Marie C. Hogan, Fiona E. Karet Frankl, Thomas F. Hiemstra

Summary: Pain is a common symptom for ADPKD patients, but has been poorly studied and managed. Developing an ADPKD-specific pain assessment tool can facilitate pain research and provide valuable tools for future studies on ADPKD pain.

CLINICAL KIDNEY JOURNAL (2021)

Article Pediatrics

Real-time continuous glucose monitoring in preterm infants (REACT): an international, open-label, randomised controlled trial

Kathryn Beardsall, Lynn Thomson, Catherine Guy, Isabel Iglesias-Platas, Mirjam M. van Weissenbruch, Simon Bond, Annabel Allison, Sungwook Kim, Stavros Petrou, Beatrice Pantaleo, Roman Hovorka, David Dunger

Summary: The study found that using real-time continuous glucose monitoring can reduce the risk of prolonged or severe hyperglycaemia and hypoglycaemia in preterm infants. Further research is needed to determine optimal glucose targets, strategies to achieve them, and the potential impact on long-term health outcomes.

LANCET CHILD & ADOLESCENT HEALTH (2021)

Article Peripheral Vascular Disease

Mechanisms Underlying Vascular Endothelial Growth Factor Receptor Inhibition-Induced Hypertension The HYPAZ Trial

Kaisa M. Maki-Petaja, Adam McGeoch, Lucy L. Yang, Annette Hubsch, Carmel M. McEniery, Paul A. R. Meyer, Fraz Mir, Parag Gajendragadkar, Nicola Ramenatte, Gayathri Anandappa, Sara Santos Franco, Simon J. Bond, Carola-Bibiane Schonlieb, Yoeri Boink, Christoph Brune, Ian B. Wilkinson, Duncan Jodrell, Joseph Cheriyan

Summary: The study found that in patients receiving the VEGF inhibitor pazopanib, the drug led to hypertension, possibly through increasing peripheral vascular resistance and reducing microvascular density and diameter.

HYPERTENSION (2021)

Article Cardiac & Cardiovascular Systems

Innate Lymphoid Cells Promote Recovery of Ventricular Function After Myocardial Infarction

Xian Yu, Stephen A. Newland, Tian X. Zhao, Yuning Lu, Andrew S. Sage, Yanyi Sun, Rouchelle S. Sriranjan, Marcella K. L. Ma, Brian Y. H. Lam, Meritxell Nus, James E. Harrison, Simon J. Bond, Xiang Cheng, Jean-Sebastien Silvestre, James H. F. Rudd, Joseph Cheriyan, Ziad Mallat

Summary: ILC2s play a critical role in cardiac healing and improvement of heart function after myocardial infarction. Activation of ILC2 using low-dose IL-2 could be a novel therapeutic strategy to promote a reparative response after MI.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2021)

Article Medicine, General & Internal

Study protocol: Minimum effective low dose: anti-human thymocyte globulin (MELD-ATG): phase II, dose ranging, efficacy study of antithymocyte globulin (ATG) within 6 weeks of diagnosis of type 1 diabetes

Charlotte S. Wilhelm-Benartzi, Sarah E. Miller, Sylvaine Bruggraber, Diane Picton, Mark Wilson, Katrina Gatley, Anita Chhabra, M. Loredana Marcovecchio, A. Emile J. Hendriks, Hilde Morobe, Piotr Jaroslaw Chmura, Simon Bond, Barbel Aschemeier-Fuchs, Mikael Knip, Timothy Tree, Lut Overbergh, Jaivier Pall, Olivier Arnaud, Michael J. Haller, Almut Nitsche, Anke M. Schulte, Chantal Mathieu, Adrian Mander, David Dunger

Summary: MELD-ATG is a multicenter trial for 5-25 year old patients with T1D, aiming to investigate the impact of different ATG treatment doses on insulin production and blood sugar control, with effectiveness evaluation over a 12-month period.

BMJ OPEN (2021)

Article Medicine, General & Internal

Early phase clinical trials extension to guidelines for the content of statistical analysis plans

Victoria Homer, Christina Yap, Simon Bond, Jane Holmes, Deborah Stocken, Katrina Walker, Emily J. Robinson, Graham Wheeler, Sarah Brown, Samantha Hinsley, Matthew Schipper, Christopher J. Weir, Khadija Rantell, Thomas Prior, Ly-Mee Yu, John Kirkpatrick, Alun Bedding, Carrol Gamble, Piers Gaunt

Summary: This paper presents guidelines for the content of statistical analysis plans for early phase clinical trials. These guidelines specify the minimum reporting analysis requirements by providing extensions and modifications to existing guidance based on a review by various stakeholders.

BMJ-BRITISH MEDICAL JOURNAL (2022)

Article Medicine, General & Internal

Visualising harms in publications of randomised controlled trials: consensus and recommendations

Rachel Phillips, Suzie Cro, Graham Wheeler, Simon Bond, Tim P. Morris, Siobhan Creanor, Catherine Hewitt, Sharon Love, Andre Lopes, Iryna Schlackow, Carrol Gamble, Graeme MacLennan, Chris Habron, Anthony C. Gordon, Nikhil Vergis, Tianjing Li, Riaz Qureshi, Colin C. Everett, Jane Holmes, Amanda Kirkham, Clare Peckitt, Sarah Pirrie, Norin Ahmed, Laura Collett, Victoria Cornelius

Summary: This study aims to improve the communication of harm outcomes in publications of randomised controlled trials through the development of recommendations for visually presenting harm outcomes. Through a consensus study, experts in clinical trials identified and recommended 10 visualisations, along with a decision tree to assist trialists in choosing appropriate visualisations. Visualisations provide a powerful tool for communicating harm in clinical trials, offering clearer presentation of information and more informative interpretations.

BMJ-BRITISH MEDICAL JOURNAL (2022)

Article Medicine, General & Internal

Azathioprine immunosuppression and disease modification in Parkinson's disease (AZA-PD): a randomised double-blind placebo-controlled phase II trial protocol

Julia C. Greenland, Emma Cutting, Sonakshi Kadyan, Simon Bond, Anita Chhabra, Caroline H. Williams-Gray

BMJ OPEN (2020)

Meeting Abstract Allergy

How Reaction Severity Is Affected By Cofactors And Repeat Challenges: A Prospective Study Of Peanut Allergic Adults

Shelley Dua, James DOwey, Monica Ruiz Garcia, Simon Bond, Stephen Durham, Ian Kimber, Clare Mills, Graham Roberts, Isabel Skypala, James Wason, Pamela Ewan, Robert Boyle, Andrew Clark

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

No Data Available